CO4910131A1

CO4910131A1 - NEW SUBSTITUTED IMIDAZOLE COMPOUNDS

Info

Publication number: CO4910131A1
Application number: CO97000803A
Authority: CO
Inventors: Jerry I Adams
Original assignee: Smithkline Beecham Corp
Priority date: 1997-01-10
Filing date: 1997-01-10
Publication date: 2000-04-24

Abstract

Un compuesto representado por la fórmula (I):R1 es un anillo de 4-pirimidinilo sustituido con C1-4 alcoxi y es sustituido opcionalmente adicionalmente e independientemente por C1-4 alquilo, halógeno, hidroxil, C1-4 alcoxi, C1-4 alquiltio, C1-4 alquilsulfinilo, CH2 OR12 , amino, mono y di C1-6 alquilo amino sustituido, N(R10)C(O)Rc o un anillo de N-heterociclilo que tiene de 5 a 7 miembros y contiene opcionalmente un heteroátomo adicional seleccionado de oxígeno, azufre o NR15 ; R1 es fenilo, naft-1-il o naft-2-il, o un heteroarilo, opcionalmente sustituido por uno o dos sustituyentes, cada uno de los cuales es seleccionado independientemente, y que, para un sustituyente de 4-fenilo, 4-naft-1-il, 5-naft-2-il o 6-naft-2-il es halógeno, ciano, nitro (C(Z)NR7 R17 , C(Z)OR16 , (CR10 R20 )v COR12 , SR5 , SOR5 , OR12 C1-4 alquilo sustituido por halo, C1-4 alquilo, ZC(Z)R12 , NR10 C(Z)16 , o (CR10 R20 )vNR10 R20 y que para otras posiciones de sustitución, es halógeno, ciano, C(Z)NR13 R14 , C(Z)OR3 , (CR10 R20 )m"COR3 , S(O)mR3 , OR3 , C1-4 alquilo sustituido por halo, C1-4 alquilo, (CR10 R20 )m"NR10 C(Z)R3 , NR10 S(O)m´R8 , NR10 S(O)m´NR7 R17 , ZC(Z)R3 o (CR10 R20 )m"NR13 R14 ; n es un entero que tiene un valor de 1 a 10; m es 0, o el entero 1 ó 2; m´ es un entero que tiene un valor de 1 ó 2; m" es O, o un entero que tiene un valor de 1 a 5; v es 0, o un entero que tiene un valor de 1 ó 2; R2 es un heterociclilo opcionalmente sustituido, o un medio heterociclil C1-10 alquilo opcionalmente sustituido; Z es oxígeno o azufre; Rc es hidrógeno, C1-6 alquilo, C3-7 cicloalquilo, arilo, arilC1-4 alquilo, heteroarilo, heteroarilC1-4 alquilo, heterociclilo, o heterociclil C1-4 alquilo; R3 es heterociclilo, heterociclil C1-10 alquilo o R8 ; R5 es hidrógeno, C1-4 alquilo, C2-4 alquenilo,...A compound represented by formula (I): R1 is a C1-4alkoxy substituted 4-pyrimidinyl ring and is optionally additionally and independently substituted by C1-4alkyl, halogen, hydroxyl, C1-4alkoxy, C1-4alkylthio , C1-4 alkylsulfinyl, CH2 OR12, amino, mono and di C1-6 amino substituted alkyl, N (R10) C (O) Rc or an N-heterocyclyl ring having 5 to 7 members and optionally containing an additional heteroatom selected from oxygen, sulfur or NR15; R1 is phenyl, naphth-1-yl or naphth-2-yl, or a heteroaryl, optionally substituted by one or two substituents, each of which is independently selected, and which, for a 4-phenyl substituent, 4- naft-1-yl, 5-naft-2-yl or 6-naft-2-yl is halogen, cyano, nitro (C (Z) NR7 R17, C (Z) OR16, (CR10 R20) v COR12, SR5, SOR5, OR12 C1-4 alkyl substituted by halo, C1-4 alkyl, ZC (Z) R12, NR10 C (Z) 16, or (CR10 R20) vNR10 R20 and that for other substitution positions, is halogen, cyano, C (Z) NR13 R14, C (Z) OR3, (CR10 R20) m "COR3, S (O) mR3, OR3, C1-4 halo-substituted alkyl, C1-4 alkyl, (CR10 R20) m" NR10 C ( Z) R3, NR10 S (O) m´R8, NR10 S (O) m´NR7 R17, ZC (Z) R3 or (CR10 R20) m "NR13 R14; n is an integer that has a value from 1 to 10 ; m is 0, or the integer 1 or 2; m´ is an integer that has a value of 1 or 2; m "is O, or an integer that has a value from 1 to 5; v is 0, or an integer having a value of 1 or 2; R2 is an optionally substituted heterocyclyl, or a heterocyclic medium optionally substituted C 1-10 -alkyl; Z is oxygen or sulfur; Rc is hydrogen, C1-6alkyl, C3-7cycloalkyl, aryl, arylC1-4alkyl, heteroaryl, heteroarylC1-4alkyl, heterocyclyl, or heterocyclylC1-4alkyl; R3 is heterocyclyl, heterocyclyl C1-10 alkyl, or R8; R5 is hydrogen, C1-4 alkyl, C2-4 alkenyl, ...