CO4810228A1

CO4810228A1 - DERIVATIVES OF PYRAZOLE PIRIDAZINE, PROCESSES FOR ITS PREPARATION AND PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM

Info

Publication number: CO4810228A1
Application number: CO99005569A
Authority: CO
Inventors: Paul Beswick; Ian Campbell; Mathews Neil; Alan Naylor
Original assignee: Glaxo Group Ltd
Priority date: 1999-02-02
Filing date: 1999-02-02
Publication date: 1999-06-30

Abstract

Los compuestos de la fórmula (I)y derivados farmacéuticamente aceptables de los mismos, en los cuales:R° es halógeno, alquilo de 1 a 6 átomos de carbono, alcoxi de 1 a 6 átomos de carbono, alcoxi de 1 a 6 átomos de carbono substituido por uno o más átomos de flúor, o O(CH2 )n NR4 R5 ;R1 y R2 se seleccionan independientemente de H, alquilo de 1 a 6 átomos de carbono, alquilo de 1 a 6 átomos de carbono substituido por uno o más átomos de flúor, alcoxi de 1 a 6 átomos de carbono, hidroxialquilo de 1 a 6 átomos de carbono, S-alquilo de 1 a 6 átomos de carbono, C(O)H, C(O)alquilo de 1 a 6 átomos de carbono, alquilsulfonilo de 1 a 6 átomos de carbono, alcoxi de 1 a 6 átomos de carbono substituido por uno o más átomos de flúor, O(CH2 )n CO2 -alquilo de 1 a 6 átomos de carbono, O(CH2 )n S-alquilo de 1 a 6 átomos de carbono, (CH2 )n NR4 R5 , (CH2 )n S-alquilo de 1 a 6 átomos de carbono o C(O)NR4 R5 ; con la condición que cuando R° sea un halógeno y esté en la posición 4, al menos uno de R1 y R2 es alquilsulfonilo de 1 a 6 átomos de carbono, alcoxi de 1 a 6 átomos de carbono substituido por uno o más átomos de flúor, O(CH2 )n CO2 -alquilo de 1 a 6 átomos de carbono, O(CH2 )n S-alquilo de 1 a 6 átomos de carbono (CH2 )n NR4 R5 o (CH2 )n S-alquilo de 1 a 6 átomos de carbono, C(O)NR4 R5 ;R3 es alquilo de 1 a 6 átomos de carbono o NH2 ;R4 y R5 se seleccionan independientemente de H, o alquilo de 1 a 6 átomos de carbono o, juntos con el átomo de nitrógeno al cual están unidos, forman un anillo saturado de 4 a 8 miembros; yn es un número de 1 a 4.Compounds of formula (I) and pharmaceutically acceptable derivatives thereof, in which: R ° is halogen, alkyl of 1 to 6 carbon atoms, alkoxy of 1 to 6 carbon atoms, alkoxy of 1 to 6 carbon atoms carbon substituted by one or more fluorine atoms, or O (CH2) n NR4 R5; R1 and R2 are independently selected from H, alkyl of 1 to 6 carbon atoms, alkyl of 1 to 6 carbon atoms substituted by one or more fluorine atoms, alkoxy of 1 to 6 carbon atoms, hydroxyalkyl of 1 to 6 carbon atoms, S-alkyl of 1 to 6 carbon atoms, C (O) H, C (O) alkyl of 1 to 6 atoms of carbon, alkylsulfonyl of 1 to 6 carbon atoms, alkoxy of 1 to 6 carbon atoms substituted by one or more fluorine atoms, O (CH2) n CO2 -alkyl of 1 to 6 carbon atoms, O (CH2) n S -alkyl of 1 to 6 carbon atoms, (CH2) n NR4 R5, (CH2) n S-alkyl of 1 to 6 carbon atoms or C (O) NR4 R5; with the proviso that when R ° is a halogen and is in the 4-position, at least one of R1 and R2 is alkylsulfonyl of 1 to 6 carbon atoms, alkoxy of 1 to 6 carbon atoms substituted by one or more fluorine atoms , O (CH2) n CO2-alkyl of 1 to 6 carbon atoms, O (CH2) n S-alkyl of 1 to 6 carbon atoms (CH2) n NR4 R5 or (CH2) n S-alkyl of 1 to 6 carbon atoms, C (O) NR4 R5; R3 is alkyl of 1 to 6 carbon atoms or NH2; R4 and R5 are independently selected from H, or alkyl of 1 to 6 carbon atoms or, together with the nitrogen atom to which they are attached, they form a 4-8 membered saturated ring; and n is a number from 1 to 4.