CO4761068A1 - NEW ANTAGONISTS NK-2 / NK-3 - Google Patents
NEW ANTAGONISTS NK-2 / NK-3Info
- Publication number
- CO4761068A1 CO4761068A1 CO96061957A CO96061957A CO4761068A1 CO 4761068 A1 CO4761068 A1 CO 4761068A1 CO 96061957 A CO96061957 A CO 96061957A CO 96061957 A CO96061957 A CO 96061957A CO 4761068 A1 CO4761068 A1 CO 4761068A1
- Authority
- CO
- Colombia
- Prior art keywords
- alkyl
- 6alkyl
- aminocarbonyl
- carbonyl
- alkoxy
- Prior art date
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Un compuesto de fórmula (I):o una sal del mismo, o un solvato del mismo, en el cual, Ar es un grupo de arilo o cicloalcadienilo C5-7 opcionalmente sustituido, o un grupo heterocíclico aromático de un solo anillo o de anillos condensados opcionalmente sustituido;R es alquilo C1-6 , cicloalquilo C3-7 , cicloalquil C3-7- alquilo, fenilo o fenil-alquilo C1-6 opcionalmente sustituido, un anillo heteroaromático de 5 miembros opcionalmente sustituido que comprende hasta 4 heteroátomos seleccionados de O y N, hidroxi-alquilo C1-6 , amino-alquilo C1-6 , alquil C1-6 - aminoalquilo, di-alquil C1-6 -aminoalquilo, acil C1-6 -aminoalquilo, alcoxi C1-6 -alquilo, alquil C1-6 -carbonilo, carboxi, alcoxi C1-6 -carbonilo, alcoxi C1-6 - carbonil-alquilo C1-6 , aminocarbonilo, alquil C1-6 - aminocarbonilo, di-alquilC1-6 - aminocarbonilo, halógeno-alquilo C1-6 ; o R es un grupo -(CH2 )p - en el cual p es 2 ó 3, grupo que forma un anillo con un átomo de carbono de Ar.R1 representa hidrógeno o hasta 4 sustituyentes opcionales seleccionados de la lista constituida por: alquilo C1-6 , alquenilo C1-6 , arilo, alcoxi C1-6 , hidroxi, halógeno, nitro, ciano, carboxi, caboxamido, sulfonamido, alcoxi C1-6 - carbonilo, trifluorometilo, aciloxi, ftalimido, amino o mono- y di-alquil C1-6 - amino;R2 representa un resto -O- (CH2 )n -X en el cual X es alquilo sustituido opcionalmente con 1 ó 2 grupos seleccionados de hidroxi y amino; carboxi, ciano, alcoxi C1-6 - carbonilo, aminocarbonilo, mono- o di-alquil C1-6 - aminocarbonilo, aminoalquil C1-6 - aminocarbonilo o mono- o di-alquil C1-6 -aminoalquil C1-6 -aminocarbonilo; o X es un grupo -NX1 X2 ...A compound of formula (I): or a salt thereof, or a solvate thereof, in which, Ar is an optionally substituted C5-7 aryl or cycloalkadienyl group, or a single ring or ring aromatic heterocyclic group optionally substituted condensates; R is C 1-6 alkyl, C 3-7 cycloalkyl, C 3-7 cycloalkyl-alkyl, phenyl or optionally substituted phenyl-C 1-6 alkyl, an optionally substituted 5-membered heteroaromatic ring comprising up to 4 heteroatoms selected from O and N, hydroxy-C1-6alkyl, amino-C1-6alkyl, C1-6alkyl-aminoalkyl, di-C1-6alkyl-aminoalkyl, C1-6alkyl-aminoalkyl, C1-6alkoxy -alkyl, C1-alkyl 6 -carbonyl, carboxy, C1-6-alkoxy -carbonyl, C1-6-alkoxy-carbonyl-C1-6-alkyl, aminocarbonyl, C1-6-alkyl-aminocarbonyl, di-C1-6-aminocarbonyl, halogen-C1-6-alkyl; or R is a group - (CH2) p - in which p is 2 or 3, a ring-forming group with a carbon atom of Ar.R1 represents hydrogen or up to 4 optional substituents selected from the list consisting of: C1-alkyl -6, C1-6 alkenyl, aryl, C1-6 alkoxy, hydroxy, halogen, nitro, cyano, carboxy, caboxamido, sulfonamido, C1-6 alkoxy-carbonyl, trifluoromethyl, acyloxy, phthalimido, amino or mono- and di-alkyl C1-6-amino, R2 represents a residue -O- (CH2) n -X in which X is alkyl optionally substituted with 1 or 2 groups selected from hydroxy and amino; carboxy, cyano, C1-6 alkoxy-carbonyl, aminocarbonyl, mono- or di-C1-6alkyl-aminocarbonyl, amino- C1-6alkyl-aminocarbonyl or mono- or di-C1-6alkyl-C1-6 aminoalkyl-aminocarbonyl; or X is a group -NX1 X2 ...
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT95MI002461 IT1276170B1 (en) | 1995-11-24 | 1995-11-24 | New quinoline 4-carboxamide derivatives - have NK3 and/or NK2 binding activity, useful for treating respiratory, inflammatory gastrointestinal, renal and CNS disorders |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO4761068A1 true CO4761068A1 (en) | 1999-04-27 |
Family
ID=11372596
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO96061957A CO4761068A1 (en) | 1995-11-24 | 1996-11-25 | NEW ANTAGONISTS NK-2 / NK-3 |
Country Status (3)
| Country | Link |
|---|---|
| CO (1) | CO4761068A1 (en) |
| IT (1) | IT1276170B1 (en) |
| ZA (1) | ZA969810B (en) |
-
1995
- 1995-11-24 IT IT95MI002461 patent/IT1276170B1/en active IP Right Grant
-
1996
- 1996-11-22 ZA ZA9609810A patent/ZA969810B/en unknown
- 1996-11-25 CO CO96061957A patent/CO4761068A1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ITMI952461A0 (en) | 1995-11-24 |
| ITMI952461A1 (en) | 1997-05-24 |
| IT1276170B1 (en) | 1997-10-27 |
| ZA969810B (en) | 1998-05-22 |
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