CO4750712A1 - ORGANOMETALLIC ADDITION TO KETONES - Google Patents
ORGANOMETALLIC ADDITION TO KETONESInfo
- Publication number
- CO4750712A1 CO4750712A1 CO96041392A CO96041392A CO4750712A1 CO 4750712 A1 CO4750712 A1 CO 4750712A1 CO 96041392 A CO96041392 A CO 96041392A CO 96041392 A CO96041392 A CO 96041392A CO 4750712 A1 CO4750712 A1 CO 4750712A1
- Authority
- CO
- Colombia
- Prior art keywords
- compound
- formula
- acid
- het
- halo
- Prior art date
Links
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- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
La invención proporciona un procedimiento para preparar un compuesto de la fórmula I o una de sus sales de adición de ácidos o de bases, en la que R es fenilo opcionalmente sustituido por 1 a 3 sustituyentes, seleccionados cada uno independientemente entre halo y trifluorometilo;R1 es alquilo de C1 -C6 ; y "Het" es pirimidinilo opcionalmente sustituido por 1 a 3 sustituyentes, seleccionados cada uno independientemente entre alquilo de C1 -C4 , alcoxi de C1 -C4 , halo, oxo, bencilo y benciloxi, que comprende la reacción de un compuesto de fórmula II en la que R es como se ha definido anteriormente para un compuesto de fórmula (I), con un compuesto de fórmula: III en la que R1 y "Het" son como se ha definido anteriormente para un compuesto de fórmula (I) y X es cloro, bromo o yodo, en presencia de cinc, yodo y/o un ácido de lewis y un disolvente orgánico aprótico: estando seguido dicho procedimiento opcionalmente por la conversión del compuesto de fórmula (I) en una sal de adición de ácidos o de bases del mismo.The invention provides a process for preparing a compound of formula I or one of its acid or base addition salts, wherein R is phenyl optionally substituted by 1 to 3 substituents, each independently selected from halo and trifluoromethyl; R1 it is C1-C6 alkyl; and "Het" is pyrimidinyl optionally substituted by 1 to 3 substituents, each independently selected from C1-C4 alkyl, C1-C4 alkoxy, halo, oxo, benzyl and benzyloxy, comprising the reaction of a compound of formula II in where R is as defined above for a compound of formula (I), with a compound of formula: III where R1 and "Het" are as defined above for a compound of formula (I) and X is chlorine, bromine or iodine, in the presence of zinc, iodine and / or a lewis acid and an aprotic organic solvent: said procedure being optionally followed by the conversion of the compound of formula (I) into an acid or base addition salt of the same.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB95161212 | 1995-08-05 |
Publications (1)
Publication Number | Publication Date |
---|---|
CO4750712A1 true CO4750712A1 (en) | 1999-03-31 |
Family
ID=40930144
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CO96041392A CO4750712A1 (en) | 1995-08-05 | 1996-08-05 | ORGANOMETALLIC ADDITION TO KETONES |
Country Status (1)
Country | Link |
---|---|
CO (1) | CO4750712A1 (en) |
-
1996
- 1996-08-05 CO CO96041392A patent/CO4750712A1/en unknown
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