CO4750712A1 - ORGANOMETALLIC ADDITION TO KETONES - Google Patents

ORGANOMETALLIC ADDITION TO KETONES

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Publication number
CO4750712A1
CO4750712A1 CO96041392A CO96041392A CO4750712A1 CO 4750712 A1 CO4750712 A1 CO 4750712A1 CO 96041392 A CO96041392 A CO 96041392A CO 96041392 A CO96041392 A CO 96041392A CO 4750712 A1 CO4750712 A1 CO 4750712A1
Authority
CO
Colombia
Prior art keywords
compound
formula
acid
het
halo
Prior art date
Application number
CO96041392A
Other languages
Spanish (es)
Inventor
Michael Butters
Alan John Pettman
Julie Ann Harrison
Original Assignee
Pfizer Res & Dev
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Res & Dev filed Critical Pfizer Res & Dev
Publication of CO4750712A1 publication Critical patent/CO4750712A1/en

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  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

La invención proporciona un procedimiento para preparar un compuesto de la fórmula I o una de sus sales de adición de ácidos o de bases, en la que R es fenilo opcionalmente sustituido por 1 a 3 sustituyentes, seleccionados cada uno independientemente entre halo y trifluorometilo;R1 es alquilo de C1 -C6 ; y "Het" es pirimidinilo opcionalmente sustituido por 1 a 3 sustituyentes, seleccionados cada uno independientemente entre alquilo de C1 -C4 , alcoxi de C1 -C4 , halo, oxo, bencilo y benciloxi, que comprende la reacción de un compuesto de fórmula II en la que R es como se ha definido anteriormente para un compuesto de fórmula (I), con un compuesto de fórmula: III en la que R1 y "Het" son como se ha definido anteriormente para un compuesto de fórmula (I) y X es cloro, bromo o yodo, en presencia de cinc, yodo y/o un ácido de lewis y un disolvente orgánico aprótico: estando seguido dicho procedimiento opcionalmente por la conversión del compuesto de fórmula (I) en una sal de adición de ácidos o de bases del mismo.The invention provides a process for preparing a compound of formula I or one of its acid or base addition salts, wherein R is phenyl optionally substituted by 1 to 3 substituents, each independently selected from halo and trifluoromethyl; R1 it is C1-C6 alkyl; and "Het" is pyrimidinyl optionally substituted by 1 to 3 substituents, each independently selected from C1-C4 alkyl, C1-C4 alkoxy, halo, oxo, benzyl and benzyloxy, comprising the reaction of a compound of formula II in where R is as defined above for a compound of formula (I), with a compound of formula: III where R1 and "Het" are as defined above for a compound of formula (I) and X is chlorine, bromine or iodine, in the presence of zinc, iodine and / or a lewis acid and an aprotic organic solvent: said procedure being optionally followed by the conversion of the compound of formula (I) into an acid or base addition salt of the same.

CO96041392A 1995-08-05 1996-08-05 ORGANOMETALLIC ADDITION TO KETONES CO4750712A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB95161212 1995-08-05

Publications (1)

Publication Number Publication Date
CO4750712A1 true CO4750712A1 (en) 1999-03-31

Family

ID=40930144

Family Applications (1)

Application Number Title Priority Date Filing Date
CO96041392A CO4750712A1 (en) 1995-08-05 1996-08-05 ORGANOMETALLIC ADDITION TO KETONES

Country Status (1)

Country Link
CO (1) CO4750712A1 (en)

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