CO2023012549A2 - Monoclonal antibody or antigen-binding fragment thereof that specifically binds to gd2 (gd2 ganglioside), and use thereof - Google Patents
Monoclonal antibody or antigen-binding fragment thereof that specifically binds to gd2 (gd2 ganglioside), and use thereofInfo
- Publication number
- CO2023012549A2 CO2023012549A2 CONC2023/0012549A CO2023012549A CO2023012549A2 CO 2023012549 A2 CO2023012549 A2 CO 2023012549A2 CO 2023012549 A CO2023012549 A CO 2023012549A CO 2023012549 A2 CO2023012549 A2 CO 2023012549A2
- Authority
- CO
- Colombia
- Prior art keywords
- ganglioside
- antigen
- binding fragment
- specifically binds
- monoclonal antibody
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3076—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells against structure-related tumour-associated moieties
- C07K16/3084—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells against structure-related tumour-associated moieties against tumour-associated gangliosides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
- C07K2317/41—Glycosylation, sialylation, or fucosylation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/734—Complement-dependent cytotoxicity [CDC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Pharmacology & Pharmacy (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Cell Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Genetics & Genomics (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
La presente invención se refiere al campo de la biotecnología y la medicina, en particular a un anticuerpo monoclonal o fragmento de unión al antígeno del mismo que se une específicamente al GD2 (gangliósido GD2). La invención se refiere además a ácidos nucleicos que codifican dicho anticuerpo, vectores de expresión, células huésped y métodos para producirlos, métodos para producir los anticuerpos según la invención, composiciones farmacéuticas que comprenden el anticuerpo según la invención, composiciones farmacéuticas que comprenden el anticuerpo según la invención y otros compuestos terapéuticamente activos, métodos para tratar enfermedades o trastornos mediados por GD2, usos de los anticuerpos o composiciones farmacéuticas de los mismos para tratar enfermedades o trastornos mediados por GD2, y usos de los anticuerpos y otros compuestos terapéuticamente activos para tratar enfermedades o trastornos mediados por GD2.The present invention relates to the field of biotechnology and medicine, in particular to a monoclonal antibody or antigen-binding fragment thereof that specifically binds to GD2 (GD2 ganglioside). The invention further relates to nucleic acids encoding said antibody, expression vectors, host cells and methods for producing them, methods for producing the antibodies according to the invention, pharmaceutical compositions comprising the antibody according to the invention, pharmaceutical compositions comprising the antibody according to the invention and other therapeutically active compounds, methods for treating GD2-mediated diseases or disorders, uses of the antibodies or pharmaceutical compositions thereof for treating GD2-mediated diseases or disorders, and uses of the antibodies and other therapeutically active compounds for treating diseases or GD2-mediated disorders.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
RU2021107773A RU2796937C2 (en) | 2021-03-24 | Monoclonal antibody or its antigen-binding fragment which specifically binds to gd2 (gd2 ganglioside) and its use | |
PCT/RU2022/050096 WO2022203552A1 (en) | 2021-03-24 | 2022-03-24 | Monoclonal antibody that specifically binds to gd2 |
Publications (1)
Publication Number | Publication Date |
---|---|
CO2023012549A2 true CO2023012549A2 (en) | 2023-10-09 |
Family
ID=83395963
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CONC2023/0012549A CO2023012549A2 (en) | 2021-03-24 | 2023-09-22 | Monoclonal antibody or antigen-binding fragment thereof that specifically binds to gd2 (gd2 ganglioside), and use thereof |
Country Status (10)
Country | Link |
---|---|
CN (1) | CN117677695A (en) |
AR (1) | AR125219A1 (en) |
CL (1) | CL2023002843A1 (en) |
CO (1) | CO2023012549A2 (en) |
CR (1) | CR20230456A (en) |
EC (1) | ECSP23072412A (en) |
MX (1) | MX2023011246A (en) |
TW (1) | TW202304989A (en) |
UY (1) | UY39687A (en) |
WO (1) | WO2022203552A1 (en) |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2005070967A2 (en) * | 2004-01-22 | 2005-08-04 | Merck Patent Gmbh | Anti-cancer antibodies with reduced complement fixation |
NZ603581A (en) * | 2010-06-19 | 2015-05-29 | Sloan Kettering Inst Cancer | Anti-gd2 antibodies |
WO2014144763A2 (en) * | 2013-03-15 | 2014-09-18 | Memorial Sloan Kettering Cancer Center | High affinity anti-gd2 antibodies |
-
2022
- 2022-03-24 WO PCT/RU2022/050096 patent/WO2022203552A1/en active Application Filing
- 2022-03-24 MX MX2023011246A patent/MX2023011246A/en unknown
- 2022-03-24 CN CN202280024459.8A patent/CN117677695A/en active Pending
- 2022-03-24 UY UY0001039687A patent/UY39687A/en unknown
- 2022-03-24 CR CR20230456A patent/CR20230456A/en unknown
- 2022-03-24 TW TW111111114A patent/TW202304989A/en unknown
- 2022-03-25 AR ARP220100720A patent/AR125219A1/en unknown
-
2023
- 2023-09-22 EC ECSENADI202372412A patent/ECSP23072412A/en unknown
- 2023-09-22 CO CONC2023/0012549A patent/CO2023012549A2/en unknown
- 2023-09-25 CL CL2023002843A patent/CL2023002843A1/en unknown
Also Published As
Publication number | Publication date |
---|---|
CR20230456A (en) | 2023-12-13 |
UY39687A (en) | 2022-08-31 |
CL2023002843A1 (en) | 2024-03-22 |
WO2022203552A1 (en) | 2022-09-29 |
CN117677695A (en) | 2024-03-08 |
ECSP23072412A (en) | 2023-10-31 |
MX2023011246A (en) | 2023-10-30 |
AR125219A1 (en) | 2023-06-28 |
TW202304989A (en) | 2023-02-01 |
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