CO2023007829A2 - Mutaciones en regiones constantes de anticuerpos felinos - Google Patents

Mutaciones en regiones constantes de anticuerpos felinos

Info

Publication number
CO2023007829A2
CO2023007829A2 CONC2023/0007829A CO2023007829A CO2023007829A2 CO 2023007829 A2 CO2023007829 A2 CO 2023007829A2 CO 2023007829 A CO2023007829 A CO 2023007829A CO 2023007829 A2 CO2023007829 A2 CO 2023007829A2
Authority
CO
Colombia
Prior art keywords
mutations
antibody constant
constant regions
feline antibody
feline
Prior art date
Application number
CONC2023/0007829A
Other languages
English (en)
Inventor
Lisa Marie Bergeron
Henry Luis Campos
Sandra Ann Marie Lightle
Original Assignee
Zoetis Services Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zoetis Services Llc filed Critical Zoetis Services Llc
Publication of CO2023007829A2 publication Critical patent/CO2023007829A2/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70535—Fc-receptors, e.g. CD16, CD32, CD64 (CD2314/705F)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/72—Increased effector function due to an Fc-modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

La invención se refiere generalmente a variantes de anticuerpos felinos y usos de estos. Específicamente, la invención se refiere a mutaciones en la región constante de anticuerpo felino para mejorar diversas características.
CONC2023/0007829A 2020-12-18 2023-06-15 Mutaciones en regiones constantes de anticuerpos felinos CO2023007829A2 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202063127313P 2020-12-18 2020-12-18
PCT/US2021/064097 WO2022133252A1 (en) 2020-12-18 2021-12-17 Mutations in feline antibody constant regions

Publications (1)

Publication Number Publication Date
CO2023007829A2 true CO2023007829A2 (es) 2023-07-21

Family

ID=79730576

Family Applications (1)

Application Number Title Priority Date Filing Date
CONC2023/0007829A CO2023007829A2 (es) 2020-12-18 2023-06-15 Mutaciones en regiones constantes de anticuerpos felinos

Country Status (14)

Country Link
EP (1) EP4263596A1 (es)
JP (1) JP2024503212A (es)
KR (1) KR20230121056A (es)
CN (1) CN116547298A (es)
AU (1) AU2021400322A1 (es)
CA (1) CA3202074A1 (es)
CL (1) CL2023001781A1 (es)
CO (1) CO2023007829A2 (es)
EC (1) ECSP23044286A (es)
IL (1) IL303732A (es)
MX (1) MX2023006898A (es)
PE (1) PE20231640A1 (es)
TW (1) TW202233687A (es)
WO (1) WO2022133252A1 (es)

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8308235D0 (en) 1983-03-25 1983-05-05 Celltech Ltd Polypeptides
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US5807715A (en) 1984-08-27 1998-09-15 The Board Of Trustees Of The Leland Stanford Junior University Methods and transformed mammalian lymphocyte cells for producing functional antigen-binding protein including chimeric immunoglobulin
GB8422238D0 (en) 1984-09-03 1984-10-10 Neuberger M S Chimeric proteins
US5225539A (en) 1986-03-27 1993-07-06 Medical Research Council Recombinant altered antibodies and methods of making altered antibodies
US4946778A (en) 1987-09-21 1990-08-07 Genex Corporation Single polypeptide chain binding molecules
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
US6284471B1 (en) 1991-03-18 2001-09-04 New York University Medical Center Anti-TNFa antibodies and assays employing anti-TNFa antibodies
US5698762A (en) 1994-12-09 1997-12-16 Dauerman; Leonard Microwave-assisted pyrolysis of waste polyaromatic hydrocarbons
US20030031671A1 (en) 2001-08-01 2003-02-13 Sydney Welt Methods of treating colon cancer utilizing tumor-specific antibodies
WO2006031370A2 (en) 2004-08-19 2006-03-23 Genentech, Inc. Polypeptide variants with altered effector function
US8546543B2 (en) 2004-11-12 2013-10-01 Xencor, Inc. Fc variants that extend antibody half-life
US8367805B2 (en) 2004-11-12 2013-02-05 Xencor, Inc. Fc variants with altered binding to FcRn
EP2332985A3 (en) 2004-11-12 2012-01-25 Xencor, Inc. Fc variants with altered binding to FcRn
US20110123440A1 (en) * 2005-03-29 2011-05-26 Genevieve Hansen Altered Antibody FC Regions and Uses Thereof
US8790651B2 (en) * 2011-07-21 2014-07-29 Zoetis Llc Interleukin-31 monoclonal antibody
MX2021004313A (es) * 2018-10-18 2021-05-27 Kindred Biosciences Inc Variantes de fc con union alterada al receptor de fc neonatal (fcrn) para uso veterinario.
WO2020116560A1 (ja) * 2018-12-05 2020-06-11 株式会社バイカ・セラピュティクス 抗体のＦｃ領域改変体

Also Published As

Publication number Publication date
AU2021400322A1 (en) 2023-06-22
PE20231640A1 (es) 2023-10-16
CN116547298A (zh) 2023-08-04
ECSP23044286A (es) 2023-07-31
CA3202074A1 (en) 2022-06-23
TW202233687A (zh) 2022-09-01
IL303732A (en) 2023-08-01
CL2023001781A1 (es) 2023-12-22
KR20230121056A (ko) 2023-08-17
WO2022133252A1 (en) 2022-06-23
MX2023006898A (es) 2023-06-26
EP4263596A1 (en) 2023-10-25
JP2024503212A (ja) 2024-01-25

Similar Documents

Publication Publication Date Title
CO2022014695A2 (es) Variantes de anticuerpos caninos
CO2022014684A2 (es) Variantes de anticuerpos felinos
TR201901841T4 (tr) Her antikorlarının sabit dozlaması.
CL2021003218S1 (es) Recortadora de pelo.
EA202191806A1 (ru) Антитело против человеческого il-4ra и его применение
UY28312A1 (es) Pirazolopirimidinas sustituidas con 6-ciclimetilo y 6-alquilmetilo
CO2023004102A2 (es) Variantes de anticuerpos caninos
BR112017024922A2 (pt) stent e método de uso
CL2020001273A1 (es) Emulsiones para el tratamiento tópico de infecciones dérmicas y de infecciones de mucosas.
CO2023007829A2 (es) Mutaciones en regiones constantes de anticuerpos felinos
CO2023004107A2 (es) Variantes de anticuerpos felinos
CO2023007146A2 (es) Variantes de anticuerpos bovinos
EA201992365A1 (ru) Микрофлюидные диффузионные устройства и системы, а также способы их изготовления и применения
CO2023009994A2 (es) Mutaciones en regiones constantes de anticuerpos caninos
EA202192101A1 (ru) Соединения и их применение
BR112022004141A2 (pt) Uso não terapêutico
EA202192532A1 (ru) Мирикизумаб для применения в способе лечения болезни крона
CL2021003175S1 (es) Cortador de pelo.
TR202019577U4 (tr) Abajur bağlanti aparatinda yeni̇li̇k
EA201991614A1 (ru) СПЕЦИФИЧНЫЕ К ИЗОФОРМЕ, ПЕРМИССИВНЫЕ ПО ОТНОШЕНИЮ К КОНТЕКСТУ ИНГИБИТОРЫ TGFβ1 И ИХ ПРИМЕНЕНИЕ
ES1280939Y (es) Dispositivo de iluminación de uso personal.
佐藤紘子 Comparison of the predictive ability of albuminuria and dipstick proteinuria for mortality in the Japanese population: the Yamagata (Takahata) study
TR202104726A2 (tr) Köfte form maki̇nasinda yeni̇li̇k
CL2019003110S1 (es) Botella para perfume.
Левченко Odesa and Novorossiysk University in metric books