CO2019013654A2 - Chimeric antigen receptors targeting flt3 - Google Patents

Chimeric antigen receptors targeting flt3

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Publication number
CO2019013654A2
CO2019013654A2 CONC2019/0013654A CO2019013654A CO2019013654A2 CO 2019013654 A2 CO2019013654 A2 CO 2019013654A2 CO 2019013654 A CO2019013654 A CO 2019013654A CO 2019013654 A2 CO2019013654 A2 CO 2019013654A2
Authority
CO
Colombia
Prior art keywords
flt3
cars
chimeric antigen
antigen receptors
antibodies
Prior art date
Application number
CONC2019/0013654A
Other languages
Spanish (es)
Inventor
Yik Andy Yeung
Barbra Johnson Sasu
Danielle Elizabeth Dettling
Cesar Adolfo Sommer
Moustafa Marc Hamze
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of CO2019013654A2 publication Critical patent/CO2019013654A2/en

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    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A61K39/001154—Enzymes
    • A61K39/001162—Kinases, e.g. Raf or Src
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    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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    • A61K39/46—Cellular immunotherapy
    • A61K39/461—Cellular immunotherapy characterised by the cell type used
    • A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
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    • A61K39/46—Cellular immunotherapy
    • A61K39/463—Cellular immunotherapy characterised by recombinant expression
    • A61K39/4631—Chimeric Antigen Receptors [CAR]
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    • A61K39/46—Cellular immunotherapy
    • A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
    • A61K39/4643—Vertebrate antigens
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    • A61K39/464454—Enzymes
    • A61K39/464462—Kinases, e.g. Raf or Src
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2887—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
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    • A61K2039/515—Animal cells
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    • A61K2039/6056—Antibodies
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
    • A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the cancer treated
    • A61K2239/48—Blood cells, e.g. leukemia or lymphoma
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
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    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
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    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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    • C07K2319/00—Fusion polypeptide
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    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies

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Abstract

Se proporcionan en la presente anticuerpos que se unen específicamente a la tirosina cinasa 3 similar a Fms (FLT3), receptores de antígenos quiméricos (CAR) que se unen específicamente a FLT3 y células inmunitarias modificadas que expresan dichos CAR (por ejemplo, linfocitos T con CAR específicos para FLT3). La invención también proporciona la confección de estos anticuerpos, CAR y células inmunitarias modificadas. La invención también proporciona el uso de dichos anticuerpos, CAR y células inmunitarias modificadas, por ejemplo, para el tratamiento de una afección asociada con células malignas que expresan FLT3 (por ejemplo, cáncer).Provided herein are antibodies that specifically bind to Fms-like tyrosine kinase 3 (FLT3), chimeric antigen receptors (CARs) that specifically bind to FLT3, and modified immune cells that express such CARs (e.g., T lymphocytes with CAR specific for FLT3). The invention also provides for the manufacture of these antibodies, CARs and modified immune cells. The invention also provides the use of such antibodies, CARs and modified immune cells, eg, for the treatment of a condition associated with malignant cells expressing FLT3 (eg, cancer).

CONC2019/0013654A 2017-06-02 2019-12-03 Chimeric antigen receptors targeting flt3 CO2019013654A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201762514574P 2017-06-02 2017-06-02
US201762514634P 2017-06-02 2017-06-02
US201862660908P 2018-04-20 2018-04-20
PCT/US2018/035492 WO2018222935A1 (en) 2017-06-02 2018-05-31 Chimeric antigen receptors targeting flt3

Publications (1)

Publication Number Publication Date
CO2019013654A2 true CO2019013654A2 (en) 2020-01-17

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CONC2019/0013654A CO2019013654A2 (en) 2017-06-02 2019-12-03 Chimeric antigen receptors targeting flt3

Country Status (16)

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US (1) US20230181634A1 (en)
EP (1) EP3630837A1 (en)
JP (2) JP7317718B2 (en)
KR (1) KR20200014777A (en)
CN (1) CN110831970A (en)
AU (1) AU2018278321A1 (en)
BR (1) BR112019024604A2 (en)
CA (1) CA3062328A1 (en)
CO (1) CO2019013654A2 (en)
IL (1) IL270896A (en)
MX (1) MX2019013923A (en)
PE (1) PE20191847A1 (en)
PH (1) PH12019502637A1 (en)
SG (1) SG10202108528QA (en)
TW (2) TWI778068B (en)
WO (1) WO2018222935A1 (en)

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