CO2019002609A2 - Recombinant binding proteins and their uses - Google Patents

Recombinant binding proteins and their uses

Info

Publication number
CO2019002609A2
CO2019002609A2 CONC2019/0002609A CO2019002609A CO2019002609A2 CO 2019002609 A2 CO2019002609 A2 CO 2019002609A2 CO 2019002609 A CO2019002609 A CO 2019002609A CO 2019002609 A2 CO2019002609 A2 CO 2019002609A2
Authority
CO
Colombia
Prior art keywords
recombinant binding
binding proteins
nucleic acids
proteins
recombinant
Prior art date
Application number
CONC2019/0002609A
Other languages
Spanish (es)
Inventor
Ignacio Dolado
Clara Metz
Ulrike Fiedler
Heike Maria Strobel
Original Assignee
Molecular Partners Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Molecular Partners Ag filed Critical Molecular Partners Ag
Publication of CO2019002609A2 publication Critical patent/CO2019002609A2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

Se desvelan nuevas proteínas de unión recombinantes, que comprenden dominios diseñados con repeticiones de anquirina con especificidad de unión para el HER2, y que comprenden dominios diseñados con repeticiones de anquirina con especificidad de unión para la seroalbúmina, así como los ácidos nucleicos que codifican dichas proteínas de unión recombinantes, composiciones farmacéuticas que comprenden dichas proteínas de unión recombinantes o ácidos nucleicos y el uso de dichas proteínas de unión recombinantes, ácidos nucleicos o composiciones farmacéuticas en el tratamiento de enfermedades.New recombinant binding proteins are disclosed, which comprise domains designed with ankyrine repeats with binding specificity for HER2, and which comprise domains designed with anchyrine repeats with binding specificity for serum albumin, as well as the nucleic acids encoding said proteins. recombinant binding agents, pharmaceutical compositions comprising said recombinant binding proteins or nucleic acids and the use of said recombinant binding proteins, nucleic acids or pharmaceutical compositions in the treatment of diseases.

CONC2019/0002609A 2016-09-22 2019-03-21 Recombinant binding proteins and their uses CO2019002609A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP16190221 2016-09-22
PCT/EP2017/073768 WO2018054971A1 (en) 2016-09-22 2017-09-20 Recombinant binding proteins and their use

Publications (1)

Publication Number Publication Date
CO2019002609A2 true CO2019002609A2 (en) 2019-05-31

Family

ID=57046984

Family Applications (1)

Application Number Title Priority Date Filing Date
CONC2019/0002609A CO2019002609A2 (en) 2016-09-22 2019-03-21 Recombinant binding proteins and their uses

Country Status (20)

Country Link
US (2) US10717772B2 (en)
EP (1) EP3515933B9 (en)
JP (1) JP6976335B2 (en)
KR (1) KR102270315B1 (en)
CN (1) CN109790206A (en)
AR (1) AR109680A1 (en)
AU (1) AU2017331329B2 (en)
BR (1) BR112019005587A2 (en)
CA (1) CA3036301C (en)
CL (1) CL2019000729A1 (en)
CO (1) CO2019002609A2 (en)
ES (1) ES2953516T3 (en)
IL (1) IL265489B (en)
MX (1) MX2019003298A (en)
MY (1) MY196882A (en)
NZ (1) NZ751689A (en)
PH (1) PH12019500596A1 (en)
SA (1) SA519401369B1 (en)
WO (1) WO2018054971A1 (en)
ZA (1) ZA201901592B (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2020289383A1 (en) 2019-06-04 2021-12-23 Molecular Partners Ag Designed ankyrin repeat domain with improved stability
AU2020286600A1 (en) * 2019-06-04 2021-12-23 Molecular Partners Ag Recombinant FAP binding proteins and their use
UY38739A (en) 2019-06-04 2020-12-31 Molecular Partners Ag MULTI-SPECIFIC PROTEINS
WO2021116469A2 (en) 2019-12-11 2021-06-17 Molecular Partners Ag Recombinant peptide-mhc complex binding proteins and their generation and use
KR20230006558A (en) 2020-05-06 2023-01-10 몰리큘라 파트너스 아게 Novel ankyrin repeat binding proteins and uses thereof
CN115996945A (en) * 2020-05-14 2023-04-21 分子合作伙伴股份公司 Recombinant CD40 binding proteins and uses thereof
CN115768786A (en) 2020-05-14 2023-03-07 分子合作伙伴股份公司 Multispecific proteins
EP4263607A1 (en) 2020-12-16 2023-10-25 Molecular Partners AG Novel slow-release prodrugs
WO2022190016A1 (en) 2021-03-09 2022-09-15 Molecular Partners Ag Novel darpin based multi-specific t-cell engagers
JP2024509241A (en) 2021-03-09 2024-02-29 モレキュラー パートナーズ アクチェンゲゼルシャフト Novel DARPin-based CD123 engager
CA3211248A1 (en) 2021-03-09 2022-09-15 Nina RESCHKE Novel darpin based cd33 engagers
EP4305063A1 (en) 2021-03-09 2024-01-17 Molecular Partners AG Protease cleavable prodrugs
WO2023110983A1 (en) 2021-12-14 2023-06-22 Molecular Partners Ag Designed repeat domains with dual binding specificity and their use
WO2024028278A1 (en) 2022-08-01 2024-02-08 Molecular Partners Ag Charge modified designed repeat domains and their use
WO2024038307A1 (en) 2022-08-19 2024-02-22 Novartis Ag Dosing regimens for sars-cov-2 binding molecules

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SE509359C2 (en) 1989-08-01 1999-01-18 Cemu Bioteknik Ab Use of stabilized protein or peptide conjugates for the preparation of a drug
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ATE448301T1 (en) 2000-09-08 2009-11-15 Univ Zuerich COLLECTION OF PROTEINS WITH REPEATING SEQUENCES (REPEAT PROTEINS) THAT CONTAIN REPETITIVE SEQUENCE MODULES
PT1567641E (en) * 2001-08-24 2012-08-21 Uvic Industry Partnerships Inc Proaerolysin containing protease activation sequences and methods of use for treatment of prostate cancer
CN101056646A (en) 2004-11-12 2007-10-17 拜耳先灵医药股份有限公司 Recombinant newcastle disease virus
EP1902131B1 (en) 2005-07-08 2009-11-11 University of Zurich Phage display using cotranslational translocation of fusion polypeptides
EP2198022B1 (en) 2007-09-24 2024-03-06 University Of Zurich Designed armadillo repeat proteins
JP2011504740A (en) 2007-11-27 2011-02-17 アブリンクス エン．ヴェー． Amino acid sequence directed to heterodimeric cytokines and / or their receptors, and polypeptides containing the same
JP5954990B2 (en) 2008-11-03 2016-07-20 モレキュラー・パートナーズ・アーゲーＭｏｌｅｃｕｌａｒ Ｐａｒｔｎｅｒｓ Ａｇ Binding protein that inhibits VEGF-A receptor interaction
AR081361A1 (en) 2010-04-30 2012-08-29 Molecular Partners Ag MODIFIED UNION PROTEINS THAT INHIBIT THE RECEPTOR INTERACTION OF THE VASCULAR ENDOTELIAL GROWTH FACTOR FROM GLICOPROTEIN TO VEGF-A
EP3514169B1 (en) * 2010-11-26 2024-03-06 Molecular Partners AG Designed repeat proteins binding to serum albumin
KR20140039203A (en) 2011-04-29 2014-04-01 얀센 바이오테크 인코포레이티드 Il4/il13 binding repeat proteins and uses
KR20150023957A (en) 2012-06-28 2015-03-05 몰리큘라 파트너스 아게 Designed ankyrin repeat proteins binding to platelet-derived growth factor
US10093740B2 (en) * 2012-10-15 2018-10-09 Universitat Zurich Bispecific HER2 ligands for cancer therapy
EP2738180A1 (en) * 2012-11-30 2014-06-04 Molecular Partners AG Binding proteins comprising at least two binding domains against HER2.
EP3004152B1 (en) 2013-05-31 2020-09-30 Molecular Partners AG Designed ankyrin repeat proteins binding to hepatocyte growth factor
CA2979602C (en) 2015-04-02 2022-12-20 Molecular Partners Ag Designed ankyrin repeat domains with binding specificity for serum albumin

Also Published As

Publication number Publication date
CN109790206A (en) 2019-05-21
MY196882A (en) 2023-05-08
CA3036301C (en) 2021-04-20
PH12019500596A1 (en) 2019-07-29
KR20190050802A (en) 2019-05-13
CL2019000729A1 (en) 2019-06-14
US10717772B2 (en) 2020-07-21
RU2019111628A3 (en) 2020-10-30
SA519401369B1 (en) 2022-12-22
US20180155402A1 (en) 2018-06-07
AU2017331329B2 (en) 2020-10-29
US20210130420A1 (en) 2021-05-06
EP3515933A1 (en) 2019-07-31
IL265489B (en) 2021-07-29
WO2018054971A1 (en) 2018-03-29
MX2019003298A (en) 2019-09-26
ZA201901592B (en) 2021-04-28
AR109680A1 (en) 2019-01-09
KR102270315B1 (en) 2021-06-29
RU2019111628A (en) 2020-10-19
CA3036301A1 (en) 2018-03-29
ES2953516T3 (en) 2023-11-14
EP3515933B1 (en) 2023-06-07
EP3515933C0 (en) 2023-06-07
AU2017331329A1 (en) 2019-04-04
EP3515933B9 (en) 2023-08-16
JP2019531093A (en) 2019-10-31
JP6976335B2 (en) 2021-12-08
IL265489A (en) 2019-05-30
NZ751689A (en) 2021-07-30
BR112019005587A2 (en) 2019-06-11

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