CO2018002590A2 - Sistemas y métodos para utilizar estructuras biomiméticas que proporcionan comunicación en tejidos vivientes - Google Patents

Sistemas y métodos para utilizar estructuras biomiméticas que proporcionan comunicación en tejidos vivientes

Info

Publication number
CO2018002590A2
CO2018002590A2 CONC2018/0002590A CO2018002590A CO2018002590A2 CO 2018002590 A2 CO2018002590 A2 CO 2018002590A2 CO 2018002590 A CO2018002590 A CO 2018002590A CO 2018002590 A2 CO2018002590 A2 CO 2018002590A2
Authority
CO
Colombia
Prior art keywords
systems
methods
vascular
provide communication
living tissues
Prior art date
Application number
CONC2018/0002590A
Other languages
English (en)
Inventor
P Joseph Vacanti
Original Assignee
Massachusetts Gen Hospital
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Massachusetts Gen Hospital filed Critical Massachusetts Gen Hospital
Publication of CO2018002590A2 publication Critical patent/CO2018002590A2/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
    • A61L27/3808—Endothelial cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M21/00—Bioreactors or fermenters specially adapted for specific uses
    • C12M21/08—Bioreactors or fermenters specially adapted for specific uses for producing artificial tissue or for ex-vivo cultivation of tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/04—Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
    • A61F2/06—Blood vessels
    • A61F2/062—Apparatus for the production of blood vessels made from natural tissue or with layers of living cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/507—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials for artificial blood vessels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/52—Hydrogels or hydrocolloids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M25/00—Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
    • C12M25/10—Hollow fibers or tubes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M25/00—Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
    • C12M25/14—Scaffolds; Matrices
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/067—Hepatocytes
    • C12N5/0671—Three-dimensional culture, tissue culture or organ culture; Encapsulated cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/50—Proteins

Abstract

Una plataforma para crear tejidos diseñados incluye un tubo vascular que define un diámetro vascular y está configurado para recibir células de siembra del sistema vascular, un tubo no vascular que define un diámetro del tubo no vascular y está configurado para recibir células de siembra del sistema orgánico y una barrera formada entre el tubo vascular y el tubo no vascular.
CONC2018/0002590A 2015-08-14 2018-03-13 Sistemas y métodos para utilizar estructuras biomiméticas que proporcionan comunicación en tejidos vivientes CO2018002590A2 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562205214P 2015-08-14 2015-08-14
PCT/US2016/044435 WO2017030762A1 (en) 2015-08-14 2016-07-28 Systems for and methods for using biomimetic structures providing communication in living tissue

Publications (1)

Publication Number Publication Date
CO2018002590A2 true CO2018002590A2 (es) 2018-08-10

Family

ID=58051540

Family Applications (1)

Application Number Title Priority Date Filing Date
CONC2018/0002590A CO2018002590A2 (es) 2015-08-14 2018-03-13 Sistemas y métodos para utilizar estructuras biomiméticas que proporcionan comunicación en tejidos vivientes

Country Status (15)

Country Link
US (2) US11534530B2 (es)
EP (1) EP3334821A4 (es)
JP (2) JP2018525200A (es)
KR (1) KR20180057618A (es)
CN (2) CN108138127A (es)
AU (2) AU2016307768B2 (es)
CA (1) CA2995578A1 (es)
CO (1) CO2018002590A2 (es)
IL (1) IL257528B2 (es)
MX (1) MX2018001888A (es)
MY (1) MY197045A (es)
NZ (1) NZ740635A (es)
SG (1) SG10202009014TA (es)
WO (1) WO2017030762A1 (es)
ZA (1) ZA201801713B (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI2470228T1 (en) 2009-08-28 2018-02-28 Sernova Corporation Cell transplantation procedures and devices
EP4044965A4 (en) * 2019-10-18 2023-11-01 Carnegie Mellon University SINGLE-LAYER CELL PLASTER IN AN EXTRACELLULAR MATRIX SCREEN
US20230380415A1 (en) 2022-04-22 2023-11-30 3D Biolabs, Llc Liquid-tight case for tissue device and system having same

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6143293A (en) * 1998-03-26 2000-11-07 Carnegie Mellon Assembled scaffolds for three dimensional cell culturing and tissue generation
DE60017900T2 (de) 1999-04-30 2006-04-06 Massachusetts General Hospital, Boston Herstellung von dreidimensionalem vaskularisierten gewebe mittels der verwendung von zweidimensionalen mikrohergestellten formen
US7759113B2 (en) 1999-04-30 2010-07-20 The General Hospital Corporation Fabrication of tissue lamina using microfabricated two-dimensional molds
WO2002053193A2 (en) 2001-01-02 2002-07-11 The Charles Stark Draper Laboratory, Inc. Tissue engineering of three-dimensional vascularized using microfabricated polymer assembly technology
AU2003275140A1 (en) 2002-09-23 2004-04-08 Massachusetts Institute Of Technology Theree-dimensional construct for the design and fabrication of physiological fluidic networks
AU2003284875A1 (en) * 2002-10-17 2004-05-04 Vacanti, Joseph P. Biological scaffolding material
WO2004065616A2 (en) 2003-01-16 2004-08-05 The General Hospital Corporation Use of three-dimensional microfabricated tissue engineered systems for pharmacologic applications
WO2005034624A2 (en) 2003-05-21 2005-04-21 The General Hospital Corporation Microfabricated compositions and processes for engineering tissues containing multiple cell types
JP4893099B2 (ja) 2005-05-12 2012-03-07 東レ株式会社 人工腎臓
US7790028B1 (en) * 2005-09-28 2010-09-07 The Charles Stark Draper Laboratory, Inc. Systems, methods, and devices relating to a cellularized nephron unit
US9198749B2 (en) * 2006-10-12 2015-12-01 C. R. Bard, Inc. Vascular grafts with multiple channels and methods for making
JP2010523268A (ja) * 2007-04-12 2010-07-15 ザ ジェネラル ホスピタル コーポレーション バイオミメティック血管網及びそれを使用するデバイス
EP2268326B1 (en) * 2008-04-30 2016-11-23 Ethicon, Inc Tissue engineered blood vessel
CA3198597A1 (en) * 2008-07-16 2010-01-21 Donald E. Ingber Organ mimic device with microchannels and methods of use and manufacturing thereof
US20130196438A1 (en) 2009-04-30 2013-08-01 Cordis Corporation Tissue engineered blood vessels
CN202129066U (zh) 2011-06-14 2012-02-01 东南大学 一种微流控微球制备装置
EP2734557B1 (en) * 2011-07-20 2022-09-07 UroGen Pharma Ltd. Production of thermoreversible hydrogels for therapeutic applications
US9456893B2 (en) * 2011-07-29 2016-10-04 Southwest Research Institute Engineered tissue implants and methods of use thereof
KR20140084013A (ko) 2011-09-12 2014-07-04 오가노보, 인크. 조작된 이식형 조직 및 기관을 위한 플랫폼 및 이들의 제조 방법
WO2014052835A1 (en) * 2012-09-29 2014-04-03 Nortis, Inc. Microfluidic system for reproducing functional units of tissues and organs in vitro
US20150050686A1 (en) 2013-08-13 2015-02-19 Lawrence Livermore National Security, Llc Omnidirectional, multiaxial bioprinted tissue system, techniques and applications
EP4026571A1 (en) * 2013-11-05 2022-07-13 President And Fellows Of Harvard College Method of printing a tissue construct with embedded vasculature
US10159979B2 (en) 2013-11-11 2018-12-25 King Abdullah University Of Science And Technology Microfluidic device for high-volume production of monodisperse emulsions
US10773214B2 (en) 2016-03-03 2020-09-15 Micromedics Inc. Biomimetically designed modular microfluidic-based capillaries and lymphatic units for kidney and liver dialysis systems, organ bio-reactors and bio-artificial organ support systems
EP3801659A4 (en) 2018-05-25 2022-04-06 The General Hospital Corporation ADDITIONAL MANUFACTURING OF COMPLEX IMPLANTABLE LIVING DEVICES

Also Published As

Publication number Publication date
AU2023200874A1 (en) 2023-03-16
US20180236134A1 (en) 2018-08-23
AU2016307768A1 (en) 2018-04-05
CN115708731A (zh) 2023-02-24
EP3334821A4 (en) 2019-07-17
WO2017030762A1 (en) 2017-02-23
MX2018001888A (es) 2018-06-20
JP2022116142A (ja) 2022-08-09
ZA201801713B (en) 2019-01-30
EP3334821A1 (en) 2018-06-20
NZ740635A (en) 2023-12-22
RU2018108802A3 (es) 2020-01-27
MY197045A (en) 2023-05-23
AU2016307768B2 (en) 2022-11-17
IL257528B2 (en) 2023-10-01
KR20180057618A (ko) 2018-05-30
IL257528A (en) 2018-04-30
IL257528B1 (en) 2023-06-01
CN108138127A (zh) 2018-06-08
SG10202009014TA (en) 2020-10-29
RU2018108802A (ru) 2019-09-16
US20230372588A1 (en) 2023-11-23
US11534530B2 (en) 2022-12-27
JP2018525200A (ja) 2018-09-06
CA2995578A1 (en) 2017-02-23

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