CN85108692A - Polyglycol ether is at the graft copolymerization of polyurethane surface - Google Patents
Polyglycol ether is at the graft copolymerization of polyurethane surface Download PDFInfo
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- CN85108692A CN85108692A CN 85108692 CN85108692A CN85108692A CN 85108692 A CN85108692 A CN 85108692A CN 85108692 CN85108692 CN 85108692 CN 85108692 A CN85108692 A CN 85108692A CN 85108692 A CN85108692 A CN 85108692A
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- graft copolymerization
- polyglycol ether
- group
- polyurethane surface
- end group
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Abstract
Polyglycol ether is at the polyurethane surface graft copolymerization, belong to the high-molecular biologic medical material tech field, make matrix with urethane, cerium salt is made initiator, in polyurethane surface graft copolymerization, this method can be used for preparing the high-molecular biologic medical material to the polyglycol ether that end group has a Dan Shuanjian group after metallizing.
Description
Polyglycol ether belongs to the high-molecular biologic medical material tech field at the graft copolymerization of polyurethane surface.
Continuous development along with polymer science, polymeric biomaterial is medically more and more being used, people have done number of research projects to the preparation of high-molecular biologic medical material, have prepared many polymer medical materials, and are applied to human body or other organism.For example: organo-silicone rubber, urethane, polymethyl acrylic acid-beta-hydroxy ethyl ester, polyvinyl chloride and polyethylene oxide etc.But these materials, have because of mechanical property can not meet the demands, what have is relatively poor because of blood adaptability, is restricted in application.In order to improve the anticoagulation function of material, people have designed various preparation methods, in the hope of obtaining having the material of better anticoagulation function, and are exactly one of them in the method that polyurethane surface carries out graft copolymerization.For example: with cerium salt Ce
4+Acrylamide triggered graft copolymerization on poly(ether-urethene), the anticoagulation function of the product after the grafting increases than its matrix poly(ether-urethene).But because this method adopts is the small molecule monomer acrylamide, grafted chain different in size, and the grafted chain structure is line style, thereby the anticoagulation function of material awaits to improve.In order further to improve the anticoagulant property of material, the polyglycol ether that the present invention has adopted end group to have the Dan Shuanjian group carries out the graft copolymerization of urethane, and this polyethers is a kind of macromonomer, and structure can be expressed as:
CH
2＝CR′R″O
CH
2CH
2O
nR
R is C
1～C
4Alkyl; R ' is H, CH
3; R " is
-CH
2-; N is 10～500.
Macromonomer is the very important intermediate of a class, and it not only itself has macromolecular character, and has the reactivity of small molecule monomer simultaneously.
For the such macromonomer of weevil base polyalkylene glycol acrylate ester, common preparation method is:
The weak point of this method is that the pyridinium salt that reaction produces is difficult for removing in aftertreatment, need consume a large amount of solvents during washing, and product yield is not high, has only about 50% usually.
(reference: (1) " polymer communication " 281(1982);
〔2〕C.A 73 26534j〕
The objective of the invention is: the polyglycol ether macromonomer that has the Dan Shuanjian group with end group carries out graft copolymerization at polyurethane surface, its grafted chain structure is the brush type, because this structure is more near the simulation of organism, so can improve the anticoagulation function of material.
Content of the present invention is:
The first step: with excessive
Join MO
CH
2CH
2O
nIn the toluene solution of R, 1～10 hour reaction times, 0～100 ℃ of temperature of reaction.After the reaction, filter, recrystallization promptly obtains the white powder product
M is in the about 70～80%(formula of (I) yield: Li, Na, K, metal ions such as Rb).
Second step: with the copolymerization of urethane (PU) and the first step product (I) usefulness cerium salt initiation grafting:
Advantage of the present invention is: carry out graft copolymerization at polyurethane surface with macromonomer, its graft effect is higher than the small molecule monomer grafting.Because its grafted chain is brush type structure, and more near the simulation of organism.For example, this is similar very to anti-thrombotic substance-mucopolysaccharide just in the structure of blood vessel surface.Therefore improved the anticoagulation function of material.On the other hand, the wetting ability of polyurethane surface also obtains bigger improvement.
The inventive method can be used for preparing the polymer medical material.The various storage blood of intravital artificial organ of biological example (artificial heart, artificial liver, artificial blood vessel, kidney machine etc.) and organism outer contacting blood hold the material of ware, device (as the blood collector in the surgical operation, blood storage container and apparatus for purifying blood etc.).
Specific examples of the present invention is: the first step 6.0g monohydroxy polyglycol ether adds in the 50ml toluene, inject the naphthalene sodium reagent, 60 ℃ are reacted half an hour, add 1.1g toluene acrylate chloride, 40 ℃ were reacted 3 hours, add molten Jie of 80ml acetone back standing over night, filtration again, filtrate is separated out solid, filtration, drying.Promptly get the polyether ester product.
Second step: reaction system is led to N
2, adding distil water 15ml, polyurethane film 0.1g adds ceric ammonium nitrate, adds the first step product polyether ester 1.5g, stirring, and reaction is 8 hours under the room temperature, takes out washing, drying.
Claims (4)
1, a kind of polyurethane surface graft copolymerization belongs to the high-molecular biologic medical material tech field.Make matrix with urethane, cerium salt is made initiator, the invention is characterized in that the polyglycol ether that adopts end group to have the Dan Shuanjian group carries out graft copolymerization at polyurethane surface, and grafted chain is brush type structure.
2, graft copolymerization according to claim 1, the chemical structural formula that wherein said end group has the polyglycol ether of Dan Shuanjian group is:
CH
2＝CR′R″-O
CH
2CH
2O
nR
In the formula: R ' is H, CH
- 3; R " is
-CH
2-;
R is C
1～C
4Alkyl; N is 10～500
3, graft copolymerization according to claim 1 wherein when the polyglycol ether that said end group has a Dan Shuanjian group is:
The time, its preparation method is: use
And MO
CH
2CH
2O
nCH
3React in toluene solution, M is Li in the formula, Na, K, metal ions such as Rb.
4, claim 1 or 2 or 3 described graft copolymerizations can be used for preparing the polymer medical material, and the various storage blood appearance ware containers or the device of artificial organ and organism outer contacting blood can also carry out surface hydrophilic modification to polyurethane material in the organism.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 85108692 CN85108692A (en) | 1985-12-21 | 1985-12-21 | Polyglycol ether is at the graft copolymerization of polyurethane surface |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 85108692 CN85108692A (en) | 1985-12-21 | 1985-12-21 | Polyglycol ether is at the graft copolymerization of polyurethane surface |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN85108692A true CN85108692A (en) | 1987-06-24 |
Family
ID=4796100
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 85108692 Pending CN85108692A (en) | 1985-12-21 | 1985-12-21 | Polyglycol ether is at the graft copolymerization of polyurethane surface |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN85108692A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101386684B (en) * | 2008-10-21 | 2011-08-31 | 东南大学 | Method for preparing high hydrophilic film on medical polyurethane material surface |
| CN105899244A (en) * | 2013-11-14 | 2016-08-24 | pfm医用钛有限公司 | Polyurethane having an antithrombogenic coating |
| CN109294460A (en) * | 2018-10-25 | 2019-02-01 | 山东大学 | A kind of UV solidification Liquid optical clear adhesive of color inhibition and preparation method thereof |
-
1985
- 1985-12-21 CN CN 85108692 patent/CN85108692A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101386684B (en) * | 2008-10-21 | 2011-08-31 | 东南大学 | Method for preparing high hydrophilic film on medical polyurethane material surface |
| CN105899244A (en) * | 2013-11-14 | 2016-08-24 | pfm医用钛有限公司 | Polyurethane having an antithrombogenic coating |
| CN105899244B (en) * | 2013-11-14 | 2019-02-19 | pfm医用钛有限公司 | Polyurethane with antithrombotic coating |
| CN109294460A (en) * | 2018-10-25 | 2019-02-01 | 山东大学 | A kind of UV solidification Liquid optical clear adhesive of color inhibition and preparation method thereof |
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|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| WD01 | Invention patent application deemed withdrawn after publication |