CN85108504A - 一种制备节育显影粘堵剂的工艺方法 - Google Patents

一种制备节育显影粘堵剂的工艺方法 Download PDF

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CN85108504A
CN85108504A CN 85108504 CN85108504A CN85108504A CN 85108504 A CN85108504 A CN 85108504A CN 85108504 CN85108504 CN 85108504 CN 85108504 A CN85108504 A CN 85108504A CN 85108504 A CN85108504 A CN 85108504A
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任彩元
王贺祥
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Northwest University
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Northwest University
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Priority to CN 85108504 priority Critical patent/CN85108504A/zh
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Abstract

一种制备节育显影粘堵剂的工艺方法，其要点在于原料的重量百分比组成为：醇溶性共聚尼龙10-16，乙醇30-40，苯酚14-20，铜锌合金10-20，甘油5-10，流程为尼龙经乙醇浸泡加入苯酚，加热回流，溶解冷却再同铜锌合金和甘油的混合物研匀，即可制出目前尚未见到的男女通用节育显影粘堵剂，且显影期长达1110天以上。四年临床证明，绝育率高，并发症和副反应小，术后体温正常。内脏机能、夫妇性生活未见异常，粘堵男女6.04万例无一例后遗症。

Description

本发明是一种制备节育显影粘堵剂的工艺方法。此粘堵剂供计划生育临床作男女非手术绝育的一种显影期达1110天以上的粘堵药物。
国外的粘堵绝育技术虽起始较早，但因其绝育效果不理想，临床应用例数少，故在此不作比较。我国自1970年开始进行粘堵绝育工作的探索研究，以上海新华医院等单位研制的“复方苯酚糊剂”为最先进，83年获得发明奖。“复方苯酚糊剂”其绝育效果较好，但它①只供女性绝育应用。不便于夫妇任一方因某种原因不能施行粘堵术的情况下，自由商议选择。②其苯酚含量为30%，腐蚀性强，并发症、副反应高达50%;同时含有发热源胆影酸，术后发烧持续3-10日，其中38°-39℃者占11.8%，89℃以上者占4%。③显影时间，仅在四小时至三天的范围内对术后复查不便。④注射时要用推进器加压注入，手术操作不便，且对药物注入量不易掌握。
本发明的目的，是要设计一种既能粘堵输卵管，又能粘堵输精管，且能较长期显影，并发症、副反应小，操作简便的绝育粘堵剂的配方和生产工艺。
本发明是通过如下方式完成的：
根据生理特点和医学高分子化学知识设计配方，经体外模拟实验和动物试验后，筛选出定型配方和生产工艺。
一、本发明的配方及各组份的作用列表如下：
1.醇溶性三元共聚尼龙配比∶尼龙6∶尼龙66∶MXD-10＝45∶40∶15
2.铜锌合金的成份配比：铜（75%）、锌（25%）
二.生产工艺
称取三元共聚尼龙置烧瓶中，加入乙醇浸泡四小时后，加入苯酚，在恒温水浴锅上加热回流（水浴恒温94±2℃）搅拌使其完全溶解呈粘稠胶状物，冷却至室温。另取铜锌合金（铜75%、锌25%）加甘油研匀，再分次加入尼龙溶液，研匀即成（见说明书附图）。
按本发明设计出的配方和生产工艺制出的粘堵剂，经四年临床应用证明对人体无害;绝育率高，男性为98.43%，女性为97.7%;男女通用，便于夫妇选择;显影期长达1110天以上，便于复查;并发症、副反应小，男性并发症发生率为0.74%，女性月经无变化率99.34%，术后四日体温正常率97.36%，体温在37.2℃-37.9℃者仅占2.14%，且在五日内均恢复正常;内脏机能，夫妇性生活等未见异常;粘稠度合适，易于注入，手术操作方便;经粘堵男女2万余例未发现一例后遗症，是一种受群众欢迎和信任的非手术绝育粘堵药物。

Claims (7)

1、一种制备节育显影粘堵剂的工艺方法，配料中有苯酚，其特征是：原料配方重量百分比为尼龙10-16，乙醇30-40，苯酚14-20，铜锌合金10-20，甘油5-10。由此配方制成的粘堵剂，供临床作男女非手术绝育的一种显影期长达1110天以上的粘堵药物。
2、根据权利要求1中所述尼龙其特征是醇溶性三元共聚尼龙。
3、根据权利要求2中所述醇溶性三元共聚尼龙其特征是：成份配比，尼龙6∶尼龙66∶MXD-10＝45∶40∶15。
4、根据权利要求1中所述铜锌合金特征是：成份配比为，铜75%，锌25%。
5、一种制备节育显影粘堵剂的工艺方法，其特征是：称取三元共聚尼龙置烧瓶中，加入乙醇浸泡，加入苯酚，在恒温水浴锅上加热回流搅拌使其完全溶解呈粘稠胶状物，冷却至室温。另取铜锌合金加甘油研匀，再分次加入尼龙溶液，研匀即成。
6、根据权利要求5中所述工艺方法，其特征是：乙醇浸泡四小时。
7、根据权利要求5中所述的工艺方法，其特征是：水浴恒温94±2℃。
CN 85108504 1985-11-14 1985-11-14 一种制备节育显影粘堵剂的工艺方法 Pending CN85108504A (zh)

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CN 85108504 CN85108504A (zh) 1985-11-14 1985-11-14 一种制备节育显影粘堵剂的工艺方法

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000054746A1 (en) * 1999-03-17 2000-09-21 Sujoy Kumar Guha An improved reversible contraceptive for male and female

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000054746A1 (en) * 1999-03-17 2000-09-21 Sujoy Kumar Guha An improved reversible contraceptive for male and female

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