CN85107146A - The vortex foamite system and the manufacture method thereof of endermic and through mucous membrane - Google Patents

Abstract

The invention provides a kind of system through skin and through mucous membrane, it comprises the inside part and a kind of activating agent that is contained in the inside part of macropore of a microporous exterior portion of being made by polymeric foams, a macropore.It relies on its inner chemical energy, utilizes Bernoulli effect, with the speed that satisfies optimal absorption and pressure the concentrated solution of activating agent is diffused into blood circulation between device and adjacent skin separating surface through subcutaneous transmission in the long scheduled time.It has avoided too high dose and the fluctuation of concentration and the consequent retroaction of medicine, does not produce wound, does not damage the internal, also has the benefit that is limited to topical therapeutic.

Description

The vortex foamite system and the manufacture method thereof of endermic and through mucous membrane

The present invention relates to therapeutic transfer system, particularly relate to endermic and system through mucous membrane, work to the part or the whole body of health in this system introduces human body with that control well and predetermined speed with medicine, medicament or other material in a time elongated segment and that determine localized area.The present invention also comprises having These characteristics, but is used for the local transfer system that transmits in people's body cavity.

It is well-known technology that the various therapeutics transporters and the system of above-mentioned some or all advantageous characteristic can be provided according to reports.These transporters and system can classify according to their load mode, for example are divided into the device of diffusion, the device of infiltration, elastomeric device or easy machinery, and the system that can be corroded or the system that can not be corroded.Novel apparatus of the present invention is the diffusion system that can not be corroded, and it utilizes part to exert profit (Bernoulli) effect and carries out its function.

The endermic system of those in the scope of the invention for example, its principal benefits are eliminated usually when the non-enterally administer thing of use, at the characteristic fluctuation of patient's vivo medicine concentration.Usually owing to,, can come into force for a long time so that health is accepted enough medicines with too much medicine.Make the people regrettably, the significantly fluctuation meeting of the high dose of initial medicine or administration standard produces retroaction in patient's body.Supply with the method longer-term of medicine and supply medicine constantly through skin, thus not need for intravenous injection institute must give above the medicine of high dose.Such as by those endermic devices that the present invention implemented, the more advantages better than intravenous methods are arranged, promptly use these devices, do not produce wound.

Relevant issues with oral medication supply medicine in body of mammals have also been overcome by the device through skin and through mucous membrane.Often use the oral medicine of aspirin tablet and so on tongue, esophagogastric damage often to occur, in some situation, demonstrated and used the aspirin tablet can cause tumor.Be placed on skin or the mucosa through pre-installed the putting of skin by medicine being transmitted point, and supply lower with medicine constant density, avoided this potential problem.These devices also provide a benefit extra, that be limited to topical therapeutic, that is to say that device can directly paste the affected part, with to partial disease, like an elephant tumor, provide specific treatment.

In order to improve above-mentioned problem, various subcutaneous injections have been proposed before this, aspirated and have contained the medicinal substances band.Discharge medicine though these devices are described as be in one predetermined period with constant concentration standard, they are expensive, and they need carefully be monitored by the internist, and they usually and then cause danger as the focus of bacterial infection.

The system that skin or mucomembranous surface are carried medicine of crossing that also has other, they and the present invention are more closely related.Because the subcutaneous transmission of their dependence activating agents is diffused into the blood circulation between the separating surface of applicator and patient skin, although each system uses different power to supply the chemical energy of Bernoulli effect necessity of institute of the present invention foundation, to transmit through skin effectively.In this invention, Bernoulli effect helps under speed that is enough to satisfy the most desirable absorption and pressure the concentrated solution of activating agent is offered skin.The endermic transporter of operating by this way is former also not to be disclosed.

Many devices of obtaining patent all transmit activating agent according to lazy diffusion.The activating agent of being close to skin that these devices do not provide present use Bernoulli effect to provide effectively directly flows.These devices are set up meter or activating agent are discharged into the environment that intravital liquid can hold, such as gastrointestinal tract, perhaps use endermic application, these devices must contain the pattern of certain covering, are discharged into surrounding to place restrictions on activating agent by evaporation or alternate manner.The present invention also can be designed to directly not carry medicine by of the present invention near skin or mucosa.Typical diffused device segmentation is below described.

The patent No. is that 4291015 United States Patent (USP) has been described a kind of polymeric diffusion substrate that comprises vasodilation, and it is by polar plasticizer, and such as glycerol, polymeric substrate and water-soluble polymer are formed together with vasodilation.The endermic transmission of active component is by implementing on the skin of diffusion concentration gradient standard being used the patient and the diffusion stromal surface.Neutral gasket material pastes one side of device, not with patient's contact skin.

The patent No. is that 4220153 United States Patent (USP) has disclosed one by being centered around the transporter that porous group thing around the chemical vessel, the saturated with water gel is formed, and can comprise a kind of medicine and a kind of water-soluble liquid when it has just begun.Because flooding mechanism needs two-way a large amount of transmission, this device is designed to be mainly used in the environment that aqueous liquid is in vivo held.

The patent No. is that 4308867 United States Patent (USP) has been described a disperser, and it comprises that an internal support, one contain the polymer layer of activating agent and the polymeric membrane of an outside.These two polymer layers are to select according to their relative diffusion coefficient and solubility, enter the speed of external environment so can control activating agent release.In addition, in its machine for releasing still only be diffusion.

Many devices of obtaining patent rely on the needed pressure of osmotic pumps feed system work.For example, the patent No. is that 4008719 United States Patent (USP) has disclosed a kind of like this device, and wherein, activating agent is included in one by in the internal interval that a plurality of semi-permeable lamina centered on.Lamina allows the fluid of transmission unhinderedly to pass through, and but stops activating agent to pass through, thereby sets up a kind of transmission of pure material in internal interval, and osmotic pressure is provided.The disadvantage of these devices is structure more complicated, because they need the manufacturing technology of more complicated, so manufacturing cost is more expensive; This just makes and must use them must pay high price.

It is the pressure of machinery by the mode that endermic applicator discharges needed power that another kind of supply causes activating agent.Several devices of obtaining patent rely on swellable polymer, just expand and cause reducing for the activating agent effective volume when polymer contacts with liquid.The result that pressure increases drives activating agent and enters into desired environment from system.It in the patent No. example that has disclosed these devices in 4320759,4350271 and 4223061 the United States Patent (USP).

The present invention has now disclosed a three-phase system, and it relies on favourable Bernoulli Jacob's liquid flow effect can be used to pass epidermis or mucosa transmission activating agent.This system is sent to the acceptance surface with activating agent together with transmitting liquid.Transmitting liquid is used for the intersection from the active agent delivery auto levelizer of internal system and adjacent body surface.In vivo, cross epidermal area or mucosa when the blood capillary transportation of substances, its speed is controlled by the speed that material supplies to biological surface often.The system of this device relies on the inner physical-chemical for system can guarantee that biological surface often obtains enough, effective activating agent.More particularly, the shown flowing effect of Bernoulli Jacob's liquid helps being used for guaranteeing that proper amount of activating agent arrives biological surface.Further, the additonal pressure that is in fact provided by Bernoulli effect is used for improving the highest possible diffusion rate of activating agent by skin or mucosa.

The system of three phases of this novelty comprises the part of an outside, the part of a inside and a kind of activating agent.The preferably foraminous polymeric foams of exterior portion, the size in hole are approximately long 1000 holes of every English inch, so just form around a space the complete structure that we opens in two ends.Yet it can adopt various shapes, a kind of circular cone shape with longitudinal space of special recommendation.The part of the inside is preferably made by polymeric foams equally, but the size in the hole that it had is long 600 holes of about every English inch, and it is made and can cosily allocate into by the formed spatial shape of exterior portion.When the inside is partly put in position, it outside the part each unimpeded opening a Free Surface should be arranged.The 3rd is the activating agent that comprises medicine mutually, and preferably with a kind of form of medicine-containing gel, inside part and exterior portion joined the inside part in conjunction with the former a certain moment for it.

People expect that endermic device can pack its each member separately, also can be used as an entire package.Like this, user just might prepare the medicine for fresh application, this medicine exposed to weather not before using immediately.To show the activating agent of certain degeneration such as those permanent exposed to weathers necessary often to using for this method.Equally, by as independent element supply system, give the chance that user provides special medicine or composition and change drug level or the like, so that guarantee the working condition of the desired the best of treatment.

Activating agent is to supply with via the free end of the inside part.It flow to the inside part by transmitting liquid by microporous exterior portion, leaves the surface of Free Surface or the inside part then and is sent to and applies ointment or plaster a little.This mobile suction builds on the Bernoulli effect basis, and Bernoulli effect automatically will transmit liquid and be driven into the bigger zone of hole dimension from the little zone of hole dimension.The shape of device and orientation preferably further help liquid directly to flow at least one Free Surface of the inside part.Like this, just apply than ambient pressure fluid pressure slightly larger near transmitting the surface.This additional pressure is applicable to stable and improves diffusion rate.

The within and without that is used in the novel endermic administrator structure partly is by polymeric porous foam body, and is made such as the polymeric porous foam body that is formed by alkyd resin, and at that time, water is as foaming agent.They can be made by many other polymer resins, and necessary condition only is that they have the ability that forms incorrosive loose structure, and they are to take off dioxane ((CH ₂) ₄O ₂), the high-load of its TDA taurine N,N diacetic acid (TDA) is 1,000,000/.Such material, more example comprises polyurethane, polyester, polypropylene or polyvinyl resin.Such structure has desirable pliability for general use, so that avoid over-drastic stimulation, but for special application, also can be semirigid, for example, when device is to throw in interior body region, there, bear the pressure that makes its big large deformation on the device probably, this pressure is tending towards compressing it, thereby has hindered the working method of its desired constant rate of speed.Selected foamed materials permission is easily die-cut or shell the shape that becomes to need, and this point also is important.

When making this in batches and put, two tangent planes need be arranged usually, have difference with regard to the pore size that makes foams like this.The pore size of polymeric matrix is can be by the function of the suitable various machined parameters of controlling of the people who is skilled in technique.

In order to make endermic applicator according to bernoulli principle work, the foams part does not need uniform microcellular structure, replaces a kind of structure of the regional area that the pore size that provides bigger and smaller must be arranged.Such structure provides sets up the mobile needed framework of Bernoulli Jacob, in its inside, transmits liquid and guides the inside part into from the exterior portion of device.The variation of pore size takes place suddenly on the interface of two parts often between the exterior portion of device and the inside part.

But this situation is not inevitable, because can use a transition system in this scope of invention, in this transition system, the size of micropore becomes big gradually towards the zone, the inside.The size range of exterior portion foam cell is from a hole, long 1000 holes to 3500 of every English inch, and the size range of the inside part foam cell is from a hole, long 200 holes to 600 of every English inch, and such foams effect is better.The ratio of big hole dimension and orifice size was advisable with 1.67: 1, but this ratio also can increase to 18: 1, or was reduced to 1.8: 1(or decreased to 1.8 to l).

Utilizing Bernoulli effect is key of the present invention, and it provides the needed power in minor air cell that liquid enters the macropore of the inside from the exterior portion that is full of micropore through the gel of infiltration medicine that drives.According to the Denier Bernoulli Jacob who represents by mathematical formulae (Daniel Bernoulli) principle, remain constant along the gross energy of the every bit on liquid flow surface, so when pressure reduced, the liquid velocity in system must increase.The 3rd variable in such liquid flow system is that liquid need be through them and the cross-sectional area in mobile pipeline or hole.When the cross-sectional area of system increases, press to exert to reduce, but when this thing happens, as described above, speed just increased.Thereby in native system, when transmitting flow of liquid through system, it is come the less zone of pore size earlier and produces partial pressure.The pressure differential that is produced causes that transmitting liquid flow to the inside part that has than large micropore from the exterior portion of installing.Preferably, the population structure of device also helps dissolved or dispersive medicine is concentrated on the surface of skin or mucosa.Resemble very much Bernoulli effect and push away or inhale water is entered thicker carrier pipe through meticulous carrier pipe, the shape of installing the best truncated cone is applicable to that liquid that guiding is loaded with medicine flows to and is close to the vortex part that the large-size micropore is arranged skin, the inside.The effect of above-mentioned directed flow not only concentrates on skin surface with medicine, and applies a projecting atmospheric pressure on the liquid that is loaded with medicine of skin being close to.Thereby, usually by dissolved drug pass through that the Concentraton gradient of skin produces, through the speed of skin diffusion, here the barometric gradient that novel structure produced owing to this device is increased.So as seen, system only relies on its internal physical-chemical driving force, and without any need for the power that adds.

Should note this point, system will work effectively, must need to have solid contact between the inside part and the exterior portion, so that a mobile successive passage of guiding liquids is provided.But the access method that guarantees this close ties is to make the inside part bigger by 10 than the space of external branch cutting.This layout has and can easily separate, thus the advantage that can reuse.Yet native system is not limited to this method, and can take stacked or other structure, and they provide contact necessary between ingredient, allows to transmit liquid and unhinderedly flows in a large number.Further, be desirably in the scope of the present invention and occur a kind ofly having any pore size distribution of needing with the mobile single unit system of guiding liquids.

Device can be taked the truncated cone, cylinder, and disk or any other form, and it can be as transmitting the pipeline that liquid flow to the inside part, part inside, it obtains medicine, and via at least one Free Surface discharge of the inside part.Truncated cone is extremely desirable for most of endermic application.The inside part or minor air cell that this shape directly helps the liquid of carrying active agent to flow to be close to skin, this type of flow promote with Bernoulli effect or guiding water almost completely identical via the mode that thin carrier pipe enters thicker carrier pipe.Certainly, the wide pedestal of device must be close to skin.At the top of the truncated cone or disk, also the narrow end that exposes minor air cell under atmospheric pressure to the open air must be arranged, for example, it can not be topped by impermeable adhesive tape, is preferably, and it should be not topped and exposed to air.When activating agent irreversibly directed access to plant inside and when being close to skin surface under no any external force effect, the shape of truncated cone also can prevent medicine by the inside part the top or cause inconvenient and uneconomic loss during the outer surface of microporous exterior portion.Although circular cone shape or disc-shape have these advantages, but therefore this invention is not restricted, but can advantageously use very big exterior portion and the inside part of shape change, to not be when device be not when being used for endermic application, for example, when device is when being used in the body cavity, the cylinder bodily form or tubular just better.

The outer surface of the inside part of macropore can be adorned so that the dispersive gel of medicine such as the method for spraying or soaking with any method easily.This glycerin jelly that the dispersive gel of medicine preferably is made up of glycerol, water, gelatin and one or more materials medicinal or chemistry, it can be used as rolling band easily, coats the inside part of macropore.Certainly, medicine can be made up of other material, but in general, preferably a kind of soft solid that under body temperature, melts of its gel, and can be used for skin or mucosa safely, for example, it is not a stimulant.The effect of gelatin super fatting agent or buffer agent in medicine-containing gel at this moment, provides stability of drug, can reduce the damage for the surface layer and the mucosa of health.

The device of combination is available by any suitable mode of connection that adheres to, and comprises that sticking with glue band is attached to the way that the pedestal of truncated cone clings on the skin on the skin, but must be careful, does not stop up the terminal narrow positions to skin surface in minor air cell.

In order to use this device, at the microporous exterior portion filled with fluid of device, water preferably, but also can be any in the various known humectant of not chafe or mucosa, or solvable and liquid medicine.For example, in the place that requires depth of penetration,, can advantageously make water and a kind of penetrating agent such as liquid glycerol such as transmitting anesthetis by lower lip.In order to fill this device and it to be started working, water or other transmission liquid should be added, and it is impregnated in the microporous exterior portion.The volume that transmits liquid is according to being disinclined to the volume of device, and for optimal work, transmits liquid and should be full of microporous exterior portion.The length of pharmaceutical release time and the size of dosage are that thickness and the density by the medicine that is applied decides, and the part of outside when needs, in the course of treatment that prolongs, for example needs 48 hours, can get wet again.Because any impurity all is filtered and is deposited in the hole of exterior portion, so bottled water or tap water can be used.

The present invention can use many activating agents expediently, and used special medicine often limits the physical property of system.This is because medicine is applied directly to the result in affected part with wanting most convenient.For example, pilocarpine a kind ofly is used for the treatment of glaucomatous medicine, can directly be coated onto easily on patient's the eyes, and at that time, its transmits through placing down the of the present invention concrete device below the face.Other can comprise chemotherapeutant and contraceptive for the medicine that special applicator uses.Can with typical chemotherapeutant be adriamycin and cisplatin.When this device uses these medicines, can utilize circadian rhythm (characteristic of health, the variation clocklike that in 24 hours periods, occurs such as temperature, blood cell count and cell division speed) to alleviate these medicines and toxic action be arranged what living things system was held.Because most of chemotherapeutants promptly infect isolated cell, such as gastric cells, the highest safe dose changes along with normal soma division speed all day.Thereby, in order to obtain high benefit from chemotherapeutant, must control the amount of these chemotherapeutants that absorbed by health firmly.Can reach this control by two kinds of common approach.First kind is that applicator is placed near the lump place, so that medicine is directly supplied in concentrated area, rather than earlier in systemic circulation or pass through gastrointestinal tract.Second kind, can lean on adjusting to control the diffusion rate of chemotherapeutant via skin or mucosa by the chemical energy that system produces.This can pass through to change the size of applicator, the amount of regulating the transmission liquid that places many micropores exterior portion, and the drug dose of adjusting threading the inside part is finished.

Passing through the injection of additional or parenteral assistant medicament of regulation food routinely gives the family beast with antibiotics or other medicines.These two kinds of Therapeutic Method all require for giving a large amount of medicines, even for the prophylactic treatment of routine.Endermic applicator of the present invention is attached to the internal ear of cow, can be effectively and give continuously and pharmaceutical quantities, and this dosage is to splash into low concentration in the super cycle in a few days.

In this way, avoided the concentration of the too much medicine that interior absorption gave, and, medicine storage or completely cut off in the tissue that meat maybe can run out, for example the probability in milk just reduces greatly.This has just reduced the human danger that unnecessarily is faced with antibiotics or other medicines is brought when consumption milk or meat, and has reduced to pass thing via variation or cellular content and transmit the immunity that produces for drug effect.

Iodine is the many normal body functions of a kind of execution, regulates desired material such as thyroid.Usually, the tablet of iodine is made for the treatment of the thyroid situation of activity transition with the form of biologically share, and as the medicament of antiradiation.Many sensory organ are positioned at the place that whole body needs iodine, so that permission is normally carried out function with the biosystem that they interrelate.When iodine deficiency, not only the bodily tissue function is inefficacious, and exists radioiodine to gather and damage peripheral cell and organize this bigger danger.As described, the tablet of iodine has been used to remedy these problems, but tablet has and is difficult to absorb and causes the unsettled shortcoming of the characteristic concentration relevant with oral medication.Endermic applicator on being worn over thyroid or during left knee joint back, can being used for supplying needed iodine, thereby preventing the deficiency of iodine, has avoided the absorption problem that interrelates with tablet simultaneously.Have been found that this invention that has potassium iodide, can after exposure, block 90 percent radioiodine immediately, after exposure three hours to four hours, can also block 50 percent, and can when the blocking-up that is used for fetus, locate safely.Can select to be referred to as usually this a kind of use in several of elemental iodine solution, potassium iodide, ethanol or ammonia of white iodine.

Many advantageous particularlies when the skin system uses that are applicable to the medicine of vagina diffusion by means of novelty.The contraceptive and the medicament of treatment vaginal infection and sexually transmitted disease (STD), such as kanamycin, sulfate, nystatin and nonoxinol-9, advantageous particularly when using by means of native system.In so concrete device, watery body fluid is absorbed in the exterior portion, and activation system transmits medicine under the situation of extraneous activation not having.

In a concrete device of the present invention, comprise the inside part of the polymeric matrix of the weak nonoxinol-9 that connects as the macropore of device.The porous foam body of this concrete device discharges spermicide active nonoxinol-9 in body cavity with constant speed, up to being applied to mechanical pressure, till the pressure that produces when joining, so nonoxinol discharges with high concentration.These polymeric matrixs preferably contain the nonoxinol-9 of about 5%-9%.The chemical property of octoxinol or nonoxinol allows it to be connected under acid condition with a little less than the polymeric matrix of anion.

Hormone also can be by means of the using through the skin system of novelty, for example insulins.

Following Example has been described the method that a kind of manufacturing has the polymeric matrix of above-mentioned character.

Example

(Vito section (Witoc) changes alkyd resin

Foamed resin) 100%(by weight)

Octoxinol or nonoxinol-9

(Polytergent B300-Olympic

(Olin) company) 2%(by weight)

Toluene di-isocyanate (T (BAFS

Wyandotti) 2% of weight

Tertiary amine R ₃0.01% of N weight

0.01% of aliphatic series isocyanates weight

Polysiloxane surfactant

0.01% of (organic associating carbide) weight

The inside of device is partly measured all these components in accordance with regulations to supply to and is gone in the mixing apparatus and form.At that time, these components are constantly mixed under the boundary-layer of dry air, and water adds as foaming agent.As a result, product is removed after residual Cisse Li Yeni (transliteration of the Cytheleyene) gas at evacuation under the temperature of three days and 51 ℃ and is solidified.Following cure cycle is available, to be used to make a kind of more linear polymer.

(a) evening ,-35 ℃;

(b) on daytime subsequently ,-45 ℃;

(c) next evening, 60 ℃.

Low initial solidification temperature generates a kind of more linear polymer, and it comes easier cutting compared with the polymer of close coupling, and piece material polyreaction in the morning finishes the back cutting, but the aging easy degree of improving cutting.

Do not add in mixture octoxinol or the nonoxinol-9, exterior portion can use the mode identical with the inside part to form, and certainly, the condition of technical process changes to some extent, so that make the size in exterior portion hole littler than the size in part hole, the inside.

Accompanying drawing is represented the concrete device of the best of the present invention.In accompanying drawing, the inside part 2 of macropore is configured in the inside of microporous exterior portion 1, and it has the suprabasil easy on and off surface 3 and 4 separately that is positioned at disc or frustum shaped device.

Claims (23)

1, a kind of device that transmits medicine to epidermis or mucomembranous surface comprises:

(a) microporous exterior portion of making by polymeric foams, and

(b) the inside part that is configured in exterior portion the inside and macropore that get in touch massively with it, that be suitable for adding therein medicine, that make by polymeric foams.

Wherein, the inside of macropore partly has at least a Free Surface not to be communicated with microporous exterior portion, the inside part of macropore between 2: 1 and 1.67: 1, or is reduced to 1.8: 1 (or decreased to 1.8to 1) for the dimension scale in the hole of microporous exterior portion.

2, by claim 1 described device, wherein, described device is a disc-shape.

3, by claim 1 described device, wherein, described device is a frustoconical shape.

4, by claim 1 described device, wherein, described device is a cylindrical shape.

5, by claim 1 described device, wherein, polymeric foams is polyester, polyethylene or polypropylene.

6, by claim 1 described device, wherein, the every English inch of described microporous exterior portion length has 1000 to 3000 holes, and the every English inch of the inside part length of described macropore has 200 to 600 holes.

7,, also comprise an adhesive tape on the outer surface that attaches to described device by claim 1 described device.

8, a kind of device that transmits medicine to the surface of epidermis and mucosa comprises:

(a) microporous exterior portion of making by polymeric foams;

(b) the inside part that is configured in exterior portion the inside and macropore that get in touch massively with it, that be suitable for packing into therein medicine, that make by polymeric foams.

(c) be contained in a kind of medicine in the inside part of macropore.

Wherein, the inside of macropore partly has at least a Free Surface not to be communicated with microporous exterior portion, the inside part of macropore for the dimension scale in the hole of microporous exterior portion between 18: 1 and 1.67: 1.

9, by claim 8 described devices, wherein, described device is a disc-shape.

10, by claim 8 described devices, wherein, described device is a frustoconical shape.

11, by claim 8 described devices, wherein, described device is a cylindrical shape.

12, by claim 8 described devices, wherein, polymeric foams are to take off 1,4 dioxane ((CH ₂) ₄O ₂) the polyester foams, and the high-load of the horizontal sour oxalic acid of amino second (TDA) be 1,000,000/.

13, by claim 8 described devices, wherein, medicine is supplied with as medicine-containing gel.

14, by claim 13 described devices, wherein, medicine-containing gel comprises glycerol, water, gelatin and one or more water miscible medicines.

15, by claim 13 described devices, wherein, medicine-containing gel is the outer surface that is coated in the inside part of macropore.

16, by claim 8 described devices, wherein, medicine is a kind of chemotherapeutant.

17, by claim 8 described devices, wherein, medicine is a kind of spermicide.

18, by claim 17 described devices, wherein, spermicide is nonoxinol or octoxinol, and it is blended in the inside part that forms macropore in the polymer foam substrate.

19, by claim 8 described devices, wherein, medicine is a kind of antibacterial.

20, by claim 8 described devices, wherein, medicine is the thyroid regulator.

21, by claim 8 described devices, wherein, medicine is potassium iodide (KI), and a kind of antiradiation drug is as the radioiodine blocker.

22, by claim 8 described devices, wherein, medicine is a kind of hormone.

23, by claim 8 described devices, wherein, medicine is an insulin.

Images