CN85101832A - The method for preparing 7-(3-aryl-1-piperazinyl)-3-quinolone carboxylic acid and 7-(3-encircles ethyl-1-piperazinyl)-3-quinolone carboxylic acid - Google Patents
The method for preparing 7-(3-aryl-1-piperazinyl)-3-quinolone carboxylic acid and 7-(3-encircles ethyl-1-piperazinyl)-3-quinolone carboxylic acid Download PDFInfo
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- CN85101832A CN85101832A CN85101832.7A CN85101832A CN85101832A CN 85101832 A CN85101832 A CN 85101832A CN 85101832 A CN85101832 A CN 85101832A CN 85101832 A CN85101832 A CN 85101832A
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- Prior art keywords
- carboxylic acid
- represent
- phenyl
- fluorine
- compound
- Prior art date
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- 238000000034 method Methods 0.000 title claims description 27
- 150000001875 compounds Chemical class 0.000 claims abstract description 82
- 238000002360 preparation method Methods 0.000 claims abstract description 16
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 claims description 100
- -1 methoxyl group Chemical group 0.000 claims description 48
- 238000006243 chemical reaction Methods 0.000 claims description 29
- 229910052731 fluorine Inorganic materials 0.000 claims description 26
- 239000011737 fluorine Substances 0.000 claims description 25
- 229910052799 carbon Inorganic materials 0.000 claims description 18
- 239000000460 chlorine Substances 0.000 claims description 18
- 125000004432 carbon atom Chemical group C* 0.000 claims description 17
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims description 16
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- 239000003814 drug Substances 0.000 claims description 16
- 229910052739 hydrogen Inorganic materials 0.000 claims description 16
- 239000001257 hydrogen Substances 0.000 claims description 16
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 15
- 125000000217 alkyl group Chemical group 0.000 claims description 15
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 15
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims description 14
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 14
- HJZQMXIVAIMIQA-UHFFFAOYSA-N 1-fluoro-4-oxoquinoline-3-carboxylic acid Chemical compound C1=CC=C2C(=O)C(C(=O)O)=CN(F)C2=C1 HJZQMXIVAIMIQA-UHFFFAOYSA-N 0.000 claims description 13
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- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 claims description 11
- 125000004093 cyano group Chemical group *C#N 0.000 claims description 11
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims description 9
- 239000011230 binding agent Substances 0.000 claims description 9
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims description 9
- 229910052794 bromium Inorganic materials 0.000 claims description 9
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- XAKBSHICSHRJCL-UHFFFAOYSA-N [CH2]C(=O)C1=CC=CC=C1 Chemical group [CH2]C(=O)C1=CC=CC=C1 XAKBSHICSHRJCL-UHFFFAOYSA-N 0.000 claims description 7
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 7
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Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
The present invention is relevant new compound 1-cyclopropyl base-1,4-dihydro-4-oxo-3-quinoline carboxylic acid and preparation method thereof and antiseptic-germicide and contain the fodder additives of this compound.
The general formula of this new compound is: (1) wherein: R
1R
2And X
1The group that representative is described in specification sheets.
Description
The present invention is relevant new compound 1-cyclopropyl base-1,4-dihydro-4-oxo-3-quinoline carboxylic acid and preparation method thereof and antiseptic-germicide and contain the fodder additives of this compound.
Have now found that the new compound 1-cyclopropyl base-6-fluoro-1 of formula I, 4-dihydro-4-oxo-7-(1-piperazinyl)-the 3-quinoline carboxylic acid
Wherein:
R
1Represent hydrogen; the alkyl of the straight or branched of 1-4 carbon atom; these alkyl are arbitrarily replaced by following groups: hydroxyl, methoxyl group, amino, dimethylamino, fontanel element; for example fluorine or chlorine, cyano group or contain the carbalkoxy of 1 or 2 carbon atom at moieties; also representative contains oxoalkyl group, the phenacyl up to 4 carbon atoms, or contains the acyl group of 1-4 carbon atom.
R
2Represent phenyl and cyclohexyl, cyclohexyl arbitrarily by following groups one to triple replacements: the fontanel element, for example chlorine, bromine or fluorine, methyl, phenyl, cyano group, hydroxyl, methoxyl group, benzyloxy, amino, methylamino, dimethylamino, piperidino-(1-position only) or nitro are also represented methylene radical dioxo phenyl, methylene radical dioxo cyclohexyl, furyl, tetrahydrofuran base or thienyl.
X
1Represent hydrogen and fluorine
With these compounds available hydrate pharmaceutically, acid salt, basic metal and alkaline earth salt have high anti-microbial activity.
The preferred compound of formula I is these compounds, wherein:
R
1Represent hydrogen, contain the straight or branched alkyl of 1-4 carbon atom; these alkyl are arbitrarily replaced by following groups: hydroxyl, methoxyl group, halogen; for example fluorine or chlorine, cyano group or the carbalkoxy of 1 or 2 carbon atom is arranged at moieties are also represented oxoalkyl group, phenacyl, formyl radical or ethanoyl up to 4 carbon atoms
R
2Represent phenyl and cyclohexyl, cyclohexyl arbitrarily by following groups one to triple replacements: chlorine, bromine, fluorine, methyl, phenyl, cyano group, hydroxyl, methoxyl group, benzyloxy, amino,
Pyridine subbase or nitro are also represented thienyl
X
1Represent hydrogen or fluorine
The particularly preferred compound of formula I is these compounds,
Wherein:
R
1Represent hydrogen; the straight or branched alkyl that contains 1-3 carbon atom; these alkyl arbitrarily have the carbalkoxy of 1 or 2 carbon atom by hydroxyl, methoxyl group cyano group or at moieties, also represent oxoalkyl group, phenacyl, formyl radical or ethanoyl up to 4 carbon atoms
R
2Represent phenyl and cyclohexyl, cyclohexyl arbitrarily by following groups one to triple replacements: chlorine, bromine, fluorine, methyl, phenyl, hydroxyl, methoxyl group, benzyloxy, amino,
Pyridine subbase or nitro, and thienyl
X
1Represent hydrogen or fluorine
Also find the compound 1-cyclopropyl base-7-fluoro-1 of formula II, 4-dihydro-4-oxo-3-quinoline carboxylic acid,
Wherein:
X
1Above-mentioned connotation is arranged
X
2Represent halogen, particularly fluorine or chlorine
With formula III
Piperazine,
Wherein:
R
1And R
2Above-mentioned implication is arranged
Be suitable in the presence of acid binding agent, reacting the compound (method A) that obtains formula I.
According to the present invention, the compound of formula I also can be by the compound 7-(1-of formula IV
The piperazine base)-the 3-quinolone carboxylic acid:
Wherein: R
2And X
1Above-mentioned implication is arranged
Compound with formula (V)
Wherein:
R
1Above-mentioned implication is arranged but can not be hydrogen
On behalf of fluorine, bromine, iodine, hydroxyl, acidic group, phenoxy group or nitro-phenoxy, X be suitable for reacting in the presence of acid binding agent and obtains (method B).
According to the present invention, the compound of formula I also can be at the compound 7-(1-of formula IV
The piperazine base)-obtain during Michael's receptor reaction of 3-quinolone carboxylic acid and formula VI,
Wherein:
R
3Represent CN, CH
3CO or COOR
4
R
4Represent methylidene or ethyl (method C).
In the reaction of usefulness method A, if the 2-phenyl
Piperazine and 1-cyclopropyl 6,7,8-three fluoro-1,4-dihydro-4-oxo-3-quinoline carboxylic acid is as raw material, and so, reaction process can be represented by following reaction formula:
In the reaction of usefulness method B, if iodoethane and 1-cyclopropyl-6,8-two fluoro-1,4-dihydro-4-oxo-7-(3-phenyl-1-
The piperazine base)-the 3-quinoline carboxylic acid is as raw material, so, reaction process can below reaction formula represent,
In the reaction of usefulness method C, if 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(3-phenyl-1-
The piperazine base)-3-quinoline carboxylic acid and methyl vinyl ketone be as raw material, so, reaction process can below reaction formula represent,
As some quinolone carboxylic acids (II) of initial compounds is knownly (to see German prospectus DE-OS 3,142,854:7-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-3-quinoline carboxylic acid), these compounds can prepare by following synthetic route:
Z
1，Z
2＝Cl、F
According to this synthetic route, acylations in the presence of magnesium acetate generates aroyl malonic ester (3) (organic chemistry (Organi-cum), the third edition, 438 pages, 1964) to diethyl malonate (2) with suitable benzoyl fluoride or Benzoyl chloride (1).
In the water-bearing media that sulfuric acid or Catalyzed by p-Toluenesulfonic Acid dosage are arranged; first partial hydrolysis and decarboxylation by compound (3) obtain aroyl ethyl acetate (4) with good productive rate, and this compound changes into corresponding 2-benzoyl-3-ethoxy ethyl acrylate (5) with orthoformic acid triethyl ester and diacetyl oxide.Compound (5) and cyclopropylamine in solvent, for example reaction in methylene dichloride, ethanol, chloroform, hexanaphthene or the toluene front-end volatiles, heat release a little, the intermediate that obtains requiring (6).
(6) → (7) cyclization preferably carries out in 80-180 ℃ of scope at the about 60-300 of temperature ℃.
The available thinner has dioxan, dimethyl sulfoxide (DMSO), N-Methyl pyrrolidone, tetramethylene sulfone, hexamethylphosphorictriamide, N preferably, dinethylformamide.
For the suitable acid binding agent of this step reaction is sodium tert-butoxide, butyllithium, phenyl-magnesium-bromide, sodium methylate, sodium hydride, yellow soda ash or salt of wormwood.(Z in the time will taking off hydrogen fluoride
2=F), show with Potassium monofluoride or Sodium Fluoride to be suitable especially.Base excess 10%(mole) also be favourable.
Under alkalescence or acidic conditions, the ester hydrolysis of compound (7) in the end one the step carry out, generate suitable compound 1-cyclopropyl base-6-fluoro-1,4-dihydro-4-oxo-3-quinoline carboxylic ester (II).
As 2,3,4 of this synthetic route raw material, 5-phenyl tetrafluoride formyl chloride (1) (X
1=X
2=Z
2=F, Z
1=Cl), known 2,3,4 from document, 5-tetrafluoro formic acid (G.G.Yakobson, V.N.Odinokov and N.N.Vorozhtsov Jr., Zh.Obsh.Khim.36,139(1966)) obtain with usual method with thionyl chloride.2,3,4,5-phenyl tetrafluoride formyl chloride boiling point is 75-80 ℃/17 millibars, 2,3,4, and 5-tetra fluoro benzene formyl fluoride boiling point is 46-47 ℃/20 millibars (n
20 D: 1.4375).
As 2,4 of raw material, 5-trifluoro-benzoyle fluoride (I) (X
1=H, X
2=Z
1=Z
2=F) known 2,4,5 from document with similar methods, and the preparation of-trifluoro-benzoic acid (I.J.Degraw, M.Corey and W.A.Skinner, chemical engineering data magazine, 13,587(1968)).Its boiling point is 53-56 ℃/18 millibars (n
20 D: 1.4546).
Replace as the 2-of raw material
Piperazine is known, can the method from document (for example: United States Patent (USP) 4,166,180 obtain; Medical chemistry magazine (J.Med.Chem.) 26,1116(1983)).
Recorded and narrated following compounds as an example:
The 2-phenyl
Piperazine, 2-(4-chloro-phenyl-)
Piperazine, 2-(4-fluorophenyl)
Piperazine, 2-(4-bromophenyl)
Piperazine, 2-(4-aminomethyl phenyl)
Piperazine, 2-(4-xenyl)
Piperazine, 2-(4-p-methoxy-phenyl)
Piperazine, 2-(4-benzyloxy phenyl)
Piperazine, 2-(4-hydroxy phenyl)
Piperazine, 2-(3-hydroxyl-phenyl)
Piperazine, 2-(2-hydroxy phenyl)
Piperazine, 2-(4-nitrophenyl)
Piperazine, 2-(4-aminophenyl)
Piperazine, 2-4(
Pyridine subbase phenyl)
Piperazine, 2-(3, the 4-Dimethoxyphenyl
Piperazine, 2-(3,4, the 5-trimethoxyphenyl)
Piperazine, 2-(3,4-dimethoxy-6-aminomethyl phenyl
Piperazine, 2-(3, the 4-methylenedioxyphenyl)
Piperazine, 2-(4-cyano-phenyl)
Piperazine, 2-(2-thienyl)
Piperazine or 2-(2-furyl)
Piperazine.According to our the control oneself application (LeA23 097) of identical data, 2-cyclohexyl
Piperazine is by corresponding 2-aryl
The piperazine shortening obtains; 2-cyclohexyl for example
Piperazine (fusing point 82-83 ℃).
The compound that is used as the formula (V) of raw material is known.Recorded and narrated following compounds as an example: methyl-iodide, monobromomethane, iodoethane, monobromoethane, ethyl chloride, 3-hydroxypropyl chlorine, 4-hydroxypropyl chlorine, positive propyl bromo, isopropyl bromide, n-butyl bromide, isobutyl bromide, sec-butyl chloride, formic acid, formic anhydride, diacetyl oxide, Acetyl Chloride 98Min..
According to the present invention, the compound of used formula VI is known.Record and narrate following compounds as an example:
Vinyl cyanide, methyl vinyl ketone, methyl acrylate and ethyl propenoate.
Use method A; The reaction of compound (II) and compound (III) is preferably in the thinner to be carried out, and thinner has: dimethyl sulfoxide (DMSO), N, N-dimethyl carbonamidine, hexamethylphosphorictriamide, tetramethylene sulfone, water, alcohol are as methyl alcohol, ethanol, b propanol, Virahol.Or 1 monomethyl ester, or pyridine.Equally, the mixture of available these thinners.
All common inorganic and organic acid wedding agents all can be used as acid binding agent.These acid binding agents preferably include: alkali metal hydroxide, alkaline earth metal carbonate, organic amine and amidine.The record of particularly suitable following compounds: triethylamine, 1,4-diazabicyclo (2.2.2) octane (DABCO), cross amine (excess amine) or 1,8-diazabicyclo (5.4.0)-7-hendecene (DBu).
Temperature of reaction can change in wide region.Generally, be reflected between temperature 20 and 200 ℃, be preferably between 80 and 180 ℃ and carry out.
Reaction can under atmospheric pressure also can under high pressure be carried out.Usually,, between about 1 and 100 crust, be preferably between 1 and 10 crust and carry out at pressure.
According to the present invention, when implementing present method, 1 mole carboxylic acid (II) is with 1 to 5 mole, best 1 to 3 mole
Piperazine (III).
The reaction of compound (IV) and compound (V) is preferably in the thinner to be carried out, thinner has dimethyl sulfoxide (DMSO), dioxan, N.N-dimethyl carbonamidine, hexamethylphosphorictriamide, tetramethylene sulfone, water, alcohol, as methyl alcohol, ethanol, n-propyl alcohol, Virahol, 1 monomethyl ester.Equally, the mixture of available these thinners.
All common inorganic and organic acid wedding agents all can be used as acid binding agent.These acid binding agents preferably include: alkali metal hydroxide, alkaline earth metal carbonate, organic amine and amidine.The record of particularly suitable following compounds: triethylamine, 1,4-diazabicyclo (2.2.2) octane (DABCO) or 1,8-diazabicyclo (5.4.0)-7-hendecene (DBu).
Temperature of reaction can change in wide region.Usually, be reflected between about 20 and 180 ℃ of the temperature, between 40 and 110 ℃, carry out especially.
Reaction under atmospheric pressure also can under high pressure be carried out.Usually, be reflected between pressure about 1 and 100 crust, be preferably between 1 and 10 crust and carry out.
According to the present invention, usefulness method B implements when of the present invention, and 1 mole compound (IV) is with 1 to 4 mole, best 1. to 1.5 moles compound (V).
Compound (I) carries out in thinner with the reaction (method C) of compound (VI), and thinner has: N, the mixture of N-dimethyl carbonamidine, dioxan, tetrahydrofuran (THF), pyridine, water or these thinners.Temperature of reaction can change in wide region.Usually, be reflected between about 0 and 140 ℃ of the temperature, be preferably between 10 and 100 ℃ and carry out.
Reaction can under atmospheric pressure also can under high pressure be carried out.Usually, be reflected between pressure about 1 and 100 crust, be preferably between 1 and 10 crust and carry out.
According to the present invention, when implementing present method, 1 mole compound (I) is with 1 to 5 mole, best 1 to 2 mole compound (VI).
Except the compound that in these examples, describes in detail, also recorded and narrated following compounds as new active compound:
1-cyclopropyl-6-fluoro-1,4-dihydro-7-(4-methyl-3-phenyl-1-
The piperazine base)-4-oxo-3-quinoline carboxylic acid,
4-(4-butyl-3-phenyl-1-
The piperazine base)-and 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-3-quinoline carboxylic acid,
1-cyclopropyl-6-fluoro-1,4-dihydro-7-(4-(2-hydroxyethyl)-3-phenyl-1-
The piperazine base)-4-oxo-3-quinoline carboxylic acid,
1-cyclopropyl-6-fluoro-1,4-dihydro-7-(4-(2-methoxy ethyl)-3-phenyl-1-
The piperazine base)-4-oxo-3-quinoline carboxylic acid,
7-(4-(2-amino-ethyl)-3-phenyl-1-
The piperazine base)-and 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-3-quinoline carboxylic acid,
1-cyclopropyl-6-fluoro-1,4-dihydro-7-(4-(2-dimethylamino-ethyl)-3-phenyl-1-
The piperazine base)-4-oxo-3-quinoline carboxylic acid,
1-cyclopropyl-6-fluoro-7-(4-(2-fluoro ethyl)-3-phenyl-1-
The piperazine base)-1,4-dihydro-4-oxo-3-quinoline carboxylic acid,
7-(4-(2-cyanoethyl)-3-phenyl-1-
The piperazine base)-and 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-3-quinoline carboxylic acid,
1-cyclopropyl-6-fluoro-1,4-dihydro-7-(4-(2-methoxycarbonyl-ethyl)-3-phenyl-1-
The piperazine base)-4-oxo-3-quinoline carboxylic acid,
1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(4-phenacyl-3-phenyl-1-
The piperazine base)-the 3-quinoline carboxylic acid,
1-cyclopropyl-6-fluoro-7-(4-formyl radical-3-phenyl-1-
The piperazine base)-1,4-dihydro-4-oxo-3-quinoline carboxylic acid,
7-(4-ethanoyl-3-phenyl-1-
The piperazine base)-and 1-cyclopropyl-6-fluorine 1,4-dihydro-4-oxo-3-quinoline carboxylic acid,
1-cyclopropyl-6-fluoro-1,4-dihydro-7-(3-(4-methylcyclohexyl)-1-
The piperazine base)-4-oxo-3-quinoline carboxylic acid,
1-cyclopropyl-6-fluoro-1,4-dihydro-7-(3-(3,4,5-trimethoxyphenyl)-1-
The piperazine base)-4-oxo-3-quinoline carboxylic acid,
1-cyclopropyl-6-fluoro-1,4-dihydro-7-(3-(3,4-methylenedioxyphenyl)-1-
The piperazine base)-4-oxo-3-quinoline carboxylic acid,
The 7-(3-(4-cyano-phenyl)-1-
The piperazine base)-and 1-cyclopropyl-6-fluorine 1,4-dihydro-4-oxo-3-quinoline carboxylic acid,
7-(3-(3-aminophenyl)-1-
The piperazine base)-and 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-3-quinoline carboxylic acid,
1-cyclopropyl-6-fluoro-7-(3-(2-furyl)-1-
The piperazine base)-1,4-dihydro-4-oxo-3-quinoline carboxylic acid,
1-cyclopropyl-6-fluoro-1,4-dihydro-7-(3-(2-tetrahydrofuran base)-1-
The piperazine base)-4-oxo-3-quinoline carboxylic acid,
1-cyclopropyl-6-fluoro-1,4-dihydro-7-(3-(4-hydroxy-cyclohexyl)-1-
The piperazine base)-4-oxo-3-quinoline carboxylic acid,
7-(3-(3-aminocyclohexyl)-1-
The piperazine base)-and 1-cyclopropyl-6-fluoro-1,4-bifluoride-4-oxo-3-quinoline carboxylic acid,
1-cyclopropyl-7-(4-ethyl-3-phenyl-1-
The piperazine base)-6,8-two fluoro-1,4-dihydro-4-oxo-3-quinoline carboxylic acid,
1-cyclopropyl-6,8-two fluoro-7-(3-(4-fluorophenyl)-4-(3-oxo-butyl)-1-
Piperazine-1,4-dihydro-4-oxo-3-quinoline carboxylic acid,
1-cyclopropyl-6,8-two fluoro-7-(4-formyl radical-3-(2-thienyl)-1-
The piperazine base)-1,4-dihydro-4-oxo-3-quinoline carboxylic acid.
The compound that obtains according to the present invention is a low toxicity, and to Gram-positive and gram-negative bacteria, particularly intestines there is not the brood cell Cordycepps, mainly comprise those to various antibiotic, for example penicillin, cynnematin, aminoglycoside, sulphonamide and tsiklomitsin etc. have drug-fast germ to show antibacterial range widely.
These valuable character make these compounds of application become possibility, in medicine, be used as chemotherapeutical active compound, and as inorganic and organism, particularly various types of organism, for example polymkeric substance, lubricant, dyestuff, fiber, leather, paper and timber etc. reach the material that food and water are preserved usefulness.
The microorganism of wide range is effective to the compound that obtains according to the present invention to resisting very.Can resist Gram-negative and gram-positive bacteria and bacterioide microorganism with these compounds, and prevention, improvement and/or treatment are by these germ diseases.
The compound that obtains according to the present invention is effective to opposing bacterium and bacterioide microorganism.Therefore, these compounds are particularly suitable in medical science and veterinary science prevention and the chemotherapy infection by these germ parts and whole body.
For example, can treat and/or prevent disease by the germ partial and/or whole body of following germ or their mixing: micrococcaceae, Staphylococcus for example is as aurococcus, staphylococcus epidermidis; Lactobacillaceae, streptococcus for example, as streptococcus pyogenes, α-and beta hemolytic streptococcus, non--gamma-Hemolytic streptococcus, faecalis and Diplococcus pneumococcus; Enterobacteriaceae, for example Escherichia of coliform: Escherichia bacterium such as intestinal bacteria, enterobacter, as enteroaerogen cloaca (Cloacae) enterobacteria, klebsiella is as pneumobacillus, serratia is as sticking Serratia; The distortion Cordycepps: proteus, as proteus vulgaris, Morganella, Proteus rettgeri, Proteus mirabilis; Pseudomonadaceae, for example false unicellular Pseudomonas is as the false unicellular bacterium of green pus; Bacteroides, Bacteroides for example is as bacteroides fragilis; Mycoplasma is as a former pulmonitis strain; Mycobacterium, as Mycobacterium tuberculosis, hansen's bacillus and special-shaped mycobacterium.
The disease of recording and narrating below as with compound of the present invention prevention, improve and/or the example of treatment disease:
Otitis; Pharyngitis; Pneumonia; Peritonitis; Pyelonephritis; Urocystitis; Endocarditis; Systemic infection; Bronchitis; Sacroiliitis; Local infection and septic diseases.
The present invention includes medicament, these medicaments are except containing the pharmaceutically suitable vehicle of nontoxic inert, also with good grounds one or more compounds of the present invention, or this medicament is made up of one or more active compounds according to the present invention, and this this medicaments preparation method.
The present invention also comprises the medicament with the dose unit preparation.This meaning is that medicament exists with different dosage form, for example tablet, coated tablet, capsule, pill, suppository and injection, and the multiple of the content of active compound and function or individual dose adapts in the formulation.Dose unit can comprise, for example 1,2,3, or 4 unitary dose or 1/2,1/3 or 1/4 unitary dose.Unitary dose preferably contains for the active compound amount of once taking and is equivalent to 1,1/2,1/3 or 1/4 of day clothes dosage.
The vehicle that the nontoxic inert used of preparation medicament pharmaceutically is suitable for using is interpreted as solid, the thinner of semisolid or liquid, filler, all constituent auxiliarys.
Have as preferred medicament is describable: tablet, coated tablet, capsule, pill, granula, suppository, solution, suspension, emulsion, paste, ointment, gel, missible oil, washing lotion, pulvis and sprays.
Tablet, coated tablet, capsule, the compound that pill and granula can contain active compound and use with general vehicle, for example: (a) weighting material and swelling agent, starch for example, lactose, sucrose, glucose, N.F,USP MANNITOL and silicon-dioxide, (b) tackiness agent, carbonyl methylcellulose gum for example, alginate, gelatin, and polyvinylpyrrolidone, (c) wetting agent, as glycerine, (d) decomposition agent, as agar, lime carbonate and sodium bicarbonate, (e) solution retarding agent as paraffin, (f) absorbs accelerator, as quaternary ammonium compound, (g) treating compound is as cetyl alcohol or glycerine Stearinsaeure, (h) sorbent material, as kaolin or wilkinite, (i) lubricant is as calcium stearate, Magnesium Stearate and solid polyoxyethylene glycol, or be listed in the mixture that (a) arrives (i) following material.
Tablet, coated tablet, capsule, pill and granula can obtain with general coating and shell bag method, arbitrarily comprise opacifying agent, also such composition; Preferred inner a certain position, by the mode of random delayed action, such composition discharges one or more active compounds, and can be used as the example of putting into composition is polymkeric substance and wax.
One or more active compounds also can microencapsulation form exist arbitrarily with above-mentioned one or more vehicle.
Suppository also can contain general water miscible or water-insoluble vehicle except containing one or more active ingredient beyond the region of objective existences, for example polyoxyethylene glycol, fat, as cocoa fat and higher ester (as C
14-alcohol and C
16The ester that-lipid acid generates) or the mixture of these materials.
Ointment, paste, missible oil and gel are except containing one or more active ingredient beyond the region of objective existences, also can contain general vehicle, for example: animal and plant fat, wax, paraffin, starch, tragocants, derivatived cellulose, polyoxyethylene glycol, siloxanes, wilkinite, silicon-dioxide, talcum and zinc oxide, or the mixture of such material.
Powder and sprays are removed and are contained one or more active ingredient beyond the region of objective existences, also contain general vehicle, for example: lactose, talcum, silica gel, aluminium hydroxide, Calucium Silicate powder and polyamide powder, or the mixture of these materials.Sprays also contains chlorofluorocarbon except containing general propelling agent.
Solution and milk sap remove and contain one or more active compounds, also contain general vehicle, for example: solvent, solubilizing agent and emulsifying agent, as water, ethanol, Virahol, ethyl-carbonate, second vinegar ethyl ester, phenylcarbinol, phenylamino benzoic acid methyl alcohol ester, propylene glycol, 1,3-butyleneglycol, dimethyl formamide, oil, particularly oleum gossypii seminis, peanut oil, Fructus Maydis oil, sweet oil, Viscotrol C and sesame oil, the ester fat acid ester of glycerine, Sericosol N, tetrahydrofurfuryl alcohol, polyoxyethylene glycol and anhydro sorbitol, or the mixture of these materials.
For administered parenterally, solution and milk sap also can be isotonic sterile form with blood and exist.
Suspension is except containing one or more active ingredient beyond the region of objective existences, also contain common vehicle, for example: liquid diluent, as water, ethanol or propylene glycol, suspension agent, as isooctadecanol, polyoxyethylene sorbitol, anhydro sorbitol fat, Microcrystalline Cellulose, inclined to one side aluminium hydroxide, wilkinite, agar, the tragacanth gum of ethoxylation, or the mixture of these materials.
The prescription of recording and narrating also can contain tinting material, sanitas and improve smell and the additive of fragrance, for example: spearmint oil, Oil of Eucalyptus, and sweetener, as asccharin.
The active compound of using in the treatment preferably should exist with above-mentioned medicine type, and its concentration is about about 0.1-99.5% of mixture total weight amount, preferably about 0.5-95%.
Above-mentioned medicament also can contain other medicinal activity compounds except containing the resulting compound of with good grounds the present invention.
Above-mentioned medicament is produced with common mode according to known method, for example uses one or more active compounds and a kind of vehicle or multiple mixed with excipients.
Active compound or medicament can be partial, and be oral, parenteral, and endoperitoneal mode is preferably with oral or parenteral mode administration, for example intravenous injection or intramuscular injection.
In order to reach the result of hope, generally speaking, arbitrarily with several form of medication, with per 24 hours, the about 0.5-500 of per kilogram of body weight, preferably one or more active compound administrations of 1-50 milligram prove favourable in people's medicine and veterinary drug.Individual administration contains one or more active compounds, and it measures preferably about 0.5-250, particularly 1-60 milligram/kg body weight.Yet, in some cases, need depart from above-mentioned dosage, particularly be related to the physiological function and the body weight of treatment target, the kind of the character of disease and seriousness, preparation and the kind of administration, last time, time of administration or interval all will be considered to change dosage.
Therefore, in some cases, use the amount of lacking than above-mentioned active compound also can satisfy the demand, and under the other situation, above-mentioned active compound must be excessive.The especially dosage and the administration type of the optimum activity compound that needs, can be at an easy rate by the expert in present technique field knowledge ground decision according to him.
New compound of the present invention can be common concentration supply with, also can fit over together and supply with feed or feed formulations or tap water.Use this method, may prevent, improve and/or treat the infection that causes by Gram-negative or gram-positive bacteria.In feed, use to reach with this method and promote growth and improvement.
The compound that obtains according to the present invention equally also is applicable to the infectation of bacteria of prevention and treatment fish.
1-ethyl-6-fluoro-1 is disclosed in medical chemistry magazine (J.Med.Chem.23,1358(1980)), 4-dihydro-4-oxo-7-(1-
The piperazine base)-3-quinoline carboxylic acid (nofloxacin) has antibacterial properties.But, the compound that obtains according to the present invention is better than nofloxacin, can find out significantly that from following table following table has been listed minimum inhibition concentration (MIC) value of some compounds that obtain according to the present invention and the minimum inhibition concentration value (MIC) of nofloxacin.
The preparation example
The preparation of raw material (II)
Example A
1-cyclopropyl-6,7-8-three fluoro-1,4-dihydro-4-oxo-3-quinoline carboxylic acid
24.3 gram magnesium is rotating and is being suspended in 50 milliliters of dehydrated alcohols.Add 5 milliliters of tetracol phenixin, when when beginning reaction, in the time of temperature 50-60 ℃, with 160 gram diethyl malonates, the mixture of the dry toluene of 100 milliliters of dehydrated alcohols and 400 milliliters is added drop-wise in the reactant.Mixture is cooled to-5 °-10 ℃ temperature 50-60 ℃ reheat 1 hour with dry ice/acetone, and with the gram of 212.5 in 80 milliliters of dry toluenes 2,3,4, the 5-phenyl tetrafluoride formyl chloride slowly drips wherein under this temperature.Mixture stirred 1 hour at temperature 0-5 ℃, made it reach ambient temperature overnight, and then used when ice-cooled, poured in the mixture of 400 milliliters of frozen water and 25 milliliters of vitriol oils.Two-phase separately extracts with toluene.The blended toluene solution is washed with saturated Nacl solution, uses Na
2SO
4Drying, and solvent is removed with vacuum.Obtain 335 grams 2,3,4,5-tetra fluoro benzene formyl radical diethyl malonate is as crude product.
0.3 adding, the gram tosic acid contains 284.8 grams 2,3,4, in the milk sap of 300 ml waters of 5-tetra fluoro benzene formyl radical diethyl malonate crude product.This mixture heating up to the boiling, stirred 5 hours powerfully, refrigerative milk sap with dichloromethane extraction several times, the blended dichloromethane solution is washed once with saturated Nacl solution, uses Na
2SO
4Dry.And solvent is removed with distillation under vacuum condition.Fractionation resistates under high vacuum obtains 160.2 grams 2,3,4, and 5-tetrafluoro ethyl benzoylacetate, its boiling point are 100-110 ℃/0.09～0.1 millibar, fusing point 47-49 ℃.
110.7 restrain 2,3,4, the 5-tetrafluorobenzoyl ethyl, the mixture of 93.5 gram ethyl orthoformates and 107 gram diacetyl oxides was 150 ℃ of heating of temperature 2 hours.Volatiles vacuumizes down with water pump then, under the high vacuum during about 120 ℃ of temperature, removes with distillation at last.Stay 123.9 gram 2-(2,3,4,5-tetra fluoro benzene formyl radical)-3-ethoxy ethyl acrylate crude product.This product is enough pure to the next step.
23.2 the gram cyclopropylamine is stirring and with being added drop-wise under the water cooling 123.9 gram 2-(2,3,4,5-tetra fluoro benzene formyl radical is being arranged in 250 milliliters of ethanol)-solution of 3-ethoxy ethyl acrylate in.When thermopositive reaction reduced, mixture at room temperature continued to stir 1 hour, and solvent is removed with vacuum, and resistates is recrystallization from hexanaphthene/sherwood oil.Obtain 115 gram 2-(2,3,4,5-tetra fluoro benzene formyl radical)-3-cyclopropyl aminoacrylic acid ethyl ester, 63-65 ℃ of its fusing point.
21.2 being added in, the gram Sodium Fluoride contains 107.8 gram 2-(2,3,4 in 400 milliliters of anhydrous dimethyl formamides; 5-tetra fluoro benzene formyl radical)-solution of 3-cyclopropyl aminoacrylic acid ethyl ester in; then, reaction mixture stirred 2 hours under refluxing, and the reaction mixture with heat is poured on ice again.The throw out suction filtration, fully washing is dry under vacuum 100 ℃ of temperature on the calcium chloride.Obtain 91.2 gram 1-cyclopropyl-6,7,8-three fluoro-1,4-dihydro-4-oxo-3 quinoline carboxylic acid ethyl ester, its fusing point is 167-168 ℃.
94 gram 1-cyclopropyl-6,7,8-three fluoro-1,4-dihydro-4-oxo-3-quinoline carboxylic acid ethyl ester, 600 milliliters of Glacial acetic acid, the mixture heating up of 450 ml waters and 70 milliliters of vitriol oils refluxed 1.5 hours.Then, the suspension of heat is poured on ice, the throw out suction filtration, and water is fully washed, and is dry in a vacuum 100 ℃ of temperature, obtains the pure 1-cyclopropyl-6,7 of 88.9 grams, 8-three fluoro-1,4-dihydro-4-oxo-3-quinoline carboxylic acid (II) (X with this method
1=X
2=F), its fusing point is 228-320 ℃ (decomposition).
Example B
1-cyclopropyl-6,7-two fluoro-1,4-dihydro-4-oxo-3-quinoline carboxylic acid
Present method with example A simulated condition under implement, from 2,4, the 5-trifluoro-benzoyle fluoride begins, through the following steps: 2,4, (boiling point: 92-95 ℃/0.5 millibar of 5-trifluoromethyl benzonitrile ethyl acetoacetic acid diethyl ester; Fusing point: 53-55 ℃) → 2(2; 4; 5-trifluoromethyl benzonitrile acyl group)-3-ethoxy ethyl acrylate (oil) → 2(2; 4,5-trifluoromethyl benzonitrile acyl group)-3-cyclopropyl aminoacrylic acid ethyl ester (oil) → 1-cyclopropyl-6,7-two fluoro-1; 4-dihydro-4-oxo-3-quinoline carboxylic acid ethyl ester (fusing point 230-233 ℃) → 1-cyclopropyl-6; 7-two fluoro-1,4-dihydro-4-oxo-3-quinoline carboxylic acid (fusing point 302-303 ° has decomposition)
The preparation of active compound (I)
Example 1
The 7-chloro-1-cyclopropyl-6-fluoro-1 that in 6 milliliters of dimethyl sulfoxide (DMSO), contains 2.8 grams (0.01 mole), 4-dihydro-4-oxo-3-quinoline carboxylic acid, the 2-phenyl of 1.8 grams (0.011 mole)
1 of piperazine and 2.2 grams (0.02 mole), the mixture of 4-diazabicyclo (2.2.2) octane was 140 ℃ of heating of temperature 4 hours.Solution concentrates under high vacuum, and resistates is worked as 20 ml waters and stirred together, regulates pH value to 7 with 2N hydrochloric acid.The throw out suction filtration, water and methyl alcohol are washed, and boil in 30 ml methanol.Obtain 1.3 gram (theoretical amount 32%) 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(3-phenyl-1-
The piperazine base)-and the 3-quinoline carboxylic acid, 218-220 ° of (decomposition is arranged) (recrystallization from ethylene glycol monoethyl ether) of its fusing point.
When 1-cyclopropyl-6,7-three fluoro-1,4-dihydro-4-oxo-3-quinoline carboxylic acid correspondingly with the 2-phenyl
Obtain identical product during the piperazine reaction.
Following compounds is with suitable
Piperazine is used with example 1 similar methods and is obtained:
Example 14
60 milliliter 48% concentrated hydrobromic acid is added in the solution of the product that obtains from example 6 that contains 2.5 grams (4.9 mmole) in 30 milliliters of ethanol, and mixture stirred 1 hour for 55 ℃ in temperature.Concentrate in a vacuum then, resistates stirs with 50 ml waters, the throw out suction filtration.Obtain 1.5 gram (theoretical amount 66%) 1-cyclopropyl-6-fluoro-1,4-dihydro-7-(3-(4-hydroxy phenyl)-1-
The piperazine base)-and 4-oxo-3-quinoline carboxylic acid hydrobromate, 295-298 ° of its fusing point (decomposition is arranged).
Example 15
2.8 the 1-cyclopropyl-6,7 of gram (0.01 mole), 8-three fluoro-1, the 2-(2-thienyl of 4-dihydro-4-oxo-3-quinoline carboxylic acid (example A) and 1.8 grams (0.011 mole) in 6 milliliters of dimethyl sulfoxide (DMSO))
1 of piperazine and 2.2 grams (0.02 mole), 4-diazabicyclo (2.2.2) octane is heated to 140 ℃ together, reaches 2 hours.Mixture concentrates under high vacuum, and resistates stirs with 20 ml waters, and the throw out suction filtration boils in 20 ml methanol.Obtain 2.4 gram (theoretical amount 56%) 1-cyclopropyl-6,8-two fluoro-1,4-dihydro-4-oxo-7-(3-(2-thienyl)-1-
The piperazine base)-and the 3-quinoline carboxylic acid, 252-254 ℃ of its fusing point (decomposition is arranged).Recrystallization from ethylene glycol monoethyl ether, fusing point remains unchanged.
Following compounds is used with example 15 similar methods and is obtained:
1.1 the product and the 0.6 gram triethylamine and 0.9 that from example 1 obtain of gram (2.7 mmole) in 10 milliliters of dimethyl formamides restrains iodoethane 80 ℃ of heating of temperature 3 hours.The reaction mixture vacuum concentration, resistates and 10 ml waters stir together, recrystallization from ethylene glycol monoethyl ether.Obtain 0.75 gram (theoretical amount 49%) 1-cyclopropyl-7-(4-ethyl-3-phenyl-1-
The piperazine base)-and 6-fluoro-1,4-dihydro-4-oxo-3-quinoline carboxylic acid hydriodate, 240-243 ° of its fusing point (decomposition is arranged).
Example 20
1.1 the product and the 1.05 gram methyl ethyl ketones that from example 1 obtain of gram (2.7 mmole) in 15 milliliters of ethanol heated 8 hours under refluxing.The throw out suction filtration is washed with ethanol.Obtain 0.9 gram (theoretical amount 70%) 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(4-(3-oxo butyl-1-
The piperazine base)-and the 3-quinoline carboxylic acid, 224-226 ° of its fusing point (decomposition is arranged).
Example 21
0.8 compound and 0.6 milliliter of strong formic acid of 98-100% of obtaining from example 16 in 6 milliliters of dimethyl formamides of gram (1.9 mmole) heated 8 hours under refluxing.The reaction mixture vacuum concentration, resistates stirs with 20 ml waters, and the sodium hydrogen carbonate solution with 5% is regulated pH value to 5.The throw out suction filtration of separating, water and methyl alcohol are washed, recrystallization from ethylene glycol monoethyl ether.Obtain 0.6 gram (theoretical amount 70%) 1-cyclopropyl-6,8-two fluoro-7-(4-formyl radical-3-phenyl-1-
The piperazine base)-1,4-dihydro-4-oxo-3-quinoline carboxylic acid, 242-245 ° of its fusing point (decomposition is arranged)
Example according to tablet of the present invention
Every contains:
291.5 milligrams of the compounds of example
27.5 milligrams of Microcrystalline Celluloses
36.0 milligrams of W-Gums
Poly-(l-vinyl-2-pyrrolidone, insoluble 15.0 milligrams
2.5 milligrams of the silicon-dioxide of high dispersing
2.5 milligrams of Magnesium Stearates
375.0 milligram
The Nitrocellulose glued membrane contains:
Poly-(neighbour-hydroxy phenyl-neighbour-methyl) 3.9 milligrams
Mierocrystalline cellulose 15 chemical pure (hydroxypropyls
Methylcellulose gum, American Pharmacopeia)
Macrogol????4000????rec????INN
(polyoxyethylene glycol Ph.G) 1.3 milligrams
1.3 milligrams of titanium dioxide
(titanium dioxide British Pharmacopoeia) 6.5 milligrams
Errata
Errata
Claims (5)
1, the 1-of formula I cyclopropyl-6-fluoro-1,4-dihydro generation-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid's preparation method
Wherein:
R
1Represent hydrogen; the alkyl that contains the straight or branched of 1 to 4 carbon atom; these alkyl are arbitrarily replaced by following groups: hydroxyl, methoxyl group, amino, dimethylamino, fontanel element; for example fluorine or chlorine, cyano group or contain the carbalkoxy of 1 or 2 carbon atom at moieties; also represent oxidation of alkyl, phenacyl, or contain the acyl group of 1 to 4 carbon atom up to 4 carbon atoms
R
2Represent phenyl and cyclohexyl, cyclohexyl arbitrarily by following groups one to triple replacements: the fontanel element, for example chlorine, bromine or fluorine, methyl, phenyl, cyano group, hydroxyl, methoxyl group, benzyloxy, amino, methylamino, dimethylamino, piperidino-(1-position only) or nitro are also represented methylene radical dioxo phenyl, methylene radical dioxo cyclohexyl, furyl, tetrahydrofuran base or thienyl
X
1Represent hydrogen and fluorine
With these compounds at pharmaceutically available hydrate, acid salt, the preparation method of basic metal and alkaline earth salt is characterized in that, perhaps
A) or the compound 1-cyclopropyl of (II) base-7-fluoro-1,4-dihydro-4-oxo-3-quinoline carboxylic acid
Wherein, X
1Above-mentioned connotation is arranged, X
2Represent the piperazine reaction of fontanel element, particularly fluorine or chlorine and formula III,
Wherein: R
1And R
2Above-mentioned implication is arranged, and it is suitable having acid binding agent to exist in the reaction; Perhaps
B) the compound 7-of formula IV (1-piperazinyl) quinolone carboxylic acid
Wherein: R
1And R
2Above-mentioned implication is arranged,
With the compound reaction of formula (V),
Wherein: R
1Above-mentioned implication is arranged, but hydrogen not
X represents fluorine, chlorine, bromine, iodine, hydroxyl, acyloxy, phenoxy group or 4-nitrophenoxy,
It is suitable having acid binding agent to exist in the reaction;
Perhaps
C) Michael's receptor of the compound 7-of formula IV (1-piperazinyl) quinolone carboxylic acid and formula VI reaction
Wherein: R
3Represent CN, CH
3CO or COOR
4, R
4Represent methylidene or ethyl.
2, according to the compound 1-cyclopropyl base-6-fluoro-1 of claim 1 preparation formula I, 4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid's method, wherein:
R
1Represent hydrogen; the straight or branched alkyl that contains 1 to 4 carbon atom; these alkyl are arbitrarily replaced by following groups: hydroxyl, methoxyl group, fontanel element; for example fluorine or chlorine, cyano group or the carbalkoxy of 1 or 2 carbon atom is arranged at moieties; also represent oxoalkyl group, phenacyl, formyl radical or ethanoyl up to 4 carbon atoms
R
2Represent phenyl and cyclohexyl, cyclohexyl arbitrarily by following groups one to triple replacements: chlorine, bromine, fluorine, methyl, phenyl, hydroxyl, methoxyl group, benzyloxy, amino, piperidino-(1-position only) or nitro, also represent thienyl,
X
1Represent hydrogen or fluorine
3, according to the compound 1-cyclopropyl base-6-fluoro-1 of claim 1 preparation formula I, 4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid's method, wherein:
R
1Represent hydrogen; alkyl straight chain or side chain that contains 1 to 3 carbon atom; these alkyl are arbitrarily replaced by following groups: hydroxyl, methoxyl group, cyano group or the carbalkoxy of 1 or 2 carbon atom is arranged at moieties; also represent oxoalkyl group, phenacyl, formyl radical or ethanoyl up to 4 carbon atoms
R
2Represent phenyl and cyclohexyl, cyclohexyl arbitrarily by following groups one to triple replacements: chlorine, bromine, fluorine, methyl, phenyl, hydroxyl, methoxyl group, benzyloxy, amino, piperidino-(1-position only) or nitro, also represent thienyl,
X
1Represent hydrogen or fluorine
4, preparation method according to claim 1 wherein makes 1-cyclopropyl-6,7-two fluoro-1,4-dihydro-4-oxo-3-quinoline carboxylic acid.
5, medicaments preparation method is characterized in that the compound 1-cyclopropyl base-6-fluoro-1 of formula I, 4-dihydro-4-oxo-7-(1-piperazinyl) the 3-quinoline carboxylic acid
Wherein:
R
1Represent hydrogen; the alkyl that contains the straight or branched of 1 to 4 carbon atom; these alkyl are arbitrarily replaced by following groups: hydroxyl, methoxyl group, amino, dimethylamino, fontanel element; for example fluorine or chlorine, cyano group or contain the carbalkoxy of 1 or 2 carbon atom; also representative contains oxoalkyl group, the phenacyl up to 4 carbon atoms, or contains the acyl group of 1 to 4 carbon atom
R
2Represent phenyl and cyclohexyl, cyclohexyl arbitrarily by following groups one to triple replacements: the fontanel element, for example chlorine, bromine or fluorine, methyl, phenyl, cyano group, hydroxyl, methoxyl group, benzyloxy, amino, methylamino, dimethylamino, piperidino-(1-position only) or nitro are also represented methylene radical dioxo phenyl, methylene radical dioxo cyclohexyl, furyl, tetrahydrofuran base or thienyl
X
1Represent hydrogen and fluorine
With these compounds at available hydrate pharmaceutically, acid-adducting salt, basic metal and alkaline earth salt and inert, non-ionic, suitable mixed with excipients pharmaceutically.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 85101832 CN1014410B (en) | 1984-06-04 | 1985-04-01 | Process for preparing 7-(3-aryl-1-piperazinyl)-and 7-(3-cyclohexyl-1-piperazinyl)-3 quinolonecarboxylic acids |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19843420798 DE3420798A1 (en) | 1984-06-04 | 1984-06-04 | 7- (3-ARYL-L-PIPERAZINYL) - AND 7- (3-CYCLOHEXYL-L-PIPERAZINYL) -3-CHINOLONIC CARBONIC ACIDS |
| CN 85101832 CN1014410B (en) | 1984-06-04 | 1985-04-01 | Process for preparing 7-(3-aryl-1-piperazinyl)-and 7-(3-cyclohexyl-1-piperazinyl)-3 quinolonecarboxylic acids |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN85101832A true CN85101832A (en) | 1987-01-31 |
| CN1014410B CN1014410B (en) | 1991-10-23 |
Family
ID=25741502
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 85101832 Expired CN1014410B (en) | 1984-06-04 | 1985-04-01 | Process for preparing 7-(3-aryl-1-piperazinyl)-and 7-(3-cyclohexyl-1-piperazinyl)-3 quinolonecarboxylic acids |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1014410B (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1091103C (en) * | 1999-04-02 | 2002-09-18 | 中国科学院上海药物研究所 | Compounds of carbostyrils and their preparation and use |
| CN102093149A (en) * | 2010-12-08 | 2011-06-15 | 天津理工大学 | Method for preparing carboxylic acid compound by promoting rapid hydrolysis of cyan |
| CN106660990A (en) * | 2014-06-18 | 2017-05-10 | 皮埃尔与玛丽·居里大学-巴黎第六大学 | Novel fluoroquinolones and use thereof to treat bacterial infections |
-
1985
- 1985-04-01 CN CN 85101832 patent/CN1014410B/en not_active Expired
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1091103C (en) * | 1999-04-02 | 2002-09-18 | 中国科学院上海药物研究所 | Compounds of carbostyrils and their preparation and use |
| CN102093149A (en) * | 2010-12-08 | 2011-06-15 | 天津理工大学 | Method for preparing carboxylic acid compound by promoting rapid hydrolysis of cyan |
| CN106660990A (en) * | 2014-06-18 | 2017-05-10 | 皮埃尔与玛丽·居里大学-巴黎第六大学 | Novel fluoroquinolones and use thereof to treat bacterial infections |
| CN106660990B (en) * | 2014-06-18 | 2019-10-18 | 皮埃尔与玛丽·居里大学-巴黎第六大学 | Novel fluoquinolone and its purposes for being used to treat bacterium infection |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1014410B (en) | 1991-10-23 |
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