CN2932257Y - Freeze drying machine for defrosting, cleaning and sterilizing by the same solution - Google Patents
Freeze drying machine for defrosting, cleaning and sterilizing by the same solution Download PDFInfo
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- CN2932257Y CN2932257Y CN 200620051344 CN200620051344U CN2932257Y CN 2932257 Y CN2932257 Y CN 2932257Y CN 200620051344 CN200620051344 CN 200620051344 CN 200620051344 U CN200620051344 U CN 200620051344U CN 2932257 Y CN2932257 Y CN 2932257Y
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Abstract
A freeze drying machine group which is capable of being defrosted, cleaned, and sterilized by the same kind of solution comprises a freeze drying case, a condenser, an ozone preparing apparatus, an ozone water preparing apparatus, a defrost water heating and delivery apparatus, and a clean condensing air input pipe, wherein the ozone preparing apparatus is connected with the ozone water preparing apparatus through the delivery pipe, the ozone water preparing apparatus which is provided with the purify water, the water for injection, and a feed inlet is connected with the freeze drying case and the condenser through the delivery pipe, the defrost water heating and delivery apparatus is connected with the freeze drying case and the condenser through the delivery pipe respectively, and the clean condensing air input pipe is connected with the drying case and the condenser. The procession of defrosting, cleaning, sterilizing of the utility model is capable of fulfilling in one step by adopting ozone water under a lower temperature, thereby having the advantages of apparatus well-sealing performance, linkage and equipment aging prevention, high safety, safe and reliable process of defrosting, cleaning, and sterilizing, time and energy saving and the like.
Description
Technical field
The utility model belongs to a kind of freeze drying unit, is specifically related to a kind of freeze drying unit of finishing defrosting, cleaning, three kinds of technological processes of sterilization with a kind of one step of solution that adopts.
Background technology
The effect of freeze drier is to remove moisture content or other solvent by distillation from the biological products that freeze.Except that the stability that obtains long preservation, other intrinsic biologically active and structures have also been kept through cryodesiccated biological products.The freeze drier major part comprises freeze drying box and the condenser that links to each other by pipeline, butterfly valve.The goods that are used for freeze-drying are placed on the shelf of freeze drying box, and the moisture content that distils out or other solvent collection are in condenser.Behind one batch of product of every production, the process that freeze drier must defrost, clean, sterilizes is removed the frost in the condenser and in the connecting line, and freeze drying box and condenser are cleaned and sterilize, in order to produce next time.Distinguish with sterilization method, existing freeze drier has two kinds, a kind ofly is to use pure steam sterilizing, and another kind is ozone gas sterilization under the normal temperature.Two kinds of sterilization methods all have corresponding shortcoming, the particularly defrosting of the freeze drying unit of two kinds of forms, cleaning, sterilization process flow process, be to adopt different medium or do not carry out, so not only lost time but also energization consumption at same medium timesharing, the substep of same physical state.
1, the defrosting of the freeze drying unit of steam sterilizing, cleaning, sterilization process flow process:
The on-line cleaning of the freeze drying unit of steam sterilizing is to use water for injection, by the pressurization of delivery pump, passes through in the freeze drying box and the spray equipment in the condenser, sprays, and reaches cleaning performance.At freeze drying box and 121 ℃ of steam of the inner feeding of water vapor condenser, and keep certain hour, sterilization effect reaches a high temperature.Sterilization back equipment also need be through just re-using after the cooling.Defrosting is general adopts 50 ℃～60 ℃ waters for injection or purified water to carry out heat water-spraying+flood, and also can adopt to feed 100 ℃～105 ℃ pure steam defrostings or vacuum defrosting.
More than three kinds of technological processes be that timesharing, substep carry out.Defective is as follows: the one, and the energy consumption height; The 2nd, high-temperature sterilization (about 121 ℃), the equipment sterilization finishes, and cooling was wanted about 8 hours naturally, adopted the cooling cool to room temperature to want consumed energy; The 3rd, in the high-temperature steam sterilization process, equipment produces vibration, jitter phenomenon, and the equipment sealing property suffers damage; The 4th, high-temperature sterilization quickens the degree of aging of valve, flange connection pad, and the sealing property of equipment is difficult to guarantee; The 5th, the high-temperature sterilization poor safety performance.The 6th, defrosting, cleaning, sterilization are separately carried out, and lose time and the energy.
2, defrosting, cleaning, the sterilization process flow process of the lyophilizer group of ozone gas sterilization under the normal temperature:
The on-line cleaning of the lyophilizer group of ozone gas sterilization is to use water for injection, by the pressurization of delivery pump, passes through in the freeze drying box and the spray equipment in the condenser, sprays, and reaches cleaning performance.At freeze drying box and the inner ozone gas that feeds of condenser, and keep certain hour, reach sterilization effect.Defrosting is general adopts 50 ℃～60 ℃ waters for injection or purified water to carry out heat water-spraying+flood, and also can adopt to feed 100 ℃～105 ℃ pure steam defrostings or vacuum defrosting.
Three kinds of technological processes of defrosting, cleaning, sterilization of the freeze drying unit of ozone gas sterilization also are that timesharing, substep carry out, except that lose time and the energy, also have other shortcoming as follows: the one, ozone concentration control is inaccurate, ozone concentration is low, it is not thorough to sterilize, the ozone concentration height can oxidation furnaces and parts thereof.The 2nd, the ozone gas sterilization can produce the appearance of the bacterial strain of anti-ozone in long-term use, ozone gas resolves into oxygen and the very active antozone with strong oxidation (O) in air, bumping with thalline with the Brownian movement of gas contacts, and moment oxidation takes place bacterium is killed.Because bacterium can not survive separately, it must colonize on the dust particle.Ozone gas is difficult to enter in the bacterial body of dust particle inside by the Brownian movement collision, and sterilization effect weakens to some extent, and the chance that produces the oxytolerant bacterial strain is bigger.
The utility model content
Technical problem to be solved in the utility model is to overcome the deficiencies in the prior art, providing a kind of adopts finish automatic defrosting, cleaning, three kinds of technological processes of sterilization same one step of medium, the equipment good seal performance, anti-leak, anti-ageing equipment, the security performance height, make defrosting, cleaning, sterilization process process not only safe and reliable, but also save time and save the energy available with a kind of solution defrosting, clean, the freeze drying unit of sterilization.
The utility model solves above-mentioned technical problem by the following technical solutions.
Available freeze drying unit of the present utility model with a kind of solution defrosting, cleaning, sterilization, comprise freeze drying box and condenser, condenser links to each other with freeze drying box by pipeline, be provided with shelf and drying box on-line cleaning device in the freeze drying box, be provided with condenser on-line cleaning device in the condenser, it is characterized in that also comprising ozone gas preparation facilities, Ozone Water preparation facilities, defrost water heating and conveying device and clean compressed air intake line; The ozone gas preparation facilities links to each other with the Ozone Water preparation facilities by conveyance conduit, the Ozone Water preparation facilities is by the drying box on-line cleaning device in conveyance conduit and the freeze drying box, or respectively with freeze drying box in drying box on-line cleaning device link to each other with condenser on-line cleaning device in the condenser, the Ozone Water preparation facilities is provided with the purified water inlet, water for injection inlet and charge door, defrost water heating and conveying device link to each other with condenser on-line cleaning device with freeze drying box by conveyance conduit respectively, and the clean compressed air intake line links to each other with condenser on-line cleaning device with drying box on-line cleaning device respectively by pipeline.
Described ozone gas preparation facilities comprises ozonized gas generator and ozone gas by-pass valve control; Described Ozone Water preparation facilities comprises that ozone is absorbed injector, basin, delivery pump, transfer pipeline by-pass valve control and circulation line by-pass valve control by water; Ozonized gas generator is absorbed injector set gas access with ozone by water through the ozone gas by-pass valve control and links to each other, the purified water inlet, water for injection inlet and charge door are located at the top of basin, the water for injection inlet is provided with the water for injection shower nozzle, the top of basin is provided with import, the bottom is provided with outlet, described outlet links to each other with delivery pump by basin control of export valve, the delivery pump delivery outlet connects ozone is absorbed injector by water water inlet, ozone is output into two branches by the delivery port that water absorbs injector, one branch links to each other with the import of basin by the circulation line by-pass valve control, another branch links to each other by the transfer pipeline by-pass valve control or with drying box on-line cleaning device, or link to each other with condenser on-line cleaning device with drying box on-line cleaning device respectively, the lower end of basin control of export valve also is provided with the basin discharge outlet; Described defrost water heating and conveying device comprise temporary jar, defrost water delivery pump and heat exchanger, temporary jar inlet links to each other with the freeze drying box bottom by control valve, control valve is passed through in outlet successively, the defrost water delivery pump, heat exchanger links to each other with condenser on-line cleaning device, the bottom of condenser is provided with the condenser discharge outlet, the clean compressed air intake line comprises the clean compressed air source and the pipeline of clean compressed air by-pass valve control is housed that the clean compressed air source communicates with drying box on-line cleaning device and condenser on-line cleaning device respectively by the pipeline that the clean compressed air by-pass valve control is housed.Be provided with agitating device in the described basin, tank wall is provided with cooling jacket, and cooling jacket is provided with cooling water inlet and coolant outlet.Described ozone gas by-pass valve control and ozone are provided with the ozone gas filter by the pipeline that water absorbs between the injector, and ozone gas filter and ozone are provided with flow between the water absorption injector and take into account the detection sampler; Pipeline between described defrost water delivery pump and the heat exchanger is provided with the defrost water filter; The transfer pipeline by-pass valve control is provided with filter with the pipeline that drying box on-line cleaning device, condenser on-line cleaning device link to each other.
Advantage of the present utility model is: with respect to existing freeze drying unit, online defrosting of the present utility model, cleaning, sterilization can adopt one step of Ozone Water to carry out, and carry out at a lower temperature, reduced production time, increased the effective production time of freeze drying unit greatly, improve production efficiency and service life of equipment, had energy-conservation, time-saving and efficiency, equipment good seal performance, anti-leak, anti-ageing equipment, security performance advantages of higher.
The utility model adopts the Ozone Water sterilization, and with respect to the freeze drying unit of ozone gas sterilization, the sterilization principle has further raising, and sterilization effect is better, and the chance that produces the bacterial strain of anti-ozone is wanted much less than the chance that produces the bacterial strain of anti-ozone with the ozone gas sterilization.
Description of drawings
Fig. 1 is the structural representation of the utility model embodiment;
Fig. 2 is the utility model ozone is absorbed injector by water a structural representation cutaway view.
Each label is represented among the figure:
1, ozone gas preparation facilities 1-1, ozonized gas generator
1-2, ozone gas by-pass valve control 1-3, ozone gas filter
1-4, detection sampler 1-5, flowmeter
2, clean compressed air intake line 2-1, clean compressed air by-pass valve control
2-2, clean compressed air source 2-3, the compressed air by-pass valve control that opens circuit
3, Ozone Water preparation facilities 3-1, ozone are absorbed injector by water
3-101, gas access 3-102, water inlet
3-103, delivery port 3-2, delivery pump
3-3, basin control of export valve 3-4, basin discharge outlet
3-5, basin 3-6, charge door
3-7, transfer pipeline by-pass valve control 3-8, circulation line by-pass valve control
3-9, water for injection shower nozzle 3-10, water for injection inlet
3-11, purified water are gone into 3-12, cooling water inlet
3-13, coolant outlet 3-14 cooling jacket
3-15, outlet 3-16, import
3-17, agitating device 3-18, filter
4, freeze drying box 4-1, drying box on-line cleaning device
4-2, shelf 4-3, drying box inlet by-pass valve control
5, condenser 5-1, connection control valve
5-2, condenser inlet by-pass valve control 5-3, condenser on-line cleaning device
5-4, condenser discharge outlet 6, defrost water heating and conveying device
6-1, the temporary jar 6-2 of defrost water, defrost water delivery pump
6-3, defrost water filter 6-4, heat exchanger
6-5, control valve
The specific embodiment
As shown in Figure 1, of the present utility model available with a kind of solution defrosting, clean, the freeze drying unit of sterilization, comprise freeze drying box 4, condenser 5, ozone gas preparation facilities 1, Ozone Water preparation facilities 3, defrost water heating and conveying device 6 and clean compressed air intake line 2, condenser 5 links to each other with freeze drying box 4 by pipeline, and on this pipeline, be provided with and connect control valve 5-1, be provided with shelf 4-2 and drying box on-line cleaning device 4-1 in the freeze drying box 4, be provided with condenser on-line cleaning device 5-3 in the condenser 5, ozone gas preparation facilities 1 links to each other with Ozone Water preparation facilities 3 by conveyance conduit, Ozone Water preparation facilities 3 is by the drying box on-line cleaning device 4-1 in conveyance conduit and the freeze drying box 4 link to each other with condenser on-line cleaning device 5-3 in the condenser 5 (also can link to each other with drying box on-line cleaning device 4-1), Ozone Water preparation facilities 3 is provided with purified water inlet 3-11, water for injection inlet 3-10 and charge door 3-6, defrost water heating and conveying device 6 link to each other with condenser on-line cleaning device 5-3 with freeze drying box 4 by conveyance conduit respectively, and clean compressed air intake line 2 links to each other with condenser on-line cleaning device 5-3 with drying box on-line cleaning device 4-1 respectively by pipeline.Ozone gas preparation facilities 1 comprises ozonized gas generator 1-1 and ozone gas by-pass valve control 1-2; Ozone Water preparation facilities 3 comprises that ozone is absorbed injector 3-1, basin 3-5, delivery pump 3-2, transfer pipeline by-pass valve control 3-7 and circulation line by-pass valve control 3-8 by water; As shown in Figure 2, ozone is absorbed injector 3-1 by water and is provided with the gas access 3-101 that is positioned at the middle part and water inlet 3-102, the delivery port 3-103 at two ends, ozonized gas generator 1-1 is absorbed injector 3-1 set gas access 3-101 with ozone by water through ozone gas by-pass valve control 1-2 and links to each other, ozone gas by-pass valve control 1-2 and ozone are provided with ozone gas filter 1-3 by the pipeline that water absorbs between the injector 3-1, and ozone gas filter 1-3 and ozone are absorbed by water and is provided with flowmeter 1-5 between the injector 3-1 and detects sampler 1-4.Purified water inlet 3-11, water for injection inlet 3-10 and charge door 3-6 are located at the top of basin 3-5, water for injection inlet 3-10 is provided with water for injection shower nozzle 3-9, be provided with agitating device 3-17 in the basin 3-5, tank wall is provided with cooling jacket 3-14, cooling jacket 3-14 is provided with cooling water inlet 3-12 and coolant outlet 3-13, the top of basin 3-5 is provided with import 3-16, the bottom is provided with outlet 3-15, outlet 3-15 links to each other with delivery pump 3-2 by basin control of export valve 3-3, delivery pump 3-2 delivery outlet connects ozone is absorbed injector 3-1 by water water inlet 3-102, ozone is output into two branches by the delivery port 3-103 that water absorbs injector 3-1, one branch by circulation line by-pass valve control 3-8 with the pipeline basin 3-5 that is linked back, link to each other with the import 3-16 of basin 3-5, another branch links to each other with condenser on-line cleaning device 5-3 with drying box on-line cleaning device 4-1 respectively by transfer pipeline by-pass valve control 3-7, transfer pipeline by-pass valve control 3-7 and drying box on-line cleaning device 4-1, the pipeline that condenser on-line cleaning device 5-3 links to each other is provided with filter 3-18, and be provided with drying box inlet by-pass valve control 4-3 in the import department of drying box on-line cleaning device 4-1, then be provided with condenser inlet by-pass valve control 5-2 in the import department of condenser on-line cleaning device 5-3; The lower end of basin control of export valve 3-3 also is provided with basin discharge outlet 3-4.Defrost water heating and conveying device 6 comprise temporary jar 6-1, defrost water delivery pump 6-2 and heat exchanger 6-4, the inlet of temporary jar 6-1 links to each other with freeze drying box 4 bottoms by control valve 6-5, outlet links to each other with condenser on-line cleaning device 5-3 by control valve, defrost water delivery pump 6-2, heat exchanger 6-4 successively, and the pipeline between defrost water delivery pump 6-2 and the heat exchanger 6-4 is provided with defrost water filter 6-3; The bottom of condenser 5 is provided with condenser discharge outlet 5-4.Clean compressed air intake line 2 comprises clean compressed air source 2-2 and the pipeline of clean compressed air by-pass valve control 2-1 is housed, clean compressed air source 2-2 communicates with drying box on-line cleaning device 4-1 and condenser on-line cleaning device 5-3 respectively by the pipeline that clean compressed air by-pass valve control 2-1 is housed, and is being provided with the compressed air that cuts off the Ozone Water transfer pipeline by-pass valve control 2-3 that opens circuit with the Ozone Water transfer pipeline place of communicating.
By the size of freeze drying unit, ozonized gas generator 1-1 is chosen as: the volume of establishing freeze drying box 4 is that V1, condenser 5 volumes are that V2, the conduit volume that connects freeze drying box 4 and condenser 5 are V3, and the spatial volume of then sterilizing is V=V1+V2+V3." disinfection technology standard " with reference to Ministry of Health of the People's Republic of China's promulgation, ozone gas is 2～4ppm to the sterilization concentration of the bacterium that swims in the air, sedimentation bacterium sterilization concentration to body surface is 10～15ppm, and one hour fading rate of ozone gas (S) is about 62.25%.Ozone concentration C is 10ppm in the air if get, and converts the cubic meter into 19.63mg/.Select ozonized gas generator ozone generating capacity W (milligram/hour) to be:
W＝CV/(1-S)＝19.63×V/(1-0.6225)
What more than calculate is to adopt the required ozone gas amount of ozone gas sterilization, and through facts have proved, if adopt the Ozone Water sterilization, then the ozone gas aequum is above-mentioned 1～10 times.According to the aforementioned calculation method, select the suitable ozonized gas generator 1-1 of ozone gas output.By pipeline output ozone gas, the gas output tube road is absorbed injector with ozone in the Ozone Water preparation facilities by water and links to each other.
Corresponding freeze drying unit freeze-drying area is 5～60 square metres.Each by-pass valve control of Ozone Water preparation facilities 3 and ozone gas preparation facilities 1 and pipeline drift diameter are at 15～20mm, and pipe thickness is at 2mm ± 0.5mm, and material is PVC, ABS or polytetrafluoroethylene (PTFE).Basin 3-5 be volume 1～5 cubic metre 304, the tank body of 304L, 316,316L stainless steel.Ozone is absorbed injector 3-1 by water and sees Fig. 2, and its A end interface is ozone gas inlet 3-101, and the B end is delivery port 3-103, and the C end is water inlet 3-102.Material is a stainless steel.Water enters from C end, bore from big to small, flow velocity is accelerated, and enters the B end, bore is big from little change, continue to keep high flow rate, but pressure reduces, current are in turbulence state, increase with the ozone gas contact area, make ozone gas soluble in water.Above-mentioned delivery pump 3-2 is a stainless steel centrifugal pump, and its flow is 2～20 tons/hour, and preferred 2～5 tons/hour, lift is at 20～50 meters, and preferred 40～50 meters, material is a stainless steel.
Each by-pass valve control of heating of defrosting Ozone Water and conveying device 6 and pipeline drift diameter are at 15～20mm, and pipe thickness is at 2mm ± 0.5mm, and material is PVC, ABS or polytetrafluoroethylene (PTFE).Temporary jar of 6-1 of defrost water be volume 0.5～1 cubic metre 304,304L, 316,316L stainless steel tank body.Heat exchanger 6-4 is a shell and tube, and heat exchange area is 1～5 square metre, and wherein the tubulation gap is the industrial steam passage, and the tubulation internal diameter is the Ozone Water passage, and material is 304,304L, 316,316L stainless steel.
Clean compressed air source 2-2 is the tolerance greater than 3 cubic metres/hour, and oil and moisture be less than 0.01ppm, the dust particle diameter less than 0.1 μ m aseptic, do not have oil, an anhydrous gas.
Defrosting of the present utility model, cleaning, sterilization process process are: 1) at first prepare Ozone Water, add the purified water of G/2 amount in the Ozone Water basin by the inlet of the purified water on basin 3-5 3-11, being calculated as of purified water total consumption (ton): G=2 * K * m/10, wherein K is an empirical coefficient, the K=0.5-1.5 ton/square metre, m is the freeze drying box drying area.Close purified water inlet 3-11, open basin control of export valve 3-3, circulation line by-pass valve control 3-8 and delivery pump 3-2, allow purified water between pipeline and basin 3-5, circulate.Open ozonized gas generator 1-1, open ozone gas by-pass valve control 1-2,1-3 filters through the ozone gas filter, 1～10 times of output ozone gas by aforementioned W=CV/ (1-S)=19.63 * V/ (1-0.6225) amount of calculation, sampler 1-4 after testing, after flowmeter 1-5 detection is qualified, arrive ozone and absorbed injector 3-1 by water, enter in the purified water therein and dissolve, make Ozone Water, deliver to basin 3-5 by delivery pump 3-2 by circulation line by-pass valve control 3-8 again, move in circles, circulation dissolving through 20～60 minutes, can reach the Ozone Water of concentration, close valve circulation line by-pass valve control 3-8 greater than 0.3mg/L.2) freeze drying box cleans, sterilizes: open transfer pipeline by-pass valve control 3-7, the drying box inlet by-pass valve control 4-3 of freeze drying box 4, Ozone Water is transferred pump 3-2 and extracts out from the basin 3-5 of Ozone Water, filter through filter 3-18, deliver to the drying box on-line cleaning device 4-1 in the freeze drying box 4, to carrying out spray Cleaning for High Capacity in the freeze drying box 4, when cleaning, sterilize.Clean, the water after the sterilization flow into the defrost water heating that links to each other with freeze drying box 4 and temporary jar of 6-1 of conveying device 6 in as the Ozone Water that defrosts.Ozone Water among the basin 3-5 repeats step 1) after all being delivered to freeze drying box 4, and the Ozone Water of the same amount of preparation is used as condenser 5 washing and sterilizings.3) condenser defrosting, cleaning, sterilization: the defrosting Ozone Water among the temporary jar 6-1 is extracted out by defrost water delivery pump 6-2 again, after defrost water filter 6-3 filtration, through over-heat-exchanger 6-4, make the defrosting Ozone Water be warmed up to 60 ℃ ± 10 ℃, enter into condenser on-line cleaning device 5-3, condenser 5 is sprayed, defrosting, cleaning, sterilization, defrost water is discharged by condenser discharge outlet 5-4.4) condenser cleans, sterilizes: removed frost, close drying box inlet by-pass valve control 4-3, open the condenser inlet by-pass valve control 5-2 of condenser 5 tops again, to be transferred Ozone Water that pump 3-2 extracts out from the basin 3-5 of Ozone Water by condenser on-line cleaning device 5-3 spray, condenser 5 is carried out washing and sterilizing, and the Ozone Water after the sterilization is drained by condenser discharge outlet 5-4.Finish the technological process of the online defrosting of single, cleaning, sterilization.5) dry up freeze drying box 4 and condenser 5: the Ozone Water of the Ozone Water of basin 3-5 and temporary jar 6-1 all is delivered in the condenser 5 by pump, make ozone gas preparation facilities 1 and Ozone Water preparation facilities 3 be in the state of quitting work, closes compression air break by-pass valve control 2-3, close Ozone Water and enter the condenser inlet by-pass valve control 5-2 of condenser 5, close the defrost water delivery pump 6-2 of defrost water heating and conveying device 6.Open clean compressed air source 2-2, opening the clean compressed air by-pass valve control 2-1 that clean compressed air enters freeze drying box 4 blows off Ozone Water in the freeze drying box 4 to condenser 5, after treating that freeze drying box 4 moisture are blown off by clean compressed air, close clean compressed air and enter the clean compressed air by-pass valve control 2-1 of freeze drying box 4, close the drying box inlet by-pass valve control 4-3 of freeze drying box 4, closing control valve 6-5.Open the clean compressed air by-pass valve control 2-1 that clean compressed air enters condenser 5, enter condenser clean compressed air by-pass valve control 2-1, close the valve of condenser discharge outlet 5-4 closing clean compressed air after the clean discharge of water partial pressure in the condenser 5.
After freeze drying unit of the present utility model is produced 10～15 batches continuously, for preventing the ozone water solution defrosting, clean, the issuable bacterial strain of anti-ozone in the sterilization process, defrost in Ozone Water, clean, after sterilization is carried out 10-15 batch continuously, with concentration is 1%～4%, temperature is that 60 ℃ ± 10 ℃ sodium hydroxide solution once defrosts, clean, sterilization process, 1) at first prepares sodium hydroxide solution: the basin 3-5 that water for injection is injected the Ozone Water preparation facilities by water for injection inlet 3-10, and open the port lid of the charge door 3-6 of basin, open agitating device 3-17, add solid-state NaOH while stirring, open cooling water inlet 3-12 simultaneously, 3-5 cools off to basin, the dissolving while cooling off, being mixed with concentration is 1%～4%, temperature is 60 ℃ ± 10 ℃ a sodium hydroxide solution; Cooling water is discharged by coolant outlet 3-13.2) freeze drying box sterilization: make basin control of export valve 3-3, transfer pipeline by-pass valve control 3-7, compressed air by-pass valve control 2-3 and the drying box inlet by-pass valve control 4-3 that opens circuit be in opening, by delivery pump 3-2, above-mentioned sodium hydroxide solution is delivered to drying box on-line cleaning device 4-1 in the freeze drying box 4, the bacterial strain of anti-ozone is killed in spray cooling lyophilizer case 4 inside.Sodium hydroxide solution after the sterilization flow among the temporary jar 6-1 as the defrosting sodium hydroxide solution.3) condenser defrosting, sterilization: the defrosting sodium hydroxide solution among the temporary jar 6-1, extract out by defrost water delivery pump 6-2 again, make sodium hydrate aqueous solution be warmed up to 60 ℃ ± 10 ℃ through heat exchanger 6-4, enter into condenser 5, by condenser on-line cleaning device 5-3 spray condenser 5 inner chambers, kill the bacterial strain of anti-ozone of condenser 5 inside, defrost, sterilize, defrost water is discharged by condenser discharge outlet 5-4.Finish the online defrosting of sodium hydroxide solution single, sterilization process process.4) water for injection cleans, dries up: open the water for injection inlet 3-10 on the basin 3-5,3-9 injects water for injection in basin 3-5 by the water for injection shower nozzle, cleaning basin inside, make basin control of export valve 3-3, transfer pipeline by-pass valve control 3-7, drying box inlet by-pass valve control 4-3 are in opening, by delivery pump 3-2, the rinse water among the basin 3-5 are delivered to drying box on-line cleaning device 4-1 from pot bottom, freeze drying box 4 is cleaned, and rinse water flows among the temporary jar 6-1.Rinse water is extracted out by defrost water delivery pump 6-2, enters into condenser 5, through condenser on-line cleaning device 5-3, condenser 5 is cleaned, until the pH value of rinse water is to stop after the neutrality cleaning.Dry up freeze drying box 4 and condenser 5 again: the rinse water of the rinse water of basin 3-5 and temporary jar 6-1 all is delivered in the condenser 5 by pump, make ozone gas preparation facilities 1 and Ozone Water preparation facilities 3 be in the state of quitting work, a 2-3 is closed in closes compression air break control, close the condenser inlet by-pass valve control 5-2 of condenser 5, close the defrost water delivery pump 6-2 of heating of defrosting Ozone Water and conveying device.Open clean compressed air source 2-2, open the clean compressed air by-pass valve control 2-1 that clean compressed air enters freeze drying box 4, Ozone Water in the freeze drying box 4 is blown off to condenser 5, after treating that freeze drying box 4 moisture are blown off by clean compressed air, close clean compressed air and enter the clean compressed air by-pass valve control 2-1 of freeze drying box 4, close the drying box inlet by-pass valve control 4-3 of freeze drying box 4, closing control valve 6-5.Open the clean compressed air by-pass valve control 2-1 that clean compressed air enters condenser 5, enter condenser clean compressed air by-pass valve control 2-1 closing clean compressed air after the clean discharge of water partial pressure in the condenser 5, close the condenser inlet by-pass valve control 5-2 of condenser 5, close the valve of condenser discharge outlet 5-4.Make freeze drying box 4 and condenser 5 be in air-tight state.The technological process of whole online defrosting, cleaning, sterilization is finished.
The utility model and existing freeze drying unit economic benefit advantage contrast table
The utility model in Ozone Water defrosting, clean, after sterilization carries out 10-15 batch continuously, also can defrost, clean, sterilizing to change into concentration is the defrosting of 75%-90% ethanolic solution, cleans, sterilizes by sodium hydroxide solution.
Claims (4)
1, a kind of available freeze drying unit with a kind of solution defrosting, cleaning, sterilization, comprise freeze drying box (4) and condenser (5), condenser (5) links to each other with freeze drying box (4) by pipeline, be provided with shelf (4-2) and drying box on-line cleaning device (4-1) in the freeze drying box (4), be provided with condenser on-line cleaning device (5-3) in the condenser (5), it is characterized in that also comprising ozone gas preparation facilities (1), Ozone Water preparation facilities (3), defrost water heating and conveying device (6) and clean compressed air intake line (2); Ozone gas preparation facilities (1) links to each other with Ozone Water preparation facilities (3) by conveyance conduit, Ozone Water preparation facilities (3) is by the drying box on-line cleaning device (4-1) in conveyance conduit and the freeze drying box (4), or respectively with freeze drying box (4) in drying box on-line cleaning device (4-1) link to each other with condenser on-line cleaning device (5-3) in the condenser (5), Ozone Water preparation facilities (3) is provided with purified water inlet (3-11), water for injection inlet (3-10) and charge door (3-6), defrost water heating and conveying device (6) link to each other with condenser on-line cleaning device (5-3) with freeze drying box (4) by conveyance conduit respectively, and clean compressed air intake line (2) links to each other with condenser on-line cleaning device (5-3) with drying box on-line cleaning device (4-1) respectively by pipeline.
2, freeze drying unit according to claim 1 is characterized in that described ozone gas preparation facilities (1) comprises ozonized gas generator (1-1) and ozone gas by-pass valve control (1-2); Described Ozone Water preparation facilities (3) comprises that ozone is absorbed injector (3-1), basin (3-5), delivery pump (3-2), transfer pipeline by-pass valve control (3-7) and circulation line by-pass valve control (3-8) by water; Ozonized gas generator (1-1) is absorbed injector (3-1) set gas access (3-101) with ozone by water through ozone gas by-pass valve control (1-2) and links to each other, purified water inlet (3-11), water for injection inlet (3-10) and charge door (3-6) are located at the top of basin (3-5), water for injection inlet (3-10) is provided with water for injection shower nozzle (3-9), the top of basin (3-5) is provided with import (3-16), the bottom is provided with outlet (3-15), described outlet (3-15) links to each other with delivery pump (3-2) by basin control of export valve (3-3), delivery pump (3-2) delivery outlet connects ozone is absorbed injector (3-1) by water water inlet (3-102), ozone is output into two branches by the delivery port (3-103) that water absorbs injector (3-1), one branch links to each other with the import (3-16) of basin (3-5) by circulation line by-pass valve control (3-8), another branch links to each other by transfer pipeline by-pass valve control (3-7) or with drying box on-line cleaning device (4-1), or link to each other with condenser on-line cleaning device (5-3) with drying box on-line cleaning device (4-1) respectively, the lower end of basin control of export valve (3-3) also is provided with basin discharge outlet (3-4); Described defrost water heating and conveying device (6) comprise temporary jar (6-1), defrost water delivery pump (6-2) and heat exchanger (6-4), the inlet of temporary jar (6-1) links to each other with freeze drying box (4) bottom by control valve (6-5), control valve is passed through in outlet successively, defrost water delivery pump (6-2), heat exchanger (6-4) links to each other with condenser on-line cleaning device (5-3), the bottom of condenser (5) is provided with condenser discharge outlet (5-4), clean compressed air intake line (2) comprises clean compressed air source (2-2) and the pipeline of clean compressed air by-pass valve control (2-1) is housed that clean compressed air source (2-2) communicates with drying box on-line cleaning device (4-1) and condenser on-line cleaning device (5-3) respectively by the pipeline that clean compressed air by-pass valve control (2-1) is housed.
3, freeze drying unit according to claim 2, it is characterized in that being provided with in the described basin (3-5) agitating device (3-17), tank wall is provided with cooling jacket (3-14), and cooling jacket (3-14) is provided with cooling water inlet (3-12) and coolant outlet (3-13).
4, according to claim 2 or 3 described freeze drying units, it is characterized in that described ozone gas by-pass valve control (1-2) and ozone are provided with ozone gas filter (1-3) by the pipeline that water absorbs between the injector (3-1), ozone gas filter (1-3) and ozone are absorbed by water and are provided with flowmeter (1-5) between the injector (3-1) and detect sampler (1-4); Pipeline between described defrost water delivery pump (6-2) and the heat exchanger (6-4) is provided with defrost water filter (6-3); The pipeline that transfer pipeline by-pass valve control (3-7) links to each other with drying box on-line cleaning device (4-1), condenser on-line cleaning device (5-3) is provided with filter (3-18).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200620051344 CN2932257Y (en) | 2006-06-15 | 2006-06-15 | Freeze drying machine for defrosting, cleaning and sterilizing by the same solution |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200620051344 CN2932257Y (en) | 2006-06-15 | 2006-06-15 | Freeze drying machine for defrosting, cleaning and sterilizing by the same solution |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN2932257Y true CN2932257Y (en) | 2007-08-08 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200620051344 Expired - Lifetime CN2932257Y (en) | 2006-06-15 | 2006-06-15 | Freeze drying machine for defrosting, cleaning and sterilizing by the same solution |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN2932257Y (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100398965C (en) * | 2006-06-14 | 2008-07-02 | 湖南千山制药机械股份有限公司 | Freeze dryer set and process for defrosting, cleaning, and sterilizing by using same solution |
-
2006
- 2006-06-15 CN CN 200620051344 patent/CN2932257Y/en not_active Expired - Lifetime
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100398965C (en) * | 2006-06-14 | 2008-07-02 | 湖南千山制药机械股份有限公司 | Freeze dryer set and process for defrosting, cleaning, and sterilizing by using same solution |
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Effective date of abandoning: 20080702 |
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| C25 | Abandonment of patent right or utility model to avoid double patenting |