CN2827495Y - Counter-flow chromatograph equipment with filler - Google Patents
Counter-flow chromatograph equipment with filler Download PDFInfo
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- CN2827495Y CN2827495Y CN 200520023003 CN200520023003U CN2827495Y CN 2827495 Y CN2827495 Y CN 2827495Y CN 200520023003 CN200520023003 CN 200520023003 CN 200520023003 U CN200520023003 U CN 200520023003U CN 2827495 Y CN2827495 Y CN 2827495Y
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- tubing string
- belt pulley
- gear
- rotary drum
- adverse current
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Abstract
The utility model relates to counter-flow chromatogram equipment with filler for scale preparation, which belongs to the technical field of substance separation and comprises a motor, belts, rotating shafts, connecting rods, gears, revolving drums, separating tube columns, an introduction tube, an eduction tube, a revolving outer frame, filling materials, etc., wherein belt pulleys are driven directly by the motor, and the belt pulleys are connected with each other by the tooth-shaped belts; the belt pulleys are connected with the gears by the connecting rods, and the gears are engaged with each other and are fixed on the rotating shafts; the revolving drums are also fixed on the rotating shafts; the separating tube columns are wrapped on the revolving drums and are led out from the end surfaces of a supporting frame with the introduction tube and the eduction tube along the revolving outer frame at the end surfaces of the revolving drums; the separating tube columns are filled with the filling materials, the separating tube columns are filled with required solvent firstly, and solvent which is balanced with the solvent in the separating tube columns is led in from the introduction tube; separated products are led out from the eduction tube. The utility model which has the advantages of simple structure and high mass transfer efficiency can enlarge the volume of the separating tube columns and provides equipment conditions for the application of the filling materials and tubes with large apertures. The utility model can satisfy the requirements of industrial production.
Description
Technical field
The utility model relates to a kind of Packed scale preparation adverse current chromatogram equipment, belongs to the separating substances technical field.
Background technology
Adverse current chromatogram is a kind of novel chromatographic technique based on liquid liquid solvent extraction, and the precision that can be used for the close material of various types of properties is separated.This technology is the beginning of the seventies in last century, is initiated by American Japanese Yi Dong (Ito).Through 30 years of development, from installing technology, from the process to the theory, technology itself is gradually ripe.In a sense, 21st century is biological century, and various correlation techniques are all developing rapidly, but the purifies and separates of biological substance has become the important restraining factors of bioengineering development.Thereby the purifies and separates technology, particularly possess the separating and purifying technology of scale preparation ability, more and more be subjected to the attention of domestic and international scientific and technological circle and industrial quarters.The insider has initiated the adverse current chromatogram international conference.Held in London in 2000 for first, second 2002 in Beijing, the 3rd 2004 in Tokyo.Estimate that the 4th was held in Washington in 2006.
Adverse current chromatogram is except that having developed numerous processes, and device also develops into polytype.
The people in the industry is interested to be two classes: a class is that compact small-sized can be used as analyzed and semipreparative analytic type, and another kind of is can be used for the commercial scale preparation industrial.The utility model belongs to back one class.
Existing adverse current chromatogram equipment adopts the planet helix tube type mostly, and separating core is a hollow pipe.Hollow pipe is wrapped on the rotary drum, and rotary drum can rotate; Rotary drum itself rotates around a central shaft again, and the rotation that is commonly called as the former is rotation, and the latter's rotation is revolution, and whole device is a planetary motion.
Planetary structure can cause a kind of field of force of complexity, and the two not miscible liquid phases that help walking relatively in the hollow pipe are fully mixed and separated, thereby causes the separation process of multi-stage counter current extraction formula.But this structure is comparatively complicated, and rotating speed is higher, and device fabrication is difficult, moves also safety relatively inadequately, is unsuitable for industry and amplifies.Domestic professor Du Qizhen once did an improvement, patent name: " a kind of improved adverse current chromatogram equipment ", the patent No.: 200320123083.0.As depicted in figs. 1 and 2, this patent is that the twin shaft with the conventional counter-current chromatogram changes single shaft into, and capacity has also amplified some, and structure is simple relatively.But owing to separate tubing string is large diameter hollow pipe, so the mixing of the two-phase solvent in the tubing string is abundant inadequately, and mass-transfer efficiency is lower, and axial backmixing is also relatively more serious, separating power a little less than.From view of theory, also have in the design many can improvements.Abroad (mainly being Britain) also the someone be devoted to the development of scale preparation adverse current chromatogram, but be multiaxial type all, the groping of amplification rule, the manufacturing of equipment all has big difficulty.For adapting to the new century both at home and abroad to the needs of chemical separation technology, particularly to Chinese herbal medicine effective ingredients separate, the needs of the preparation of natural biological component separation and the extraordinary pure material that needs, countercurrent chromatography has all been obtained bigger achievement on apparatus and method, countercurrent chromatography itself also begins to be understood by people gradually and pay attention to.Domestic existing many schools, institute and enterprises all have been equipped with the adverse current chromatogram device, but are the midget plant of comparatively ripe multiaxial type half preparation type all, as comparatively current high speed adverse current chromatogram (HSCCC).
Adverse current chromatogram really will play a role on engineering, must be that scale preparation and separating power are very strong.From installing, must be convenient to operation, safeguard that security of operation adapts to wide.The multiaxial type device is difficult to satisfy this requirement.The single axle device need be explored new model.On separation principle, improve separative efficiency, suitable separation system (dicyandiamide solution and and the coupling of solute) at first will be arranged, higher mass-transfer efficiency is avoided axial back mixing.The utility model is exactly for this purpose and a kind of single shaft, capacious, the Packed preparative scale adverse current chromatogram equipment that propose.The inventor is engaged in adverse current chromatogram work for many years, and one of them participated in twice international conference, recognizes that the home and abroad does not still have the device similar or identical with the utility model at present, and the result of literature survey also is like this.
Summary of the invention
Technical problem to be solved in the utility model provides a kind of adverse current chromatogram device, when selecting suitable separation system (appropriate solvent system and and the coupling of solute) for use, the separator tube column volume can be amplified and mass transfer can be strengthened, has higher mass-transfer efficiency, avoid axial backmixing to greatest extent, improve separating power.
A kind of Packed adverse current chromatogram equipment, it comprises motor (301), belt pulley (302), belt pulley (303), flute profile belt (304), rotating shaft (305), belt pulley (306), flute profile belt (307), fast pulley (308), connecting rod (309), gear (310), gear (311), rotating shaft (312), rotary drum (313), separates tubing string (314), inlet tube (315), fairlead (316), rotation housing (317) and filler (401).
Mechanical connecting part: belt pulley (302) is directly driven by motor (301), belt pulley (302) is connected by flute profile belt (304) with belt pulley (303), belt pulley (303) is connected by rotating shaft (305) with rotation housing (317), belt pulley (306) then is connected by flute profile belt (307) with fast pulley (308), belt pulley (306) is connected by connecting rod (309) with gear (310), gear (310) and gear (311) are engaged, gear (311) is fixed in the rotating shaft (312), and rotary drum (313) also is to be fixed in the rotating shaft (312).
Piping connection portion: separate tubing string (314) and be wound on the rotary drum (313), be connected by non-rotating seal nipple with fairlead (316) with inlet tube (315) in rotary drum (313) end, inlet tube (315) and fairlead (316) are drawn from supporting frame end face (320) along rotation housing (317).
Separate and fill filler (401) in the tubing string (314).Filler (401) comprises dumped packing and structured packing two classes, and material can be metal, plastics, pottery and glass.Dumped packing comprises all kinds such as ring type, net formula and ball formula.
Separate tubing string (314) and formed by the pipe coiling, tubing string adopts diameter greater than 1 centimetre, less than 20 centimetres metal tubes or plastic tube.Tubing string can the coiled single or multiple lift, and each layer tubing string directly is communicated with.
Tubing string can be wound on the columniform rotary drum (313).Cylindrical blade diameter length ratio is 0.1～10.
Support the rotary drum (313) that separates tubing string (314) and driven by variable speed machine (301), rotary drum (313) range of speeds is between 0～300 rev/min.
The utility model is simple in structure, and for the application of large-aperture pipe and filler provides appointed condition, the separator tube column volume can be amplified to more than 30 liters, has mass transfer effect preferably simultaneously, can satisfy industrial requirement.
Description of drawings
Adverse current chromatogram schematic diagram when Fig. 1 is individual layer for the separation tubing string in Du Qizhen professor's the patent " a kind of improved adverse current chromatogram equipment ".
Adverse current chromatogram schematic diagram when Fig. 2 is multilayer layer for the separation tubing string in Du Qizhen professor's the patent " a kind of improved adverse current chromatogram equipment ".
Fig. 3 is a schematic diagram of the present utility model.
Fig. 4 is for separating tubing string part (among Fig. 3 318) section enlarged diagram.
The specific embodiment
With reference to accompanying drawing 3, Fig. 3 is a schematic diagram of the present utility model.The utility model mainly comprises the separation tubing string (314) that is wrapped on the rotary drum (313) and inlet tube (315), fairlead (316), inlet tube (315), fairlead (316) and separate tubing string (314) and directly be connected by joint, seal nipple without spin.
Separating tubing string (314) can the coiled individual layer, also can the coiled multilayer, between each layer by separating directly connection of tubing string (314) itself.Tubing string (314) is wound on the rotary drum (313), rotates with rotary drum (313).Inlet tube (315), fairlead (316) can be realized mechanical unwinding by the relative motion of housing (317) and rotary drum (313), need not the rotatory sealing joint.
Motor (301) can speed change.Motor (301) drives belt pulley (302) and rotates with identical direction, and belt pulley (302) drives belt pulley (303) by flute profile belt (304) and rotates with identical direction.Because belt pulley (303) is fixed in the rotating shaft (305),, belt pulley (303) also rotates with the direction identical with motor with rotation housing (317) so driving rotating shaft (305).Rotation housing (317) drives the connecting rod (309) that is installed on the rotation housing (317) by bearing and revolves round the sun around rotating shaft (305), and the revolution direction is identical with the rotation direction of motor.Be fixedly mounted on the belt pulley (306) on the connecting rod (309) owing to be fixed on the belt pulley (308) supported on the frame end face (319) and the effect generation rotation opposite with direction of motor rotation of belt (307), rotational angular is big or small with to rotate housing identical.Gear (310) is fixedly mounted on the connecting rod (309), therefore has unequal angular velocity with belt pulley (306).Gear (310) is identical, engaged with gear (311) number of teeth, and the existing rotation of gear (310) has the large-scale equal revolution of angular speed, thus gear (311) have the size equate the angular speed that direction is opposite with gear (310) angular speed twice.Gear (311) and rotary drum (313) all are fixed in the rotating shaft (312), make rotary drum (313) also have and gear (311) unequal angular velocity.Therefore rotary drum (313) has size and equates with the angular speed twice of rotation housing (317), the direction unequal angular velocity, and such angular speed concerns to make and need not any rotatory sealing joint by inlet tube (315) and fairlead (316) unwinding automatically.
The partial enlarged drawing that separates tubing string (314) as shown in Figure 4, Fig. 4 is for separating tubing string part (among Fig. 3 318) section enlarged diagram.Filler (401) is wrapped in rotary drum (313) at separation tubing string (314) and goes up filling before, fills full marks from tubing string (314).
In equipment when operation, be full of with the solvent that needs earlier and separate tubing string (314), then will be full of solvent that the solvent that separates tubing string (314) balances each other from inlet tube (315) introducing, separated product is drawn by fairlead (316).
Equipment can be used for the precision of the close mixture of character and separates, and is particularly useful for the separation of natural drug active ingredient.When separating for separator, earlier be full of separation tubing string (314) with the solvent of two the mutual balances phase (being commonly referred to as " fixedly phase ") in mutually, separate tubing string (314) by external injection port adding for separator, separate tubing string (314) and rotate with turning to make with the rotating speed of needs then, with external pump another phase of the solvent phase of mutual balance (being commonly referred to as " phase flows ") is pumped into from inlet tube (315), through flowing out from fairlead (316) along with flowing of separating, can reach the purpose of separation according to the demonstration collection effluent of corresponding online checkout equipment for separator.
Claims (5)
1, a kind of Packed adverse current chromatogram equipment, it is characterized in that this equipment comprises motor (301), belt pulley (302), belt pulley (303), flute profile belt (304), rotating shaft (305), belt pulley (306), flute profile belt (307), fast pulley (308), connecting rod (309), gear (310), gear (311), rotating shaft (312), rotary drum (313), separates tubing string (314), inlet tube (315), fairlead (316), rotation housing (317) and filler (401); Its annexation:
Mechanical connecting part: belt pulley (302) is directly driven by motor (301), belt pulley (302) is connected by flute profile belt (304) with belt pulley (303), belt pulley (303) is connected by rotating shaft (305) with rotation housing (317), belt pulley (306) then is connected by flute profile belt (307) with fast pulley (308), belt pulley (306) is connected by connecting rod (309) with gear (310), gear (310) and gear (311) are engaged, gear (311) is fixed in the rotating shaft (312), and rotary drum (313) also is to be fixed in the rotating shaft (312);
Piping connection portion: separate tubing string (314) and be wound on the rotary drum (313), be connected by non-rotating seal nipple with fairlead (316) with inlet tube (315) in rotary drum (313) end, inlet tube (315) and fairlead (316) are drawn from supporting frame end face (320) along rotation housing (317);
Separate and fill filler (401) in the tubing string (314).
2, a kind of Packed adverse current chromatogram equipment according to claim 1 is characterized in that, separates tubing string (314) and is formed by the pipe coiling, and tubing string adopts diameter greater than 1 centimetre, less than 20 centimetres metal tubes or plastic tube.
3, a kind of Packed adverse current chromatogram equipment according to claim 2 is characterized in that, tubing string is wound on the columniform rotary drum (313), and cylindrical blade diameter length ratio is 0.1～10.
4, a kind of Packed adverse current chromatogram equipment according to claim 2 is characterized in that tubing string coiled individual layer.
5, a kind of Packed adverse current chromatogram equipment according to claim 2 is characterized in that, tubing string coiled multilayer, and each layer tubing string directly is communicated with.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200520023003 CN2827495Y (en) | 2005-06-03 | 2005-06-03 | Counter-flow chromatograph equipment with filler |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200520023003 CN2827495Y (en) | 2005-06-03 | 2005-06-03 | Counter-flow chromatograph equipment with filler |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN2827495Y true CN2827495Y (en) | 2006-10-18 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200520023003 Expired - Fee Related CN2827495Y (en) | 2005-06-03 | 2005-06-03 | Counter-flow chromatograph equipment with filler |
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| Country | Link |
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| CN (1) | CN2827495Y (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108008052A (en) * | 2017-12-15 | 2018-05-08 | 大连海洋大学 | New Formulas I type current chromatographic column |
-
2005
- 2005-06-03 CN CN 200520023003 patent/CN2827495Y/en not_active Expired - Fee Related
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108008052A (en) * | 2017-12-15 | 2018-05-08 | 大连海洋大学 | New Formulas I type current chromatographic column |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C17 | Cessation of patent right | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20061018 |