CN2798221Y - Spinal narrow depressor for rat - Google Patents
Spinal narrow depressor for rat Download PDFInfo
- Publication number
- CN2798221Y CN2798221Y CN 200520009289 CN200520009289U CN2798221Y CN 2798221 Y CN2798221 Y CN 2798221Y CN 200520009289 CN200520009289 CN 200520009289 CN 200520009289 U CN200520009289 U CN 200520009289U CN 2798221 Y CN2798221 Y CN 2798221Y
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- spinal
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- rat
- plate
- screw
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Abstract
The utility model relates to a spinal marrow depressor for a rat, which belongs to an apparatus used for forming an animal experiment model. The utility model is formed by assembling screws 2, a simulation spinal plate 4 and a spinal marrow depressing plate 6. Compared with the prior art, the spinal marrow depressor for a rat, which is used for forming an experimental model of spinal depression of a rat has the advantages that the spinal marrow depressor for a rat is designed and manufactured according to the characteristic of an anatomic structure of a spinal marrow of the rat, has a simple and compact structure, can be well fixed on a spinal column, and can not loose and fall to effect on the spinal depression even if the rat moves; the operation technique is simple, so the utility model can not easily hurt the spinal marrow; the observation index of the spinal marrow depressing model is objective, so the experiment repeatability is strong; the utility model can also be used for forming acute and chronic spinal marrow depressing injure models; after the spinal marrow depressing model is successfully formed, an ischemia reperfusion model can be formed by unscrewing the screws.
Description
One, technical field
The utility model belongs to what and sets up the utensil that animal experimental model is used, and is specifically related to a kind of rat spinal cord compression device.
Two, background technology
The chronic compressing damage of spinal cord is the main cause that causes the patient to paralyse clinically.How setting up science practicality, repeated strong animal experimental model, to explore the molecular mechanism and the methods of treatment of the chronic compressing damage of spinal cord, is neuromedicine worker problem demanding prompt solution.Be applied at present oppress the animal experimental model that ischemia injury research institute makes, exist many problems.In the prior art, the animal that the chronic compressing model in backbone the place ahead is generally commonly used is rabbit or dog, lessly use rat, its method is to be screwed into one piece of screw to form compressing between the 4th, 5 cervical vertebras, this method easily causes the coup injury rather than the compressing damage of spinal cord, and can form tractive and compressing even damage to the gentle pipe of esophagus, influence feed and the breathing of animal used as test; The chronic compressing model of the backbone way of escape generally all is to adopt to open an aperture between the lamina of thoracic vertebra of rat, is screwed into the method for one piece of screw then, and easy coup injury spinal cord of this method and reliability are low; The chronic compressing model of a kind of rat spinal cord appears in recent years, it is that a poly (methyl methacrylate) plate is installed on the 8th, 9 lamina of thoracic vertebra of rat, pass poly (methyl methacrylate) plate center compressing spinal cord with screw, but it must be sewn on poly (methyl methacrylate) plate on the soft tissue, this causes the soft tissue ischemic necrosis easily, and fixing not firmly can't make the spinal compression model at all.
Three, summary of the invention
Drawback at the prior art existence, plan is according to the special syndeton feature in joint before and after the rat vertebra, manufacture and design a kind of rat spinal cord compression device, the chronic compressing model of rat spinal cord that it is set up with it is fixed, simple to operate, safe and practical, repeated strong, objective to the level of compression observation index of spinal cord, can overcome the defective that prior art exists fully.
Technical solution adopted in the utility model is as follows.
A kind of rat spinal cord compression device includes screw, it is characterized in that:
1) it simulates vertebral plate and spinal compression plate in addition; 2) it is curved along its length to simulate vertebral plate, the middle part offers the screw that is complementary with screw, the forward end in both sides of the edge has the hanging wire groove of two symmetries, front end is provided with two and simulates anterior articular process, simulate and be provided with between the anterior articular process and the rectangular baffle plate of vertebral plate face, the rear end is provided with the posterior articular process that simulates that is swallow-tail form; 3) spinal compression plate broad ways is curved, and screw is screwed in the screw that simulates vertebral plate, and the top contacts with spinal compression plate upper surface.
Use the rat spinal cord compression device of the utility model structure, make the spinal compression animal experimental model in two steps: the first step, after doing intraperitoneal anesthesia with rat, under sterile working, appear chest 10 to waist 3 vertebral plates, excise whole vertebral plate and the forward and backward articular process of waist 1 centrum, appear the spinal cord of waist 1 centrum correspondence; The spinal compression plate is directly placed on the spinal cord of exposure, again the anterior articular process that simulates that simulates vertebral plate is fitted on the posterior articular process of chest 12 vertebras, be stuck on the spinous process of waist 2 vertebras simulating posterior articular process; Screw is screwed in the screw that simulates vertebral plate, contacts with spinal compression plate upper surface until the screw top; Layer-by-layer suture is exposed to nut outside the skin then.In second step, from postoperative first day is screwed into 0.25mm with screw, twists once every 3 to 4 days and paralyses fully until rat pair lower limb, is urinary and fecal inconvenience.In whole process,, observe the degree of depth that understanding spinal compression situation and screw are screwed into by clapping rat spine side position X-ray sheet.
Adopt the utility model rat spinal cord compression device to make rat spinal cord compressing empirical model, compared with prior art have the following advantages:
1, it is that anatomical structure characteristics according to the rat vertebra manufacture and design, and is simple in structure, compact, can be fixed on well on the backbone, can not cause its loose or dislocation to influence spinal compression because of the activity of rat.
2, operation technique is simple, is difficult for injuring spinal cord.
3, objective to the observation index of spinal compression empirical model, experimental repeatability is strong.
4, all can make the acute and chronic compressing damage model of spinal cord with it: after spinal compression modelling success, also can make ischemia-reperfusion injury model by unscrewing screw.
Four, description of drawings
Accompanying drawing is the assembly structure synoptic diagram of the utility model rat spinal cord compression device.
In the drawings, 1-baffle plate 2-screw 3-screw 4-simulates vertebral plate 5-and simulates posterior articular process 6-spinal compression plate 7-and simulate anterior articular process 8-hanging wire groove.
Five, embodiment
Further specify the concrete structure of the utility model rat spinal cord compression device below in conjunction with accompanying drawing.
A kind of rat spinal cord compression device includes screw 2, it is characterized in that:
1) it simulates vertebral plate 4 and spinal compression plate 6 in addition; 2) it is curved along its length to simulate vertebral plate 4, the middle part offers the screw 3 that is complementary with screw 2, the forward end in both sides of the edge has the hanging wire groove 8 of two symmetries, front end is provided with two and simulates anterior articular process 7, simulate and be provided with between the anterior articular process and the rectangular baffle plate 1 of vertebral plate face, the rear end be provided be swallow-tail form simulate posterior articular process 5; 3) spinal compression plate 6 broad ways are curved, and screw 2 is screwed in the screw 3 that simulates vertebral plate 4, and the top contacts with spinal compression plate 6 upper surfaces.
Claims (1)
1, a kind of rat spinal cord compression device includes screw (2), it is characterized in that:
1) it simulates vertebral plate (4) and spinal compression plate (6) in addition;
2) it is curved along its length to simulate vertebral plate (4), the middle part offers the screw (3) that is complementary with screw (2), the forward end in both sides of the edge has the hanging wire groove (8) of two symmetries, front end is provided with two and simulates anterior articular process (7), simulate and be provided with between the anterior articular process and the rectangular baffle plate of vertebral plate face (1), the rear end be provided be swallow-tail form simulate posterior articular process (5);
3) spinal compression plate (6) broad ways is curved, and screw (2) is screwed in the screw (3) that simulates vertebral plate (4), and the top contacts with spinal compression plate (6) upper surface.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200520009289 CN2798221Y (en) | 2005-05-16 | 2005-05-16 | Spinal narrow depressor for rat |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200520009289 CN2798221Y (en) | 2005-05-16 | 2005-05-16 | Spinal narrow depressor for rat |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN2798221Y true CN2798221Y (en) | 2006-07-19 |
Family
ID=36869467
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200520009289 Expired - Fee Related CN2798221Y (en) | 2005-05-16 | 2005-05-16 | Spinal narrow depressor for rat |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN2798221Y (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101617959B (en) * | 2008-07-04 | 2012-05-02 | 上海中医药大学附属曙光医院 | External connection fixing device for manufacturing rat spine subluxation animal model |
-
2005
- 2005-05-16 CN CN 200520009289 patent/CN2798221Y/en not_active Expired - Fee Related
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101617959B (en) * | 2008-07-04 | 2012-05-02 | 上海中医药大学附属曙光医院 | External connection fixing device for manufacturing rat spine subluxation animal model |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C19 | Lapse of patent right due to non-payment of the annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |