CN2691632Y - Tumour magnetic heat therapeutic instrument - Google Patents
Tumour magnetic heat therapeutic instrument Download PDFInfo
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- CN2691632Y CN2691632Y CN 200320120141 CN200320120141U CN2691632Y CN 2691632 Y CN2691632 Y CN 2691632Y CN 200320120141 CN200320120141 CN 200320120141 CN 200320120141 U CN200320120141 U CN 200320120141U CN 2691632 Y CN2691632 Y CN 2691632Y
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Abstract
The utility model relates to a tumour magnetic heat therapeutic instrument, whose alternating field frequency is 10-1000 kHz and density of field is 1-200kA/m. The utility model is characterized in that the structure includes a central operation control, an alternating field generator, an electromagnetic inducting coil, a therapeutic bed, a water cooling device, an image detector, a temperature controlling device, an accessory equipment, a printer, an operation desk and a power off protecting device. The central operation control comprises a microprocessor, a display, a keyboard, a mouse, a programmable logic controller, a potentiometer, a relay and a switch. The alternating field generator comprises a thyritron AC voltage regulator, a rectifier transformer, a tube type oscillator or a semi-conductor frequency generator and a cooling water pipe. The alternating field generator is provided with an alternating current which is provided with a current flow with a happening frequency, a controlling frequency and an adjusting frequency of 10-1000kHz. The electromagnetic inducting coil connected with the alternating field generator can generate an alternating field with a magnetic field intensity of 1-200kA.
Description
Technical field
It is that 10-1000kHz, field intensity are the tumor magnetic thermotherapy treatment instrument of 1-200kA/m that this utility model relates to a kind of alternating magnetic field frequency.
Background technology
The electromagnetic wave heating tumor thermotherapy therapeutic instrument of using clinically at present is to adopt the electromagnetic radio-frequency (RF) thermotherapeutic therapeutic instrument of upper frequency (as 13.56-2450MHz), microwave heat therapeutic therapeutic instrument etc., because frequency has characteristics such as heating normal structure and tissue penetration difference greater than the electromagnetic wave of 10MHz, defective such as the application of above-mentioned thermotherapy treatment instrument exists that the tumor heating is inhomogeneous, easy damaged normal structure and heat tissue and position are restricted.
Summary of the invention
It is that 10-1000kHz, field intensity are the tumor magnetic thermotherapy treatment instrument of 1-200kA/m that the purpose of this utility model provides a kind of alternating magnetic field frequency.Tumor magnetic thermotherapy is that a kind of magnetic hysteresis of utilizing the magnetic material that imports the in-vivo tumour position to produce under the effect of external alternating magnetic field is given birth to heat effect heating tumor, selectively killing tumor cell, the thermotherapy new method of treatment tumor.Lot of experiments shows, because magnetic material can import tumor by modes such as heeling-in, injection, mediation and master, passive targets in the magnetic thermotherapy, and adopt the alternating magnetic field of the following lower frequency of 1000kHz to be used for the treatment of, it have magnetic field penetration good, do not damage normal structure, can treat the tumor of any position and volume safely and effectively, and the tumor heating has accurate polarization or technical characteristics such as targeting, the interior temperature homogeneity of tumor, is a kind of new method of tumor thermotherapy safely and effectively.
The interact magnetic hysteresis that produces of the alternating magnetic field that this utility model tumor magnetic thermotherapy treatment instrument utilizes electromagnetic induction coil and the magnetic material that imports the human tumor position is given birth to heat effect and tumor tissues is reached more than 40.5-45 ℃ and 45 ℃ treat tumor.This utility model is applicable to the nano powder, micro-powder of ferromagnetism, ferrimagnetism and superparamagnetism and various magnetic materials such as thread, bar-shaped import tumor in modes such as heeling-in, injection, mediation and main passive targets tumor magnetic thermotherapy.
This utility model tumor magnetic thermotherapy treatment instrument mainly partly is made up of central operation controller, alternating magnetic field generating means, electromagnetic induction coil, therapeutic bed, water-cooling apparatus, image detector, temperature measurement and control instrument, auxiliary facilities, printer, operating board, cut protection device etc.
Central operation controller and operating board, printer, power supply, the alternating magnetic field generating means, monitor, water-cooling apparatus, temperature measurement and control instrument, image detector, therapeutic bed and auxiliary facilities link to each other with connecting line, electromagnetic induction coil links to each other with lead with the alternating magnetic field generating means and links to each other with the water-cooling apparatus water pipe, the alternating magnetic field generating means links to each other with the water-cooling apparatus water pipe, the alternating magnetic field generating means, electromagnetic induction coil, temperature measurement and control instrument, image detector, monitor is equipped on the therapeutic bed, display and printer are placed on the operating board, operating board, the central operation controller, power supply, water-cooling apparatus and auxiliary facilities are configured in around the therapeutic bed or a side.
The central operation controller is made up of software and hardwares such as microprocessor, display, keyboard, mouse, programmable logic controller (PLC), potentiometer, relay, switch and treatment, diagnosis and control softwares, the field frequency, the intensity that are used for automatic processing, adjustment, control temperature data and electromagnetic induction coil, have functions such as the patient's of foundation diagnosis, treatment data base and memorizer, show simultaneously and respectively install duty and fault alarm etc.
The alternating magnetic field generating means is made up of brilliant lock AC voltage regulator, rectifier transformer, valve generator or devices such as semiconductor device frequency generator, cooling water pipe fitting, having generation, controlling and adjusting frequency is the alternating current of the 10-1000kHz and the magnitude of current, and to make coupled electromagnetic induction coil produce magnetic field intensity be the function of the alternating magnetic field of 1-200kA/m.
Electromagnetic induction coil is the coil that the coil of hollow copper tubing or other hollow core conductor coiled and the various conductors that are equipped with cooling system are made.
Therapeutic bed has shell and is made up of engineering plastics or copper skeleton and engineering plastics, device has motor, variator, driver in the shell, have advance and retreat, lifting, rotate, stop functions such as accurately steady, safe and reliable, appearance looks elegant, dispose electromagnetic induction coil on the therapeutic bed simultaneously, have send to, return, function such as rotation so that be suitable for the treatment needs of human body different parts and different magnetic induction heatings.
Water-cooling apparatus is made up of the cooling water pipeline of water tank, water pump or tap water, water pump and electromagnetic induction coil and the configuration of alternating magnetic field generating means; and be equipped with adjusting, control, warning, protector; prevent that by control cooling water pressure and discharge electromagnetic induction coil is overheated, protection alternating magnetic field generating means.
Image detector is made up of lesion detection instrument such as MR imaging apparatus, x-ray ct device and ultrasonic imaging devices, is used for observation treatment front and back tumor shape, size, curative effect and thermotherapy biological study.
Temperature measurement and control instrument is by diminishing temperature sensor, adopt fibre optic temperature sensor, resistive conductor critesistor etc., or harmless temperature device, adopt MR imaging apparatus, ultrasonic imaging device and x-ray ct device, microwave CT, microwave radiometer etc.] the mensuration tumor temperature, and the measured temperature signal passed to central operation controller and display device, adjust by automatic function software or operating board manually-operated, the magnetic field intensity of control electromagnetic induction coil, frequency, realization is to the real-time Monitoring and Controlling of tumor temperature, makes in the therapeutic process treatment temperature accurate, stable, effectively, safety and reliable.
Auxiliary device belongs to the apolegamy device, can match body detection device and adjuvant therapy device etc.
Operating board is by programmable logic controller (PLC), potentiometer, multiple electronic device such as relay and switch is formed, be used for start, shutdown and field frequency and intensity manual or program control operation adjustment alternating magnetic field generating means and electromagnetic induction coil, the position of electromagnetic induction coil, the hydraulic pressure of water-cooling apparatus, flow and temperature, the operative temperature measure and control device, image detector, auxiliary device, monitor, the operation of part such as couch motion and printer, transmitter receiver is set up and the real-time communication for the treatment of patient simultaneously, concrete condition according to patient is carried out complementary adjustment to treatment, can show simultaneously the duty of each several part and fault alarm etc.
Cut protection device is when having a power failure suddenly, and stand-by power supply starts automatically, ensures that water cooling system continued operation more than 1 hour, and the central operation controller is preserved automatically, and treatment information, other function of equipment are recovered halted state automatically, therapeutic bed is return original position.
This utility model characteristics: the interact magnetic hysteresis that produces of the alternating magnetic field that this utility model tumor magnetic thermotherapy treatment instrument utilizes electromagnetic induction coil and the magnetic material that imports the human tumor position is given birth to heat effect and tumor tissues is reached more than 40.5-45 ℃ and 45 ℃ treat tumor.The present invention is applicable to the nanometer, micro-powder of ferromagnetism, ferrimagnetism and superparamagnetism and various magnetic materials such as thread, bar-shaped import tumor in modes such as heeling-in, injection, mediation and main passive targets tumor magnetic thermotherapy.
Tumor magnetic thermotherapy is that a kind of magnetic hysteresis of utilizing the magnetic material that imports the in-vivo tumour position to produce under the effect of external alternating magnetic field is given birth to heat effect heating tumor, utilizes tumor cell poor heat resistance selectively killing tumor cell, the thermotherapy new method of treatment tumor.When tumor magnetic thermotherapy treatment instrument uses, the mobile device of lesions position by therapeutic bed that lesions position has been imported the patient of magnetic material moves in the middle of the other or electromagnetic induction coil of electromagnetic induction coil, start alternating magnetic field generating means in the therapeutic instrument of preheating, make the alternating magnetic field of electromagnetic induction coil generation treatment needs and focus is carried out the magnetic thermotherapy treatment, close the alternating magnetic field generating means through after certain treatment time, finish treatment, closed therapeutic instrument in 30 minutes later on.Because magnetic material can import tumor by modes such as heeling-in, injection, mediation and main passive targets in the magnetic thermotherapy, and adopt the alternating magnetic field of the following lower frequency of 1000kHz to be used for the treatment of, it have magnetic field penetration good, do not damage normal structure, can treat the tumor of any position and volume safely and effectively, and the tumor heating has accurate polarization or technical characteristics such as targeting, the interior temperature homogeneity of tumor, is a kind of new method of tumor thermotherapy safely and effectively.
Description of drawings
The utility model is described in further detail below with reference to accompanying drawing.
Fig. 1 is a tumor magnetic thermotherapy treatment instrument basic structure block diagram.
Fig. 2 is the floor map of tumor magnetic thermotherapy treatment instrument.
Fig. 3 is that the A of floor map of tumor magnetic thermotherapy treatment instrument is to looking sketch map.
Fig. 4 is that the B of floor map of tumor magnetic thermotherapy treatment instrument is to looking sketch map.
The specific embodiment
With reference to accompanying drawing 1-4, this utility model tumor magnetic thermotherapy treatment instrument mainly partly is made up of central operation controller, alternating magnetic field generating means 7, electromagnetic induction coil 8, therapeutic bed 1, water-cooling apparatus 6, image detector 10, temperature measurement and control instrument 11, auxiliary facilities 5, printer 12, operating board 13, power supply and cut protection device 4 etc.
Alternating magnetic field generating means 7 is made up of brilliant lock AC voltage regulator, rectifier transformer, valve generator or devices such as semiconductor device frequency generator, cooling water pipe fitting, having generation, controlling and adjusting frequency is the alternating current of the 10-1000kHz and the magnitude of current, and to make coupled electromagnetic induction coil 8 produce magnetic field intensities be the function of the alternating magnetic field of 1-200kA/m.
Therapeutic bed 1 has shell 9 and is made up of engineering plastics or copper skeleton and engineering plastics, device has motor, variator, driver in the shell 9, have advance and retreat, lifting, rotate, stop functions such as accurately steady, safe and reliable, appearance looks elegant, dispose electromagnetic induction coil 8 on the therapeutic bed simultaneously, have send to, return, function such as rotation so that be suitable for the treatment needs of human body different parts and different magnetic induction heatings.
Water-cooling apparatus 6 is made up of the cooling water pipeline of water tank, water pump or tap water, water pump and electromagnetic induction coil 8 and 7 configurations of alternating magnetic field generating means; and be equipped with adjusting, control, warning, protector; prevent that by control cooling water pressure and discharge electromagnetic induction coil 8 is overheated, protection alternating magnetic field generating means 7.
Temperature measurement and control instrument 11 is by diminishing temperature sensor, as fibre optic temperature sensor, resistive conductor critesistor etc., or harmless temperature device, as MR imaging apparatus, ultrasonic imaging device and x-ray ct device, microwave CT, microwave radiometer etc.] the mensuration tumor temperature, and the measured temperature signal passed to central operation controller and display device 14, adjust by automatic function software or operating board manually-operated, the magnetic field intensity of control electromagnetic induction coil, frequency, realization is to the real-time Monitoring and Controlling of tumor temperature, makes in the therapeutic process treatment temperature accurate, stable, effectively, safety and reliable.
Power-failure protecting is adorned 4 and is put when having a power failure suddenly, and stand-by power supply starts automatically, ensures that water cooling system continued operation more than 1 hour, and central operation controller 2 is preserved automatically, and treatment information, other function of equipment are recovered halted state automatically, therapeutic bed 1 is return original position.
Embodiment 1:
Get 16 of lotus human colon carcinoma LS174T nude mices, behind mensuration and the calculating gross tumor volume, be divided into two groups at random by gross tumor volume, first group is matched group, every nude mice tumor locus injection pure water 0.1ml, second group of every nude mice injection 0.1ml contains the water preparation of a certain amount of nano-magnetic powder, second group of nude mice inserted in the electromagnetic induction coil of above-mentioned tumor magnetic thermotherapy treatment instrument, in frequency is that 100KHz, field intensity are under the alternating magnetic field of 30KA/m tumor temperature to be heated to 42-43 ℃ of treatment 1 hour, treat and put to death above-mentioned nude mice after 10 days, separate tumor, take by weighing tumor weight.The result shows that first group of tumor weighs 4.2 ± 0.8g, and second group of tumor weighs 1.3 ± 0.3g, and the tumour inhibiting rate of treatment group is 75%, and the P value is less than 0.01.Simultaneously, second group of nude mice carried out body weight and untoward reaction observation, show no obvious abnormalities, after nude mice is put to death, core, vitals such as brain, spleen, kidney, intestinal, liver do pathologic finding, show no obvious abnormalities treatment back ten days.
Embodiment 2:
Get 16 of lotus human colon carcinoma LS174T nude mices, behind mensuration and the calculating gross tumor volume, be divided into two groups at random by gross tumor volume, first group is matched group, every nude mice tumor locus injection pure water 0.2ml, second group of every nude mice injection 0.2ml contains the water preparation of a certain amount of nano-magnetic powder, second group of nude mice inserted in the electromagnetic induction coil of above-mentioned tumor magnetic thermotherapy treatment instrument, in frequency is that 200KHz, field intensity are under the alternating magnetic field of 20KA/m tumor temperature to be heated to 42-43 ℃ of treatment 1 hour, treat and put to death above-mentioned nude mice after 10 days, separate tumor, take by weighing tumor weight.The result shows that first group of tumor weighs 2.77 ± 0.75g, and second group of tumor weighs 0.19 ± 0.11g, and the tumour inhibiting rate of treatment group is 93%, and the P value is less than 0.01.Simultaneously, second group of nude mice carried out body weight and untoward reaction observation, show no obvious abnormalities, after nude mice is put to death, core, vitals such as brain, spleen, kidney, intestinal, liver do pathologic finding, show no obvious abnormalities treatment back ten days.
Experimental result shows that tumor magnetic thermotherapy treatment instrument of the present invention has the significantly effectively function of treatment tumor, and has the characteristics of safe without toxic side effect.
Claims (4)
1, a kind of tumor magnetic and thermal cure instrument is characterized in that structure comprises central operation controller, alternating magnetic field generating means, therapeutic bed and electromagnetic induction coil, water-cooling apparatus, image detector, temperature measurement and control instrument, auxiliary facilities, printer, operating board, cut protection device;
Central operation controller and operating board, printer, power supply, the alternating magnetic field generating means, monitor, water-cooling apparatus, temperature measurement and control instrument, image detector, therapeutic bed and auxiliary facilities link to each other with connecting line, electromagnetic induction coil links to each other with lead with the alternating magnetic field generating means and links to each other with the water-cooling apparatus water pipe, the alternating magnetic field generating means links to each other with the water-cooling apparatus water pipe, the alternating magnetic field generating means, electromagnetic induction coil, temperature measurement and control instrument, image detector, monitor is equipped on the therapeutic bed, display and printer are placed on the operating board, operating board, the central operation controller, power supply, water-cooling apparatus and auxiliary facilities are configured in around the therapeutic bed or a side;
The central operation controller is made up of microprocessor, display, keyboard, mouse, programmable logic controller (PLC), potentiometer, relay, switch;
The alternating magnetic field generating means is made up of brilliant lock AC voltage regulator, rectifier transformer, valve generator or semiconductor device generator, cooling water pipe fitting;
Therapeutic bed has shell and is made up of engineering plastics or copper skeleton and engineering plastics, device has on motor, variator, driver, the therapeutic bed and disposes electromagnetic induction coil in the shell, and electromagnetic induction coil is made by the coil of hollow copper tubing or other hollow core conductor coiled and the various conductors of outfit chiller;
Water-cooling apparatus is made up of the cooling water pipeline that water tank, water pump or tap water, water pump and electromagnetic induction coil and alternating magnetic field generating means are equipped with, and the configuration water yield and hydraulic pressure adjusting, control, warning and protector;
Image detector has MR imaging apparatus or x-ray ct device or ultrasonic imaging device;
Temperature measuring equipment comprises fibre optic temperature sensor, resistive conductor critesistor by diminishing temperature sensor, or harmless temperature device, comprises MR imaging apparatus, ultrasonic imaging device, x-ray ct device, microwave CT and microwave radiometer;
Operating board is made up of programmable logic controller (PLC), potentiometer, relay and switch.
2, the tumor thermotherapy therapeutic instrument of stating according to claim 1 is characterized in that auxiliary device belongs to the apolegamy device, apolegamy body detection device and adjuvant therapy device.
3, the tumor magnetic thermotherapy treatment instrument of stating according to claim 1 is characterized in that cut protection device disposes the power failure power supply.
4, the tumor magnetic thermotherapy treatment instrument of stating according to claim 1 is characterized in that electromagnetic induction coil adopts the electromagnetic induction coil of pie electrode, coaxial coil group or three kinds of different magnetic inductive mode of heatings of ceoncentrically wound coil.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200320120141 CN2691632Y (en) | 2003-12-03 | 2003-12-03 | Tumour magnetic heat therapeutic instrument |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200320120141 CN2691632Y (en) | 2003-12-03 | 2003-12-03 | Tumour magnetic heat therapeutic instrument |
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| Publication Number | Publication Date |
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| CN2691632Y true CN2691632Y (en) | 2005-04-13 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN 200320120141 Expired - Lifetime CN2691632Y (en) | 2003-12-03 | 2003-12-03 | Tumour magnetic heat therapeutic instrument |
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Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101934116A (en) * | 2010-08-20 | 2011-01-05 | 上海世鹏实验室科技发展有限公司 | Phototherapy device |
| CN104535610A (en) * | 2015-01-16 | 2015-04-22 | 哈尔滨工业大学 | Adjustable magnetic field generating device |
| CN107174742A (en) * | 2017-05-02 | 2017-09-19 | 深圳磁实科技有限公司 | Superconducting intense magnetic field device for oncotherapy |
| CN107929945A (en) * | 2017-12-12 | 2018-04-20 | 山东省肿瘤防治研究院 | A kind of apparats for treating tumor for integrating external high frequency thermotherapy and magnetic induction treatment |
| CN108525128A (en) * | 2018-03-26 | 2018-09-14 | 清华大学 | Application of the liquid metal as tumour magnetic thermotherapy medium |
| CN108578893A (en) * | 2017-11-30 | 2018-09-28 | 重庆科技学院 | A kind of magnetic hysteresis thermotherapy set of endo-luminal ultrasound positioning |
| CN110354392A (en) * | 2019-08-02 | 2019-10-22 | 北京大学第三医院（北京大学第三临床医学院） | A kind of coil mechanism, heat generating device and heat treatment unit for thermotherapy |
| CN110652656A (en) * | 2019-10-30 | 2020-01-07 | 南京逐路电子科技有限公司 | Tumor magnetic induction thermotherapy system |
| CN114159212A (en) * | 2021-10-26 | 2022-03-11 | 北京大学（天津滨海）新一代信息技术研究院 | Thermotherapy coil handle and apparatus |
| US11480452B2 (en) * | 2019-08-14 | 2022-10-25 | Vega Grieshaber Kg | Field device housing with a monitoring device |
| WO2024010313A1 (en) * | 2022-07-04 | 2024-01-11 | 주식회사 이노비오젠 | Combined radiation and magnetic heat therapy apparatus for animals |
-
2003
- 2003-12-03 CN CN 200320120141 patent/CN2691632Y/en not_active Expired - Lifetime
Cited By (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101934116A (en) * | 2010-08-20 | 2011-01-05 | 上海世鹏实验室科技发展有限公司 | Phototherapy device |
| WO2012022077A1 (en) * | 2010-08-20 | 2012-02-23 | Song Shipeng | Phototherapy device |
| CN104535610A (en) * | 2015-01-16 | 2015-04-22 | 哈尔滨工业大学 | Adjustable magnetic field generating device |
| CN107174742A (en) * | 2017-05-02 | 2017-09-19 | 深圳磁实科技有限公司 | Superconducting intense magnetic field device for oncotherapy |
| CN107174742B (en) * | 2017-05-02 | 2024-05-07 | 商澎 | Superconducting strong magnetic field device for tumor treatment |
| CN108578893A (en) * | 2017-11-30 | 2018-09-28 | 重庆科技学院 | A kind of magnetic hysteresis thermotherapy set of endo-luminal ultrasound positioning |
| CN108578893B (en) * | 2017-11-30 | 2021-11-19 | 重庆科技学院 | Magnetic hysteresis heating treatment device for ultrasonic positioning in cavity |
| CN107929945A (en) * | 2017-12-12 | 2018-04-20 | 山东省肿瘤防治研究院 | A kind of apparats for treating tumor for integrating external high frequency thermotherapy and magnetic induction treatment |
| CN108525128A (en) * | 2018-03-26 | 2018-09-14 | 清华大学 | Application of the liquid metal as tumour magnetic thermotherapy medium |
| CN110354392A (en) * | 2019-08-02 | 2019-10-22 | 北京大学第三医院（北京大学第三临床医学院） | A kind of coil mechanism, heat generating device and heat treatment unit for thermotherapy |
| US11480452B2 (en) * | 2019-08-14 | 2022-10-25 | Vega Grieshaber Kg | Field device housing with a monitoring device |
| CN110652656A (en) * | 2019-10-30 | 2020-01-07 | 南京逐路电子科技有限公司 | Tumor magnetic induction thermotherapy system |
| CN114159212A (en) * | 2021-10-26 | 2022-03-11 | 北京大学（天津滨海）新一代信息技术研究院 | Thermotherapy coil handle and apparatus |
| WO2024010313A1 (en) * | 2022-07-04 | 2024-01-11 | 주식회사 이노비오젠 | Combined radiation and magnetic heat therapy apparatus for animals |
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| C14 | Grant of patent or utility model | ||
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Expiration termination date: 20131203 Granted publication date: 20050413 |