CN2569446Y - Preamplifier for diaphragm gripping instrument - Google Patents
Preamplifier for diaphragm gripping instrument Download PDFInfo
- Publication number
- CN2569446Y CN2569446Y CN 02279113 CN02279113U CN2569446Y CN 2569446 Y CN2569446 Y CN 2569446Y CN 02279113 CN02279113 CN 02279113 CN 02279113 U CN02279113 U CN 02279113U CN 2569446 Y CN2569446 Y CN 2569446Y
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- CN
- China
- Prior art keywords
- preamplifier
- operational amplifier
- analog switch
- input
- patch
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- Expired - Fee Related
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Abstract
The utility model relates to a preamplifier for a diaphragm gripping instrument, which belongs to the technology of an electronic circuit, particularly a circuit which is used for the diaphragm gripping instrument in the physics experimental technology of cell biology. The utility model solves the problems of the reduction of the volume of the preamplifier and convenient batch production. The preamplifier adopts an integrated circuit as an analog switch. Current I#-[d]is smaller than 100fA. A broadband integrated operational amplifier is adopted to be used as an operational amplifier, and a gain bandwidth product is bigger than 1 MHz. Bias current I#-[b]is smaller than 10fA, 1kHz, and noise is smaller than 25nV/_ H#-[2]. An input circuit adopts the space erecting and loading technique to reduce the volume of the preamplifier. The total volume of a probe is led to be only 20 by 13 by 51 mm #+ [3], and consequently, the utility model is suitable for the experiment of a forceps with a plurality of diaphragms. In addition, the utility model has the advantages of the simplification of the technology of production and installation, convenient debugging, and low cost.
Description
Technical field
The utility model belongs to the electronic circuit technology field, particularly is used for the circuit arrangement of patch-clamp instrument in the cell biological Physical Experiment technology.
Background technology
The pre-amplification circuit of existing patch-clamp instrument be German Nobel laureate Erwin Neher in early 1980s design (see Bert Sakmann ﹠amp; Erwin Neher work＜Single-Channe1Recording＞2nd Ed.Plenum Press, New York, 1995.P95～127.,), the HEKA company of Germany is based on this circuit over 20 years, manufacture the preamplifier that combines with thick film integrated circuit, amplifier and discrete component, be installed on the patch-clamp instrument of models such as EPC-7, EPC-8 that the said firm produces, EPC-9.In addition, the preamplifier of the patch-clamp instrument of company's production of the U.S., Japan is a basic engineering with this circuit also a lot.Though partial circuit has been integrated in the little thick film circuit at present, owing to some discrete components have been used, still big (38 * 18 * 67mm of probe cumulative volume
3), in the experiment of the many patch-clamp of needs, the narrow and small upper space of inverted microscope is difficult to hold probe such more than two.The preamplifier circuit complexity, the Installation and Debugging difficulty.Special-purpose thick film circuit is because little in batches, and production cost is very high.
Summary of the invention
The preamplifier that is used for the patch-clamp instrument that the utility model provides, mainly the problem of Xie Jueing is to dwindle the volume of patch-clamp instrument preamplifier, so that above inverted microscope, vacate more space other equipment is installed, and help carrying out many patch clamp experiments, be beneficial to the new cell biological Physical Experiment of design.Be convenient to simultaneously produce in batches.
The utility model is used for the preamplifier of patch-clamp instrument, comprises analog switch, operational amplifier and resistance, electric capacity, it is characterized in that:
(1) described analog switch is an integrated circuit, and described operational amplifier is the broadband integrated operational amplifier,
(2) the preamplifier input connect simulation make and break contact 2 and operational amplifier inverting input,
And by building-out capacitor 1 connection compensating signal 1 input,
(3) analog switch contact 1 concatenation operation amplifier in-phase input end and command voltage input, and
By filter capacitor ground connection,
(4) operational amplifier output terminal connects the preamplifier input through high G Ω feedback resistance, and warp
Low G Ω feedback resistance connects the analog switch common junction, and the latter connects by building-out capacitor 2
Compensating signal 2 inputs, analog switch control termination control logic level,
(5) operational amplifier two power ends connect positive and negative power supply respectively.
The described preamplifier that is used for the patch-clamp instrument, it is further characterized in that described analog switch leakage current I
D＜100fA, described operational amplifier gain bandwidth product＞1MHz, bias current I
B＜10fA, 1kHz noise＜25nV/
The described preamplifier that is used for the patch-clamp instrument, input circuit can adopt space frame packing technique.
The utility model has reduced the volume of preamplifier greatly.The probe cumulative volume only is 20 * 13 * 51mm
3, be at present minimum in the world patch-clamp instrument preamplifier probe, thereby be suitable for carrying out very much many patch clamp experiments.Simplified the production mounting process, Installation and Debugging are convenient, improved production efficiency, and cost is low simultaneously, adopts the standard chips of homemade element and producer, avoids the special-purpose thick film circuit of manufacturing price costliness.
Description of drawings
Fig. 1 is the pre-amplification circuit of patch-clamp instrument in the prior art.
Fig. 2 is an electrical block diagram of the present utility model.
Embodiment
Now further provide embodiment of the present utility model in conjunction with Fig. 2, integrated operational amplifier A in broadband among Fig. 2 can select the accurate amplifier of product LMC6081 of NSC company for use; Analog switch B can select the product A DG613 of AD company for use, and its contact 1, contact 2, common junction D, control end E are as shown.IN is the preamplifier input, and OUT is an operational amplifier output terminal, C
1Be building-out capacitor 1, can select 1pF electric capacity for use, C
2Be building-out capacitor 2, select 10pF electric capacity for use, C
3Be filter capacitor, select 4.7nF for use, R
1Be low G Ω feedback resistance, resistance can be 0.5G Ω, R
2Be high G Ω feedback resistance, resistance can be 50G Ω, and the end points comp1 that is connected with the outside is compensating signal 1 input, and comp2 is compensating signal 2 inputs, and LK is a control logic level input, and MI is the command voltage input.
Claims (3)
1. a preamplifier that is used for the patch-clamp instrument comprises analog switch, operational amplifier and resistance, electric capacity, it is characterized in that:
(1) described analog switch is an integrated circuit, and described operational amplifier is that the integrated computing in broadband is put
Big device,
(2) the preamplifier input connects simulation make and break contact 2 and the anti-phase input of operational amplifier
End also passes through building-out capacitor 1 connection compensating signal 1 input,
(3) analog switch contact 1 concatenation operation amplifier in-phase input end and command voltage input,
And by filter capacitor ground connection,
(4) operational amplifier output terminal connects the preamplifier input through high G Ω feedback resistance,
And through low G Ω feedback resistance connection analog switch common junction, the latter is by compensation
Hold 2 and connect compensating signal 2 inputs, analog switch control termination control logic level,
(5) operational amplifier two power ends connect positive and negative power supply respectively.
2. the preamplifier that is used for the patch-clamp instrument as claimed in claim 1 is characterized in that described analog switch leakage current I
D＜100fA, described operational amplifier gain bandwidth product＞1MHz, bias current I
B＜10fA, 1kHz noise＜25nV/
3. the preamplifier that is used for the patch-clamp instrument as claimed in claim 1 or 2 is characterized in that input circuit adopts space frame packing technique.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 02279113 CN2569446Y (en) | 2002-09-11 | 2002-09-11 | Preamplifier for diaphragm gripping instrument |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 02279113 CN2569446Y (en) | 2002-09-11 | 2002-09-11 | Preamplifier for diaphragm gripping instrument |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN2569446Y true CN2569446Y (en) | 2003-08-27 |
Family
ID=33742269
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 02279113 Expired - Fee Related CN2569446Y (en) | 2002-09-11 | 2002-09-11 | Preamplifier for diaphragm gripping instrument |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN2569446Y (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103328972A (en) * | 2011-07-20 | 2013-09-25 | 加利福尼亚大学董事会 | Compensated patch-clamp amplifier for nanopore polynucleotide sequencing and other applications |
-
2002
- 2002-09-11 CN CN 02279113 patent/CN2569446Y/en not_active Expired - Fee Related
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103328972A (en) * | 2011-07-20 | 2013-09-25 | 加利福尼亚大学董事会 | Compensated patch-clamp amplifier for nanopore polynucleotide sequencing and other applications |
| CN103328972B (en) * | 2011-07-20 | 2014-04-02 | 加利福尼亚大学董事会 | Compensated patch-clamp amplifier for nanopore polynucleotide sequencing and other applications |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C19 | Lapse of patent right due to non-payment of the annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |