CN2436105Y - MIniature wound closure apparatus - Google Patents

MIniature wound closure apparatus Download PDF

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Publication number
CN2436105Y
CN2436105Y CN 00251080 CN00251080U CN2436105Y CN 2436105 Y CN2436105 Y CN 2436105Y CN 00251080 CN00251080 CN 00251080 CN 00251080 U CN00251080 U CN 00251080U CN 2436105 Y CN2436105 Y CN 2436105Y
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China
Prior art keywords
pipe
curved surface
wound
pipe handle
socket
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Expired - Lifetime
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CN 00251080
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Chinese (zh)
Inventor
蒲忠杰
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Lepu Medical Technology Beijing Co Ltd
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蒲忠杰
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Priority to CN 00251080 priority Critical patent/CN2436105Y/en
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Abstract

The utility model relates to a miniature wound closure apparatus for closing miniature blood vessel trauma. The utility model is composed of a haemostasis element, a conveying element and a self-locking element, wherein, the front end of the haemostasis element is provided with a three-dimensional curved surface knitted and wound by memory alloy wires which are tightly contacted, and the back end is filiform to fixedly connect with the front end into integration. The conveying element is composed of a tube cylinder and a tube handle. The self-locking element is composed of a lock tube and a lock head, wherein, the middle part of the lock tube is provided with external threads corresponding to internal threads of the tube handle. The lock head is composed of a cylindrical surface and a conical head with an opening slit. The utility model uses the three-dimensional curved surface wound by memory alloy wires as a barrier for temporarily blocking blood flow. The barrier uses a delivery system made of biocompatible materials to conveniently, safely and accurately convey into blood vessels with wounds.

Description

Micro Wound Sealer
This utility model relates to medical apparatus and instruments, specifically a kind of miniature wound closure device.Be used for sealing the miniature wound that intervention diagnosis and therapy is performed the operation and other reason causes.
Intervention diagnosis and therapy is meant the various passages by human body, and the miniature instrument that some are special is sent into each position of human body and carried out medical diagnosis on disease and treatment.Intervention diagnosis and therapy is a kind of novel medical skill, belongs to miniature trauma operation, and patient is painful few, and cost is cheap, and therapeutic domain is wide, and is evident in efficacy.This operation often needs open at the blood vessel place of human body the openning of a long 2mm-15mm, treat that diagnosis and treatment finish after, seal this wound that can't sew up with traditional sewing method how simply, safely, be a challenge.Special person-time surge year by year when intervene operation, and under the situation that patient reduces the hospital stays year by year, the method and apparatus of seeking the simple and safe miniature wound of sealing just seems more and more important.
United States Patent (USP) 5948425 has been invented a kind of apparatus and method of sealing Wicresoft's wound.This apparatus is delivered to the wound with a solid colleage stopper.This solid colleage stopper is a biological absorptive material, treat certain hour after, this stopper is absorbed by the human body wound.But this solid stopper can't guarantee good fit with wound circumference often to cause infection.United States Patent (USP) 6007563 has also been invented the sealing that a kind of device carries out Wicresoft's wound.It stops blood to rush down outside wound with a bioresorbable solid thin-sheet from blood vessel is earlier temporary transient, then to the blood-clotting agent of wound injecting fluid, treat that blood-clotting agent solidifies after, the wound sealing finishes.After being placed on endovascular bioresorbable thin slice and treating some months, could all dissolve.In patent 6007563, temporarily stop the solid piece of blood outflow after the wound sealing, not taken out.It also is to be used to seal miniature wound that United States Patent (USP) 5868788 has been invented a kind of apparatus.This character of apparatus is the outflow that temporarily stops blood with sacculus.Send blood vessel at the sacculus air deflating state to by wound, then airbag aeration.The sacculus of inflation is close to wound just can stop blood to outflow along wound.Penetrate liquid blood-clotting agent to wound stream then,, sacculus is lost heart take out when liquid blood-clotting agent is cured to half when coagulating state.After the blood-clotting agent full solidification, the wound sealing finishes.This invention apparatus does not need temporarily to stop the part of blood outflow to be placed in the blood vessel for a long time with being used for, and superior than patent 6007563.But because the cost that sacculus is made and the complexity of technology, the apparatus cost is higher.More seriously, the sacculus back shape of losing heart is uncontrollable, and the sacculus after losing heart partly solidifies when removing outside the attitude medicine wound by filling, and can destroy the form and the balance of medicine.
The purpose of this utility model is to overcome above-mentioned deficiency, a kind of miniature wound closure device is provided, be used to seal miniature blood vessel wound, it utilizes the barrier of the three-dimension curved surface of shape-memory alloy wire coiled as the temporary interruption blood flow, and the induction system that this barrier is made with biocompatible materials can make things convenient for, safety, deliver in the wound blood vessel exactly.
The purpose of this utility model is achieved in that
A kind ofly seal the Micro Wound Sealer that miniature blood vessel wound is used, by the hemostasis element, delivery element and form from locking element,
The hemostasis element is made of front-end and back-end two parts, and front end be to compile the coiled three-dimension curved surface by memory alloy wire, thread with silk between closely link to each other, the central hair of curved surface exposes curved surface; It is thread that the rear end is, and its material is and the material of biocompatibility that the rear end fixes as one with front end perpendicular to the three-dimension curved surface of front end;
Delivery element is made of socket and pipe handle two parts, socket is open column shape, its material is the material with biocompatibility, the pipe handle is hollow bushing-like, but its material is the biocompatible polymer material of bearing certain pressure, the pipe handle has front port to be connected with socket, and this front port is with excessive conical surface connection tube handle body; In the pipe handle rear port screw thread is arranged;
Constitute by lock pipe and tapered end from locking element; Lock Guan Weiyi hollow pipe, its material are and the macromolecular material of biocompatibility that its middle part has external screw thread corresponding with pipe handle female thread; Tapered end is made of the open circles cylinder and the conical surface head of disjunctor, and this conical surface head has centre bore and open slots, and the conical surface of this head is corresponding with the excessive conical surface of pipe handle;
Being configured to of above-mentioned each assembly: the inner chamber that is loaded on the pipe handle of delivery element from the tapered end of locking element, the tapered end face of cylinder is loaded on the endoporus of lock pipe, the lock pipe be threadedly connected to the pipe handle, the center of lock pipe, tapered end, pipe handle and socket is passed in the rear end of hemostasis element, this front end enters human vas.
The three-dimension curved surface of the front end of described hemostasis element can be sphere, the face of cylinder; Also can be the plane, this planar shape can be circle, triangle, rectangle.
The silk footpath of the front-end and back-end of described hemostasis element can equate that the silk footpath that also can be the rear end is greater than front end, and its connection can be welding, bonding, also can be the connecting body structure of a rhizoid.
The material of described memory alloy wire can be NiTi, iron-based, copper-based memory alloy.
Described and material good biocompatibility can be a rustless steel, titanium alloy, memorial alloy, non-toxic plastic.
The front end of described hemostasis element can be made of the combination silk that memory alloy wire and biocompatibility macromolecule shell constitute, this biocompatible polymer material is coated on the appearance of memorial alloy, and the cross section of silk can be rounded, semicircle, oval, rectangle, triangle, polygon, abnormity.
Described pipe handle has for the side mouth that carries out the medicine injection,
The external diameter of the socket of described delivery element is between 0.4-15mm, and the corresponding internal diameter of external diameter is between 0.2-14.9mm.
This utility model has following actively useful effect:
This utility model provides a kind of simple, safe apparatus to be used for sealing miniature wound.The principle of this apparatus is to utilize the characteristics of marmem.Adopt the shape-memory alloy wire three-dimension curved surface of closely contact formation mutually, temporarily stop the outflow of blood along wound.During dormant state, memory alloy wire is constrained in the light-wall pipe linearly or the three-dimensional curve shape.During use, memory alloy wire is pushed out outside the pipe, and under unconfined situation, this memory spun gold is converted into three-dimension curved surface.This curved surface can temporarily stop the outflow of blood along wound.Penetrate liquid blood-clotting agent to wound stream then, treat that blood-clotting agent is solidified into when partly solidifying attitude, withdraws from memory alloy wire along carrier pipe.Because it is very little that the size of carrier pipe can be done, and may command, overcome the shortcoming that air bag brings in the United States Patent (USP) 5868778.This utility model is simple in structure simultaneously, and is easy to operate.
Be described further below in conjunction with accompanying drawing:
Fig. 1 is the structural representation of this utility model one embodiment;
Fig. 2 is the structural representation of this utility model plane curved face type hemostasis element, is vertical view;
Fig. 3 is the A-A cutaway view of Fig. 2;
Fig. 4 is the structural representation of this utility model face of cylinder type hemostasis element, is vertical view;
Fig. 5 is the B-B cutaway view of Fig. 4;
Fig. 6 is the C-C cutaway view of Fig. 4;
Fig. 7 is the structural representation of this utility model spherical hemostasis element, is vertical view;
Fig. 8 is the D-D cutaway view of Fig. 7;
Fig. 9 is the E-E cutaway view of Fig. 7;
Figure 10 is the assembly drawing of this utility model from locking element;
Figure 11 is the tapered end part sketch map among Figure 10;
Figure 12 is the right side view of Figure 11;
Figure 13 is the F-F cutaway view of Figure 12;
Figure 14 is the use block diagram of Micro Wound Sealer of the present utility model, shows step a;
The same Figure 14 of Figure 15 shows step b;
The same Figure 14 of Figure 16 shows step c;
The same Figure 14 of Figure 17 shows steps d;
The same Figure 14 of Figure 18 shows step e;
Accompanying drawing number:
1. element 11. front ends 110. memory alloy wires stop blooding
12. rear end
2. delivery element 21. sockets 22. are managed handles
221. pipe handle front port 222. pipe handle rear ports 223. female threads
224. the excessive conical surface
3. from locking element 31. lock pipes 32. tapered ends
321. hollow cylinder 322. conical surface heads 323. external screw threads
324. slit 325. centre bores 326. conical surfaces
4. sheath pipe
5. blood-clotting agent
6. blood vessel
Please refer to Fig. 1, the utility model is a kind of Micro Wound Sealer that miniature blood vessel wound is used that seals, and by the hemostasis element, delivery element and self-locking element form,
Hemostasis element 1 is made of front end 11 and rear end 12 two parts, front end 11 be by memory alloy wire volume around Become three-dimension curved surface, closely link to each other between silk and the silk, the central hair of curved surface exposes curved surface; Rear end 12 is silk Shape, its material are the material with biocompatibility, and rear end 12 is perpendicular to the three-dimension curved surface of front end 11, with Front end 11 fixes as one;
Delivery element 2 is made of socket 21 and pipe handle 22 two parts, and socket 21 is open column shape, its material For with the material of biocompatibility, pipe handle 22 is hollow bushing-like, but its material is bearing certain pressure Biocompatible polymer material, the pipe handle have front port 221 to be connected with socket 21, this front port 221 With the excessive conical surface 224 tube connector handle bodies; In the pipe handle rear port 222 screw thread 223 is arranged;
Self-locking element 3 is made of lock tube 31 and tapered end 32; Lock tube 31 is a hollow pipe, and its material is and life The macromolecular material of phase capacitive, its middle part have external screw thread 323 corresponding with pipe handle internal thread 223; Tapered end 32 open circles cylinder 321 and conical surface heads 322 by disjunctor consist of, and this conical surface head has centre bore 325 Hes Open slots 324, the conical surface 326 of this head is corresponding with the excessive conical surface 224 of pipe handle;
Being configured to of above-mentioned each assembly: the tapered end 32 of self-locking element 3 is loaded on the pipe handle 22 of defeated element 2 Inner chamber, the tapered end face of cylinder is loaded on the endoporus of lock tube 31, and the screw thread 323 of lock tube 31 is connected in pipe handle 22, ends The center of lock tube 31, tapered end 32, pipe handle 22 and socket 21, this front end 11 are passed in the rear end 12 of blood element 1 Enter human vas 6.
The three-dimension curved surface of the front end 11 of described hemostasis element 1 can be sphere, the face of cylinder; Also can be for flat Face, the shape on this plane can be circle, triangle, rectangle.
The front end 11 of described hemostasis element 1 and the string diameter of rear end 12 can equate, also can be rear end 12 String diameter is greater than front end 11, and its connection can be welding, bonding, also can be the connecting body structure of a rhizoid.
The material of described memory alloy wire can be NiTi, iron-based, copper-based memory alloy.
Described and material good biocompatibility can be stainless steel, titanium alloy, memorial alloy, nontoxic Plastics.
The front end 11 of described hemostasis element 1 can be by memory alloy wire and biocompatibility macromolecule shell structure The combination silk that becomes consists of, and this biocompatible polymer material is coated on the appearance of memorial alloy, the horizontal stroke of silk The cross section can be rounded, semicircle, oval, rectangle, triangle, polygon, abnormity.
Described pipe handle 22 has for the side mouth that carries out drug injection,
The external diameter of the socket 21 of described delivery element 2 exists with the corresponding internal diameter of external diameter between 0.4-15mm 0.2-14.9mm between.
Embodiment describes in detail:
Fig. 1 has provided a kind of example of the present utility model.This apparatus is by hemostasis element 1, delivery element 2 and form from locking element 3.When this apparatus is treated the time spent, pin hemostasis element 1 from locking element 3, hemostasis element 1 can not be moved in delivery element 2.The element 1 that just stops blooding emphatically below, delivery element 2 and set forth from locking element 3.
Hemostasis element 1 is made up of front end 11 and rear end 12 two parts, as shown in Figure 3.Front end 11 can be made by different shape memory alloy wires such as NiTi, iron-based, cuprio.This alloy silk with super elastic characteristics is compiled the three-dimension curved surface that coiled has different shape by mould.Whole curved surface is compiled around between, silk and the silk by certain rule by memory alloy wire and is closely linked to each other.The central hair of curved surface exposes curved surface.In Fig. 3, three-dimension curved surface is a simple plane, silk adopt a screw type mode compile around.At planar center, memory alloy wire 110 exposes the plane.But three-dimension curved surface is other any three-dimension curved surface of coiled also.Form the memory alloy wire of fore-end 11, its cross section can adopt different shape, as circle, triangle, rectangle, semicircle.Fig. 2, Fig. 3, Fig. 4, Fig. 5, Fig. 6, Fig. 7, Fig. 8, Fig. 9 have provided other two kinds of curved surfaces commonly used (face of cylinder and sphere).Rear end part 12 can be made up of the material of any good biocompatibility, as rustless steel, titanium alloy, memorial alloy, plastics etc.The diameter of the rear end part silk preferably diameter than the fore-end silk is big slightly, to increase thrust.Fore-end can be connected by any method with rear end part, as welding, bonding.Fore-end 11 and rear end part 12 also can be manufactured by a rhizoid.For the tinsel that reduces hemostasis element fore-end 11 when the just intravasation, the blood vessel wall of stabbing.Fore-end can be made of the composite filament that memory alloy wire core and biocompatibility macromolecule shell constitute.The high sub-material of this bio-compatible can adopt the whole bag of tricks to be coated on the appearance of memory alloy wire core.The purpose of delivery element 2 is to carry and constraint hemostasis element 1.It is made of socket 21 and pipe handle 22 two parts.Socket 21 can be made by all biocompatible materialses.The macromolecule multiple tube that preferably adopts stainless-steel thin-wall pipe, titanium alloy tube, tinsel to strengthen constitutes.External diameter is at 0.4-15mm, and internal diameter is between 0.2-14.9mm.The socket 21 of delivery element also can be made the open column shape structure of other shape.The profile of post and inner chamber can be made different shape, as triangle, semicircle etc.The connection handle of pipe handle 22 coloured silks and two logical types, but make by the biocompatible polymer material of bearing certain pressure, as PolyCarboriate, ABS, PVC, etc.Pipe handle front port 221 is connected with socket 21, rear port 222 be connected from locking element 23.One female thread is arranged in the rear port 222, and be connected from the locking element microgroove.Pipe handle 22 also can have the side mouth, to carry out the injection of medicine, as shown in Figure 1.Constitute by part 31 and part 32 from locking element 3.Figure 10 has provided the assembling sketch map from locking element 3.Part 31 is cylindric.The cylinder internal diameter is a bit larger tham the external diameter on the face of cylinder 321 in the part 32.Cylinder one end has a horn mouth, makes with 322 capacitive macromolecular materials in the part 32.Figure 11, Figure 12, Figure 13 have provided the sketch map of part 32.It is made by biocompatible materials.Figure 10 provides the assembly drawing of part 31 and 32.During use, when dextrorotation part 31, surface 323 in locking element 3 contacts with surface 223 in the delivery element, along with part 31 forward, the centre bore 325 that is made of slit 324 contacts with surface 223 in the delivery element, along with part 31 forward, the centre bore 325 that is made of slit 324 will be more and more littler, up to the tinsel of locking hemostasis element.When left-handed part 31, part 31 retreats, centre bore 325 chaps, loosening tinsel.
Narrate using method of the present utility model below: loosening from locking element 3 after apparatus is by sheath pipe 4 intravasations, hemostasis element 1 can move freely along socket 21.At this moment, promoting the hemostasis element forward shifts out outside the socket 21 its fore-end.The fore-end 11 of hemostasis element is because its memory effect changes the three-dimension curved surface that is in contact with one another between filamentation and the silk.At this moment, pinning can not move tinsel with respect to socket 21 from locking element 3.Pull back whole apparatus, tight-lipped close joining of three-dimension curved surface and blood vessel, three-dimension curved surface temporarily stops blood to flow out along vascular wound.Pull out sheath pipe 4, to surrounding injection liquid or semi-liquid blood-clotting agent of wound, treat that medicine stays for some time around the socket 21, be converted into half curdled appearance can not arbitrarily flow the time, apparatus is moved forward a segment distance slightly.Then, loosening from locking element 3, hemostasis element 1 can be relatively moved along socket 21.The socket 21 of holding with a firm grip, the element front end position 11 of will stopping blooding is along in the socket 21 complete shift-in sockets.Lock then from locking element 3, withdraw from whole apparatus.And after the medicine that is injected into the wound treated full solidification, the wound sealing finished.Figure 14-Figure 18 is the detailed maps of whole use.
Figure 14 shows step a, and Micro Wound Sealer is delivered in the blood vessel along the sheath pipe;
Figure 15 shows step b, and the hemostasis element is pushed out pipe handle 21, forms three-dimension curved surface;
Figure 16 shows step c, and the three-dimension curved surface of hemostasis element contacts with wound, and the injection portion blood-clotting agent;
Figure 17 shows steps d, the figure c that continues, and blood-clotting agent has filled up whole wound;
Figure 18 shows step e, withdraws from whole system.

Claims (8)

1. Micro Wound Sealer of using of the miniature blood vessel wound of sealing, by the hemostasis element, delivery element and form from locking element is characterized in that:
Hemostasis element (1) is made of front end (11) and rear end (12) two parts, and front end (11) be by memory alloy wire volume coiled three-dimension curved surface, thread with silk between closely link to each other, the central hair of curved surface exposes curved surface; Rear end (12) is thread, and its material is and the material of biocompatibility that rear end (12) fix as one with front end (11) perpendicular to the three-dimension curved surface of front end (11);
Delivery element (2) is made of socket (21) and pipe handle (22) two parts, socket (21) is open column shape, its material is the material with biocompatibility, pipe handle (22) is hollow bushing-like, but its material is the biocompatible polymer material of bearing certain pressure, the pipe handle has front port (221) to be connected with socket (21), and this front port (221) is with the excessive conical surface (224) connection tube handle body; In the pipe handle rear port (222) screw thread (223) is arranged;
Constitute by lock pipe (31) and tapered end (32) from locking element (3); Lock pipe (31) is a hollow pipe, and its material is and the macromolecular material of biocompatibility that its middle part has external screw thread (323) corresponding with pipe handle female thread (223); Tapered end (32) is made of the open circles cylinder (321) and the conical surface head (322) of disjunctor, and this conical surface head has centre bore (325) and open slots (324), and the conical surface of this head (326) is corresponding with the excessive conical surface (224) of pipe handle;
Being configured to of above-mentioned each assembly: the tapered end (32) from locking element (3) is loaded on the inner chamber of the pipe handle (22) of delivery element (2), the tapered end face of cylinder is loaded on the endoporus of lock pipe (31), the screw thread (323) of lock pipe (31) is connected in pipe handle (22), the center of lock pipe (31), tapered end (32), pipe handle (22) and socket (21) is passed in the rear end (12) of hemostasis element (1), and this front end (11) enters human vas (6).
2. Micro Wound Sealer as claimed in claim 1 is characterized in that: the three-dimension curved surface of the front end (11) of described hemostasis element (1) can be sphere, the face of cylinder; Also can be the plane, this planar shape can be circle, triangle, rectangle.
3. Micro Wound Sealer as claimed in claim 1, it is characterized in that: the silk footpath of the front end (11) of described hemostasis element (1) and rear end (12) can equate, the silk footpath that also can be rear end (12) is greater than front end (11), its connection can be welding, bonding, also can be the connecting body structure of a rhizoid.
4. Micro Wound Sealer as claimed in claim 1 is characterized in that: the material of described memory alloy wire can be NiTi, iron-based, copper-based memory alloy.
5. Micro Wound Sealer as claimed in claim 1 is characterized in that: described and material good biocompatibility can be a rustless steel, titanium alloy, memorial alloy, non-toxic plastic.
6. Micro Wound Sealer as claimed in claim 1, it is characterized in that: the front end (11) of described hemostasis element (1) can be made of the combination silk that memory alloy wire and biocompatibility macromolecule shell constitute, this biocompatible polymer material is coated on the appearance of memorial alloy, and the cross section of silk can be rounded, semicircle, oval, rectangle, triangle, polygon, abnormity.
7. Micro Wound Sealer as claimed in claim 1 is characterized in that: described pipe handle (22) has for the side mouth that carries out the medicine injection,
8. Micro Wound Sealer as claimed in claim 1 is characterized in that: the external diameter of the socket (21) of described delivery element (2) is between 0.4-15mm, and the corresponding internal diameter of external diameter is between 0.2-14.9mm.
CN 00251080 2000-08-31 2000-08-31 MIniature wound closure apparatus Expired - Lifetime CN2436105Y (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN 00251080 CN2436105Y (en) 2000-08-31 2000-08-31 MIniature wound closure apparatus

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN 00251080 CN2436105Y (en) 2000-08-31 2000-08-31 MIniature wound closure apparatus

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CN2436105Y true CN2436105Y (en) 2001-06-27

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1306910C (en) * 2002-06-14 2007-03-28 洛马林达大学医学中心 Vascular wound closure device and method
CN100374083C (en) * 2003-08-14 2008-03-12 洛马林达大学医学中心 Vascular wound closure device

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1306910C (en) * 2002-06-14 2007-03-28 洛马林达大学医学中心 Vascular wound closure device and method
CN100374083C (en) * 2003-08-14 2008-03-12 洛马林达大学医学中心 Vascular wound closure device

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Owner name: BEIJING YUEPU MEDICAL APPARATUS CO. LTD.

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Effective date: 20070727

C41 Transfer of patent application or patent right or utility model
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Address after: 102200, Beijing Changping science and Technology Park, super Road, No. 3, building 37

Patentee after: Beijing Lepu Medical Device Co., Ltd.

Address before: 723001 No. 106, Chen Jiaying family building, Hanzhoung Teachers College, Hanzhoung, Shaanxi

Patentee before: Pu Zhongjie

C56 Change in the name or address of the patentee

Owner name: LE PU (BEIJING) MEDICAL DEVICES CO.

Free format text: FORMER NAME OR ADDRESS: BEIJING YUEPU MEDICAL APPARATUS CO. LTD.

CP01 Change in the name or title of a patent holder

Address after: No. 3, building 37, super Road, Changping science and Technology Park, Beijing, China: 102200

Patentee after: Lepu (Beijing) Medical Equipment Co.,Ltd.

Address before: No. 3, building 37, super Road, Changping science and Technology Park, Beijing, China: 102200

Patentee before: Beijing Lepu Medical Device Co., Ltd.

EE01 Entry into force of recordation of patent licensing contract

Assignee: Beijing Tiandihexie Technology Co., Ltd.

Assignor: Lepu (Beijing) Medical Instrument Co., Ltd.

Contract fulfillment period: 2008.6.16 to 2009.6.16

Contract record no.: 2008110000014

Denomination of utility model: MIniature wound closure apparatus

Granted publication date: 20010627

License type: General permission

Record date: 20080804

LIC Patent licence contract for exploitation submitted for record

Free format text: COMMON LICENCE; TIME LIMIT OF IMPLEMENTING CONTACT: 2008.6.16 TO 2009.6.16

Name of requester: TIANDIHEXIE SCIENCE AND TECHNOLOGY CO. LTD., BEIJ

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CX01 Expiry of patent term

Expiration termination date: 20100831

Granted publication date: 20010627