CN2428773Y - Electrochemical Sensor for damage-less analysis of live tissue - Google Patents
Electrochemical Sensor for damage-less analysis of live tissue Download PDFInfo
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- CN2428773Y CN2428773Y CN 00238964 CN00238964U CN2428773Y CN 2428773 Y CN2428773 Y CN 2428773Y CN 00238964 CN00238964 CN 00238964 CN 00238964 U CN00238964 U CN 00238964U CN 2428773 Y CN2428773 Y CN 2428773Y
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Abstract
The utility model relates to an electrochemical sensor for the in-body and damage-less analysis of a live tissue. The electrochemical sensor is composed of a responder and a signal transmission conducting wire which is connected with the responder, the responder is composed of an insulation casing, a shielding layer and a sensing probe, and the sensing probe comprises a sensing electrode, a reference electrode and an auxiliary electrode. The electrochemical sensor can be used for obtaining an electrochemical signal with in-body and damage-less from the live tissue of a human or an animal, the tissue is analyzed and characterized in using the electrochemical signal, such as the benign and malignant affection of the tissue, and the utility model can be used as an in-body diagnostic device for the clinic live tissue of a tumour.
Description
The utility model relates to the galvanochemistry conduction device of a kind of biological tissue in body, nondestructive analysis.Belong to the bioelectrochemical sensor field.
Tumour is the disease of serious harm health, and its diagnosis is most important to the oncotherapy scheme determination.The clinical diagnosis of tumour tradition is by the tissue pathological slice cytological observation, and its shortcoming is a trivial operations, and speed is slow, and subjective influence factor is big, lags behind the modern clinical diagnosis quick, accurate, easy, that automaticity is high and the requirement of examination far away.Such as, the scope of tumor resection generally is one centimetre of a borderline tumor, often causes excision not exclusively to cause recurrence, or excision influences patient's quality of life too much.
The purpose of this utility model provides the electrochemical sensing device of a kind of human or animal's of can be used for biological tissue in body, nondestructive analysis.So that the living tissue of using of understanding quickly and easily has or not pathology and which kind of pathology is arranged.
Biological tissue of the present utility model comprises shown in synoptic diagram at the electrochemical sensing device of body, nondestructive analysis:
Responsor (1) and the signal that is attached thereto transmit lead (2); Described responsor (2) is made of insulation crust (3) and sensing probe (4), described sensing probe (4) is in conplane contrast electrode (5), sensitive electrode (6) and auxiliary electrode (7) by its top and forms, these three kinds of electrodes are linearly shape bikini arrangement on described plane, be that two of sensitive electrode is respectively contrast electrode and auxiliary electrode than the limit, perhaps being the rotary island formula arranges, be contrast electrode and auxiliary electrode respectively semicircular in shape be trapped among and be rotary island shape around the sensitive electrode, as synoptic diagram Fig. 2 B and shown in Figure 3; Signal transmits three leads (8) that lead (2) contains mutually insulated, and (9), (10) link to each other with contrast electrode (5), sensitive electrode (6) and the tail end of auxiliary electrode (7) respectively; Signal transmits three leads (8) of the mutually insulated of lead (2), and (9) are provided with the screen layer (11) that metal material constitutes between (10).Above-mentioned three kinds of electrodes (5) are mercurous chloride electrode or silver-silver chloride electrode; (6), (7) are all the electrode of being made by graphite, gold or platinum.Described sensing device can be made into socket and the removable plug form of sensing probe.
When using above-mentioned sensing device to measure, as shown in Figure 4, with the branch line (8) (9) (10) of the electrode (5) (6) (7) of this sensing device successively respectively with potentiostat (12) on contrast electrode (13) working electrode (14) link to each other with auxiliary electrode (15); Sensing probe (4) is closely contacted with tested tissue, begin scanning by potentiostat (12) output-0.2 to 1.2 volt (with respect to contrast electrode), simultaneously, gathered by electrochemical analysis system (16), data analyzed in record, obtain the electrochemical response curve of tissue, as shown in Figure 5.
Above-mentioned electrochemical sensing device is connected into electrochemical analysis system can carry out at body, non-destructive testing the clinical operation tumor tissues, according to the electrochemical response curve of the feature of normal, optimum, malignant tissue, easy, judge the pathology situation of tissue accurately and rapidly.Judge the excision degree of tumour apace,, reached not only the best surgical target that patient's quality of life was organized but also do not influenced to tumor resection fully for operative doctor provides the scope of cutting tissue.This electrochemical sensing device can be used for equally to human or animal's body surface organization in body, nondestructive analysis, judge the character of tissue apace, be convenient to the clinical diagnosis and the examination of tumour.This device also can be used for measuring solution or liquid mixture.
Biological tissue of the present utility model is in the electrochemical sensing apparatus features and the excellent effect of body, nondestructive analysis:
1. can carry out biological tissue in body, harmless, painless electrochemical analysis;
2. simple and easy to use;
3. test result accurately and reliably.
Brief Description Of Drawings:
Fig. 1 is the schematic appearance of biological tissue of the present utility model at the electrochemical sensing device of body, nondestructive analysis.
Wherein 1 is responsor; 2 is signal transducting wire; 4 is sensing probe.
Fig. 2 A is the vertical profile of biological tissue of the present utility model at the electrochemical sensing device of body, nondestructive analysis
The face synoptic diagram.
Wherein 3 is the edge shell; 5 is contrast electrode; 6 is sensitive electrode; 7 is auxiliary electrode; 8,
9,10 is the lead that links to each other with above-mentioned electrode successively; 11 is between above-mentioned 8,9,10 leads
Screen layer.
B is the electrode bikini distribution schematic diagram on the plane, sensing probe top of this device.(bikini is visited
Head).
Fig. 3 is that biological tissue of the present utility model is arranged synoptic diagram in the electrode rotary island formula on the plane, sensing probe top of the electrochemical sensing device of body, nondestructive analysis.(rotary island formula probe)
Fig. 4 is the electrochemical analysis system synoptic diagram of biological tissue of the present utility model in body, nondestructive analysis.
Wherein 12 is potentiostat; 13 is contrast electrode; 14 is working electrode; 15 is auxiliary electrode; 16 is electrochemical analysis system.
Fig. 5 is to use this electrochemical sensor to record the galvanochemistry of biological tissue in body, nondestructive analysis mode
Response curve, wherein:
A is the probe background;
B is that mouse muscle is organized the electrochemical response curve;
C is the chemical response curve of S180 sarcoma tissue.
In order to be illustrated more clearly in the utility model, enumerate following examples, but it there is not any restriction to scope of the present utility model.
Example 1
A kind of sensing device of the present utility model, its insulation crust (2) is for what make with organic glass, and the contrast electrode in the sensing probe (5) is a mercurous chloride electrode; Sensitive electrode (6) is made by graphite; Auxiliary electrode (7) also makes with platinum; Three kinds of electrodes are in-line according to above-mentioned order on the probe tip plane arranges, and lead (8) (9) (10) is all copper cash, studs with a screen layer between three's insulator.
Claims (8)
1. an electrochemical sensing device is characterized in that, described sensing device comprises:
Responsor (1) and the signal that is attached thereto transmit lead (2), described responsor (1) is made of insulation crust (3) and sensing probe (4), described sensing probe (4) is in conplane contrast electrode (5), sensitive electrode (6) and auxiliary electrode (7) by its top and constitutes, described signal transmits three leads (8) that lead (2) contains mutually insulated, (9), (10), link to each other with contrast electrode (5), sensitive electrode (6) and the tail end of auxiliary electrode (7) respectively.Described signal transmits three leads (8) of the mutually insulated of lead (2), studs with metal screen layer (11) between (9) and (10).
2. according to the described sensing device of claim 1, it is characterized in that described sensing probe (4) can be made of socket and removable sensing probe plug.
3. according to the described sensing device of claim 1, it is characterized in that described contrast electrode (5) is mercurous chloride electrode or silver-silver chloride electrode.
4. according to the described sensing device device of claim 1, it is characterized in that described sensitive electrode (6) is become by graphite, gold, silver, platinum or copper.
5. the sensing device of stating according to claim 1 is characterized in that, described auxiliary electrode (7) is become by graphite, gold, silver, platinum or copper.
6. the sensing device of stating according to claim 1 is characterized in that, described electrode (5), (6), (7) on the plane on sensing probe top, become in-line to arrange successively, perhaps electrode (5), (7) each semicircular in shape is trapped among electrode (6) and is the rotary island shape on every side and arranges.
7. according to the described sensing device of claim 1, it is characterized in that described insulation crust (3) is made by plastics, organic glass insulating material.
8. according to the described sensor of claim 1, it is characterized in that described screen layer (11) is made of metal material.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 00238964 CN2428773Y (en) | 2000-06-23 | 2000-06-23 | Electrochemical Sensor for damage-less analysis of live tissue |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 00238964 CN2428773Y (en) | 2000-06-23 | 2000-06-23 | Electrochemical Sensor for damage-less analysis of live tissue |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN2428773Y true CN2428773Y (en) | 2001-05-02 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 00238964 Expired - Fee Related CN2428773Y (en) | 2000-06-23 | 2000-06-23 | Electrochemical Sensor for damage-less analysis of live tissue |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN2428773Y (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107271525A (en) * | 2017-07-31 | 2017-10-20 | 沈阳工业大学 | A kind of integrated form ampere detection sensor for micro-total analysis system chip |
| CN110873743A (en) * | 2018-08-31 | 2020-03-10 | 佛山市顺德区美的电热电器制造有限公司 | Electrode structure of purine sensor |
| CN110873744A (en) * | 2018-08-31 | 2020-03-10 | 佛山市顺德区美的电热电器制造有限公司 | Electrode structure of purine sensor |
| CN110873742A (en) * | 2018-08-31 | 2020-03-10 | 佛山市顺德区美的电热电器制造有限公司 | Electrode structure of purine sensor |
-
2000
- 2000-06-23 CN CN 00238964 patent/CN2428773Y/en not_active Expired - Fee Related
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107271525A (en) * | 2017-07-31 | 2017-10-20 | 沈阳工业大学 | A kind of integrated form ampere detection sensor for micro-total analysis system chip |
| CN107271525B (en) * | 2017-07-31 | 2023-08-08 | 沈阳工业大学 | Integrated ampere detection sensor for micro total analysis system chip |
| CN110873743A (en) * | 2018-08-31 | 2020-03-10 | 佛山市顺德区美的电热电器制造有限公司 | Electrode structure of purine sensor |
| CN110873744A (en) * | 2018-08-31 | 2020-03-10 | 佛山市顺德区美的电热电器制造有限公司 | Electrode structure of purine sensor |
| CN110873742A (en) * | 2018-08-31 | 2020-03-10 | 佛山市顺德区美的电热电器制造有限公司 | Electrode structure of purine sensor |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C19 | Lapse of patent right due to non-payment of the annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |