CN221413096U - Reaction unit is used in preparation of enzalutamide - Google Patents
Reaction unit is used in preparation of enzalutamide Download PDFInfo
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- CN221413096U CN221413096U CN202323291181.1U CN202323291181U CN221413096U CN 221413096 U CN221413096 U CN 221413096U CN 202323291181 U CN202323291181 U CN 202323291181U CN 221413096 U CN221413096 U CN 221413096U
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- fixedly connected
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- pipe
- water tank
- tank
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- 238000006243 chemical reaction Methods 0.000 title claims abstract description 30
- WXCXUHSOUPDCQV-UHFFFAOYSA-N enzalutamide Chemical compound C1=C(F)C(C(=O)NC)=CC=C1N1C(C)(C)C(=O)N(C=2C=C(C(C#N)=CC=2)C(F)(F)F)C1=S WXCXUHSOUPDCQV-UHFFFAOYSA-N 0.000 title claims abstract description 25
- 229960004671 enzalutamide Drugs 0.000 title claims abstract description 25
- 238000002360 preparation method Methods 0.000 title claims description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 95
- 238000003756 stirring Methods 0.000 claims abstract description 31
- 238000004140 cleaning Methods 0.000 claims abstract description 16
- 230000005540 biological transmission Effects 0.000 claims abstract description 10
- 238000007599 discharging Methods 0.000 claims description 7
- 238000001914 filtration Methods 0.000 claims description 6
- 239000007921 spray Substances 0.000 abstract description 6
- 238000004519 manufacturing process Methods 0.000 abstract description 3
- 239000012535 impurity Substances 0.000 abstract description 2
- 239000002904 solvent Substances 0.000 abstract description 2
- 239000000376 reactant Substances 0.000 abstract 2
- 239000003153 chemical reaction reagent Substances 0.000 abstract 1
- 239000002994 raw material Substances 0.000 description 10
- 238000002156 mixing Methods 0.000 description 7
- 230000009286 beneficial effect Effects 0.000 description 4
- 239000010865 sewage Substances 0.000 description 3
- 238000003786 synthesis reaction Methods 0.000 description 3
- 238000010586 diagram Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 208000035874 Excoriation Diseases 0.000 description 1
- 238000005299 abrasion Methods 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 230000010933 acylation Effects 0.000 description 1
- 238000005917 acylation reaction Methods 0.000 description 1
- 230000009435 amidation Effects 0.000 description 1
- 238000007112 amidation reaction Methods 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000003054 catalyst Substances 0.000 description 1
- 238000013329 compounding Methods 0.000 description 1
- 238000005260 corrosion Methods 0.000 description 1
- 230000007797 corrosion Effects 0.000 description 1
- 238000012864 cross contamination Methods 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000032050 esterification Effects 0.000 description 1
- 238000005886 esterification reaction Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 150000002894 organic compounds Chemical class 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 230000036632 reaction speed Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
Landscapes
- Mixers Of The Rotary Stirring Type (AREA)
Abstract
The utility model relates to the technical field of stirring production devices and discloses a reaction device for preparing enzalutamide, which comprises a box body, wherein a rotary plate is fixedly connected with a driving end of a motor, connecting shafts are respectively and rotatably connected to the tops of the periphery of the rotary plate, driven gears are respectively and fixedly connected to the tops of the connecting shafts, stirring blades are respectively and fixedly connected to the bottoms of the connecting shafts, a transmission gear is fixedly connected to the top side inside the box body, a water pump is fixedly connected to the front side of a water tank, a water pipe is fixedly connected to the input end of the water pump, another water pipe is fixedly connected to the output end of the water pump, an annular pipe is fixedly connected to the top end of the water pipe, and a plurality of evenly distributed spray heads are fixedly connected to the bottoms of the annular pipe. In the utility model, reactants can be uniformly mixed together by stirring, so that the reactant is ensured to be uniformly distributed in the reaction process, and the solvent, the reagent, the product and residues of any impurities used in the reaction can be effectively removed by cleaning.
Description
Technical Field
The utility model relates to the technical field of stirring production devices, in particular to a reaction device for preparing enzalutamide.
Background
Enzalutamide is generally a colorless to pale yellow liquid with volatile and pungent odor. It is often used as a solvent in organic synthesis reactions, particularly in amino acid and polypeptide synthesis, because it has good solubility for many organic compounds, and enzalutamide can be used as a catalyst to participate in various chemical reactions, such as esterification, amidation, acylation, etc. It can promote the progress of the reaction and increase the yield, and in organic synthesis, the control of the reaction conditions is critical to obtain high yield and purity of the desired product. The reaction apparatus for production can ensure proper mixing, stirring and temperature control to promote the progress of the reaction.
Searching, chinese patent bulletin number: CN218872181U discloses a constant temperature reaction device for preparation of enzalutamide, which comprises a tank body, the bottom of jar body both sides all is connected with the bracing piece, and the both ends at jar body top all are connected with the inlet pipe, and the discharge gate has been seted up to the bottom of jar body, and the bottom of discharge gate is provided with keeps off material subassembly, and the center department of jar body inner chamber is connected with the second (mixing) shaft through the bearing, and the top of jar body is provided with and is used for driving second (mixing) shaft pivoted drive assembly, and the both sides equidistant second puddler that is connected with of second (mixing) shaft. According to the application, the second stirring shaft, the second stirring rod and the driving assembly are matched, so that the enzalutamide raw material in the tank body can be transversely stirred, and the first stirring shaft, the first stirring rod and the driving assembly are matched, so that the enzalutamide raw material in the tank body can be longitudinally stirred, thereby fully mixing the enzalutamide raw material and improving the reaction speed of the enzalutamide raw material.
However, the apparatus is not provided with a cleaning mechanism, and continuous reaction in the apparatus without cleaning may cause mixing of impurities and products between different reactions, thereby causing cross contamination. This may affect the purity and yield of the new reaction, and for this purpose, a reaction apparatus for preparing enzalutamide was proposed to solve the above problems.
Disclosure of utility model
In order to overcome the defects, the utility model provides a reaction device for preparing enzalutamide, which aims to solve the problems that the accumulation of residues and the corrosion action of certain chemical substances in the prior art can cause early abrasion and damage of the device, thereby reducing the service life of the device.
In order to achieve the above purpose, the present utility model adopts the following technical scheme: the utility model provides a reaction unit is used in preparation of enzalutamide, includes the box, the box right side is provided with hydrologic cycle filter unit, the inside cleaning module that is provided with of box, box top right side fixedly connected with pan feeding mouth, bottom half front side fixedly connected with discharge gate, box top fixedly connected with fixed block, fixed block right side fixedly connected with motor, motor drive end fixedly connected with revolving plate, the equal rotation in top all around of revolving plate is connected with the connecting axle, a plurality of equal fixedly connected with driven gear in connecting axle top, a plurality of equal fixedly connected with stirring leaf in connecting axle bottom, the inside top side fixedly connected with drive gear of box.
Further, hydrologic cycle filter assembly includes the water pump, the box right side is provided with the water tank, water pump fixed connection is in the water tank front side, water pump input fixedly connected with water pipe, water pump output fixedly connected with another festival water pipe, the output water pipe top fixedly connected with ring pipe, ring pipe bottom fixedly connected with a plurality of shower nozzles that distribute evenly, bottom of the case right side fixedly connected with drain pipe, the drain pipe right side runs through water tank left side top.
Further, the cleaning assembly comprises a connecting rod, the top of the connecting rod is fixedly connected with the middle part of the bottom side of the rotating plate, the bottom of the connecting rod is fixedly connected with a first hairbrush, the top of the periphery of the rotating plate is fixedly connected with a connecting block, and a plurality of hairbrushes are fixedly connected with the outer sides of the connecting blocks.
Further, a filter plate is arranged in the water tank, a chute is formed in the right side of the water tank, and the filter plate is slidably connected in the chute.
Further, a groove is formed in the middle of the transmission gear, and the driving end of the motor is rotationally connected in the groove.
Further, a plurality of the driven gears are respectively engaged with the outer circumferences of the transmission gears.
Further, the annular pipe is fixedly connected to the top side of the inside of the box body, and the top end of the water pipe penetrates through the top of the right side of the box body and is connected with the annular pipe.
Further, the bottom of the tank body is fixedly connected with a supporting table, the water tank is fixedly connected to the top of the right side of the supporting table, and the right side of the bottom of the water tank is fixedly connected with a supporting plate.
The utility model has the following beneficial effects:
1. According to the utility model, the motor drives the rotating plate to rotate, the connecting shaft is rotationally connected to the top of the periphery of the rotating plate, the driven gear is fixed to the top of the connecting shaft, the rotating plate drives the driven gears at the top of the periphery of the connecting shaft to rotate, the driven gears are respectively meshed with the periphery of the transmission gear to rotate, and the driven gears drive the bottom stirring blades to rotate through the connecting shaft, so that the beneficial effect of uniformly stirring raw materials is realized.
2. According to the utility model, water is pumped out of the water tank through the water pump, is injected into the annular pipe through the water pipe, is sprayed into the tank through the spray head, the brush I is fixedly connected to the bottom side of the rotating plate through the connecting rod, the brush II is fixedly connected to the top of the periphery of the rotating plate through the connecting block, both the brush I and the brush II are contacted with the inner wall of the tank, the water is injected into the tank, and the rotating plate rotates to drive the brush I and the brush II to slide on the inner wall of the tank, so that the beneficial effects of cleaning the tank after stirring are realized.
Drawings
Fig. 1 is a schematic perspective view of a reaction device for preparing enzalutamide according to the present utility model;
Fig. 2 is a schematic structural diagram of a box of a reaction device for preparing enzalutamide according to the present utility model;
Fig. 3 is a schematic structural diagram of a water tank of a reaction device for preparing enzalutamide.
Legend description:
1. A case; 2. a fixed block; 3. a motor; 4. a rotating plate; 5. a connecting shaft; 6. a driven gear; 7. stirring the leaves; 8. a transmission gear; 901. a water circulation filtration assembly; 9011. a water pump; 9012. a water pipe; 9013. an annular tube; 9014. a spray head; 902. cleaning the assembly; 9021. a connecting rod; 9022. a first hairbrush; 9023. a connecting block; 9024. a second hairbrush; 10. a water tank; 11. a filter plate; 12. a feed inlet; 13. a discharge port; 14. a support table; 15. a support plate; 16. and (5) a water drain pipe.
Detailed Description
The following description of the embodiments of the present utility model will be made clearly and completely with reference to the accompanying drawings, in which it is apparent that the embodiments described are only some embodiments of the present utility model, but not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the utility model without making any inventive effort, are intended to be within the scope of the utility model.
Referring to fig. 1-2, one embodiment provided by the present utility model is: the utility model provides a reaction unit is used in preparation of en miscellaneous lutamide, including box 1, box 1 right side is provided with hydrologic cycle filter unit 901, the inside washing subassembly 902 that is provided with of box 1, box 1 top right side fixedly connected with pan feeding mouth 12, box 1 bottom front side fixedly connected with discharge gate 13, box 1 top fixedly connected with fixed block 2, fixed block 2 right side fixedly connected with motor 3, motor 3 drive end fixedly connected with revolving plate 4, the equal rotation in top all around revolving plate 4 is connected with connecting axle 5, the equal fixedly connected with driven gear 6 in a plurality of connecting axle 5 tops, the equal fixedly connected with stirring leaf 7 in a plurality of connecting axle 5 bottoms, box 1 inside top side fixedly connected with drive gear 8, the recess is seted up at the middle part of drive gear 8, motor 3 drive end rotation is connected in the recess, a plurality of driven gears 6 are respectively engaged in drive gear 8 periphery.
Specifically, the box 1 is used for providing stirring space, and pan feeding mouth 12 is used for throwing in the raw materials, and discharge gate 13 is used for discharging the compounding after accomplishing the mixing, and pan feeding mouth 12 and discharge gate 13 are in the closed state when stirring, and fixed block 2 is used for fixed motor 3, and stirring leaf 7 is used for stirring the raw materials and mixes, and motor 3 drives rotating plate 4 and rotates, and rotating plate 4 drives connecting shaft 5 top driven gear 6 through connecting shaft 5 and meshes respectively at transmission gear 8 periphery rotation. The stirring blade 7 is fixed at the bottom of the connecting shaft 5, and the driven gear 6 rotates to drive the stirring blade 7 to rotate through the connecting shaft 5, so that the beneficial effect of fully stirring the raw materials is realized.
Referring to fig. 1-3, the water circulation filtering component 901 comprises a water pump 9011, a water tank 10 is arranged on the right side of a box body 1, a supporting table 14 is fixedly connected to the bottom of the box body 1, the water tank 10 is fixedly connected to the right side top of the supporting table 14, a supporting plate 15 is fixedly connected to the right side of the bottom of the water tank 10, a filter plate 11 is arranged in the water tank 10, a chute is formed in the right side of the water tank 10, the filter plate 11 is slidably connected in the chute, the water pump 9011 is fixedly connected to the front side of the water tank 10, a water pipe 9012 is fixedly connected to the input end of the water pump 9011, another water saving pipe 9012 is fixedly connected to the output end of the water pump 9011, an annular pipe 9013 is fixedly connected to the top of the output end of the water pipe 9012, the top of the output end of the water pipe 9012 penetrates through the right side top of the box body 1 and is connected with the annular pipe 9013, a plurality of evenly distributed spray heads 9014 are fixedly connected to the right side of the bottom of the box body 1, and the right side of the drain pipe 16 penetrates through the left side top of the water tank 10.
Specifically, the water circulation filter assembly 901 is used for injecting water into the box 1, the cleaning assembly 902 is matched for cleaning residues after stirring the inside of the box 1, the cleaning assembly 902 is used for cleaning residues in the box 1, the supporting table 14 is used for supporting the box 1 and providing a discharging space for the discharging hole 13, the discharging pipe 16 is used for discharging cleaned sewage into the water tank 10, the discharging pipe 16 is in a closed state during cleaning, the water tank 10 is used for storing water, the filter plate 11 is used for filtering the cleaned and discharged sewage, a water source after filtering is convenient for secondary utilization, waste of water resources is reduced, the water pump 9011 pumps water out of the water tank 10 through the water pipe 9012 at an input end, the water is injected into the annular pipe 9013 through the water pipe 9012 at an output end, and finally the water is sprayed on the inner wall of the box 1 through the spray nozzle 9014.
Referring to fig. 2, the cleaning assembly 902 includes a connecting rod 9021, wherein the top of the connecting rod 9021 is fixedly connected to the middle of the bottom side of the rotating plate 4, a first brush 9022 is fixedly connected to the bottom of the connecting rod 9021, connecting blocks 9023 are fixedly connected to the top of the periphery of the rotating plate 4, and second brushes 9024 are fixedly connected to the outer sides of the connecting blocks 9023.
Specifically, the connecting rod 9021 is fixedly connected with the middle part of the bottom side of the rotating plate 4, the first hairbrush 9022 is fixed at the bottom of the connecting rod 9021, the connecting block 9023 is fixed at the top around the rotating plate 4, the second hairbrush 9024 is fixedly connected with the front side of the connecting block 9023, the first hairbrush 9022 is contacted with the inner wall of the box body 1 of the second hairbrush 9024, the rotating plate 4 drives the first hairbrush 9022 and the second hairbrush 9024 to slide and rub on the inner wall of the box body 1 through the connecting rod 9021 and the connecting block 9023, and the residue after the inside stirring of the box body 1 is cleaned by matching with the water circulation filtering component 901.
Working principle: the raw materials are put into through the feed inlet 12, the motor 3 is started to rotate the rotating plate 4, the top around the rotating plate 4 is rotationally connected with the connecting shaft 5, the top of the connecting shaft 5 is fixedly connected with the driven gear 6, the bottom of the connecting shaft 5 is fixedly connected with the stirring blade 7, the rotating plate 4 drives the driven gear 6 to respectively mesh with the periphery of the transmission gear 8 through the connecting shaft 5, the driven gear 6 drives the stirring blade 7 to rotate to stir and mix the raw materials through the connecting shaft 5, the stirring blades 7 are more uniform in stirring, the efficiency is higher, the stirring is finished and then discharged through the discharge port 13, the water pump 9011 is started to pump water out of the water tank 10 through the input water pipe 9012, the water is injected into the annular pipe 9013 through the output water pipe 9012, finally the water is sprayed on the inner wall of the tank 1 through the spray head 9014, the rotating plate 4 drives the brush one 9022 to slide and clean the inner bottom side of the tank 1 through the connecting rod 9021, the rotating plate 4 simultaneously drives the two 9024 to slide and clean the inner periphery of the tank 1 through the connecting block 9023, after the cleaning is finished, sewage is discharged to the filter plate 11 through the water drain pipe 16, the water source 10 drops inside the water tank 10, the water source is convenient to use, and the water source is saved.
Finally, it should be noted that: the foregoing description is only illustrative of the preferred embodiments of the present utility model, and although the present utility model has been described in detail with reference to the foregoing embodiments, it will be apparent to those skilled in the art that modifications may be made to the embodiments described, or equivalents may be substituted for elements thereof, and any modifications, equivalents, improvements or changes may be made without departing from the spirit and principles of the present utility model.
Claims (8)
1. The utility model provides a reaction unit is used in preparation of enzalutamide, includes box (1), its characterized in that: the novel water circulation type water tank is characterized in that a water circulation filtering component (901) is arranged on the right side of the tank body (1), a cleaning component (902) is arranged inside the tank body (1), a feeding port (12) is fixedly connected to the right side of the top of the tank body (1), a discharging port (13) is fixedly connected to the front side of the bottom of the tank body (1), a fixing block (2) is fixedly connected to the top of the tank body (1), a motor (3) is fixedly connected to the right side of the fixing block (2), a rotary plate (4) is fixedly connected to the driving end of the motor (3), connecting shafts (5) are all rotationally connected to the tops of the rotary plate (4), driven gears (6) are fixedly connected to the tops of the connecting shafts (5), stirring blades (7) are fixedly connected to the bottoms of the connecting shafts (5), and a transmission gear (8) is fixedly connected to the top side inside the tank body (1).
2. The reaction device for preparing enzalutamide according to claim 1, wherein: hydrologic cycle filter subassembly (901) include water pump (9011), box (1) right side is provided with water tank (10), water pump (9011) fixed connection is in water tank (10) front side, water pump (9011) input fixedly connected with water pipe (9012), water pump (9011) output fixedly connected with another water conservation pipe (9012), the output water pipe (9012) top fixedly connected with annular pipe (9013), a plurality of shower nozzles (9014) of evenly distributed of annular pipe (9013) bottom fixedly connected with, box (1) bottom right side fixedly connected with drain pipe (16), drain pipe (16) right side is run through water tank (10) left side top.
3. The reaction device for preparing enzalutamide according to claim 1, wherein: the cleaning assembly (902) comprises a connecting rod (9021), the top of the connecting rod (9021) is fixedly connected with the middle of the bottom side of the rotating plate (4), a first hairbrush (9022) is fixedly connected with the bottom of the connecting rod (9021), connecting blocks (9023) are fixedly connected to the tops of the periphery of the rotating plate (4), and a second hairbrush (9024) is fixedly connected to the outer sides of the connecting blocks (9023).
4. The reaction device for preparing enzalutamide according to claim 2, wherein: the water tank (10) is internally provided with a filter plate (11), the right side of the water tank (10) is provided with a chute, and the filter plate (11) is in sliding connection in the chute.
5. The reaction device for preparing enzalutamide according to claim 1, wherein: the middle part of the transmission gear (8) is provided with a groove, and the driving end of the motor (3) is rotationally connected in the groove.
6. The reaction device for preparing enzalutamide according to claim 1, wherein: the driven gears (6) are respectively meshed with the periphery of the transmission gear (8).
7. The reaction device for preparing enzalutamide according to claim 2, wherein: the annular pipe (9013) is fixedly connected to the top side inside the box body (1), the top end of the water pipe (9012) penetrates through the top of the right side of the box body (1) and is connected with the annular pipe (9013).
8. The reaction device for preparing enzalutamide according to claim 2, wherein: the water tank is characterized in that a supporting table (14) is fixedly connected to the bottom of the tank body (1), the water tank (10) is fixedly connected to the top of the right side of the supporting table (14), and a supporting plate (15) is fixedly connected to the right side of the bottom of the water tank (10).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202323291181.1U CN221413096U (en) | 2023-12-04 | 2023-12-04 | Reaction unit is used in preparation of enzalutamide |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202323291181.1U CN221413096U (en) | 2023-12-04 | 2023-12-04 | Reaction unit is used in preparation of enzalutamide |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN221413096U true CN221413096U (en) | 2024-07-26 |
Family
ID=92011296
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202323291181.1U Active CN221413096U (en) | 2023-12-04 | 2023-12-04 | Reaction unit is used in preparation of enzalutamide |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN221413096U (en) |
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2023
- 2023-12-04 CN CN202323291181.1U patent/CN221413096U/en active Active
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