CN221333811U - Mixed structure for preparing cytarabine and daunorubicin compound liposome - Google Patents
Mixed structure for preparing cytarabine and daunorubicin compound liposome Download PDFInfo
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- CN221333811U CN221333811U CN202323150887.6U CN202323150887U CN221333811U CN 221333811 U CN221333811 U CN 221333811U CN 202323150887 U CN202323150887 U CN 202323150887U CN 221333811 U CN221333811 U CN 221333811U
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- connecting rod
- cytarabine
- mixed structure
- preparing
- guide groove
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- 239000002502 liposome Substances 0.000 title claims abstract description 32
- STQGQHZAVUOBTE-UHFFFAOYSA-N 7-Cyan-hept-2t-en-4,6-diinsaeure Natural products C1=2C(O)=C3C(=O)C=4C(OC)=CC=CC=4C(=O)C3=C(O)C=2CC(O)(C(C)=O)CC1OC1CC(N)C(O)C(C)O1 STQGQHZAVUOBTE-UHFFFAOYSA-N 0.000 title claims abstract description 23
- UHDGCWIWMRVCDJ-CCXZUQQUSA-N Cytarabine Chemical compound O=C1N=C(N)C=CN1[C@H]1[C@@H](O)[C@H](O)[C@@H](CO)O1 UHDGCWIWMRVCDJ-CCXZUQQUSA-N 0.000 title claims abstract description 23
- 229960000684 cytarabine Drugs 0.000 title claims abstract description 23
- 229960000975 daunorubicin Drugs 0.000 title claims abstract description 23
- -1 daunorubicin compound Chemical class 0.000 title claims abstract description 22
- 238000003756 stirring Methods 0.000 claims abstract description 41
- 238000002360 preparation method Methods 0.000 claims abstract description 5
- 230000005540 biological transmission Effects 0.000 claims description 20
- 230000007246 mechanism Effects 0.000 claims description 18
- 230000000694 effects Effects 0.000 abstract description 9
- 239000003814 drug Substances 0.000 abstract description 3
- 238000010008 shearing Methods 0.000 abstract description 3
- 238000000034 method Methods 0.000 description 5
- 230000009471 action Effects 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000002776 aggregation Effects 0.000 description 1
- 238000004220 aggregation Methods 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 235000012000 cholesterol Nutrition 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- STQGQHZAVUOBTE-VGBVRHCVSA-N daunorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(C)=O)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 STQGQHZAVUOBTE-VGBVRHCVSA-N 0.000 description 1
- 230000008021 deposition Effects 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000000857 drug effect Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 150000003904 phospholipids Chemical class 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
Abstract
The utility model relates to the field of medicine mixing, and discloses a mixing structure for preparing cytarabine and daunorubicin compound liposome, which solves the problems that the stress and the shearing force in a stirring barrel are uneven and the crushing effect is influenced when an ultrasonic device is arranged and fixed on the outer side of the stirring barrel, and more equipment and energy sources are needed when the ultrasonic device is arranged around the stirring barrel, and the cost in the preparation process is increased.
Description
Technical Field
The utility model relates to the field of medicine mixing, in particular to a mixing structure for preparing cytarabine and daunorubicin compound liposome.
Background
The mixed structure for preparing the cytarabine and daunorubicin compound liposome is a device for mixing the cytarabine and daunorubicin compound liposome with other raw materials in the production process of the cytarabine and daunorubicin compound liposome, and the main purpose of the mixed structure is to uniformly mix the cytarabine and daunorubicin compound liposome together, so that the drug effect is better.
In the use process of the existing mixed structure for preparing cytarabine and daunorubicin compound liposome, components such as phospholipids, cholesterol and the like of different types and proportions influence the structure and stability of the liposome, further influence the particle size and dispersibility, cause overlarge particle size or poor dispersibility of the liposome, further cause the deposition or aggregation of the liposome in a body and influence the absorption and release effects of medicines, and in order to solve the problem, an ultrasonic device is arranged at the outer side of a stirring barrel for crushing the cytarabine and daunorubicin compound liposome, but the ultrasonic device is arranged at the outer side of the stirring barrel for fixing can cause uneven stress and shearing force in the stirring barrel, so that the crushing effect is influenced, and if the ultrasonic device is fully arranged around the stirring barrel, more equipment and energy are needed, so that the cost of the preparation process is increased.
Disclosure of utility model
The utility model aims to provide a mixed structure for preparing cytarabine and daunorubicin compound liposome, which adopts the device to work, thereby solving the problems that the stress and the shearing force in a stirring barrel are uneven and the crushing effect is affected when a fixed ultrasonic device is arranged on the outer side of the stirring barrel, more equipment and energy are needed when the ultrasonic device is arranged around the stirring barrel, and the cost of the preparation process is increased.
In order to achieve the above purpose, the present utility model provides the following technical solutions: the mixing structure comprises a stirring barrel, a motor arranged above the stirring barrel, a transmission shaft arranged at the output end of the motor, stirring blades fixedly connected to the outer side of the lower part of the transmission shaft, a feed inlet arranged in the upper part of the stirring barrel, a discharge outlet arranged in the lower part of the stirring barrel, a reciprocating mechanism arranged on the outer side of the upper part of the transmission shaft, and a swinging mechanism arranged on the inner side of the stirring barrel;
The reciprocating mechanism comprises a gear which is connected to the outer side of the upper portion of the transmission shaft through a key, a rack is arranged on the outer side of the gear, a first connecting rod is fixedly connected to the outer side of the rack, a first groove is formed in the inner side of the first connecting rod, a second connecting rod is arranged on the inner side of the first groove, an ultrasonic main body is fixedly connected to the lower portion of the second connecting rod, a supporting plate is fixedly connected to the outer side of the stirring barrel, and a first guide groove is formed in the inner side of the supporting plate.
Preferably, the gear is a stub gear and the outer surface of the gear meshes with the inner surface of the rack.
Preferably, the racks are symmetrically arranged about the central axis of the stirring barrel, the racks on two sides are fixedly connected, and the racks are transversely and slidably connected with the stirring barrel.
Preferably, the first groove and the second connecting rod are in clearance fit, and the second connecting rod and the first connecting rod are connected in a sliding mode.
Preferably, the first guide groove has a circular arc shape in plan view.
Preferably, the swinging mechanism comprises an annular plate arranged between two stirring blades, the inner side of the annular plate is fixedly connected with a pushing blade, a third connecting rod is fixedly connected between the annular plate and the transmission shaft, a second guide groove is formed in the inner wall of the stirring barrel, and a guide rod is arranged on the inner side of the second guide groove.
Preferably, the middle appearance structure of the second guide groove is in a V shape, two ends of the second guide groove are horizontal annular grooves, and the second guide groove is in clearance fit with the guide rod.
Preferably, the pushing blades are equidistantly distributed on the inner side of the annular plate.
Preferably, the third connecting rod is fixedly connected with the annular plate, and the third connecting rod is vertically connected with the transmission shaft in a sliding manner.
Compared with the prior art, the utility model has the following beneficial effects:
1. According to the mixed structure for preparing the cytarabine and daunorubicin compound liposome, the reciprocating mechanism is arranged, so that when the motor rotates, the reciprocating mechanism is driven to reciprocate, and the ultrasonic main body is driven to reciprocate around the stirring barrel, so that the ultrasonic main body can crush the liposome in the solution in an omnibearing manner, and compared with the prior art, the phenomenon of uneven stress of the liposome in the solution is reduced, and the aim of better crushing effect is achieved.
2. According to the mixing structure for preparing the cytarabine and daunorubicin compound liposome, the swinging mechanism is arranged, so that the swinging mechanism is driven to swing up and down when the transmission shaft rotates, and the solutions are mixed more uniformly.
Drawings
FIG. 1 is a schematic overall perspective view of the present utility model;
FIG. 2 is a schematic diagram showing a cross-sectional front view of a stirring barrel according to the present utility model;
FIG. 3 is a schematic top view of a cross-sectional structure of a stirring barrel according to the present utility model;
FIG. 4 is a schematic view of the structure of FIG. 2A according to the present utility model;
Fig. 5 is a schematic diagram of the structure of fig. 2B according to the present utility model.
In the figure: 1. a stirring barrel; 2. a motor; 3. a transmission shaft; 4. stirring blades; 5. a feed inlet; 6. a discharge port; 7. a reciprocating mechanism; 8. a swinging mechanism; 701. a gear; 702. a rack; 703. a first connecting rod; 704. a first groove; 705. a second connecting rod; 706. an ultrasonic main body; 707. a support plate; 708. a first guide groove; 801. an annular plate; 802. pushing the blade; 803. a third connecting rod; 804. a second guide groove; 805. a guide rod.
Detailed Description
The following description of the embodiments of the present utility model will be made clearly and completely with reference to the accompanying drawings, in which it is apparent that the embodiments described are only some embodiments of the present utility model, but not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the utility model without making any inventive effort, are intended to be within the scope of the utility model.
Referring to fig. 1-5, the present utility model provides the following technical solutions: the compound liposome preparation of cytarabine and daunorubicin uses the mixed structure, including the agitator 1, set up the motor 2 above the agitator 1, set up the drive shaft 3 in the output of the motor 2, the stirring vane 4 of the outside below fixedly connected to drive shaft 3, set up the feed inlet 5 in the upper portion of the agitator 1, set up the discharge gate 6 in the lower portion of the agitator 1, the upper outside of the drive shaft 3 has reciprocating mechanisms 7, the inboard of the agitator 1 has swinging mechanisms 8;
The reciprocating mechanism 7 comprises a gear 701 which is connected to the outer side above the transmission shaft 3 by a key, a rack 702 is arranged on the outer side of the gear 701, the gear 701 is a residual gear, the outer side surface of the gear 701 is meshed with the inner side surface of the rack 702, the rack 702 is symmetrically arranged around the central axis of the stirring barrel 1, the racks 702 on two sides are fixedly connected, the racks 702 are transversely and slidingly connected with the stirring barrel 1, the gear 701 moves to one end of the whole rack 702 after contacting with the rack 702 on one side, the rack 702 is driven to move to the other end after contacting with the rack 702 on the other side, the rack 702 can reciprocate, a first connecting rod 703 is fixedly connected to the outer side of the rack 702, a first groove 704 is arranged on the inner side of the first connecting rod 703, a second connecting rod 705 is arranged on the inner side of the first groove 704, the ultrasonic main body 706 is fixedly connected below the second connecting rod 705, the supporting plate 707 is fixedly connected on the outer side of the stirring barrel 1, the first guide groove 708 is arranged on the inner side of the supporting plate 707, the first groove 704 and the second connecting rod 705 are in clearance fit, the second connecting rod 705 and the first connecting rod 703 are connected in a sliding mode, the first guide groove 708 is arc-shaped in top view appearance, when the rack 702 reciprocates, the first connecting rod 703 and the second connecting rod 705 are driven to reciprocate, further the ultrasonic main body 706 fixedly connected at the lower end of the second connecting rod 705 is driven to reciprocate, the ultrasonic main body 706 is driven to reciprocate around the stirring barrel 1 along the track of the first guide groove 708, so that the ultrasonic main body 706 can crush liposome in a solution in an omnibearing manner, compared with the prior art, the phenomenon of uneven stress of liposome in the solution is reduced, thereby achieving the purpose of better crushing effect.
The swinging mechanism 8 comprises an annular plate 801 arranged between two stirring blades 4, a pushing blade 802 is fixedly connected to the inner side of the annular plate 801, a third connecting rod 803 is fixedly connected between the annular plate 801 and a transmission shaft 3, the third connecting rod 803 is fixedly connected with the annular plate 801, and the third connecting rod 803 is vertically and slidably connected with the transmission shaft 3, so that when the transmission shaft 3 rotates, the third connecting rod 803 is driven to rotate in a following manner, a second guide groove 804 is formed in the inner wall of the stirring barrel 1, a guide rod 805 is arranged on the inner side of the second guide groove 804, the middle appearance structure of the second guide groove 804 is in a V shape, two ends of the second guide groove 804 are horizontal annular grooves, the second guide groove 804 and the guide rod 805 are in clearance fit, and when the annular plate 801 drives the guide rod 805 to move to the middle position of the second guide groove 804, the annular plate 801 is driven to move upwards or downwards, and the pushing blade 802 is driven to move up and down, so that solutions can be mixed up and down, and the aim of better mixing effect is achieved.
The transmission shaft 3 is driven to rotate by the starting motor 2, the gear 701 is driven to rotate, the rack 702 is driven to reciprocate, the first connecting rod 703 and the second connecting rod 705 are driven to reciprocate, the ultrasonic main body 706 moves in the first guide groove 708 and pushes the second connecting rod 705 to stretch and retract, the ultrasonic main body 706 reciprocates around the stirring barrel 1, so that the ultrasonic main body 706 can crush liposome in the solution in an omnibearing manner, and compared with the prior art, the phenomenon that the liposome stress in the solution is uneven is reduced, and the aim of better crushing effect is achieved.
When the transmission shaft 3 rotates, the third connecting rod 803 is driven to rotate, so that the annular plate 801 and the guide rod 805 rotate, and when the guide rod 805 moves to the middle track of the second guide groove 804, the guide rod 805 is driven to drive the annular plate 801 to move upwards or downwards, so that the solutions can be mixed up and down, and the aim of better mixing effect is achieved.
It is noted that relational terms such as first and second, and the like are used solely to distinguish one entity or action from another entity or action without necessarily requiring or implying any actual such relationship or order between such entities or actions. Moreover, the terms "comprises," "comprising," or any other variation thereof, are intended to cover a non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements does not include only those elements but may include other elements not expressly listed or inherent to such process, method, article, or apparatus.
Although embodiments of the present utility model have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made therein without departing from the principles and spirit of the utility model, the scope of which is defined in the appended claims and their equivalents.
Claims (9)
1. The utility model provides a cytarabine and daunorubicin compound liposome preparation are with mixed structure, including agitator (1), motor (2) of setting in agitator (1) top, transmission shaft (3) of setting in motor (2) output, stirring vane (4) of fixed connection in transmission shaft (3) below outside, feed inlet (5) of setting inside in agitator (1) top, discharge gate (6) of setting inside in agitator (1) below, its characterized in that: a reciprocating mechanism (7) is arranged on the outer side above the transmission shaft (3), and a swinging mechanism (8) is arranged on the inner side of the stirring barrel (1);
The reciprocating mechanism (7) comprises a gear (701) which is connected to the outer side of the upper portion of the transmission shaft (3) through a key, a rack (702) is arranged on the outer side of the gear (701), a first connecting rod (703) is fixedly connected to the outer side of the rack (702), a first groove (704) is formed in the inner side of the first connecting rod (703), a second connecting rod (705) is arranged on the inner side of the first groove (704), an ultrasonic main body (706) is fixedly connected to the lower portion of the second connecting rod (705), a supporting plate (707) is fixedly connected to the outer side of the stirring barrel (1), and a first guide groove (708) is formed in the inner side of the supporting plate (707).
2. The mixed structure for preparing cytarabine and daunorubicin compound liposome, according to claim 1, which is characterized in that: the gear (701) is a residual gear, and the outer side surface of the gear (701) is meshed with the inner side surface of the rack (702).
3. The mixed structure for preparing cytarabine and daunorubicin compound liposome, according to claim 1, which is characterized in that: the racks (702) are symmetrically arranged about the central axis of the stirring barrel (1), the racks (702) on two sides are fixedly connected, and the racks (702) are transversely and slidably connected with the stirring barrel (1).
4. The mixed structure for preparing cytarabine and daunorubicin compound liposome, according to claim 1, which is characterized in that: the first groove (704) is in clearance fit with the second connecting rod (705), and the second connecting rod (705) is connected with the first connecting rod (703) in a sliding mode.
5. The mixed structure for preparing cytarabine and daunorubicin compound liposome, according to claim 1, which is characterized in that: the first guide groove (708) has a circular arc shape in plan view.
6. The mixed structure for preparing cytarabine and daunorubicin compound liposome, according to claim 1, which is characterized in that: the swinging mechanism (8) comprises an annular plate (801) arranged between two stirring blades (4), a pushing blade (802) is fixedly connected to the inner side of the annular plate (801), a third connecting rod (803) is arranged between the annular plate (801) and the transmission shaft (3), a second guide groove (804) is formed in the inner wall of the stirring barrel (1), and a guide rod (805) is arranged on the inner side of the second guide groove (804).
7. The mixed structure for preparing cytarabine and daunorubicin compound liposome, as claimed in claim 6, wherein the mixed structure is characterized in that: the middle appearance structure of the second guide groove (804) is in a V shape, two ends of the second guide groove (804) are horizontal annular grooves, and the second guide groove (804) is in clearance fit with the guide rod (805).
8. The mixed structure for preparing cytarabine and daunorubicin compound liposome, as claimed in claim 6, wherein the mixed structure is characterized in that: the pushing blades (802) are equidistantly distributed on the inner side of the annular plate (801).
9. The mixed structure for preparing cytarabine and daunorubicin compound liposome, as claimed in claim 6, wherein the mixed structure is characterized in that: the third connecting rod (803) is fixedly connected with the annular plate (801), and the third connecting rod (803) is vertically connected with the transmission shaft (3) in a sliding manner.
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN221333811U true CN221333811U (en) | 2024-07-16 |
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| Date | Code | Title | Description |
|---|---|---|---|
| GR01 | Patent grant |