CN221117458U - Extraction element of tumour detection thing - Google Patents
Extraction element of tumour detection thing Download PDFInfo
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- CN221117458U CN221117458U CN202322868784.7U CN202322868784U CN221117458U CN 221117458 U CN221117458 U CN 221117458U CN 202322868784 U CN202322868784 U CN 202322868784U CN 221117458 U CN221117458 U CN 221117458U
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- 238000000605 extraction Methods 0.000 title claims abstract description 32
- 206010028980 Neoplasm Diseases 0.000 title claims abstract description 27
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- 239000007788 liquid Substances 0.000 claims description 21
- 230000000694 effects Effects 0.000 abstract description 5
- 210000005266 circulating tumour cell Anatomy 0.000 description 8
- 208000005443 Circulating Neoplastic Cells Diseases 0.000 description 7
- 210000004027 cell Anatomy 0.000 description 6
- 238000000034 method Methods 0.000 description 6
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- 201000011510 cancer Diseases 0.000 description 3
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000000926 separation method Methods 0.000 description 2
- 238000007400 DNA extraction Methods 0.000 description 1
- 206010027476 Metastases Diseases 0.000 description 1
- 206010057249 Phagocytosis Diseases 0.000 description 1
- 230000006907 apoptotic process Effects 0.000 description 1
- 239000000090 biomarker Substances 0.000 description 1
- 238000009534 blood test Methods 0.000 description 1
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- 238000002405 diagnostic procedure Methods 0.000 description 1
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- 238000009509 drug development Methods 0.000 description 1
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- 238000011156 evaluation Methods 0.000 description 1
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- 230000002068 genetic effect Effects 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
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- 238000012544 monitoring process Methods 0.000 description 1
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- NJPPVKZQTLUDBO-UHFFFAOYSA-N novaluron Chemical compound C1=C(Cl)C(OC(F)(F)C(OC(F)(F)F)F)=CC=C1NC(=O)NC(=O)C1=C(F)C=CC=C1F NJPPVKZQTLUDBO-UHFFFAOYSA-N 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
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- Investigating Or Analysing Biological Materials (AREA)
Abstract
The utility model discloses an extraction device of a tumor detection object, which relates to the technical field of tumor detection and comprises a base (1), an extraction box (6) provided with a magnetic body (65), an oscillation mechanism (3) and a support (4); the support (4) comprises a base body (41) arranged on the base (1) in a sliding manner, a connecting piece (42) arranged on the side face of the base body (41) and used for being connected with the oscillating mechanism (3), and an oscillating mechanism (5) arranged on the base body (41) and used for being connected with the extracting box (6) and enabling the extracting box (6) to oscillate, wherein the oscillating direction of the extracting box (6) is perpendicular to the oscillating direction of the oscillating mechanism (3). According to the utility model, through arranging the swinging mechanism (5) with the other vibration direction perpendicular to the vibration direction, more sufficient swinging vibration is realized, the effective vibration can be kept all the time in the whole stage, and the vibration effect is good.
Description
Technical Field
The utility model relates to the technical field of tumor detection, in particular to an extraction device of a tumor detection object.
Background
Circulating tumor cells refer to cancer cells that shed from a tumor and enter the circulatory system, which can spontaneously or through diagnostic procedures shed from solid tumor lesions and enter the systemic circulatory system. Most CTCs undergo apoptosis or phagocytosis after entering peripheral blood, and a small number can escape and anchor tissues or organs outside the focus, so that the CTCs develop into metastasis, and the death risk of malignant tumor patients is increased. These cells can be found by simple blood tests and can be used as biological marker detectors for cancer, indicating the presence or absence of tumors in the body, as well as their genetic status and drug sensitivity. Unlike surgical intervention, CTCs are compatible with longitudinal studies and can effectively guide treatment. CTC detection can be effectively applied to in-vitro early diagnosis, prognosis evaluation, personalized treatment, tumor recurrence monitoring, new tumor drug development and the like; currently, conventional CTC detection is divided into two steps, a CTC enrichment (or capture) step and a CTC detection analysis step.
Based on the immune magnetic bead separation principle, the CTC detection system adopting the principle needs to complete the incubation and combination steps of the antibody magnetic beads and the circulating tumor cells, and the combined antibody magnetic beads are enriched and then transferred to a reading platform or a reading box, so that the statistics of the number of the circulating tumor cells is completed. The circulating tumor cell enrichment equipment which is marketed in China at present is cellsearch system and ctcbiopsy system (non-magnetic capturing system adopts physical filtering mode) of Qiangsheng company, wherein cellsearch system adopts magnetic frame to capture circulating tumor cells; the magnetic rack is not thoroughly contacted with the target cells, so that the residues of circulating tumor cells in the liquid are easily caused, and the subsequent DNA extraction efficiency is affected.
Patent document 202220798463.7 discloses a circulating tumor cell separation and extraction device, which enables a magnetic body to be fully contacted with liquid in a liquid storage cavity through an oscillation mechanism, thereby adsorbing target cells in the liquid and improving the extraction rate of the target. Although the extraction device solves the above-mentioned technology, it is not fully achieved, and is mainly characterized in that the separated sample in the liquid storage cavity can vibrate along with the vibration when the vibration mechanism starts working, but after reaching an equilibrium state, the separated sample in the liquid storage cavity will cling to two walls of the liquid storage cavity and move along with the frequency of the vibration mechanism, so that effective vibration cannot be achieved in the state.
Disclosure of utility model
The utility model aims to solve the technical problem of providing an extraction device of a tumor detection object, which can always keep effective oscillation in the whole stage and has good oscillation effect.
The technical scheme adopted for solving the technical problems is as follows: the extracting device of the tumor detection object comprises a base, an extracting box provided with a magnetic body, an oscillating mechanism and a support;
the support comprises a base body arranged on the base in a sliding manner, a connecting piece arranged on the side face of the base body and used for being connected with the oscillating mechanism, and an oscillating mechanism arranged on the base body and used for connecting the extracting box and enabling the extracting box to oscillate, wherein the oscillating direction of the extracting box is perpendicular to the oscillating direction of the oscillating mechanism.
Further, the pedestal is including being used for placing the cavity that draws the box and enclosing the frame, swing mechanism is including setting up the pivot and the balancing weight of setting in cavity and enclosing the frame bottom on the cavity and enclosing the frame, pivot both ends rotate and connect on the base.
Further, the balancing weight comprises a body and a connecting part arranged on the upper portion of the body, the connecting part is connected with the hollow enclosing frame, and the rotating shaft is arranged in the middle of two sides of the hollow enclosing frame.
Further, the hollow enclosure frame comprises side wall plates and connecting columns, wherein the side wall plates are arranged at intervals along the oscillation direction, the connecting columns are connected between the two side wall plates, and the rotating shafts are connected to the side wall plates in a rotating mode.
Further, the body is fan-shaped, the connecting portion is rectangular, and the connecting portion is connected with the top center position of the fan-shaped body. Further, the extraction box comprises a box body, liquid storage pipes arranged in the box body in an array mode and a fixing plate buckled on the liquid storage pipes, wherein the upper ends of the liquid storage pipes are provided with bottle necks and bottle mouths;
The fixing plate is provided with a hoop which is sealed with the bottle mouth, the central part of the hoop is provided with a sleeve, and the magnetic body is arranged in the sleeve.
Further, the hoop comprises a base plate, a coaming arranged on the periphery of the base plate along the axial direction and a boss arranged in the middle of the base plate, a gap is reserved between the boss and the coaming, and the width of the gap is smaller than the thickness of the wall surface of the bottle mouth.
Further, the oscillating mechanism comprises a driving piece, a cam arranged at the power output end of the driving piece and a connecting rod with one end connected with the cam and the other end connected with the support.
The device comprises an oscillation mechanism, a swinging mechanism and an extraction box, wherein the device utilizes the oscillation mechanism and the swinging mechanism to enable liquid in the extraction box to be fully contacted with a magnetic body arranged in the extraction box, thereby adsorbing target cells in the liquid and improving the extraction rate of targets. Compared with the back and forth oscillation in the prior art, the vibration mechanism is provided with the oscillation mechanism with the other oscillation direction perpendicular to the oscillation direction of the oscillation mechanism, so that more sufficient shaking and vibration are realized, the effective oscillation can be kept all the time in the whole stage, and the oscillation effect is good.
Drawings
The utility model will be further described with reference to the accompanying drawings and examples, in which:
FIG. 1 is an exploded view of the structure of an extraction device for tumor detection according to an embodiment of the present utility model;
FIG. 2 is an exploded view of the structure of an extraction device for tumor detection according to an embodiment of the present utility model;
FIG. 3 is an exploded view of the structure of an extraction device for tumor detection according to an embodiment of the present utility model;
FIG. 4 is an exploded view showing the structure of an extraction device for tumor detection according to an embodiment of the present utility model;
Fig. 5 is an enlarged view of a portion B of fig. 4;
FIG. 6 is an exploded view of the structure of an extraction device for tumor detection according to an embodiment of the present utility model;
Fig. 7 is a cross-sectional view taken along A-A of fig. 6.
Reference numerals illustrate:
1. A base; 3. an oscillating mechanism; 31. a driving member; 32. a cam; 33. a connecting rod; 4. a support; 41. a base; 411. a side wall panel; 412. a connecting column; 42. a connecting piece; 5. a swinging mechanism; 51. a rotating shaft; 52. balancing weight; 521. a body; 522. a connection part; 6. an extraction box; 61. a case body; 62. a liquid storage tube; 63. a fixing plate; 64. a hoop; 65. a magnetic body.
Detailed Description
For a clearer understanding of technical features, objects and effects of the present utility model, a detailed description of embodiments of the present utility model will be made with reference to the accompanying drawings.
As shown in fig. 1 to 7, the device for extracting a tumor specimen comprises a base 1, an extraction box 6 provided with a magnetic body 65, an oscillating mechanism 3 and a support 4;
The support 4 comprises a base 41 arranged on the base 1 in a sliding manner, a connecting piece 42 arranged on the side surface of the base 41 and used for being connected with the oscillating mechanism 3, and an oscillating mechanism 5 arranged on the base 41 and used for connecting the extracting box 6 and enabling the extracting box 6 to oscillate, wherein the oscillating direction of the extracting box 6 is perpendicular to the oscillating direction of the oscillating mechanism 3.
The seat 41 includes the cavity that is used for placing and draws box 6 encloses the frame, and swing mechanism 5 is including setting up the pivot 51 on the cavity encloses the frame and setting up the balancing weight 52 in the cavity encloses the frame bottom, and pivot 51 both ends rotate and connect on base 1.
The balancing weight 52 includes a main body 521 and a connecting portion 522 disposed on an upper portion of the main body 521, the connecting portion 522 is connected with the hollow enclosure frame, the rotating shaft 51 is disposed in a middle portion of two sides of the hollow enclosure frame, and of course, the balancing weight may be disposed at an upper or lower position of two sides of the middle frame, so as to achieve balancing through the balancing weight.
The hollow enclosure comprises side wall plates 411 arranged at intervals along the oscillating direction and connecting posts 412 connected between the side wall plates 411, and the side wall plates 411 are rotatably connected with the rotating shaft 51.
The body 521 has a fan shape, the connecting portion 522 has a rectangular shape, and the connecting portion 522 is connected to the top center of the fan-shaped body 521.
The extraction box 6 comprises a box body 61, liquid storage pipes 62 arranged in the box body 61 in an array manner and a fixing plate 63 buckled on the liquid storage pipes 62, wherein the upper end of the liquid storage pipes 62 is provided with a bottleneck and a bottle mouth;
The fixing plate 63 is provided with a collar 64 sealed from the bottle mouth, and a sleeve is provided in the center of the collar 64 and a magnetic body 65 is provided in the sleeve.
The hoop 64 comprises a base plate, a coaming arranged on the periphery of the base plate along the axial direction and a boss arranged in the middle of the base plate, a gap is arranged between the boss and the coaming, and the width of the gap is smaller than the thickness of the wall surface of the bottle mouth.
The oscillating mechanism 3 comprises a driving piece 31, a cam 32 arranged at the power output end of the driving piece 31 and a connecting rod 33 with one end connected with the cam 32 and the other end connected with the support 4.
The device for extracting the tumor detection object comprises a vibration mechanism 3, a swinging mechanism 5 and an extraction box 6, wherein the vibration mechanism 3 and the swinging mechanism 5 are utilized to enable liquid in the extraction box 6 to be fully contacted with a magnetic body 65 arranged in the extraction box 6, so that target cells in the liquid are adsorbed, and the extraction rate of the target is improved. Compared with the back and forth oscillation in the prior art, the utility model realizes more sufficient oscillation by arranging the oscillating mechanism 5 with the other oscillating direction vertical to the oscillating direction of the oscillating mechanism 3, can always keep effective oscillation in the whole stage and has good oscillating effect.
Finally, it is further noted that relational terms such as first and second, and the like are used solely to distinguish one entity or action from another entity or action without necessarily requiring or implying any actual such relationship or order between such entities or actions. Moreover, the terms "comprises," "comprising," or any other variation thereof, are intended to cover a non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements does not include only those elements but may include other elements not expressly listed or inherent to such process, method, article, or apparatus. Without further limitation, an element defined by the phrase "comprising one … …" does not exclude the presence of other like elements in a process, method, article, or apparatus that comprises the element.
It is apparent that the above examples are given by way of illustration only and are not limiting of the embodiments. Other variations or modifications of the above teachings will be apparent to those of ordinary skill in the art. It is not necessary here nor is it exhaustive of all embodiments. While still being apparent from variations or modifications that may be made by those skilled in the art are within the scope of the utility model.
Claims (8)
1. An extraction device of a tumor detection object comprises a base (1), an extraction box (6) provided with a magnetic body (65) and an oscillation mechanism (3), and is characterized by also comprising a support (4);
The support (4) comprises a base body (41) arranged on the base (1) in a sliding mode, a connecting piece (42) arranged on the side face of the base body (41) and used for being connected with the oscillating mechanism (3), and an oscillating mechanism (5) arranged on the base body (41) and used for connecting the extraction box (6) and enabling the extraction box (6) to oscillate, and the oscillating direction of the extraction box (6) is perpendicular to the oscillating direction of the oscillating mechanism (3).
2. The device for extracting a tumor detection object according to claim 1, wherein the base body (41) comprises a hollow enclosing frame for placing the extraction box (6), the swinging mechanism (5) comprises a rotating shaft (51) arranged on the hollow enclosing frame and a balancing weight (52) arranged at the bottom of the hollow enclosing frame, and two ends of the rotating shaft (51) are rotatably connected to the base body (1).
3. The device for extracting a tumor detection object according to claim 2, wherein the balancing weight (52) comprises a body (521) and a connecting portion (522) arranged on the upper portion of the body (521), the connecting portion (522) is connected with the hollow surrounding frame, and the rotating shaft (51) is arranged in the middle of two sides of the hollow surrounding frame.
4. The device according to claim 3, wherein the hollow frame comprises side wall plates (411) arranged at intervals along the oscillation direction and connecting posts (412) connected between the side wall plates (411), and the side wall plates (411) are rotatably connected with the rotary shaft (51).
5. The device according to claim 4, wherein the body (521) has a fan shape, the connecting portion (522) has a rectangular shape, and the connecting portion (522) is connected to a top center position of the fan-shaped body (521).
6. The device for extracting the tumor detection object according to claim 1, wherein the extracting box (6) comprises a box body (61), liquid storage pipes (62) arranged in the box body (61) in an array manner and a fixing plate (63) buckled on the liquid storage pipes (62), and the upper end of the liquid storage pipes (62) is provided with a bottleneck and a bottleneck;
The fixing plate (63) is provided with a hoop (64) sealed with the bottle mouth, the center part of the hoop (64) is provided with a sleeve, and the magnetic body (65) is arranged in the sleeve.
7. The device for extracting a tumor specimen according to claim 6, wherein the collar (64) comprises a base plate, a surrounding plate arranged on the periphery of the base plate in the axial direction, and a boss arranged in the middle of the base plate, a gap is formed between the boss and the surrounding plate, and the gap width is smaller than the wall thickness of the bottle mouth.
8. The device according to any one of claims 1 to 7, wherein the oscillating mechanism (3) comprises a driving member (31), a cam (32) provided at a power output end of the driving member (31), and a connecting rod (33) having one end connected to the cam (32) and the other end connected to the support (4).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202322868784.7U CN221117458U (en) | 2023-10-25 | 2023-10-25 | Extraction element of tumour detection thing |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202322868784.7U CN221117458U (en) | 2023-10-25 | 2023-10-25 | Extraction element of tumour detection thing |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN221117458U true CN221117458U (en) | 2024-06-11 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202322868784.7U Active CN221117458U (en) | 2023-10-25 | 2023-10-25 | Extraction element of tumour detection thing |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN221117458U (en) |
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2023
- 2023-10-25 CN CN202322868784.7U patent/CN221117458U/en active Active
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