CN221085238U - Emulsifying device for polycaprolactone microsphere preparation - Google Patents

Emulsifying device for polycaprolactone microsphere preparation Download PDF

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Publication number
CN221085238U
CN221085238U CN202323095005.0U CN202323095005U CN221085238U CN 221085238 U CN221085238 U CN 221085238U CN 202323095005 U CN202323095005 U CN 202323095005U CN 221085238 U CN221085238 U CN 221085238U
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fixedly connected
emulsifying device
emulsifying
device body
wall
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CN202323095005.0U
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吴庆江
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Chengdu Hengmeisheng Biotechnology Co ltd
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Chengdu Hengmeisheng Biotechnology Co ltd
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Abstract

The utility model provides an emulsifying device for preparing polycaprolactone microspheres, which belongs to the technical field of medical treatment and comprises an emulsifying device body, wherein a supporting disc is fixedly connected to the circumferential surface of the emulsifying device body, and a purifying device and a temperature sensor are fixedly connected to the top end of the supporting disc; the connecting groove is formed in the top end of the emulsifying device body; the output shaft of motor can drive the drive bull stick and rotate, can drive the part operation in the actuating mechanism when the drive bull stick rotates, and two first gears in the actuating mechanism can drive the transmission bull stick of bottom mounting and rotate, make two transmission bull sticks can drive four first stirring leaves on surface and can stir lactone microsphere raw and other materials and the emulsification additive of inner wall on the spread groove, and finer and smoother even abundant when making the emulsification to impurity in ester microsphere raw and other materials and the emulsification additive also can filter.

Description

Emulsifying device for polycaprolactone microsphere preparation
Technical Field
The utility model belongs to the technical field of medical treatment, and particularly relates to an emulsifying device for preparing polycaprolactone microspheres.
Background
The microsphere is widely used for clinical research as a novel drug carrier system, polycaprolactone (PCL) is an artificially synthesized polyester biopolymer material, has good biocompatibility, has good permeability and compatibility for steroid drugs in pharmaceutical application, and can obtain satisfactory drug release behavior; the important characteristics of polycaprolactone and the research on biological medicine are mainly applied to medicine release carriers, tissue engineering scaffold materials and the like and other aspects.
The authority publication number CN203577680U describes an emulsifying device for vaccine production, which comprises an emulsifying device body, a rack arranged on the emulsifying device body, a temperature sensor arranged in the emulsifying device body, an ultraviolet sterilization lamp arranged in the emulsifying device body, a homogenizing head arranged in the emulsifying device body, a heater arranged in the emulsifying device body, a filter arranged in the emulsifying device body, a hydraulic telescopic rod arranged below the emulsifying device body, a driving device arranged on the rack, a main shaft connected with the output end of the driving device, a shaft sleeve arranged on the main shaft, and a sealing ring arranged at the joint of the main shaft and the emulsifying device body. The utility model has the beneficial effects that: 1. the structure is simple, the use and the installation are convenient, the operation is simple, the cost is low, and the application range is wide; 2. convenient maintenance, high uniformity of vaccine, good product quality, stable and sufficient emulsification, good sterilization effect, long service life, safety and reliability
The above-mentioned patent can simple structure, use, simple to operate, easy operation, with low costs, application scope is wide, but above-mentioned patent is difficult for realizing emulsifying polycaprolactone microsphere to above-mentioned patent can not emulsify the article rotation auxiliary emulsification of device body bottom, leads to the article of emulsification not fully even enough.
Disclosure of utility model
The utility model aims to provide an emulsifying device for preparing polycaprolactone microspheres, and aims to solve the problems that the polycaprolactone microspheres are difficult to emulsify in the prior art, and the emulsified objects are not sufficiently uniform because the objects at the bottom of the emulsifying device body cannot be rotated to assist in emulsification.
In order to achieve the above purpose, the present utility model provides the following technical solutions:
an emulsifying device for preparing polycaprolactone microspheres, comprising:
The emulsifying device comprises an emulsifying device body, wherein a supporting disc is fixedly connected to the circumferential surface of the emulsifying device body, and the top end of the supporting disc is fixedly connected with purifying equipment and a temperature sensor;
the connecting groove is formed in the top end of the emulsifying device body;
the two transmission rotating rods are rotatably connected to the upper inner wall of the connecting groove;
The top end of the driving rotating rod is rotationally connected to the upper inner wall of the connecting groove, and the bottom end of the driving rotating rod is rotationally connected to the bottom inner wall of the emulsifying groove;
The second stirring blade is fixedly connected to the circumferential surface of the driving rotating rod, and the second stirring She Huadong is connected to the bottom inner wall of the emulsifying tank; and;
The driving mechanism is arranged on the upper side of the emulsifying device body, and the driving mechanism and the driving rotating rod are connected with the two transmission rotating rods for driving.
As a preferred embodiment of the present utility model, the driving mechanism includes:
The two screens are fixedly connected to the circumferential surface of the driving rotating rod, and the top ends of the two driving rotating rods penetrate through the top ends of the connecting grooves and are rotatably connected to the top ends of the emulsifying device body;
the first gears are arranged and fixedly connected to the circumferential surfaces of the two transmission rotating rods respectively;
The second gear is fixedly connected to the circumferential surface of the driving rotating rod and meshed with the two first gears;
the N-shaped fixing block is fixedly connected to the top end of the emulsifying device body;
and the motor is fixedly connected to the top end of the N-shaped fixing block.
As a preferable scheme of the utility model, the top end of the N-shaped fixed block is fixedly connected with a second input transmission pipe, the second input transmission pipe penetrates through the top end of the emulsifying device body and is fixedly connected with the lower inner wall of the connecting groove, the top end of the second input transmission pipe is movably hinged with a flip cover through a hinge shaft, the bottom of the emulsifying device body is fixedly connected with a discharge pipe, and the circumferential surface of the discharge pipe is fixedly connected with an electric valve.
As a preferable scheme of the utility model, the bottom end of the supporting disc is fixedly connected with three supporting rods, the circumferential surfaces of the three supporting rods are fixedly connected with connecting blocks, and the top ends of the three connecting blocks are respectively provided with two threaded holes.
As a preferable scheme of the utility model, the top end of the supporting disc is fixedly connected with a temperature sensor, and the detection end of the temperature sensor penetrates through the circumferential surface of the emulsifying device body and is fixedly connected with the inner wall of one side of the connecting groove.
As a preferable scheme of the utility model, the inlet and outlet ends of the purifying equipment penetrate through the supporting disc and extend to the inner wall of the other side of the connecting groove, the discharge end of the purifying equipment is fixedly connected with a first output transmission pipe, and the first output transmission pipe penetrates through the circumferential surface of the emulsifying device body and is fixedly connected to the inner wall of one side of the connecting groove.
Compared with the prior art, the utility model has the beneficial effects that:
1. In this scheme, personnel when using the device, personnel need place the lactone microsphere raw and other materials that need emulsify in the spread groove through the second input transmission pipe, then place the emulsification additive that will need emulsify with the lactone microsphere raw and other materials in the spread groove through the second input transmission pipe, then the staff uses the PLC controller to control the start-up to temperature-sensing ware, a motor, clarification plant and heating device, the detection end through temperature-sensing ware can inspect the concrete stability in the spread groove, clarification plant is used for emulsifying the lactone microsphere raw and other materials in the spread groove, heating device is used for heating the lactone microsphere raw and other materials in the spread groove, the motor is when starting, the output shaft of motor can drive the drive bull stick and rotate, can drive the part operation in the actuating mechanism when driving the bull stick and rotate, two first gears in the actuating mechanism can drive the transmission bull stick of bottom mounting, make two transmission bull sticks can drive the inner wall's lactone microsphere raw and other materials and emulsification additive on the spread groove and stir, make emulsification time more fine and smooth even, and abundant, and impurity in the ester microsphere raw and other materials and emulsification additive also can filter impurity.
2. In this scheme, can be used to carry out high-speed screening with polycaprolactone microsphere raw and other materials and the emulsification additive in the emulsification tank through the screen cloth, make after emulsifying more abundant, efficiency when making the emulsification can promote, emulsification tank and spread groove intercommunication, the second stirring leaf is used for the high-speed stirring of polycaprolactone microsphere raw and other materials and emulsification additive in the emulsification tank makes more abundant when emulsifying.
Drawings
The accompanying drawings are included to provide a further understanding of the utility model and are incorporated in and constitute a part of this specification, illustrate the utility model and together with the embodiments of the utility model, serve to explain the utility model. In the drawings:
FIG. 1 is a perspective view of the present utility model;
FIG. 2 is a first perspective cutaway perspective view of the present utility model;
FIG. 3 is an enlarged view of a portion of the utility model at A of FIG. 2;
FIG. 4 is a second perspective cutaway perspective of the present utility model;
fig. 5 is a cut-away perspective view of a third view of the present utility model.
In the figure: 1. an emulsifying device body; 2. a purifying device; 3. an electric valve; 4. a first output transfer tube; 5. a support plate; 6. a support rod; 7. a connecting block; 8. a threaded hole; 9. an N-shaped fixed block; 10. a motor; 11. a transmission rotating rod; 12. a first gear; 13. a second gear; 14. a second input transfer tube; 15. a flip cover; 16. a temperature sensor; 17. a connecting groove; 18. driving the rotating rod; 19. a screen; 20. a discharge pipe; 21. a first stirring blade; 22. a second stirring blade; 23. a heating device.
Detailed Description
The following description of the embodiments of the present utility model will be made clearly and completely with reference to the accompanying drawings, in which it is apparent that the embodiments described are only some embodiments of the present utility model, but not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the utility model without making any inventive effort, are intended to be within the scope of the utility model.
Example 1
Referring to fig. 1-5, the present utility model provides the following technical solutions:
an emulsifying device for preparing polycaprolactone microspheres, comprising:
The emulsifying device comprises an emulsifying device body 1, wherein a supporting disc 5 is fixedly connected to the circumferential surface of the emulsifying device body 1, and a purifying device 2 and a temperature sensor 16 are fixedly connected to the top end of the supporting disc 5;
the connecting groove 17 is formed in the top end of the emulsifying device body 1;
The two transmission rotating rods 11 are arranged, and the two transmission rotating rods 11 are both rotationally connected to the upper inner wall of the connecting groove 17;
the top end of the driving rotating rod 18 is rotationally connected with the upper inner wall of the connecting groove 17, and the bottom end of the driving rotating rod 18 is rotationally connected with the bottom inner wall of the emulsifying groove;
the second stirring blade 22, the second stirring blade 22 is fixedly connected to the circumferential surface of the driving rotating rod 18, and the second stirring blade 22 is slidably connected to the bottom inner wall of the emulsifying tank; and;
the driving mechanism is arranged on the upper side of the emulsifying device body 1, and the driving mechanism and the driving rotating rod 18 are connected with and driven by the two transmission rotating rods 11.
In the specific embodiment of the utility model, the N-shaped fixing block 9 is fixed at the top end of the emulsifying device body 1 in a welding way, the motor 10 is fixed at the top end of the N-shaped fixing block 9 in a detachable connection way, the output end of the motor 10 penetrates through the top end of the N-shaped fixing block 9 and is fixedly connected to the top end of the driving rotary rod 18, the motor 10, the heating device 23, the electric valve 3, the purifying device 2 and the temperature sensor 16 are electrically connected with an external power supply, the heating device 23 is fixed at the top end of the supporting plate 5 in a detachable connection way, the heating end of the heating device 23 penetrates through the emulsifying device body 1 and is fixedly connected to the inner wall of one side of the connecting groove 17, the heating device 23 can heat the polycaprolactone microsphere raw materials and emulsifying additives which need to be emulsified in the connecting groove 17, the purified liquid is discharged through the first output conveying pipe 4 with the discharge end fixed, the purifying device 19 is fixed on the circumferential surface of the driving rotary rod 18 in a welding way, the screen 19 can be used for screening polycaprolactone microspheres and the emulsifying raw materials in the emulsifying groove and the emulsifying groove to be more fully communicated with the second emulsifying groove 22 when the emulsifying microspheres and the emulsifying additives need to be more fully stirred in the connecting groove 17, and the emulsifying microspheres are fully stirred and the emulsifying additives are fully needed to be stirred: the specific type of motor 10, heating device 23, electric valve 3, purification equipment 2 and temperature sensor 16 are selected by those skilled in the art, and the above techniques for motor 10, heating device 23, electric valve 3, purification equipment 2 and temperature sensor 16 are all of the prior art, and the description of the scheme is omitted.
Referring specifically to fig. 1-5, the driving mechanism includes:
The two screens 19 are arranged, the two screens 19 are fixedly connected to the circumferential surface of the driving rotary rod 18, and the top ends of the two driving rotary rods 11 penetrate through the top ends of the connecting grooves 17 and are rotatably connected to the top end of the emulsifying device body 1;
The first gears 12, the first gears 12 are two, and the two first gears 12 are fixedly connected to the circumferential surfaces of the two transmission rotating rods 11 respectively;
The second gear 13, the second gear 13 is fixedly connected to the circumferential surface of the drive turning rod 18, the second gear 13 is meshed with two first gears 12;
the N-shaped fixing block 9,N-shaped fixing block 9 is fixedly connected to the top end of the emulsifying device body 1;
and the motor 10 is fixedly connected to the top end of the N-shaped fixed block 9.
In this embodiment: the circumference surface of two transmission bull sticks 11 is all fixedly connected with two first stirring leaf 21, personnel is being equipped with actuating mechanism and is being driven two transmission bull sticks 11 and drive bull stick 18, personnel can use the PLC controller to start motor 10, when motor 10 starts, the output shaft of motor 10 can drive bull stick 18 rotation, the second gear 13 on surface can be driven when drive bull stick 18 rotates, second stirring leaf 22 and two screen cloth 19 rotate simultaneously, the second gear 13 itself is used for driving two first gears 12 on drive surface and rotates, two first gears 12 can drive two transmission bull sticks 11 of bottom fixed simultaneously and rotate when rotating, two transmission bull sticks 11 can drive four first stirring leaf 21 rotation on surface respectively when rotating, four first stirring leaf 21 can stir the lactone microsphere raw and other materials and the emulsification additive of inner wall on the spread groove 17, make the emulsification time finer and more exquisite.
Referring to fig. 1-3, a second input transmission pipe 14 is fixedly connected to the top end of the n-shaped fixing block 9, the second input transmission pipe 14 penetrates through the top end of the emulsifying device body 1 and is fixedly connected to the lower inner wall of the connecting groove 17, a flip 15 is movably hinged to the top end of the second input transmission pipe 14 through a hinge shaft, a discharge pipe 20 is fixedly connected to the bottom of the emulsifying device body 1, and an electric valve 3 is fixedly connected to the circumferential surface of the discharge pipe 20.
In this embodiment: the second input transmission pipe 14 adopts the welding mode to fix in the bottom of N shape fixed block 9, and second input transmission pipe 14 and N shape fixed block 9 and emulsification device body 1 intercommunication, and the people can place the lactone microballon raw and other materials that need emulsify in spread groove 17 and emulsification inslot through second input transmission pipe 14, and the valve block of electric valve 3 is used for sealing discharge pipe 20 in.
Referring to fig. 4 specifically, the bottom end of the supporting disc 5 is fixedly connected with three supporting rods 6, the circumferential surfaces of the three supporting rods 6 are fixedly connected with connecting blocks 7, and two threaded holes 8 are formed in the top ends of the three connecting blocks 7.
In this embodiment: the bottom at supporting disk 5 is fixed to three bracing piece 6 adoption welded mode, and three bracing piece 6 are used for supporting disk 5, and connecting block 7 adopts welded mode to fix the circumference surface at three bracing piece 6, and three connecting block 7 are used for being connected with three bracing piece 6, and six screw holes 8 are seted up respectively on the top of three connecting block 7, are used for the mounting bolt in six screw holes 8.
Referring to fig. 2 specifically, the top end of the supporting plate 5 is fixedly connected with a temperature sensor 16, and the detecting end of the temperature sensor 16 penetrates through the circumferential surface of the emulsifying device body 1 and is fixedly connected to an inner wall of one side of the connecting slot 17.
In this embodiment: the temperature sensor 16 is fixed on the top end of the supporting disc 5 in a detachable connection manner, and the detection end of the temperature sensor 16 can be used for detecting the temperature in the connecting groove 17.
Referring to fig. 1-5 specifically, the inlet and outlet ends of the purifying device 2 penetrate through the supporting plate 5 and extend to the inner wall of the other side of the connecting groove 17, the outlet end of the purifying device 2 is fixedly connected with the first output transmission pipe 4, and the first output transmission pipe 4 penetrates through the circumferential surface of the emulsifying device body 1 and is fixedly connected to the inner wall of one side of the connecting groove 17.
In this embodiment: the inlet end and the outlet end of the purification equipment 2 are used for filtering the lactone microsphere raw materials and the impurities contained in the emulsifying additive in the connecting groove 17, and after the filtration is finished, the filtered lactone microsphere raw materials are discharged through the first output transmission pipe 4 fixed at the discharge end of the purification equipment 2, so that the lactone microsphere raw materials are more uniform in emulsification.
The working principle and the using flow of the utility model are as follows: when a worker uses the device, the worker needs to place the lactone microsphere raw material to be emulsified in the connecting groove 17 through the second input transmission pipe 14, then the emulsifying additive to be emulsified with the lactone microsphere raw material is placed in the connecting groove 17 through the second input transmission pipe 14, then the worker uses the PLC controller to control and start the temperature sensor 16, the motor 10, the purifying device 2 and the heating device 23, the detection end of the temperature sensor 16 can check the specific stability in the connecting groove 17, the purifying device 2 is used for emulsifying the lactone microsphere raw material in the connecting groove 17, the heating device 23 is used for heating the lactone microsphere raw material and the emulsifying additive in the connecting groove 17, the output shaft of the motor 10 can drive the driving rotating rod 18 to rotate when the motor 10 is started, the driving rotating rod 18 can drive the second gear 13, the second stirring blade 22 and the two screens 19 on the surface to simultaneously rotate, the second gear 13 is used for driving the two first gears 12 on the driving surface to simultaneously drive the two driving rotating rods 11 on the bottom to simultaneously rotate, the two driving rods 11 simultaneously drive the two driving rods to simultaneously rotate, the four stirring blades 21 can respectively drive the first stirring blades 21 to uniformly stir the lactone microsphere raw material and the emulsifying additive, and the emulsifying additive can be fully stirred in the stirring groove 17, and the emulsifying additive can be fully stirred in the stirring groove.
Finally, it should be noted that: the foregoing description is only a preferred embodiment of the present utility model, and the present utility model is not limited thereto, but it is to be understood that modifications and equivalents of some of the technical features described in the foregoing embodiments may be made by those skilled in the art, although the present utility model has been described in detail with reference to the foregoing embodiments. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present utility model should be included in the protection scope of the present utility model.

Claims (6)

1. An emulsifying device for preparing polycaprolactone microspheres, which is characterized by comprising:
The emulsifying device comprises an emulsifying device body (1), wherein a supporting disc (5) is fixedly connected to the circumferential surface of the emulsifying device body (1), and a purifying device (2) and a temperature sensor (16) are fixedly connected to the top end of the supporting disc (5);
The connecting groove (17) is formed in the top end of the emulsifying device body (1);
The two transmission rotating rods (11) are arranged, and the two transmission rotating rods (11) are both rotationally connected to the upper inner wall of the connecting groove (17);
The top end of the driving rotating rod (18) is rotationally connected to the upper inner wall of the connecting groove (17), and the bottom end of the driving rotating rod (18) is rotationally connected to the bottom inner wall of the emulsifying groove;
The second stirring blade (22) is fixedly connected to the circumferential surface of the driving rotating rod (18), and the second stirring blade (22) is slidably connected to the bottom inner wall of the emulsifying groove; and;
The driving mechanism is arranged on the upper side of the emulsifying device body (1), and the driving mechanism and the driving rotating rod (18) are connected with the two transmission rotating rods (11) for driving.
2. The emulsifying device for preparing polycaprolactone microspheres according to claim 1, wherein the emulsifying device comprises: the driving mechanism includes:
The two screens (19) are arranged, the two screens (19) are fixedly connected to the circumferential surface of the driving rotating rod (18), and the top ends of the two driving rotating rods (11) penetrate through the top ends of the connecting grooves (17) and are rotatably connected to the top ends of the emulsifying device body (1);
The first gears (12) are arranged, and the two first gears (12) are fixedly connected to the circumferential surfaces of the two transmission rotating rods (11) respectively;
The second gear (13), the said second gear (13) is fixedly connected to the circumferential surface of the drive turning rod (18), the said second gear (13) engages with two first gears (12);
The N-shaped fixing block (9), and the N-shaped fixing block (9) is fixedly connected to the top end of the emulsifying device body (1);
and the motor (10) is fixedly connected to the top end of the N-shaped fixed block (9).
3. The emulsifying device for preparing polycaprolactone microspheres according to claim 2, wherein the emulsifying device comprises: the top fixedly connected with second input transmission pipe (14) of N shape fixed block (9), second input transmission pipe (14) run through the top of emulsification device body (1) and fixedly connected with lower inner wall in spread groove (17), the top of second input transmission pipe (14) has flip (15) through hinge activity hinge, the bottom fixedly connected with discharge pipe (20) of emulsification device body (1), the circumference surface fixedly connected with electric valve (3) of discharge pipe (20).
4. An emulsifying device for preparing polycaprolactone microspheres according to claim 3, wherein: the bottom fixedly connected with three bracing piece (6) of supporting disk (5), three the equal fixedly connected with connecting block (7) of circumference surface of bracing piece (6), three two screw holes (8) have all been seted up on the top of connecting block (7).
5. The emulsifying device for preparing polycaprolactone microspheres according to claim 4, wherein the emulsifying device comprises: the top of supporting disk (5) fixedly connected with temperature-sensing ware (16), temperature-sensing ware (16) detection end runs through the circumference surface of emulsification device body (1) and fixedly connected with one side inner wall of spread groove (17).
6. The emulsifying device for preparing polycaprolactone microspheres according to claim 5, wherein the emulsifying device comprises: the inlet and outlet ends of the purifying equipment (2) penetrate through the supporting disc (5) and extend to the inner wall of the other side of the connecting groove (17), the discharge end of the purifying equipment (2) is fixedly connected with a first output transmission pipe (4), and the first output transmission pipe (4) penetrates through the circumferential surface of the emulsifying device body (1) and is fixedly connected to the inner wall of one side of the connecting groove (17).
CN202323095005.0U 2023-11-16 2023-11-16 Emulsifying device for polycaprolactone microsphere preparation Active CN221085238U (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202323095005.0U CN221085238U (en) 2023-11-16 2023-11-16 Emulsifying device for polycaprolactone microsphere preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN202323095005.0U CN221085238U (en) 2023-11-16 2023-11-16 Emulsifying device for polycaprolactone microsphere preparation

Publications (1)

Publication Number Publication Date
CN221085238U true CN221085238U (en) 2024-06-07

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Family Applications (1)

Application Number Title Priority Date Filing Date
CN202323095005.0U Active CN221085238U (en) 2023-11-16 2023-11-16 Emulsifying device for polycaprolactone microsphere preparation

Country Status (1)

Country Link
CN (1) CN221085238U (en)

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