CN220987252U

CN220987252U - Device for establishing mouse alcohol liver model

Info

Publication number: CN220987252U
Application number: CN202323020918.6U
Authority: CN
Inventors: 丁丰; 谢晓青; 王剑钢; 沈华江
Original assignee: Affiliated Hospital of Shaoxing University
Current assignee: Affiliated Hospital of Shaoxing University
Priority date: 2023-11-09
Filing date: 2023-11-09
Publication date: 2024-05-24
Anticipated expiration: 2033-11-09

Abstract

The utility model relates to the technical field of medical equipment, in particular to a device for establishing a mouse alcoholic liver model, which comprises a base plate, wherein fixed frames are arranged at four corners of the top end of the base plate, fixed clamping plates are arranged at the bottom end of an inner cavity of each fixed frame, an adjusting component is arranged at the top end of the inner cavity of each fixed frame, a movable clamping plate is arranged at the bottom end of each adjusting component, a fixed plate is arranged at one side of the bottom end of the base plate, a shell is arranged on the outer wall of the fixed plate, a lifting component is arranged in the inner cavity of the shell, an extrusion plate is arranged at the top end of the lifting component, telescopic rods are arranged at four corners of the bottom end of the extrusion plate, and the bottom ends of a plurality of telescopic rods are fixedly connected with the bottom end of the inner cavity of the shell. The utility model solves the problem that the four limbs of the mouse are fixed on the operation desk by the adhesive tape when alcohol infusion is carried out, and the adhesive tape frequently falls off after struggling of the mouse due to limited viscosity of the adhesive tape.

Description

Device for establishing mouse alcohol liver model

Technical Field

The utility model relates to the technical field of medical appliances, in particular to a device for establishing a mouse alcoholic liver model.

Background

Alcoholic liver disease is a liver disease caused by long-term drinking, and can cause upper gastrointestinal hemorrhage, ascites and infection, hepatic encephalopathy (hepatic coma), electrolyte disorder, acid-base imbalance, etc. In order to study pathogenesis of alcoholic liver disease and screen medicines for preventing and treating alcoholic liver disease, the establishment of an animal model similar to human alcoholic liver disease has very important significance, and the mouse alcoholic liver disease model is an alcoholic liver disease animal model widely applied at present. The mouse alcoholic liver model refers to an alcoholic liver disease caused by alcohol accumulation in a mouse body, and a common mode for establishing the mouse alcoholic liver model in the prior art comprises an alcohol gastric lavage method. The alcohol gastric lavage method is to combine the gastric lavage needle with the needle cylinder, extend the gastric lavage needle into the esophagus of the mouse through the mouth of the mouse, and then inject the alcohol in the needle cylinder into the stomach of the mouse along the gastric lavage needle.

The four limbs of the mouse are fixed on the operation desk by the adhesive tape when the alcohol is poured, and the adhesive tape is limited in viscosity and frequently falls off after the mouse struggles, so that the device for establishing the mouse alcohol liver model is provided for the problem.

Disclosure of utility model

The utility model aims to provide a device for establishing a mouse alcohol liver model, so as to solve the problems in the background technology. In order to achieve the above purpose, the present utility model provides the following technical solutions: the utility model provides a device for establishing mouse alcohol liver model, includes the backing plate, the top four corners of backing plate all is provided with fixed frame, every the inner chamber bottom of fixed frame all is provided with fixed splint, every the inner chamber top of fixed frame all is provided with adjusting part, every adjusting part's bottom all is provided with movable splint, the bottom one side of backing plate is provided with the fixed plate, the outer wall of fixed plate is provided with the casing, the inner chamber of casing is provided with lifting unit, lifting unit's top is provided with the stripper plate, the bottom four corners of stripper plate all is provided with the telescopic link, a plurality of the bottom of telescopic link all with the inner chamber bottom fixed connection of casing.

Preferably, each adjusting component comprises a screw rod, a knob and a connecting component, wherein the screw rod is in threaded connection with the top end of the fixed frame, the knob is arranged on the top end of the screw rod, the bottom end of the screw rod is rotationally connected with the top end of the movable clamping plate through a bearing, and the two connecting components are respectively arranged on the left side and the right side of the inner cavity of the fixed frame and are respectively fixedly connected with the left side and the right side of the outer wall of the movable clamping plate.

Preferably, each connecting assembly comprises a connecting groove and a connecting block, the connecting groove is formed in one side of the inner wall of the fixed frame, and one end of the connecting block is slidably embedded in the inner cavity of the connecting groove and fixedly connected with the outer wall of the movable clamping plate.

Preferably, the inner cavity of the connecting groove is matched with the outer wall of the connecting block and is T-shaped.

Preferably, the lifting assembly comprises a screw rod, a handle, sliding blocks, fixing seats, connecting rods and limiting assemblies, one end of the screw rod is rotationally connected to the rear side of an inner cavity of the shell through a bearing, the other end of the screw rod extends to the front end of the shell, the handle is arranged at the front end of the screw rod, the two sliding blocks are respectively screwed on the front side and the rear side of the outer wall of the screw rod, the fixing seats are arranged at the bottom ends of the extrusion plates, one ends of the two connecting rods are respectively hinged to the top ends of the two sliding blocks, the other ends of the two connecting rods are respectively hinged to the front side and the rear side of the bottom ends of the fixing seats, and the limiting assemblies are arranged at the bottom end of the inner cavity of the shell and are fixedly connected with the top ends of the two sliding blocks.

Preferably, threads on the front side and the rear side of the outer wall of the screw rod are oppositely arranged.

Preferably, the limiting assembly comprises a limiting groove and limiting blocks, wherein the limiting groove is formed in the bottom end of an inner cavity of the shell, the limiting blocks are embedded in the inner cavity of the limiting groove in a sliding mode and are fixedly connected with the top ends of the two sliding blocks respectively, and the inner cavity of the limiting groove is matched with the outer wall of the limiting block in a T-shaped mode.

Compared with the prior art, the utility model has the beneficial effects that:

1. The four movable clamping plates are respectively driven to slide downwards through the four adjusting components, so that the four movable clamping plates are matched with the fixed clamping plates to clamp and fix the limbs of the mice, the problem that the limbs of the mice are fixed on the operating platform by using the adhesive tape when alcohol infusion is carried out, and the adhesive tape frequently falls off after struggling of the mice due to limited viscosity of the adhesive tape is solved;

2. Through the setting of lifting unit, can make the stripper plate upwards slide along the straight line under the spacing effect of a plurality of telescopic links, make stripper plate and the bottom cooperation of backing plate press from both sides the edge clamp of operation panel fixed, realized the fixed to the backing plate position, avoid the mouse struggle and lead to the backing plate to appear the condition of displacement, improved the device stability when using.

Drawings

FIG. 1 is a schematic perspective view of the present utility model;

FIG. 2 is an enlarged view of the utility model at A of FIG. 1;

FIG. 3 is a left side cross-sectional view of the housing of the present utility model;

Fig. 4 is an enlarged view of fig. 3B in accordance with the present utility model.

In the figure: 1. a backing plate; 2. a fixing plate; 3. a housing; 4. a telescopic rod; 5. an extrusion plate; 6. a screw rod; 7. a handle; 8. a slide block; 9. a fixing seat; 10. a connecting rod; 11. a limit groove; 12. a limiting block; 13. a fixed frame; 14. a fixed clamping plate; 15. a screw; 16. moving the clamping plate; 17. a knob; 18. a connecting groove; 19. and (5) connecting a block.

Detailed Description

The following description of the embodiments of the present utility model will be made clearly and completely with reference to the accompanying drawings, in which it is apparent that the embodiments described are only some embodiments of the present utility model, but not all embodiments. All other embodiments, which are obtained by a worker of ordinary skill in the art without creative efforts, are within the protection scope of the present utility model based on the embodiments of the present utility model.

Referring to fig. 1 to 4, the present utility model provides a technical solution: a device for establishing mouse alcohol liver model, including backing plate 1, the top four corners of backing plate 1 all is provided with fixed frame 13, the inner chamber bottom of every fixed frame 13 all is provided with fixed splint 14, the inner chamber top of every fixed frame 13 all is provided with adjusting part, the bottom of every adjusting part all is provided with movable splint 16, bottom one side of backing plate 1 is provided with fixed plate 2, the outer wall of fixed plate 2 is provided with casing 3, the inner chamber of casing 3 is provided with lifting unit, lifting unit's top is provided with stripper plate 5, stripper plate 5's bottom four corners all is provided with telescopic link 4, the bottom of a plurality of telescopic link 4 all with casing 3's inner chamber bottom fixed connection, drive four movable splint 16 downwardly slide respectively through four adjusting part, can make four movable splint 16 and fixed splint 14 cooperation with the four limbs clamp of mouse, the four limbs clamp of mouse are fixed, the four limbs of utilizing the sticky tape to fix the mouse at the operation panel when carrying out alcohol and pouring, because sticky limited, the sticky tape often can appear the problem that drops after the sticky tape struggles, setting up through lifting unit, can make stripper plate 5 make and use the linear motion under the position of the backing plate 4 to realize the linear motion of the backing plate 1, the device has been realized that the position is fixed with the linear motion 1 when struggling to the base plate 1, the position is fixed with the position of the top has been realized, the position to the clamp and has been realized to the position and has improved and has realized the stability and has struggled.

In this embodiment, every adjusting part is including screw rod 15, knob 17 and coupling assembling, screw rod 15 spiro union is on the top of fixed frame 13, knob 17 sets up on the top of screw rod 15, the bottom of screw rod 15 passes through the bearing rotation to be connected on the top of movable clamp plate 16, two coupling assembling set up respectively in the inner chamber left and right sides of fixed frame 13 and respectively with the outer wall left and right sides fixed connection of movable clamp plate 16, place the four limbs of mouse between four movable clamp plate 16 and fixed clamp plate 14, rotatory knob 17 makes knob 17 drive screw rod 15 rotatory, under the effect of screw rod 15 outer wall screw thread rotation force, when screw rod 15 is rotatory, can make movable clamp plate 16 slide downwards along the straight line under the limiting effect of spread groove 18 and connecting block 19, make movable clamp plate 16 and fixed clamp plate 14 cooperate with the four limbs of mouse fixed, the four limbs of mouse are fixed at the operation panel with the sticky tape when carrying out the alcohol and because sticky tape is limited, the problem that the sticky tape often can appear after the mouse struggles.

In this embodiment, each connecting component includes a connecting slot 18 and a connecting block 19, the connecting slot 18 is formed on one side of the inner wall of the fixed frame 13, one end of the connecting block 19 is slidably embedded in the inner cavity of the connecting slot 18 and fixedly connected with the outer wall of the movable clamping plate 16, and under the interaction between the connecting block 19 and the connecting slot 18, the movable clamping plate 16 can be prevented from rotating along with the screw 15 when the screw 15 rotates.

In this embodiment, the inner cavity of the connecting slot 18 is matched with the outer wall of the connecting block 19 and is in a shape of T, so that one end of the connecting block 19 is always embedded in the inner cavity of the connecting slot 18, and the stability of the connecting assembly in use is improved.

In this embodiment, lifting unit is including lead screw 6, handle 7, slider 8, fixing base 9, connecting rod 10 and spacing subassembly, the one end of lead screw 6 is rotated through the bearing and is connected in the inner chamber rear side of casing 3, the other end of lead screw 6 extends to the front end of casing 3, handle 7 sets up the front end at lead screw 6, two sliders 8 spiro union respectively in the outer wall front and back both sides of lead screw 6, fixing base 9 sets up the bottom at stripper plate 5, the one end of two connecting rods 10 articulates respectively on the top of two sliders 8, the other end of two connecting rods 10 articulates respectively in both sides around the bottom of fixing base 9, spacing subassembly sets up in the inner chamber bottom of casing 3 and with the top fixed connection of two sliders 8, make stripper plate 5 and backing plate 1 be located the upper and lower both sides of operation panel respectively, rotatory handle 7, make handle 7 drive lead screw 6 rotatory, and then make the relative screw thread rotation power of lead screw 6 both sides production, make two sliders 8 slide down to the middle part of lead screw 6 simultaneously at the spacing effect of spacing groove 11 and stopper 12, make two connecting rods 10 promote the fixing base 9 and stripper plate 5 and the spacer plate 5 at a plurality of the top of the side of limit block 12, the position is fixed at the backing plate 1 when the position is realized, and the telescopic joint is realized, the position is fixed with the backing plate 1 is realized and the telescopic device is realized, and the position is fixed when the telescopic and is used to the position is fixed.

In this embodiment, the threads on the front and rear sides of the outer wall of the screw rod 6 are disposed oppositely, so that the two sliding blocks 8 slide relatively under the limiting action of the limiting groove 11 and the limiting block 12 due to the relative rotation force of the threads on the front and rear sides of the outer wall of the screw rod 6 when the screw rod rotates.

In this embodiment, spacing subassembly is including spacing groove 11 and stopper 12, spacing groove 11 is offered in the inner chamber bottom of casing 3, the equal slidable of two stoppers 12 is embedded in the inner chamber of spacing groove 11 and respectively with the top fixed connection of two sliders 8, under the interact between spacing groove 11 and stopper 12, slider 8 can prevent when lead screw 6 is rotatory follows lead screw 6 rotatory, the stability of lifting assembly when using has been improved, the inner chamber of spacing groove 11 and the outer wall looks adaptation of stopper 12 just all are "T" font, can make the one end of stopper 12 remain embedded in the inner chamber of spacing groove 11 all the time, the stability of spacing subassembly when using has been improved.

The application method and the advantages of the utility model are as follows: when in use, the working process is as follows:

The utility model provides a four-way screw joint device for the four-way screw joint device, the utility model discloses a four-way screw joint device, including the backing plate 1, the backing plate 1 is placed on the operation panel when using, make stripper plate 5 and backing plate 1 be located the upper and lower both sides of operation panel respectively, rotatory handle 7, make handle 7 drive lead screw 6 rotatory, and then the relative screw thread of both sides produces relative screw thread rotation force around making lead screw 6 outer wall, make two sliders 8 slide to the middle part of lead screw 6 simultaneously under the spacing effect of spacing groove 11 and stopper 12, make two connecting rods 10 promote fixing base 9 and stripper plate 5 slide along sharp upwards under the spacing effect of a plurality of telescopic links 4, and then stripper plate 5 and backing plate 1 cooperation are fixed with the edge clamp of operation panel, the fixed to backing plate 1 position has been realized struggling, avoid the mouse to lead to the condition that the backing plate 1 appears the displacement, the stability when using has been improved the device, place the four-way screw joint device's four limbs between moving splint 16 and fixed splint 14, rotatory knob 17 makes knob 17 drive screw 15 rotatory, under the spacing effect of screw 15 outer wall screw thread rotation effect, when screw 15 rotatory, can make moving 16 slide down along sharp line under the spacing effect of connecting groove 18 and 19, make the mouse slide down under the spacing effect, the adhesive tape can be fixed with the adhesive tape, the mouse is fixed in the adhesive tape can take place after the four limbs to the fixed to the mouse is fixed at the adhesive tape, the four-way is fixed because the adhesive tape is fixed to the four-way is used to the four limbs is fixed to the mouse.

The foregoing has shown and described the basic principles, principal features and advantages of the utility model. It will be understood by those skilled in the art that the present utility model is not limited to the above-described embodiments, and that the above-described embodiments and descriptions are only preferred embodiments of the present utility model, and are not intended to limit the utility model, and that various changes and modifications may be made therein without departing from the spirit and scope of the utility model as claimed. The scope of the utility model is defined by the appended claims and equivalents thereof.

Claims

1. Device for establishing a mouse alcohol liver model, comprising a backing plate (1), characterized in that: the utility model discloses a die-casting machine is characterized in that fixed frame (13) are all provided with in the top four corners of backing plate (1), every the inner chamber bottom of fixed frame (13) all is provided with fixed splint (14), every the inner chamber top of fixed frame (13) all is provided with adjusting part, every adjusting part's bottom all is provided with movable splint (16), the bottom one side of backing plate (1) is provided with fixed plate (2), the outer wall of fixed plate (2) is provided with casing (3), the inner chamber of casing (3) is provided with lifting unit, lifting unit's top is provided with stripper plate (5), the bottom four corners of stripper plate (5) all is provided with telescopic link (4), a plurality of the bottom of telescopic link (4) all is connected with the inner chamber bottom fixed of casing (3).

2. An apparatus for modeling a mouse alcohol liver as claimed in claim 1 wherein: each adjusting component comprises a screw rod (15), a knob (17) and a connecting component, wherein the screw rod (15) is in threaded connection with the top end of a fixed frame (13), the knob (17) is arranged on the top end of the screw rod (15), the bottom end of the screw rod (15) is rotationally connected with the top end of a movable clamping plate (16) through a bearing, and the two connecting components are respectively arranged on the left side and the right side of an inner cavity of the fixed frame (13) and are respectively fixedly connected with the left side and the right side of the outer wall of the movable clamping plate (16).

3. An apparatus for modeling a mouse alcohol liver as claimed in claim 2 wherein: each connecting assembly comprises a connecting groove (18) and a connecting block (19), the connecting grooves (18) are formed in one side of the inner wall of the fixed frame (13), and one end of each connecting block (19) is slidably embedded in the inner cavity of each connecting groove (18) and fixedly connected with the outer wall of the movable clamping plate (16).

4. A device for modeling a mouse alcohol liver according to claim 3, wherein: the inner cavity of the connecting groove (18) is matched with the outer wall of the connecting block (19) and is T-shaped.

5. An apparatus for modeling a mouse alcohol liver as claimed in claim 1 wherein: the lifting assembly comprises a screw rod (6), a handle (7), sliding blocks (8), fixing seats (9), connecting rods (10) and limiting assemblies, one end of the screw rod (6) is rotationally connected to the rear side of an inner cavity of the machine shell (3) through a bearing, the other end of the screw rod (6) extends to the front end of the machine shell (3), the handle (7) is arranged at the front end of the screw rod (6), the two sliding blocks (8) are respectively screwed on the front side and the rear side of the outer wall of the screw rod (6), the fixing seats (9) are arranged at the bottom end of the extrusion plate (5), one ends of the two connecting rods (10) are respectively hinged to the top ends of the two sliding blocks (8), and the other ends of the two connecting rods (10) are respectively hinged to the front side and the rear side of the bottom end of the inner cavity of the machine shell (3) and are fixedly connected with the top ends of the two sliding blocks (8).

6. An apparatus for modeling a mouse alcohol liver according to claim 5, wherein: threads on the front side and the rear side of the outer wall of the screw rod (6) are oppositely arranged.

7. An apparatus for modeling a mouse alcohol liver according to claim 5, wherein: the limiting assembly comprises limiting grooves (11) and limiting blocks (12), wherein the limiting grooves (11) are formed in the bottom end of an inner cavity of the machine shell (3), the limiting blocks (12) are embedded in the inner cavity of the limiting grooves (11) in a sliding mode and are fixedly connected with the top ends of the two sliding blocks (8) respectively, and the inner cavity of the limiting grooves (11) is matched with the outer wall of the limiting blocks (12) in a T-shaped mode.