CN220969492U - Centrifugal screening device for monoclonal antibodies - Google Patents
Centrifugal screening device for monoclonal antibodies Download PDFInfo
- Publication number
- CN220969492U CN220969492U CN202321103078.7U CN202321103078U CN220969492U CN 220969492 U CN220969492 U CN 220969492U CN 202321103078 U CN202321103078 U CN 202321103078U CN 220969492 U CN220969492 U CN 220969492U
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- centrifugal
- plate
- sleeve
- box
- motor
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- 238000012216 screening Methods 0.000 title claims abstract description 22
- 238000005119 centrifugation Methods 0.000 claims description 7
- 230000002146 bilateral effect Effects 0.000 claims description 2
- 238000007493 shaping process Methods 0.000 claims description 2
- 230000007246 mechanism Effects 0.000 abstract description 6
- 238000003780 insertion Methods 0.000 abstract description 4
- 230000037431 insertion Effects 0.000 abstract description 4
- 238000000034 method Methods 0.000 abstract description 4
- 238000001179 sorption measurement Methods 0.000 abstract description 4
- 238000012360 testing method Methods 0.000 description 8
- 238000010521 absorption reaction Methods 0.000 description 2
- 238000007873 sieving Methods 0.000 description 2
- 210000003719 b-lymphocyte Anatomy 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000010370 cell cloning Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
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- Centrifugal Separators (AREA)
Abstract
The utility model discloses a centrifugal screening device for monoclonal antibodies, which belongs to the technical field of centrifugal screening devices and comprises a centrifugal box, wherein a motor is arranged at the bottom in the centrifugal box, a rotary table is connected to an output shaft of the motor, and a bearing plate is arranged below the rotary table. According to the utility model, a group of adsorption fixing mechanisms consisting of the electromagnet and the magnetic plate and a jacking mechanism consisting of the electric push rod, the plunger and the insertion cavity are designed, in the centrifugal process, the electromagnet is electrified to fix the rotating plate through the adsorption of the magnetic plate, so that the rotating frame is ensured to normally rotate, when the elastic plate needs to be replaced, the electromagnet is powered off to release the fixation, and meanwhile, the electric push rod pushes the plunger to the insertion cavity, so that the rotating frame is jacked out of the box body, the operation space of a worker is effectively increased, the replacement of the elastic plate by the worker is facilitated, the replacement efficiency is ensured, and the practicability of the device is improved.
Description
Technical Field
The utility model relates to monoclonal antibody screening, in particular to a monoclonal antibody centrifugal screening device, and belongs to the technical field of monoclonal antibody screening centrifugal screening devices.
Background
Monoclonal antibodies are highly homogeneous antibodies raised by single B-cell cloning and directed against only a specific epitope, and centrifugal screening of the monoclonal shells is required during the preparation of the monoclonal antibodies to isolate high purity monoclonal shells, usually in a cytospin.
The patent document with the patent number of CN 202221587649.4 discloses a centrifugal screening device of monoclonal antibodies, which belongs to the technical field of monoclonal antibody screening.
Above-mentioned patent is in the use, even when the fixed pipe needs to be changed, rotatory fixed sleeve, make fixed sleeve leave fixed pipe through the screw drive principle, take out fixed pipe upper end from the mounting hole again, at this moment, can take out fixed pipe between the curb plate, install according to opposite order after changing fixed pipe, alright accomplish fixed pipe and change, fixed pipe in the fixed unable fixed pipe that changes among the correlation technique, fixed pipe in this monoclonal antibody's the centrifugal sieving mechanism can be changed, but in actual operation, because fixed pipe sets up inside the box, and must receive the restriction of box when the operation, and then be inconvenient for the staff to operate, increase the processing degree of difficulty simultaneously, influence fixed pipe's change efficiency, it is lower to lead to the device practicality.
Disclosure of utility model
The utility model mainly aims to provide a centrifugal screening device for monoclonal antibodies.
The aim of the utility model can be achieved by adopting the following technical scheme:
The utility model provides a monoclonal antibody's centrifugal sieving mechanism, includes the centrifugal box, centrifugal box inner bottom is provided with the motor, be connected with the carousel on the output shaft of motor, the loading board is installed to the carousel below, install the electro-magnet in the carousel, install the swivel mount in the carousel, the swivel mount bottom is provided with the magnetic plate, two sets of chambeies of inserting have been seted up to swivel mount bottom bilateral symmetry, the loading board with install two sets of electric putter on inserting the corresponding position in chamber, install the post of inserting on electric putter's the output, the swivel mount upper end is circumference distribution has the multiunit sleeve, install the elastic plate in the sleeve, be provided with multiunit spring on the elastic plate back wall, spring one end is fixed with the connecting plate, install two sets of adapter sleeves on the connecting plate back wall symmetry, install the screw rod in the adapter sleeve.
Preferably, the motor is connected with the centrifugal box through a bolt, an output shaft of the motor is connected with the turntable through a key, the bearing plate is welded with the centrifugal box, and the output shaft penetrates through the bearing plate.
Preferably, the electromagnet is connected with the turntable through a screw, the rotating frame is spliced with the turntable, the magnetic plate is connected with the rotating frame through a screw, the inserting cavity is formed in the rotating frame, the electric push rod is connected with the bearing plate through a screw, an output shaft of the electric push rod is connected with the inserting column through a screw, and the inserting cavity is matched with the specification of the inserting column.
Preferably, the sleeve is connected with the rotating frame through a screw, and the spring is welded with the elastic plate and the connecting plate.
Preferably, the connecting sleeve is welded with the connecting plate, the connecting sleeve is in threaded connection with the screw rod barrel, and the screw rod is in threaded connection with the side wall of the sleeve.
Preferably, the upper end of the centrifugal box is connected with a box cover through a hinge, an operation panel is installed on one side wall of the centrifugal box, the operation panel is electrically connected with the motor, the electric push rod and the electromagnet, and universal wheels are installed at four corners of the bottom end of the centrifugal box through bolts.
The beneficial technical effects of the utility model are as follows:
According to the utility model, a group of adsorption fixing mechanisms consisting of the electromagnet and the magnetic plate and a jacking mechanism consisting of the electric push rod, the plunger and the insertion cavity are designed, in the centrifugal process, the electromagnet is electrified to fix the rotating plate through the adsorption of the magnetic plate, so that the rotating frame is ensured to normally rotate, when the elastic plate needs to be replaced, the electromagnet is powered off to release the fixation, and meanwhile, the electric push rod pushes the plunger to the insertion cavity, so that the rotating frame is jacked out of the box body, the operation space of a worker is effectively increased, the replacement of the elastic plate by the worker is facilitated, the replacement efficiency is ensured, and the practicability of the device is improved.
Drawings
FIG. 1 is a schematic diagram showing the structure of a preferred embodiment of a centrifugal screening apparatus for monoclonal antibodies according to the present utility model;
FIG. 2 is a front cross-sectional view of a centrifuge box in a preferred embodiment of a monoclonal antibody centrifuge screening device according to the present utility model;
FIG. 3 is an enlarged view of a preferred embodiment of a monoclonal antibody centrifugal screening apparatus according to the present utility model, shown at A in FIG. 2.
The reference numerals are explained as follows:
1-universal wheels; 2-a centrifugal box; 3-case cover; 4-an operation panel; 5-magnetic plate; 6-a turntable; 7-inserting a column; 8-inserting a cavity; 9-a sleeve; 10-rotating frame; 11-an electric push rod; 12-a carrier plate; 13-an electromagnet; 14-an electric motor; 15-an elastic plate; 16-screw; 17-a spring; 18-connecting plates; 19-connecting sleeve.
Detailed Description
In order to make the technical solution of the present utility model more clear and obvious to those skilled in the art, the present utility model will be described in further detail with reference to examples and drawings, but the embodiments of the present utility model are not limited thereto.
As shown in fig. 1-3, the centrifugal screening device for monoclonal antibodies provided in this embodiment includes a centrifugal box 2, a motor 14 is disposed at the inner bottom of the centrifugal box 2, a rotary disk 6 is connected to an output shaft of the motor 14, a carrier plate 12 is mounted below the rotary disk 6, an electromagnet 13 is mounted in the rotary disk 6, a rotary frame 10 is mounted in the rotary disk 6, a magnetic plate 5 is disposed at the bottom end of the rotary frame 10, two groups of inserting cavities 8 are symmetrically disposed at two sides of the bottom end of the rotary frame 10, two groups of electric push rods 11 are mounted at positions of the carrier plate 12 corresponding to the inserting cavities 8, an inserting column 7 is mounted at the output end of the electric push rods 11, multiple groups of sleeves 9 are circumferentially distributed at the upper end of the rotary frame 10, an elastic plate 15 is mounted in the sleeves 9, multiple groups of springs 17 are disposed on the back wall of the elastic plate 15, a connecting plate 18 is fixed at one end of the spring 17, two groups of connecting sleeves 19 are symmetrically mounted on the back wall of the connecting plate 18, and screws 16 are mounted in the connecting sleeves 19.
The motor 14 is connected with the centrifugal box 2 through bolts, an output shaft of the motor 14 is connected with the rotary table 6 in a key way, the bearing plate 12 is welded with the centrifugal box 2, the output shaft penetrates through the bearing plate 12, the motor 14 provides power for the rotary table 6, so that the rotary table 6 drives the rotary frame 10 to rotate, and further, the test tubes fixed in the sleeve 9 are centrifuged.
Electromagnet 13 passes through screw connection with carousel 6, swivel mount 10 and carousel 6 peg graft, magnetic plate 5 passes through screw connection with swivel mount 10, insert chamber 8 shaping on swivel mount 10, electric putter 11 passes through screw connection with loading board 12, electric putter 11's output shaft passes through screw connection with inserting post 7, insert chamber 8 and inserting post 7's specification phase-match, at the centrifugation in-process, electromagnet 13 circular telegram is fixed the rotor plate through the absorption to magnetic plate 5, and then guarantee swivel mount 10 normal rotation, and when needs change elastic plate 15, electromagnet 13 outage will fix and release, electric putter 11 promotes inserting post 7 simultaneously and inserts intracavity 8, and then with swivel mount 10 top out box, effectively increase staff's operating space, the staff of being convenient for changes elastic plate 15, guarantee to change efficiency.
The sleeve 9 is connected with the rotating frame 10 through screws, the spring 17 is welded with the elastic plate 15 and the connecting plate 18, and the elastic plate 15 and the spring 17 are combined to fix the test tube containing the monoclonal antibody, so that the stability during centrifugation is ensured, and the test tube fixing device is applicable to test tubes with various specifications.
The connecting sleeve 19 is welded with the connecting plate 18, the connecting sleeve 19 is in threaded connection with the screw 16, the screw 16 is in threaded connection with the side wall of the sleeve 9, the screw 16 is rotated to separate the connecting sleeve 19 from the connecting sleeve 19, and the elastic plate 15 can be fixed and removed, so that the elastic plate is convenient to replace.
The upper end of the centrifugal box 2 is connected with a box cover 3 through a hinge, an operation panel 4 is installed on one side wall of the centrifugal box 2, the operation panel 4 is electrically connected with a motor 14, an electric push rod 11 and an electromagnet 13, universal wheels 1 are installed at four corners of the bottom end of the centrifugal box 2 through bolts, the operation panel 4 controls the operation of a device, and the universal wheels 1 facilitate the movement of the device.
The working principle of the device is as follows: this device is in the time of concrete use, remove the suitable position with the device through universal wheel 1, access external power source, open case lid 3 and will hold the test tube of monoclonal antibody in sleeve 9, elastic plate 15 and spring 17 combine together this moment not only can fix the test tube that holds monoclonal antibody, stability when guaranteeing the centrifugation, and be applicable to the test tube of multiple specification, then close case lid 3, work through operating panel 4 control motor 14, motor 14 passes through carousel 6 and drives swivel mount 10 and rotate, and then carry out centrifugation to the test tube, in the centrifugation process, electro-magnet 13 circular telegram is fixed the rotor plate through the absorption to magnetic plate 5, and then guarantee that swivel mount 10 normally rotates, and when needs to change elastic plate 15, electro-magnet 13 outage will be fixed to be relieved, electric putter 11 promotes post 7 simultaneously and is as to insert in chamber 8, and then will swivel mount 10 top out the box, staff rotates screw 16 this moment and makes it and adapter sleeve 19 separation, and then remove the fixation to elastic plate 15, and then change it, this mode can effectively increase staff's operating space, the staff of being convenient for change elastic plate 15, guarantee that the staff changes efficiency.
The above is merely a further embodiment of the present utility model, but the protection scope of the present utility model is not limited thereto, and any person skilled in the art will be able to apply equivalents and modifications according to the technical solution and the concept of the present utility model within the scope of the present utility model disclosed in the present utility model.
Claims (6)
1. A centrifugal screening device for monoclonal antibodies, characterized in that: including centrifugal case (2), be provided with motor (14) in centrifugal case (2) bottom, be connected with carousel (6) on the output shaft of motor (14), loading board (12) are installed to carousel (6) below, install electro-magnet (13) in carousel (6), install swivel mount (10) in carousel (6), swivel mount (10) bottom is provided with magnetic plate (5), two sets of chambeies (8) have been seted up to swivel mount (10) bottom bilateral symmetry, loading board (12) with install two sets of electric putter (11) on the position that chambeies (8) correspond, install spliced pole (7) on the output of electric putter (11), swivel mount (10) upper end is circumference distribution has multiunit sleeve (9), install elastic plate (15) in sleeve (9), be provided with multiunit spring (17) on the back wall of elastic plate (15), spring (17) one end is fixed with connecting plate (18), install adapter sleeve (19) on the back wall symmetry, install adapter sleeve (19) in two sets of adapter sleeve (19).
2. The monoclonal antibody centrifugal screening device according to claim 1, wherein: the motor (14) is connected with the centrifugal box (2) through bolts, an output shaft of the motor (14) is connected with the rotary table (6) through keys, the bearing plate (12) is welded with the centrifugal box (2), and the output shaft penetrates through the bearing plate (12).
3. A monoclonal antibody centrifugation and screening apparatus according to claim 2, wherein: electromagnet (13) with carousel (6) pass through the screw connection, swivel mount (10) with carousel (6) are pegged graft, magnetic plate (5) with swivel mount (10) pass through the screw connection, insert chamber (8) shaping in on swivel mount (10), electric putter (11) with loading board (12) pass through the screw connection, the output shaft of electric putter (11) with insert post (7) pass through the screw connection, insert chamber (8) with the specification phase-match of inserting post (7).
4. A monoclonal antibody centrifugation and screening apparatus according to claim 3, wherein: the sleeve (9) is connected with the rotating frame (10) through screws, and the spring (17) is welded with the elastic plate (15) and the connecting plate (18).
5. The centrifugal screening device for monoclonal antibodies according to claim 4, wherein: the connecting sleeve (19) is welded with the connecting plate (18), the connecting sleeve (19) is in threaded connection with the screw rod (16) cylinder, and the screw rod (16) is in threaded connection with the side wall of the sleeve (9).
6. The apparatus for centrifugal screening of monoclonal antibodies according to claim 5, wherein: the novel centrifugal box is characterized in that a box cover (3) is connected to the upper end of the centrifugal box (2) through a hinge, an operation panel (4) is mounted on one side wall of the centrifugal box (2), the operation panel (4) is electrically connected with a motor (14), an electric push rod (11) and an electromagnet (13), and universal wheels (1) are mounted at four corners of the bottom end of the centrifugal box (2) through bolts.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202321103078.7U CN220969492U (en) | 2023-05-06 | 2023-05-06 | Centrifugal screening device for monoclonal antibodies |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202321103078.7U CN220969492U (en) | 2023-05-06 | 2023-05-06 | Centrifugal screening device for monoclonal antibodies |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN220969492U true CN220969492U (en) | 2024-05-17 |
Family
ID=91066268
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202321103078.7U Active CN220969492U (en) | 2023-05-06 | 2023-05-06 | Centrifugal screening device for monoclonal antibodies |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN220969492U (en) |
-
2023
- 2023-05-06 CN CN202321103078.7U patent/CN220969492U/en active Active
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