CN220905958U - Precooling monitoring device for sample - Google Patents

Abstract

The present application relates to a sample pre-cooling monitoring device, which includes: a box for placing samples; a temperature sensor located inside the box for measuring the temperature inside the box; and a temperature display located outside the box for displaying the temperature measured by the temperature sensor. According to the sample pre-cooling monitoring device proposed in the present application, the current temperature inside the box can be monitored in real time through the temperature sensor and the temperature display, so that the operator can know whether the pre-cooling of the box has reached the preset conditions, and whether the sample is at a suitable temperature during the operation in the box, so as to avoid invisible damage to the sample.

Description

A sample precooling monitoring device

Technical Field

The present application relates to the field of sample cryopreservation, and in particular to a sample pre-cooling monitoring device.

Background technique

At present, all laboratories involved in cryopreservation of samples face the problem of temporary transfer and handling of samples. The common method is to use an insulated box or foam box filled with dry ice, liquid nitrogen, etc. to temporarily place the samples.

However, this common treatment method lacks temperature monitoring, making it difficult to assess the actual temperature of the sample location, which can easily cause invisible sample damage. Moreover, this common incubator is usually designed for use at around 0-8°C, which is not suitable for the high thermal insulation performance required by the laboratory. In addition, the incubator, foam box and other equipment materials are relatively simple, and there is no special rack designed for the experimental sample container inside, resulting in a messy placement of samples in the box.

Utility Model Content

In view of the above problems existing in the prior art, the present application provides a sample pre-cooling monitoring device, comprising:

A box for placing samples;

a temperature sensor, located inside the box, for measuring the temperature inside the box; and

A temperature display is disposed outside the box and is used to display the temperature measured by the temperature sensor.

According to some embodiments, the precooling monitoring device further comprises:

a rack, located inside the box, for placing the samples; and

The fixing frame is located at the bottom of the box body and is used to fix the storage rack.

According to some embodiments, the temperature sensor is located at an opening of the box.

According to some embodiments, the temperature sensor includes a first temperature sensor and a second temperature sensor, wherein the first temperature sensor is located at the opening of the box, and the second temperature sensor is located at the bottom of the inner side of the box.

According to some embodiments, one or more temperature sensors are further included between the first temperature sensor and the second temperature sensor, and the one or more temperature sensors are used to measure the temperature between the opening of the box and the inner bottom of the box.

According to some embodiments, the precooling monitoring device further comprises:

A partition plate is located between the fixing frames and is used to separate the cryogenic consumables from the storage rack.

According to some embodiments, the temperature display is mounted around the outside of the box.

According to some embodiments, the material of the box body includes high-performance thermal insulation material.

According to some embodiments, the structure of the fixing frame matches the structure of the storage rack, and the structure of the storage rack matches the structure of the sample container to be placed.

According to some embodiments, a cover is provided at the opening of the box.

According to the sample precooling monitoring device proposed in this application, on the one hand, the current temperature inside the box can be monitored in real time through the temperature sensor and the temperature display, so that the operator can know whether the precooling of the box has reached the preset conditions, and whether the sample is at a suitable temperature during the operation in the box, so as to avoid invisible damage to the sample. On the other hand, a rack is installed in the box to facilitate the transfer, storage and operation of the sample. In addition, the box is made of high-density polyurethane material or high-performance insulation materials such as vacuum insulation, which can effectively isolate the temperature inside and outside the box and reduce the loss of low-temperature consumables in the box.

BRIEF DESCRIPTION OF THE DRAWINGS

In order to more clearly illustrate the technical solutions in the embodiments of the present application, the drawings required for use in the description of the embodiments will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present application. For ordinary technicians in this field, other drawings can be obtained based on these drawings without exceeding the scope of protection required by the present application.

FIG. 1 is a front view of a sample pre-cooling monitoring device according to an embodiment of the present application.

FIG. 2 is a top view of a sample pre-cooling monitoring device according to an embodiment of the present application.

FIG. 3 is a schematic diagram of a rack in a sample precooling monitoring device.

FIG. 4 is a schematic diagram of a fixing frame in a sample precooling monitoring device.

FIG. 5 is a schematic diagram of a partition plate in a sample precooling monitoring device.

Reference numerals: 1 box body, 2 storage rack, 3 partition plate, 11 first temperature sensor, 12 second temperature sensor, 13 temperature display, 14 lid, 15 handle, 16 fixing frame.

Detailed ways

The following will be combined with the drawings in the embodiments of the present application to clearly and completely describe the technical solutions in the embodiments of the present application. Obviously, the described embodiments are part of the embodiments of the present application, not all of the embodiments. Based on the embodiments in the present application, all other embodiments obtained by those skilled in the art without creative work are within the scope of protection of the present application.

Fig. 1 is a front view of a precooling monitoring device for a sample according to an embodiment of the present application. Fig. 2 is a top view of a precooling monitoring device for a sample according to an embodiment of the present application. As shown in Figs. 1 and 2, the device comprises a box 1, a temperature sensor and a temperature display 13. The box 1 is used to place the sample, the temperature sensor is located inside the box 1 and is used to measure the temperature inside the box 1, and the temperature display 13 is placed outside the box 1 and is used to display the temperature measured by the temperature sensor.

According to some embodiments, the box 1 can be any structure suitable for storing samples, for example, it can be a cuboid, a cylinder, etc. The size of the box 1 can be selected from a variety of specifications, for example, ranging from 32L to 85L. The opening of the box 1 may have a lid 14 or may not have a lid 14. In the case of a lid 14, it is beneficial to pre-cool the box 1 before storing the sample, so that the temperature can drop to the set temperature more quickly. After opening the lid, maintain any suitable angle (for example, 135°) with the opening of the box 1 to facilitate operations such as storing and removing the sample.

According to some embodiments, the box 1 can be any insulation material. In the present application, the box 1 can adopt high-performance insulation materials such as high-density polyurethane materials or vacuum insulation materials. The common insulation boxes in the prior art are only suitable for home environments, such as around minus 0 to 8 degrees Celsius, but the laboratory's requirements for insulation performance are much greater than those of the home environment. For example, the temperature of liquid nitrogen is minus 196 degrees Celsius, which can easily cause damage to common insulation boxes, and even if the insulation box is not damaged, the poor insulation effect leads to excessive consumption of liquid nitrogen, etc., resulting in additional cost expenses. The box 1 made of high-performance insulation material in the present application can more effectively isolate the temperature inside and outside the box 1, and reduce the loss of cryogenic consumables such as dry ice and liquid nitrogen in the box 1.

According to some embodiments, one or more handles 15 or groove areas may be provided on the outer side of the box body 1 to facilitate operators to move the box body 1 .

According to some embodiments, the temperature display 13 can be installed around the outside of the box 1. For example, the temperature display 13 can be pasted on the outside of the box 1, or embedded in the outside of the box 1, and the temperature display 13 is not blocked by the box, which is convenient for operators to observe the temperature.

According to some embodiments, the temperature sensor may be any sensor that can be used to measure temperature as long as its measurement range meets the requirements. For example, a non-contact temperature measuring instrument may be used to measure the temperature by a radiation temperature measurement method. Such a sensor may be used to measure the surface temperature of a moving object, a small target, and an object with a small heat capacity or a rapid temperature change (transient), and may also be used to measure the temperature distribution of a temperature field.

According to some embodiments, the temperature sensor may be located at any position inside the housing 1 , for example, at the bottom of the inner side of the housing 1 , at the opening of the housing 1 , or between the bottom and the opening.

According to some embodiments, a temperature sensor may be placed at the opening of the box 1. Generally speaking, low-temperature consumables such as dry ice and liquid nitrogen are stored at the bottom of the box 1, where the temperature is the lowest, and the opening is in contact with the outside air, where the temperature is relatively the highest. When the temperature at the opening is not higher than the preset temperature, it indicates that when the box 1 stores the sample, the temperature of the sample will not be higher than the preset temperature, which can ensure that the sample will not be damaged by high temperature.

According to some embodiments, the number of temperature sensors includes two, including a first temperature sensor 11 and a second temperature sensor 12, wherein the first temperature sensor 11 is located at the opening of the box 1, and the second temperature sensor 12 is located at the inner bottom of the box 1. In this way, not only the temperature at the opening of the box 1 can be monitored, but also the temperature at the inner bottom of the box 1 can be monitored. By monitoring the temperature at the inner bottom of the box 1, it is possible to understand whether the cryogenic consumables are consumed too much, so as to prompt the operator to replenish the cryogenic consumables in time when they are consumed too much.

According to some embodiments, one or more temperature sensors may be placed between the first temperature sensor 11 and the second temperature sensor 12 to measure the temperature between the opening of the box 1 and the inner bottom of the box 1. The sample is usually located between the opening and the inner bottom of the box 1. By providing more temperature sensors, the temperature at the location of the sample can be reflected more accurately and directly.

In the prior art, the incubator and other equipment are relatively simple, and are not specially designed for experimental sample containers, such as EP tubes (centrifuge tubes), resulting in chaotic placement of samples in the incubator. When a temporary operating panel is placed in the incubator, it may not be compatible with the incubator and require additional pre-cooling.

In view of the above problems, the present application provides a rack 2 adapted to the box 1 and a fixing frame 16 installed at the bottom of the box 1. As shown in Figures 3 and 4, the fixing frame 16 is fixed at the bottom of the box 1 near the four corners of the box 1, and is used to fix the rack 2 and the partition plate 3 placed inside the box 1. In addition, the structure of the fixing frame 16 matches the structure of the rack 2 and the partition plate 3. The rack 2 is located inside the box 1 and is used to place samples. In addition, the structure of the rack 2 matches the structure of the sample container to be placed, and the structure of the rack 2 can be designed for common sample containers in the laboratory. For example, if the sample container is a test tube, the rack 2 can be provided with a round hole matching the test tube; for another example, if the sample container is a rectangular container, the rack 2 can be provided with a groove matching the rectangular container, etc. According to some embodiments, the rack 2 can contact the inner wall of the box 1 all around, or there is a certain gap with the inner wall, for example, the spacing can be 5cm. According to some embodiments, the rack 2 may be made of low-temperature resistant stainless steel material that can quickly conduct heat, so that the rack 2 can be quickly pre-cooled.

In the prior art, low-temperature consumables such as dry ice and ice cubes are placed at the bottom of the incubator, and samples are placed on the low-temperature consumables. However, this layout is not conducive to the stable placement of samples, and the temperature distribution inside the box 1 is also seriously uneven.

In this regard, according to some embodiments, the present application sets a partition plate 3 inside the box body 1, as shown in FIG5. The partition plate 3 can be a perforated structure or a straight plate structure. The partition plate 3 is located between the fixed frames 16 in the box body 1, and low-temperature consumables such as dry ice and ice cubes are located between the inner wall of the box body 1 and the partition plate 3. The partition plate 3 separates the low-temperature consumables from the shelf 2. When the shelf 2 is placed in the box body 1, the shelf 2 is located in the partition plate 3. The shelf 2 can contact the partition plate 3, or there is a certain gap between the shelf 2 and the partition plate 3.

By setting a partition plate 3 inside the box 1, it is not necessary to place all the cryogenic consumables at the bottom of the box 1, but they can be placed between the inner wall of the box 1 and the partition plate 3, so that the temperature distribution of the inner wall of the box 1 is more uniform.

According to the sample precooling monitoring device proposed in the present application, on the one hand, the current temperature inside the box 1 can be monitored in real time through the temperature sensor and the temperature display 13, so that the operator can know whether the precooling of the box 1 has reached the preset conditions, and whether the sample is at a suitable temperature during the operation in the box, so as to avoid invisible damage to the sample. On the other hand, the device rack 2 is installed in the box 1 to facilitate the transfer, storage and operation of the sample. In addition, the box 1 adopts high-performance insulation materials such as high-density polyurethane materials or vacuum insulation materials, which can effectively isolate the temperature inside and outside the box 1 and reduce the loss of low-temperature consumables in the box 1.

The embodiments of the present application are described in detail above. Specific examples are used herein to illustrate the principles and implementation methods of the present application. The description of the above embodiments is only used to help understand the method and its core idea of the present application. At the same time, changes or deformations made by those skilled in the art based on the ideas of the present application, the specific implementation methods and the scope of application of the present application, all belong to the scope of protection of the present application. In summary, the content of this specification should not be construed as a limitation on the present application.

Claims (9)

1. A sample precooling monitoring device, comprising: A box for placing samples; a temperature sensor, located inside the box, for measuring the temperature inside the box; and A temperature display, located outside the box, for displaying the temperature measured by the temperature sensor; a rack, located inside the box, for placing the samples; and The fixing frame is located at the bottom of the box body and is used to fix the storage rack. 2. The pre-cooling monitoring device according to claim 1 is characterized in that the temperature sensor is located at the opening of the box. 3. The pre-cooling monitoring device according to claim 1 is characterized in that the temperature sensor includes a first temperature sensor and a second temperature sensor, wherein the first temperature sensor is located at the opening of the box body, and the second temperature sensor is located at the bottom of the inner side of the box body. 4. The pre-cooling monitoring device according to claim 3 is characterized in that one or more temperature sensors are further provided between the first temperature sensor and the second temperature sensor, and the one or more temperature sensors are used to measure the temperature between the opening of the box and the inner bottom of the box. 5. The precooling monitoring device according to claim 1, characterized in that it also includes: A partition plate is located between the fixing frames and is used to separate the cryogenic consumables from the storage rack. 6. The pre-cooling monitoring device according to claim 1 is characterized in that the temperature display is installed around the outside of the box. 7. The pre-cooling monitoring device according to claim 1 is characterized in that the material of the box body is a high-performance thermal insulation material. 8. The pre-cooling monitoring device according to claim 1, characterized in that the structure of the fixing frame matches the structure of the storage rack, and the structure of the storage rack matches the structure of the sample container to be placed. 9. The precooling monitoring device according to claim 1, characterized in that a cover is provided at the opening of the box body.