CN220861218U - Antibody purifying equipment - Google Patents
Antibody purifying equipment Download PDFInfo
- Publication number
- CN220861218U CN220861218U CN202322459244.3U CN202322459244U CN220861218U CN 220861218 U CN220861218 U CN 220861218U CN 202322459244 U CN202322459244 U CN 202322459244U CN 220861218 U CN220861218 U CN 220861218U
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- Prior art keywords
- fixedly connected
- wall
- block
- slot
- rotating block
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- 238000011091 antibody purification Methods 0.000 claims description 11
- 239000007788 liquid Substances 0.000 claims description 7
- 230000017525 heat dissipation Effects 0.000 claims description 4
- 238000005192 partition Methods 0.000 claims description 4
- 238000000746 purification Methods 0.000 abstract description 45
- 230000002349 favourable effect Effects 0.000 description 11
- 230000000694 effects Effects 0.000 description 6
- 238000010586 diagram Methods 0.000 description 3
- 239000000427 antigen Substances 0.000 description 2
- 102000036639 antigens Human genes 0.000 description 2
- 108091007433 antigens Proteins 0.000 description 2
- 230000001771 impaired effect Effects 0.000 description 2
- 230000001954 sterilising effect Effects 0.000 description 2
- 238000004659 sterilization and disinfection Methods 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 239000003480 eluent Substances 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
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- Devices For Use In Laboratory Experiments (AREA)
Abstract
The utility model discloses antibody purifying equipment, which comprises a base, wherein a clamping mechanism is arranged above the base and comprises a rotating block which is rotationally connected to the top of the base, at least four circular grooves are uniformly formed in the top of the rotating block, the inner wall of the circumferential side surface of each circular groove is slidingly connected with a bottom plate, at least two lifting plates are uniformly and fixedly connected to the top of the bottom plate, the circumferential side surfaces of the lifting plates are slidingly connected to the inner wall of the circumferential side surface of each circular groove, and the tops of the lifting plates extend to the upper part of the rotating block. According to the utility model, the two square columns are pulled out through the lifting plate, the purification test tube is placed into the circular groove, the second spring pushes the square columns to move, the square columns clamp the purification test tube, the purification test tube with different sizes can be conveniently clamped by the device, the purification test tube is prevented from being damaged, the motor is started, the motor drives the rotating shaft to rotate, the rotating shaft drives the rotating block to rotate, the rotating block drives the circular groove to rotate, and the circular groove drives the purification test tube to rotate.
Description
Technical Field
The utility model relates to the technical field of antibody purification devices, in particular to antibody purification equipment.
Background
The antibody antigen is required to be purified by using a purification device before application, such as the patent of the utility model with the application number 202221294402.3, and the name is purification equipment for the antibody and the antigen, the patent device can carry out irradiation sterilization on the top end of a lifting plate through a first ultraviolet lamp, can carry out irradiation sterilization on the top end of a bearing plate through a second ultraviolet lamp, avoids the risk that an affinity column and an eluent receiving tube are polluted to a large extent, and can drive a second clamping block to move by screwing a locking bolt, so that the affinity column can be clamped and fixed by using the first clamping block and the second clamping block, and a threaded rod is driven to rotate by a servo motor, so that the lifting rod can drive the lifting plate to lift, and the supporting plate can rotate to adjust the angle, thereby being convenient to use and good in practicability; however, the device of this patent cannot timely extract the purification effect of the test tube inspection antibody, and is inconvenient for the user to grasp the purification process of the antibody.
Disclosure of utility model
The utility model aims to solve the defects in the prior art and provides an antibody purifying device.
In order to achieve the above purpose, the present utility model adopts the following technical scheme:
the utility model provides an antibody purification equipment, the on-line screen storage device comprises a base, the top of base is provided with fixture, fixture is including rotating the rotating block of connecting at the base top, four at least circular grooves have evenly been seted up at the top of rotating block, the circumference side inner wall sliding connection of circular groove has the bottom plate, the even fixedly connected with at least two lifter plates in top of bottom plate, the circumference side sliding connection of lifter plate is in the circumference side inner wall of circular groove, the top of lifter plate extends to the top of rotating block, the spout has been seted up between the circumference side outer wall and the inner wall of lifter plate, the circumference side of base can open and shut.
Preferably, the top of the rotating block is uniformly provided with at least two movable blocks aligned with the sliding groove, the side surface of the movable block is provided with a groove, the inner wall of the bottom of the groove is in sliding connection with a square column, a second spring is fixedly connected between the side surface of the square column and the inner wall of the side surface of the groove, and one surface of the square column is in sliding connection with one surface inner wall of the sliding groove.
Preferably, the top of the rotating block is provided with a telescopic groove aligned with the movable block, the circumferential side surface of the telescopic groove is slidably connected with a telescopic column, a first spring is fixedly connected between the bottom of the telescopic column and the inner wall of the bottom of the telescopic groove, and the top of the telescopic column is fixedly connected with the bottom of the movable block.
Preferably, the bottom inner wall fixedly connected with motor of base, the output shaft fixedly connected with pivot of motor, the circumference side fixedly connected with of pivot is in the circumference side inner wall of turning block.
Preferably, the inside of rotating the piece has offered the removal groove that is located the circular slot both sides, and the bottom inner wall sliding connection of removal groove has the heat conduction piece, fixedly connected with spring three between the one side of heat conduction piece and the one side inner wall of removal groove, and the another side of heat conduction piece extends to the inside of circular slot, and the even fixedly connected with circular arc post of circumference side of heat conduction piece.
Preferably, the heat dissipation groove is formed in the heat conduction block, the partition plate is uniformly and fixedly connected between two sides of the heat dissipation groove, and the opening is uniformly formed between the top and the bottom of the partition plate.
Preferably, the inside fixedly connected with of turning block aligns the pump machine with the heat conduction block, and the feed liquor end fixedly connected with fixed pipe two of pump machine, the other end of fixed pipe two extends to the outside of turning block, and the play liquid end fixedly connected with fixed pipe three of pump machine, the other end fixedly connected with of fixed pipe three is in the one side inner wall of heat conduction block, and one side inner wall top fixedly connected with fixed pipe one of heat conduction block, and the other end of fixed pipe one extends to the outside of turning block.
Compared with the prior art, the utility model provides an antibody purifying device, which has the following beneficial effects:
Through the lifter plate that sets up, dial two square posts, put into the circular slot with the purification test tube, the square post of second promotion of spring removes, square post holds the purification test tube, be favorable to the device convenient with not unidimensional purification test tube centre gripping, prevent the impaired purification test tube, the starter motor, the motor drives the pivot and rotates, the pivot drives the rotating block and rotates, the rotating block drives the circular slot and rotates, the circular slot drives purification test tube and rotates, be favorable to the device to shake the purification test tube, promote purification test tube to the purification effect of antibody, the pulling movable block, the movable block drives the lifter plate and removes, the lifter plate drives the bottom plate and removes, the bottom plate drives the purification test tube and stretches out the circular slot, be favorable to the user to inspect purification effect of purification test tube in the middle of the device work, convenient to use holds the purification process of device to the antibody, the third promotion heat conducting block removes, heat conducting block and circular arc post are supported by the circumference side of purification test tube, circular arc post and heat conducting block can improve the area of contact of device and purification test tube, be favorable to the device keep the temperature of purification test tube, connect the fixed pipe in liquid, the pump is favorable to the device with liquid through fixed pipe and fixed pipe, the fixed pipe is three to send into in the heat conducting block, the heat is favorable to the purification effect to be further led out to the purification test tube from the device through the heat conducting block.
Drawings
FIG. 1 is a schematic diagram showing the overall structure of an antibody purification apparatus according to the present utility model;
FIG. 2 is a schematic diagram showing the internal structure of an antibody purifying apparatus according to the present utility model;
FIG. 3 is a schematic diagram showing a partial structure of an antibody purifying apparatus according to the present utility model;
Fig. 4 is an enlarged schematic view of the structure at a in fig. 2.
In the figure: 1-base, 2-motor, 3-pivot, 4-bottom plate, 5-rotating block, 6-spring one, 7-expansion tank, 8-telescopic column, 9-movable block, 10-fluting, 11-spring two, 12-square post, 13-fixed pipe one, 14-lifter plate, 15-spout, 16-circular arc post, 17-heat conduction block, 18-circular slot, 19-fixed pipe two, 20-pump, 21-fixed pipe three, 22-movable slot, 23-spring three, 24-baffle.
Detailed Description
Example 1:
referring to fig. 1, fig. 2, fig. 3 and fig. 4, an antibody purifying apparatus comprises a base 1, a clamping mechanism is arranged above the base 1, the clamping mechanism comprises a rotating block 5 which is rotationally connected to the top of the base 1, at least four circular grooves 18 are uniformly formed in the top of the rotating block 5, the inner wall of the circumferential side surface of the circular groove 18 is slidably connected with a bottom plate 4, at least two lifting plates 14 are uniformly and fixedly connected to the top of the bottom plate 4, the circumferential side surface of the lifting plates 14 is slidably connected to the inner wall of the circumferential side surface of the circular groove 18, the top of the lifting plates 14 extends to the top of the rotating block 5, a sliding groove 15 is formed between the outer wall and the inner wall of the circumferential side surface of the lifting plates 14, and the circumferential side surface of the base 1 can be opened and closed.
In the utility model, at least two movable blocks 9 aligned with a chute 15 are uniformly arranged on the top of a rotating block 5, a slot 10 is formed on the side surface of each movable block 9, a square column 12 is connected on the inner wall of the bottom of the slot 10 in a sliding manner, a spring II 11 is fixedly connected between the side surface of the square column 12 and the inner wall of the side surface of the slot 10, and one surface of the square column 12 is connected on one surface inner wall of the chute 15 in a sliding manner.
The telescopic slot 7 aligned with the movable block 9 is formed in the top of the rotating block 5, the telescopic column 8 is slidably connected to the circumferential side face of the telescopic slot 7, the first spring 6 is fixedly connected between the bottom of the telescopic column 8 and the inner wall of the bottom of the telescopic slot 7, and the top of the telescopic column 8 is fixedly connected to the bottom of the movable block 9.
The bottom inner wall fixedly connected with motor 2 of base 1, the output shaft fixedly connected with pivot 3 of motor 2, the circumference side fixedly connected with of pivot 3 rotates the circumference side inner wall of piece 5.
The inside of the rotating block 5 is provided with a movable groove 22 positioned on two sides of the circular groove 18, the inner wall of the bottom of the movable groove 22 is slidably connected with a heat conducting block 17, a spring III 23 is fixedly connected between one side of the heat conducting block 17 and one side inner wall of the movable groove 22, the other side of the heat conducting block 17 extends to the inside of the circular groove 18, and the circumferential side surface of the heat conducting block 17 is uniformly and fixedly connected with an arc column 16.
The heat conducting block 17 has heat dissipating slot inside, and baffle 24 is connected to the heat dissipating slot in two sides and holes in the top and bottom of the baffle 24.
The inside fixedly connected with of turning block 5 is with the pump machine 20 of heat conduction piece 17 alignment, and the feed liquor end fixedly connected with fixed pipe two 19 of pump machine 20, and the other end of fixed pipe two 19 extends to the outside of turning block 5, and the play liquid end fixedly connected with fixed pipe three 21 of pump machine 20, the other end fixedly connected with of fixed pipe three 21 is in the one side inner wall of heat conduction piece 17, and one side inner wall top fixedly connected with fixed pipe one 13 of heat conduction piece 17, and the other end of fixed pipe one 13 extends to the outside of turning block 5.
Working principle: pulling out two square posts 12, put into circular slot 18 with the purification test tube, square post 12 is promoted to remove by spring two 11, square post 12 holds the purification test tube, be favorable to the device convenient with not unidimensional purification test tube centre gripping, prevent the impaired purification test tube, start motor 2, motor 2 drives pivot 3 rotation, pivot 3 drives rotatory piece 5 and rotates, rotatory piece 5 drives circular slot 18 and rotates, circular slot 18 drives the purification test tube and rotates, be favorable to the device to shake the purification test tube, promote the purification effect of purification test tube to the antibody, pulling movable block 9, movable block 9 drives lifter plate 14 and removes, lifter plate 14 drives bottom plate 4 and removes, bottom plate 4 drives the purification test tube and stretches out circular slot 18, be favorable to the user to examine the purification effect of purification test tube in the device work centre, convenient for the user grasp the purification process of device to the antibody, spring three 23 promotes the heat conducting block 17 removal, heat conducting block 17 and circular arc post 16 are supported and are leaned on the circumference side of purification test tube, circular arc post 16 and heat conducting block 17 can improve the area of contact of device and purification test tube, be favorable to the device to keep the purification test tube temperature, connect fixed tube two in liquid, promote purification tube 20 to be connected in the guide tube 20, promote the purification tube to carry out device through fixed tube 20 and heat conducting pump 20, the device is favorable to carry out the purification tube from the device to the heat pump 20, the device is further to the purification tube is gone into the device through fixed tube through the heat conducting tube 17.
The foregoing is only a preferred embodiment of the present utility model, but the scope of the present utility model is not limited thereto, and any person skilled in the art, who is within the scope of the present utility model, should make equivalent substitutions or modifications according to the technical scheme of the present utility model and the inventive concept thereof, and should be covered by the scope of the present utility model.
Claims (7)
1. The utility model provides an antibody purification equipment, includes base (1), its characterized in that, the top of base (1) is provided with fixture, fixture is including rotating rotary block (5) of connecting at base (1) top, four at least circular slot (18) have evenly been seted up at the top of rotary block (5), circumference side inner wall sliding connection of circular slot (18) has bottom plate (4), the even fixedly connected with in top of bottom plate (4) is at least two lifter plates (14), circumference side sliding connection of lifter plate (14) is in circumference side inner wall of circular slot (18), the top of lifter plate (14) extends to the top of rotary block (5), spout (15) have been seted up between circumference side outer wall and the inner wall of lifter plate (14), circumference side of base (1) can open and shut.
2. An antibody purification apparatus according to claim 1, wherein at least two movable blocks (9) aligned with the chute (15) are uniformly arranged on the top of the rotating block (5), the side surface of the movable block (9) is provided with a slot (10), the bottom inner wall of the slot (10) is slidably connected with a square column (12), a spring two (11) is fixedly connected between the side surface of the square column (12) and the side inner wall of the slot (10), and one surface of the square column (12) is slidably connected with one surface inner wall of the chute (15).
3. An antibody purification apparatus according to claim 2, wherein the top of the rotating block (5) is provided with a telescopic slot (7) aligned with the movable block (9), the circumferential side surface of the telescopic slot (7) is slidably connected with a telescopic column (8), a first spring (6) is fixedly connected between the bottom of the telescopic column (8) and the bottom inner wall of the telescopic slot (7), and the top of the telescopic column (8) is fixedly connected with the bottom of the movable block (9).
4. An antibody purification apparatus according to claim 3, wherein the bottom inner wall of the base (1) is fixedly connected with a motor (2), an output shaft of the motor (2) is fixedly connected with a rotating shaft (3), and a circumferential side surface of the rotating shaft (3) is fixedly connected with a circumferential side inner wall of the rotating block (5).
5. The antibody purification device according to claim 4, wherein the inside of the rotating block (5) is provided with a moving groove (22) positioned on two sides of the circular groove (18), the bottom inner wall of the moving groove (22) is slidably connected with a heat conducting block (17), a spring III (23) is fixedly connected between one side of the heat conducting block (17) and one side inner wall of the moving groove (22), the other side of the heat conducting block (17) extends to the inside of the circular groove (18), and the circumference side surface of the heat conducting block (17) is uniformly and fixedly connected with an arc column (16).
6. The antibody purification device according to claim 5, wherein a heat dissipation groove is formed in the heat conduction block (17), a partition plate (24) is uniformly and fixedly connected between two sides of the heat dissipation groove, and openings are uniformly formed between the top and the bottom of the partition plate (24).
7. The antibody purification device according to claim 6, wherein the inside of the rotating block (5) is fixedly connected with a pump (20) aligned with the heat conducting block (17), the liquid inlet end of the pump (20) is fixedly connected with a second fixing tube (19), the other end of the second fixing tube (19) extends to the outside of the rotating block (5), the liquid outlet end of the pump (20) is fixedly connected with a third fixing tube (21), the other end of the third fixing tube (21) is fixedly connected to an inner wall of the heat conducting block (17), the top of the inner wall of the heat conducting block (17) is fixedly connected with a first fixing tube (13), and the other end of the first fixing tube (13) extends to the outside of the rotating block (5).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202322459244.3U CN220861218U (en) | 2023-09-11 | 2023-09-11 | Antibody purifying equipment |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202322459244.3U CN220861218U (en) | 2023-09-11 | 2023-09-11 | Antibody purifying equipment |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN220861218U true CN220861218U (en) | 2024-04-30 |
Family
ID=90822064
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202322459244.3U Active CN220861218U (en) | 2023-09-11 | 2023-09-11 | Antibody purifying equipment |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN220861218U (en) |
-
2023
- 2023-09-11 CN CN202322459244.3U patent/CN220861218U/en active Active
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