CN220859286U - Multi-mouse heart perfusion device - Google Patents
Multi-mouse heart perfusion device Download PDFInfo
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- CN220859286U CN220859286U CN202322754558.6U CN202322754558U CN220859286U CN 220859286 U CN220859286 U CN 220859286U CN 202322754558 U CN202322754558 U CN 202322754558U CN 220859286 U CN220859286 U CN 220859286U
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- water
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- tube
- water pump
- shunt
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- 230000010412 perfusion Effects 0.000 title claims abstract description 43
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 131
- 239000007788 liquid Substances 0.000 claims abstract description 16
- 239000007924 injection Substances 0.000 claims abstract description 4
- 238000002347 injection Methods 0.000 claims abstract description 4
- 230000001681 protective effect Effects 0.000 claims description 10
- 238000007405 data analysis Methods 0.000 claims description 9
- 238000013500 data storage Methods 0.000 claims description 9
- 238000004458 analytical method Methods 0.000 claims description 7
- 239000002504 physiological saline solution Substances 0.000 claims description 5
- 238000004364 calculation method Methods 0.000 claims description 4
- 230000000747 cardiac effect Effects 0.000 claims 2
- 241000699670 Mus sp. Species 0.000 abstract description 10
- 241000699666 Mus <mouse, genus> Species 0.000 abstract description 9
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 3
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 239000000741 silica gel Substances 0.000 description 2
- 229910002027 silica gel Inorganic materials 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 210000005240 left ventricle Anatomy 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
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- External Artificial Organs (AREA)
Abstract
The utility model relates to a multi-mouse heart perfusion device, which comprises a water pump, a shell, a water container, a water inlet pipe, a water outlet pipe and a controller, wherein the water pump is connected with the shell; the water pump, the water container, the water inlet pipe, the water outlet pipe and the controller are all arranged in the shell, the water pump, the controller and the water container are fixedly connected to the bottom surface inside the shell, the water inlet of the water pump is connected with the water container through the water inlet pipe, the water outlet of the water pump is fixedly connected with the water outlet pipe, the controller is connected with the water pump through a signal line, the rear end of the water outlet pipe is provided with a shunt pipe, and at least one shunt pipe is arranged; the controller can perform variable-frequency speed regulation on the water pump, and can regulate the pressure of water during heart perfusion; the water pump pumps out the liquid in the water container, flows through the water outlet pipe to reach the shunt tubes, enters the injection needle for heart perfusion, then enters the heart of the mice to realize heart perfusion, and each shunt tube is connected with one mouse to realize simultaneous perfusion of multiple mice.
Description
Technical Field
The utility model belongs to the technical field of medical appliances, and particularly relates to a multi-mouse heart perfusion device.
Background
In mouse experiments, heart perfusion is an indispensable step, and the perfusion result is closely related to the state of the tissue. Heart perfusion first exposes the heart of the mouse, and then the perfusion needle is inserted into the left ventricle and then is perfused with normal saline.
At present, a laboratory generally uses an injector and a needle to perfuse the heart of a mouse, the pressure is uncontrollable, the tissue of the mouse is easily damaged by the excessive pressure or the needle can be separated, and the blood in the heart cannot be perfused out due to the excessive pressure; the current perfusion pump can only perfuse one mouse at a time, sometimes a plurality of mice are required to perfuse simultaneously, and the current perfusion device cannot realize the function.
The present utility model addresses the above-described problems by providing a multi-mouse heart perfusion device.
Disclosure of utility model
In order to overcome the problems in the background art, the utility model adopts the following technical scheme:
A multi-mouse heart perfusion device comprises a water pump, a shell, a water container, a water inlet pipe, a water outlet pipe and a controller; the water pump, the water container, the water inlet pipe, the water outlet pipe and the controller are all arranged in the shell, the water pump, the controller and the water container are fixedly connected to the bottom surface inside the shell, the water inlet of the water pump is connected with the water container through the water inlet pipe, the water outlet of the water pump is fixedly connected with the water outlet pipe, the controller is connected with the water pump through a signal line, the rear end of the water outlet pipe is provided with a shunt pipe, and at least one shunt pipe is arranged; the controller can perform variable-frequency speed regulation on the water pump, and can regulate the pressure of water during heart perfusion; the water pump pumps out the liquid in the water container, flows through the water outlet pipe to reach the shunt tubes, enters the injection needle for heart perfusion, then enters the heart of the mice to realize heart perfusion, and each shunt tube is connected with one mouse to realize simultaneous perfusion of multiple mice.
Furthermore, the water pump is a centrifugal pump, and is connected with the controller to realize variable frequency speed regulation, so that the pressure of water during heart perfusion is regulated.
Further, the whole shell is cuboid, the inside of the shell is hollow, and an anti-slip layer is arranged at the bottom of the shell; preferably, the anti-slip layer is a rubber pad or a silica gel pad.
Further, the top of the shell is provided with a liquid filling opening, normal saline can be filled into the water container, the liquid filling opening is provided with a protective cover, the protective cover is movably connected with the liquid filling opening, and the protective cover can be opened or closed.
Further, a power line and a plug are arranged on the outer side of the shell, and the power line is connected with the water pump and the controller in the shell and can supply power to the whole device.
Further, pressure sensors are respectively arranged in the shunt pipe and the water container, and are connected with the controller through signal lines; the water pressure in the side shunt tube and the liquid amount in the water container can be respectively realized.
Further, the shunt tubes include a vertical pipe and at least one horizontal pipe, horizontal pipe fixed connection is at the first side of vertical pipe, vertical pipe second side and outlet pipe fixed connection, vertical pipe, horizontal pipe and outlet pipe inside intercommunication.
Further, the distal end of the transverse tube extends within the housing and is adapted to fit over a needle hub of a heart infusion.
Further, the shunt tube is provided with an electromagnetic valve, the electromagnetic valve is connected with the controller, the electromagnetic valve is a normally closed electromagnetic valve, and the controller can control the switch-on of the electromagnetic valve and control the switch-on or switch-off of the electromagnetic valve.
Further, a display and control buttons are arranged on the upper part of the shell; the display is connected with the controller, the display can display the pressure in each shunt tube, the control button can control the pressure in the shunt tube, and the control button can control the opening and closing of each shunt tube.
Further, the controller comprises a central controller, a data analysis module, a data storage module and a communication module, wherein the data analysis module, the data storage module and the communication module are respectively connected with the central controller; after the pressure value in each shunt tube is set by an operator, the pressure detected by the pressure sensor is transmitted to the data analysis module for analysis and calculation, and then the analysis result is subjected to variable frequency speed regulation on the water pump through the communication module by the central controller until the set pressure value is reached in the shunt tube; and the set pressure value is effectively archived by utilizing the data storage module, so that the next continuous use is facilitated.
The utility model has the beneficial effects that: the utility model has reasonable structure; by arranging the shunt tube, the device can simultaneously perfuse a plurality of mice; by arranging the controller and the pressure sensor, the pressure of the physiological saline in the shunt tube is ensured to be adjustable, the pressure can be adjusted to the required pressure, and the heart perfusion experiment of the mouse is facilitated; the electromagnetic valve is arranged, so that the required shunt pipe can be controlled to be opened or closed; the device that can supply many mice to carry out heart perfusion simultaneously is favorable to reducing area, has accelerated experimental efficiency greatly.
Drawings
FIG. 1 is a schematic view of the overall structure of the present utility model;
FIG. 2 is a schematic cross-sectional view of the present utility model at a first view angle;
FIG. 3 is a schematic cross-sectional view of the present utility model at a second view angle;
FIG. 4 is a schematic view of the structure of the water container of the present utility model;
FIG. 5 is a schematic view of the connection of the shunt tube and the water outlet tube of the present utility model;
In the figure, 1, a water pump; 2. a housing; 3. a water container; 4. a water inlet pipe; 5. a water outlet pipe; 6. a controller; 7. a liquid adding port; 8. a power line; 9. a plug; 10. a longitudinal tube; 11. a transverse tube; 12. an electromagnetic valve; 13. a shunt; 14. a protective cover; 15. a display; 16. control buttons.
Detailed Description
The following detailed description of the embodiments of the present utility model will be made more apparent to those skilled in the art from the following detailed description, in which the utility model is embodied in several, but not all, embodiments of the utility model. The utility model may be embodied or applied in other specific forms and features of the following examples and examples may be combined with each other without conflict, all other examples being contemplated by those of ordinary skill in the art without undue burden from the present disclosure, based on the examples of the utility model.
Examples
Referring to fig. 1-5, a multi-mouse heart perfusion device in the present embodiment includes a water pump 1, a housing 2, a water container 3, a water inlet pipe 4, a water outlet pipe 5 and a controller 6; the water pump 1, the water container 3, the water inlet pipe 4, the water outlet pipe 5 and the controller 6 are all arranged in the shell 2, the water pump 1, the controller 6 and the water container 3 are fixedly connected to the bottom surface in the shell 2, the water inlet of the water pump 1 is connected with the water container 3 through the water inlet pipe 4, the water outlet of the water pump 1 is fixedly connected with the water outlet pipe 5, the controller 6 is connected with the water pump 1 through a signal line, the rear end of the water outlet pipe 5 is provided with a shunt pipe 13, and at least one shunt pipe 13 is arranged; the controller 6 can perform variable-frequency speed regulation on the water pump 1 and can regulate the pressure of water during heart perfusion; the water pump 1 pumps out the liquid in the water container 3, flows through the water outlet pipe 5 to reach the shunt pipes 13, enters the injection needle for heart perfusion, then enters the heart of the mice to realize heart perfusion, and each shunt pipe 13 is connected with one mouse to realize simultaneous perfusion of multiple mice.
The water pump 1 is a centrifugal pump, and is connected with the controller 6 to realize variable frequency speed regulation, so as to regulate the pressure of water during heart perfusion.
The water container 3 is formed by splicing two cuboids, is integrally L-shaped, is provided with a groove, can hold physiological saline, is provided with a through hole at the joint of the water container 3 and the water pump 1, and the water inlet pipe 4 of the water pump 1 can extend into the through hole to suck the physiological saline.
Referring to fig. 1-3, the present embodiment adds the following technical features: (the structure of the housing 2 is specifically set as follows):
The whole shell 2 is cuboid, the inside is hollow, and an anti-slip layer is arranged at the bottom of the shell 2; preferably, the anti-slip layer is a rubber pad or a silica gel pad; the anti-slip layers are arranged at four corners of the bottom of the housing 2.
The top of the shell 2 is provided with a filling opening 7, physiological saline can be filled into the water container 3, the filling opening 7 is provided with a protective cover 14, the protective cover 14 is movably connected with the filling opening 7, and the protective cover 14 can be opened or closed.
In some embodiments, the liquid adding port 7 is circular, the liquid adding port 7 is arranged on the shell 2, a funnel is arranged at the lower part of the liquid adding port 7 and fixedly connected with the shell 2, and the lowest end of the funnel extends into the water container 3, so that liquid adding is accurate and convenient.
In some embodiments, the protective cover 14 is hinged to the housing 2.
The outside of the shell 2 is provided with a power line 8 and a plug 9, and the power line 8 is internally connected with the water pump 1 and the controller 6, so that the whole device can be powered.
Referring to fig. 2-3 and 5, the present embodiment has the following technical features: (the structure of the shunt tube 13 is specifically set as follows): pressure sensors are respectively arranged in the shunt tube 13 and the water container 3, and are connected with the controller 6 through signal lines; the water pressure in the side branch pipe 13 and the liquid amount in the water container 3 can be respectively obtained.
The shunt tubes 13 comprise a longitudinal tube 10 and at least one transverse tube 11, the transverse tube 11 is fixedly connected to the first side surface of the longitudinal tube 10, the second side surface of the longitudinal tube 10 is fixedly connected with the water outlet tube 5, and the longitudinal tube 10, the transverse tube 11 and the water outlet tube 5 are internally communicated; preferably, eight transverse tubes 11 are provided.
The end of the transversal tube 11 protrudes inside the housing 2 and can be adapted to the needle interface of the heart perfusion.
The shunt tube 13 is provided with the electromagnetic valve 12, the electromagnetic valve 12 is connected with the controller 6, the electromagnetic valve 12 is a normally closed electromagnetic valve 12, and the controller 6 can control the power on of the electromagnetic valve to control the opening or closing of the electromagnetic valve.
In some embodiments, a manual switch valve is provided on the shunt 13 to allow manual control of the opening and closing.
A display 15 and a control button 16 are arranged on the upper part of the shell 2; the display 15 is connected with the controller 6, the display 15 can display the pressure in each shunt tube 13, the control button 16 can control the pressure in the shunt tube 13, and the control button 16 can control the opening and closing of each shunt tube 13.
The controller 6 comprises a central controller 6, a data analysis module, a data storage module and a communication module, wherein the data analysis module, the data storage module and the communication module are respectively connected with the central controller 6; after the pressure value in each shunt tube 13 is set by an operator, the pressure detected by the pressure sensor is transmitted to a data analysis module for analysis and calculation, and then the analysis result is subjected to variable frequency speed regulation on the water pump 1 through the communication module by the central controller 6 until the set pressure value is reached in each shunt tube 13; and the set pressure value is effectively archived by utilizing the data storage module, so that the next continuous use is facilitated.
The working principle of the multi-mouse heart perfusion device is as follows: after a given pressure and a shunt tube 13 to be opened are set on a display 15, the controller 6 controls the electromagnetic valve 12 to be opened, a pressure sensor in the shunt tube 13 detects the water pressure and transmits a signal to the controller 6, the water pump 1 is subjected to variable frequency speed regulation through analysis and calculation by the controller 6, the given pressure is achieved in the shunt tube 13, the shunt tube 13 comprises a longitudinal tube 10 and a plurality of transverse tubes 11, the pressure in each transverse tube 11 is the same, the pressure sensor can be arranged in one transverse tube 11, and the pressure sensor can also be arranged in the plurality of transverse tubes 11.
When the device is used, the power supply is firstly switched on, then whether normal saline in the water container 3 is enough or not is checked, the given pressure is set on the display screen, the shunt tube 13 to be used is selected to be opened, if the perfusion pressure value is not set, the pressure value stored in the last experiment is used by default, and a plurality of mice can be simultaneously perfused by the set constant pressure, so that the experiment progress is accelerated, the experiment efficiency is improved, and the occupied area is reduced.
The above description of embodiments is only for the understanding of the present utility model. It should be noted that it will be apparent to those skilled in the art that modifications can be made to the present utility model without departing from the principles of the utility model, and such modifications will fall within the scope of the claims.
Claims (10)
1. The multi-mouse heart perfusion device is characterized by comprising a water pump, a shell, a water container, a water inlet pipe, a water outlet pipe and a controller; the water pump, the water container, the water inlet pipe, the water outlet pipe and the controller are all arranged in the shell, the water pump, the controller and the water container are fixedly connected to the bottom surface inside the shell, the water inlet of the water pump is connected with the water container through the water inlet pipe, the water outlet of the water pump is fixedly connected with the water outlet pipe, the controller is connected with the water pump through a signal line, the rear end of the water outlet pipe is provided with a shunt pipe, and at least one shunt pipe is arranged; the controller can carry out variable frequency speed regulation to the water pump, and can adjust the pressure of water when the heart is perfused.
2. The multi-mouse heart perfusion device of claim 1, wherein the whole shell is cuboid, the inside is hollow, and an anti-slip layer is arranged at the bottom of the shell.
3. The multi-mouse heart perfusion device according to claim 2, wherein a liquid filling opening is formed in the top of the housing, physiological saline can be filled into the water container, a protective cover is arranged on the liquid filling opening, and the protective cover is movably connected with the liquid filling opening.
4. The multi-mouse heart perfusion apparatus of claim 1, wherein a power cord and plug are provided on the outside of the housing, the power cord being connected internally to the water pump and controller.
5. The multi-mouse heart perfusion device of claim 1, wherein pressure sensors are respectively arranged in the shunt tube and the water container, and the pressure sensors are connected with the controller through signal lines.
6. The multi-mouse heart perfusion device of claim 1, wherein the shunt tube comprises a longitudinal tube and at least one transverse tube, the transverse tube is fixedly connected to a first side of the longitudinal tube, a second side of the longitudinal tube is fixedly connected to the outlet tube, and the longitudinal tube, the transverse tube and the outlet tube are internally communicated.
7. The multi-mouse cardiac perfusion apparatus of claim 6, wherein the lateral tube ends protrude within the housing, the lateral tube ends being adapted to interface with an injection needle of cardiac perfusion.
8. The multi-mouse heart perfusion device according to claim 6, wherein the shunt tube is provided with an electromagnetic valve, the electromagnetic valve is connected with a controller, the electromagnetic valve is a normally closed electromagnetic valve, and the controller can control the power supply to the electromagnetic valve to control the opening or closing of the electromagnetic valve.
9. The multi-mouse heart perfusion apparatus of claim 1, wherein a display and control buttons are provided on an upper portion of the housing; the display is connected with the controller.
10. The multi-mouse heart perfusion apparatus of any one of claims 1-9, wherein the controller includes a central controller, a data analysis module, a data storage module, and a communication module, each of the data analysis module, the data storage module, and the communication module being connected to the central controller; after the pressure value in each shunt tube is set by an operator, the pressure detected by the pressure sensor is transmitted to the data analysis module for analysis and calculation, and then the analysis result is subjected to variable frequency speed regulation on the water pump through the communication module by the central controller until the set pressure value is reached in the shunt tube; and effectively archiving the set pressure value by utilizing the data storage module.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202322754558.6U CN220859286U (en) | 2023-10-13 | 2023-10-13 | Multi-mouse heart perfusion device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202322754558.6U CN220859286U (en) | 2023-10-13 | 2023-10-13 | Multi-mouse heart perfusion device |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN220859286U true CN220859286U (en) | 2024-04-30 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202322754558.6U Active CN220859286U (en) | 2023-10-13 | 2023-10-13 | Multi-mouse heart perfusion device |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN220859286U (en) |
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2023
- 2023-10-13 CN CN202322754558.6U patent/CN220859286U/en active Active
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