CN220854377U - Solid phase extraction device - Google Patents
Solid phase extraction device Download PDFInfo
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- CN220854377U CN220854377U CN202322100069.9U CN202322100069U CN220854377U CN 220854377 U CN220854377 U CN 220854377U CN 202322100069 U CN202322100069 U CN 202322100069U CN 220854377 U CN220854377 U CN 220854377U
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- phase extraction
- solid phase
- ultrasonic
- extraction device
- bracket
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- 238000002414 normal-phase solid-phase extraction Methods 0.000 title claims abstract description 89
- 238000009210 therapy by ultrasound Methods 0.000 claims abstract description 9
- 238000000926 separation method Methods 0.000 abstract description 5
- 238000000605 extraction Methods 0.000 description 9
- 239000000126 substance Substances 0.000 description 6
- 238000010586 diagram Methods 0.000 description 4
- 230000002452 interceptive effect Effects 0.000 description 3
- 238000012545 processing Methods 0.000 description 3
- 238000001816 cooling Methods 0.000 description 2
- 239000000284 extract Substances 0.000 description 2
- 239000012466 permeate Substances 0.000 description 2
- 238000007789 sealing Methods 0.000 description 2
- 239000003463 adsorbent Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 210000000265 leukocyte Anatomy 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000002207 metabolite Substances 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000000630 rising effect Effects 0.000 description 1
- 239000004065 semiconductor Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 239000005341 toughened glass Substances 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 239000012780 transparent material Substances 0.000 description 1
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Abstract
The application relates to a solid phase extraction device. The solid phase extraction device comprises: a bracket; the ultrasonic assembly is arranged on the bracket and used for generating ultrasonic waves; the solid phase extraction component is connected with the ultrasonic component; and the collecting assembly is arranged on the bracket and used for collecting the separation matters generated by the solid-phase extraction assembly. The solid phase extraction device integrates ultrasonic treatment and solid phase extraction, and improves the sample treatment efficiency.
Description
Technical Field
The application relates to the field of sample extraction, in particular to a solid phase extraction device.
Background
Ultrasonic-based sample pretreatment techniques are widely used, for example, to achieve efficient disruption of platelets and leukocytes in plasma using ultrasonic waves to extract metabolites therefrom. Solid phase extraction is the separation of target and interfering substances in a sample by using a solid adsorbent. Current ultrasonic processing devices and solid phase extraction devices are separate, requiring an operator to manually transfer samples between the two devices.
Disclosure of utility model
Based on the problems, the application provides a solid phase extraction device which integrates ultrasonic treatment and solid phase extraction.
One embodiment of the present application provides a solid phase extraction device comprising: a bracket; an ultrasonic assembly for generating ultrasonic waves; the solid-phase extraction component is connected with the ultrasonic component and is used for carrying out ultrasonic treatment on a sample in the solid-phase extraction component; and the collection assembly is arranged on the bracket and used for collecting the separation matters generated by the solid-phase extraction assembly.
According to some embodiments of the application, the ultrasonic assembly comprises: the ultrasonic generator is arranged on the bracket; and the conducting rod is connected with the ultrasonic generator, and the solid phase extraction component is arranged on the conducting rod.
According to some embodiments of the application, the solid phase extraction module comprises: the bearing frame is connected with the ultrasonic assembly and is provided with bearing holes; the solid phase extraction column is arranged in the bearing hole.
According to some embodiments of the application, the collection assembly comprises: the tray is connected with the bracket in a lifting manner and is provided with a first air hole; the support seat is arranged on the tray and is provided with a container groove and a second air hole, and the second air hole is communicated with the first air hole; a separator container disposed in the container tank; the vacuum pump is connected with the first air hole; the vacuum cover is arranged on the supporting seat, and when the vacuum cover contacts with the solid-phase extraction component, the vacuum cover and the supporting seat form a closed cavity; the driver is connected with the bracket and used for driving the tray to lift.
According to some embodiments of the application, the collection assembly further comprises a cooler disposed at the support base.
According to some embodiments of the application, the vacuum enclosure is transparent.
According to some embodiments of the application, the stent comprises: a frame; a side plate provided on the frame; the door body is rotatably arranged on the frame.
According to some embodiments of the application, the support further comprises a guide bar disposed on the frame, and the collection assembly is coupled to the guide bar.
According to some embodiments of the application, the bracket further comprises a leg disposed at the bottom of the frame.
According to some embodiments of the application, the door body is provided with a viewing window.
In the solid phase extraction device, the ultrasonic assembly is connected with the solid phase extraction assembly, the ultrasonic treatment of the sample is completed in the solid phase extraction assembly, the ultrasonic treatment and the solid phase extraction are integrated, and the sample treatment efficiency is improved.
Drawings
In order to more clearly illustrate the technical solutions of the present application, the drawings that are needed in the description of the embodiments will be briefly described below, it being obvious that the drawings in the following description are only some embodiments of the present application, and that other drawings may be obtained according to these drawings by a person skilled in the art without departing from the scope of the present application as claimed.
FIG. 1 is a schematic diagram of a solid phase extraction device according to an embodiment of the present application;
FIG. 2 is a schematic diagram of the internal structure of a solid phase extraction device according to an embodiment of the present application;
FIG. 3 is a schematic view of an ultrasonic module and a solid phase extraction module according to an embodiment of the present application;
FIG. 4 is a schematic view of an embodiment of a carrier of the present application;
FIG. 5 is a schematic diagram of a collection assembly according to an embodiment of the application;
FIG. 6 is a schematic diagram showing the separation of the vacuum cover from the support base according to the embodiment of the application;
FIG. 7 is a schematic view of a tray according to an embodiment of the application;
FIG. 8 is a schematic view of a support base according to an embodiment of the present application;
FIG. 9 is a schematic view of a closed cavity in accordance with an embodiment of the present application;
FIG. 10 is a schematic view of a stent according to an embodiment of the present application;
fig. 11 is a schematic view of a guide bar according to an embodiment of the present application.
In the figure: 100. a solid phase extraction device; 1. a bracket; 11. a frame; 12. a side plate; 13. a door body; 131. an observation window; 14. a guide rod; 15. a support leg; 2. an ultrasonic assembly; 21. an ultrasonic generator; 22. a conductive rod; 3. a solid phase extraction assembly; 31. a carrier; 311. a mounting hole; 312. a bearing hole; 32. a solid phase extraction column; 4. a collection assembly; 41. a tray; 411. a first air hole; 412. a guide hole; 413. a drive hole; 42. a support base; 421. a container tank; 422. a second air hole; 43. a separator container; 44. a vacuum pump; 45. a vacuum cover; 46. a driver; 47. a first seal ring; 48. a cooler.
Detailed Description
The following description of the embodiments of the present application will be made more complete and clear by reference to the accompanying drawings of embodiments of the present application, wherein it is evident that the embodiments described are some, but not all, of the embodiments of the present application. All other embodiments, which can be made by those skilled in the art based on the embodiments of the application without making any inventive effort, are intended to be within the scope of the application.
As shown in fig. 1 and 2, an embodiment of the present application provides a solid phase extraction device 100, the solid phase extraction device 100 including a support 1, an ultrasonic assembly 2, a solid phase extraction assembly 3, and a collection assembly 4. The solid phase extraction device 100 integrates ultrasonic pretreatment and solid phase extraction, and improves sample processing efficiency.
The support 1 supports an ultrasonic module 2, a solid phase extraction module 3 and a collection module 4. The ultrasonic assembly 2 is arranged on the bracket 1 and is used for generating ultrasonic waves and transmitting the ultrasonic waves to the solid-phase extraction assembly 3.
The solid phase extraction module 3 is connected with the ultrasonic module 2. The sample is placed in the solid-phase extraction component 3, the ultrasonic wave generated by the ultrasonic component 2 is transmitted to the solid-phase extraction component 3, and the sample in the solid-phase extraction component 3 is subjected to ultrasonic treatment. For example, the sample is plasma. The solid phase extraction module 3 is also used for solid phase extraction of the sample after ultrasonic treatment to obtain a separated matter.
The collection assembly 4 is disposed on the support 1, e.g., the collection assembly 4 is located below the solid phase extraction assembly 3. The collection assembly 4 is used to collect the separation produced by the solid phase extraction assembly 3.
The solid phase extraction device 100 integrates ultrasonic wave front treatment and solid phase extraction technology, and ultrasonic wave treatment is carried out on a sample in a solid phase extraction component, so that the sample treatment efficiency is improved.
As shown in fig. 3, in some embodiments, the ultrasonic assembly 2 includes an ultrasonic generator 21 and a conductive rod 22. The ultrasonic generator 21 is arranged at the top end of the bracket, and the conducting rod 22 is connected with the ultrasonic generator 21. The ultrasonic wave generated by the ultrasonic generator 21 is conducted through the conductive rod 22. The ultrasonic generator 21 may be an existing ultrasonic generator.
As shown in fig. 3 and 4, in some embodiments, the solid phase extraction module 3 includes a carrier 31 and a solid phase extraction column 32.
The carrier 31 is provided on the conductive rod 22, for example, the carrier 31 is provided with a mounting hole 311, the conductive rod 22 penetrates into the mounting hole 311, and the carrier 31 and the conductive rod 22 are connected by a pin. The carrier 31 is provided with a plurality of carrier holes 312, optionally a plurality of carrier holes 312, the carrier holes 312 being circumferentially distributed about the axis of the carrier 31.
The solid phase extraction columns 32 are disposed in the carrying holes 312, and each carrying hole 312 corresponds to one solid phase extraction column 32. The solid phase extraction column 32 passes through the support aperture 312. The solid phase extraction column 32 is provided with an extraction layer, and a sample is injected into the solid phase extraction column 32 from the top end opening of the solid phase extraction column 32, and the sample cannot permeate through the extraction layer under normal pressure. Changing the lower part of the solid phase extraction column 32 into a vacuum condition, under the action of an upper pressure difference and a lower pressure difference, the sample penetrates through the extraction layer, the extraction layer extracts the flowing sample, the interfering substances remain in the extraction layer, and the separated substances are discharged from the bottom end opening of the solid phase extraction column 32. Alternatively, the solid phase extraction column 32 is an existing solid phase extraction column.
As shown in fig. 5 and 6, in some embodiments, the collection assembly 4 includes a tray 41, a support base 42, a separator container 43, a vacuum pump 44, a vacuum hood 45, and a drive 46.
As shown in fig. 7, the tray 41 is connected to the stand 1 so as to be movable up and down, and the tray 41 is provided with a first air hole 411.
As shown in fig. 8, the support base 42 is disposed on the top surface of the tray 41. The support base 42 is provided with a container groove 421 and a second air hole 422. The plurality of container grooves 421 are circumferentially distributed around the axis of the support base 42. The second air holes 422 communicate with the first air holes 411 of the tray 41. Alternatively, the conductive rod 22 can penetrate into the second air hole 422, the conductive rod 22 does not close the second air hole 422, and after the conductive rod 22 penetrates into the second air hole 422, the air flow can still pass through the second air hole 422.
A separator container 43 is disposed in the container groove 421, the separator container 43 is disposed below the solid phase extraction columns 32, each separator container 43 corresponds to one of the solid phase extraction columns 32, and the separator container 43 is used for collecting the separator discharged from the solid phase extraction column 32. Alternatively, the isolate container 43 is a test tube.
The vacuum pump 44 is disposed on the bracket 1, and the vacuum pump 44 is connected to the first air hole 411. Alternatively, the vacuum pump 44 is connected to the first air hole 411 by a hose.
As shown in fig. 9, a vacuum cover 45 is provided on the support base 42, and the vacuum cover 45 has a substantially sleeve shape. For example, the support base 42 includes a large diameter portion and a small diameter portion connected to each other, the outer diameter of the vacuum cover 45 is smaller than the diameter of the large diameter portion, the inner diameter of the vacuum cover 45 is slightly larger than the diameter of the small diameter portion, the vacuum cover 45 is provided on the end face of the large diameter portion, and the small diameter portion is located in the vacuum cover 45. The support base 42 can drive the vacuum cover 45 to lift. When the vacuum cover 45 is lifted to be in contact with the carrier 31 of the solid-phase extraction module 3, the carrier 31, the vacuum cover 45 and the supporting seat 42 form a closed cavity.
The driver 46 is provided on the bracket 1, the driver 46 is connected to the tray 41, and the driver 46 is used for driving the tray 41 to lift. For example, the driver 46 is a cylinder, and the driving end of the driver 46 is connected to the driving hole 413 of the tray 41.
After the sample in the solid-phase extraction column 32 is subjected to ultrasonic treatment, the driver 46 drives the tray 41 to ascend, the supporting seat 42, the separator container 43 and the vacuum cover 45 ascend along with the tray 41, and when the vacuum cover 45 is in contact with the carrier 31, the vacuum cover 45 and the supporting seat 42 form a closed cavity. The tray 41 stops moving after rising to a predetermined position. The vacuum pump 44 is started, the vacuum pump 44 pumps out the gas in the closed cavity, the bottom end of the solid phase extraction column 32 is positioned in the closed cavity, the sample permeates the extraction layer under the action of the up-down pressure difference, the extraction layer extracts the flowing sample, the interfering substances remain in the extraction layer, and the separated substances flow into the separated substance container 43 from the bottom end opening of the solid phase extraction column 32.
After the solid phase extraction is completed, the tray 41 is driven to move downward by the driver 46, and the support base 42, the separator container 43 and the vacuum cover 45 move downward following the tray 41.
Optionally, an air inlet valve and an air outlet valve are arranged on the vacuum cover 45, when the vacuum cover 45 ascends, the air inlet valve is closed, and when the support seat 42 continues to ascend after the vacuum cover 45 contacts with the bearing frame 31, more air in the closed cavity is discharged by the air outlet valve, so that the closed cavity is kept at normal pressure. When the vacuum cover 45 descends, the air inlet valve is opened, and the inside of the closed cavity is changed from a vacuum state to a normal pressure state, so that the vacuum cover 45 is convenient to descend.
A first sealing ring 47 may be provided between the support base 42 and the vacuum housing 45 to improve the sealing of the closed cavity. Seals may also be provided between the carrier 31 and the vacuum enclosure 45.
As shown in fig. 8, in some embodiments, the collection assembly 4 further includes a cooler 48, the cooler 48 being disposed on the support base 42. Optionally, the cooler 48 is a semiconductor cooling fin. The provision of the cooler 48 facilitates cooling of the separator in the separator vessel 43.
In some embodiments, the vacuum enclosure 45 is a transparent material, e.g., the vacuum enclosure 45 is a tempered glass, to facilitate operator observation of the status of sample processing.
As shown in fig. 10, in some embodiments, the bracket 1 includes a frame 11, side plates 12, and a door body 13. The frame 11 may be made of a profile. The side plates 12 close three side surfaces and top surface of the frame 11. Optionally, the side plates 12 are made of a sound-proof material to reduce noise during operation of the solid phase extraction device 100. The door 13 is rotatably provided on the frame 11. The solid phase extraction device 100 is operated to close the door 13.
As shown in fig. 11, in some embodiments, the rack 1 further includes a guide bar 14, the guide bar 14 is disposed on the frame 11, and the tray 41 of the collection assembly 4 is slidably disposed on the guide bar 14, e.g., the guide bar 14 passes through a guide hole 412 of the tray 41. The guide bar 14 guides the lifting and lowering of the tray 41.
In some embodiments, the stand 1 further comprises a leg 15, the leg 15 being provided at the bottom of the frame 11. Optionally, a plurality of legs 15 are threadedly coupled to the frame 11, the rotating legs 15 being capable of leveling the frame 11.
In some embodiments, the door 13 is provided with a viewing window 131 to facilitate an operator in viewing the operation of the solid phase extraction device 100 when the solid phase extraction device 100 is in operation.
The above description of the embodiments of the present application is provided in detail. The principles and embodiments of the present application have been described herein with reference to specific examples, which are provided to facilitate understanding of the technical solution of the present application and the core ideas thereof. Therefore, those skilled in the art will appreciate that many changes and modifications can be made in the specific embodiments and applications of the application based on the spirit and scope of the application. In view of the foregoing, this description should not be construed as limiting the application.
Claims (9)
1. A solid phase extraction device, comprising:
A bracket;
The ultrasonic assembly is arranged on the bracket and used for generating ultrasonic waves;
The solid-phase extraction component is connected with the ultrasonic component and is used for carrying out ultrasonic treatment on a sample in the solid-phase extraction component;
the collection subassembly, set up in on the support, be used for collecting the separator that the solid phase extraction subassembly produced, the collection subassembly includes:
the tray is connected with the bracket in a lifting manner and is provided with a first air hole;
The support seat is arranged on the tray and is provided with a container groove and a second air hole, and the second air hole is communicated with the first air hole;
A separator container disposed in the container tank;
The vacuum pump is connected with the first air hole;
The vacuum cover is arranged on the supporting seat, and when the vacuum cover contacts with the solid-phase extraction component, the vacuum cover and the supporting seat form a closed cavity;
The driver is connected with the bracket and used for driving the tray to lift.
2. The solid phase extraction device of claim 1, wherein the ultrasonic assembly comprises:
the ultrasonic generator is arranged on the bracket;
and the conducting rod is connected with the ultrasonic generator, and the solid phase extraction component is arranged on the conducting rod.
3. The solid phase extraction apparatus of claim 1, wherein the solid phase extraction module comprises:
The bearing frame is connected with the ultrasonic assembly and is provided with bearing holes;
The solid phase extraction column is arranged in the bearing hole.
4. The solid phase extraction device of claim 1, wherein the collection assembly further comprises a cooler disposed in the support base.
5. The solid phase extraction device according to claim 1, wherein the vacuum enclosure is transparent.
6. The solid phase extraction device of claim 1, wherein the support comprises:
a frame;
a side plate provided on the frame;
The door body is rotatably arranged on the frame.
7. The solid phase extraction device of claim 6, wherein the support further comprises a guide bar disposed on the frame, and the collection assembly is coupled to the guide bar.
8. The solid phase extraction device of claim 6, wherein the support further comprises legs disposed at the bottom of the frame.
9. The solid phase extraction device according to claim 6, wherein the door body is provided with an observation window.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202322100069.9U CN220854377U (en) | 2023-08-04 | 2023-08-04 | Solid phase extraction device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202322100069.9U CN220854377U (en) | 2023-08-04 | 2023-08-04 | Solid phase extraction device |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN220854377U true CN220854377U (en) | 2024-04-26 |
Family
ID=90782534
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202322100069.9U Active CN220854377U (en) | 2023-08-04 | 2023-08-04 | Solid phase extraction device |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN220854377U (en) |
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2023
- 2023-08-04 CN CN202322100069.9U patent/CN220854377U/en active Active
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