CN220835060U - Acylation mixer for recombinant human erythropoietin processing stock solution - Google Patents
Acylation mixer for recombinant human erythropoietin processing stock solution Download PDFInfo
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- CN220835060U CN220835060U CN202322623807.8U CN202322623807U CN220835060U CN 220835060 U CN220835060 U CN 220835060U CN 202322623807 U CN202322623807 U CN 202322623807U CN 220835060 U CN220835060 U CN 220835060U
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- wall
- fixed mounting
- mixing box
- box
- acylation
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- 238000005917 acylation reaction Methods 0.000 title claims abstract description 26
- 101000987586 Homo sapiens Eosinophil peroxidase Proteins 0.000 title claims abstract description 24
- 101000920686 Homo sapiens Erythropoietin Proteins 0.000 title claims abstract description 24
- 102000044890 human EPO Human genes 0.000 title claims abstract description 24
- 239000011550 stock solution Substances 0.000 title claims abstract description 21
- 230000010933 acylation Effects 0.000 title claims abstract description 16
- 238000003756 stirring Methods 0.000 claims abstract description 31
- 230000007246 mechanism Effects 0.000 claims abstract description 19
- 238000001914 filtration Methods 0.000 claims abstract description 17
- 238000004140 cleaning Methods 0.000 claims abstract description 16
- 241000220317 Rosa Species 0.000 claims description 15
- 238000007789 sealing Methods 0.000 claims description 10
- 239000002912 waste gas Substances 0.000 abstract description 13
- 102000003951 Erythropoietin Human genes 0.000 abstract description 6
- 108090000394 Erythropoietin Proteins 0.000 abstract description 6
- 230000002457 bidirectional effect Effects 0.000 abstract description 6
- 229940105423 erythropoietin Drugs 0.000 abstract description 6
- OXCMYAYHXIHQOA-UHFFFAOYSA-N potassium;[2-butyl-5-chloro-3-[[4-[2-(1,2,4-triaza-3-azanidacyclopenta-1,4-dien-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol Chemical compound [K+].CCCCC1=NC(Cl)=C(CO)N1CC1=CC=C(C=2C(=CC=CC=2)C2=N[N-]N=N2)C=C1 OXCMYAYHXIHQOA-UHFFFAOYSA-N 0.000 abstract description 6
- 230000008901 benefit Effects 0.000 abstract description 4
- 230000003993 interaction Effects 0.000 abstract description 3
- 239000003795 chemical substances by application Substances 0.000 description 7
- 239000012535 impurity Substances 0.000 description 6
- 239000007789 gas Substances 0.000 description 5
- 230000001680 brushing effect Effects 0.000 description 2
- 210000003013 erythroid precursor cell Anatomy 0.000 description 2
- 230000007774 longterm Effects 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 102000003886 Glycoproteins Human genes 0.000 description 1
- 108090000288 Glycoproteins Proteins 0.000 description 1
- 238000013019 agitation Methods 0.000 description 1
- 210000001185 bone marrow Anatomy 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000010437 erythropoiesis Effects 0.000 description 1
- 230000003394 haemopoietic effect Effects 0.000 description 1
- 210000003958 hematopoietic stem cell Anatomy 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000008521 reorganization Effects 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
Landscapes
- Mixers Of The Rotary Stirring Type (AREA)
Abstract
The utility model discloses a recombined human erythropoietin processing stock solution acylation mixer, which relates to the technical field of erythropoietin processing and comprises a mixing box, wherein a bottom plate is fixedly arranged at the bottom of the mixing box, a stirring mechanism is arranged in the mixing box, a filtering mechanism is arranged on one side of the mixing box, the stirring mechanism comprises a first motor, stirring rods and stirring blades, the first motor is fixedly arranged on the inner wall of one side of the mixing box, the stirring rods are movably arranged on the inner wall of the mixing box, and the number of the stirring rods is two. According to the utility model, under the interaction of the connecting pipe, the filter box, the filter screen, the air inlet nozzle, the sliding block bidirectional threaded rod, the cleaning brush, the rubber ring and the connecting block, waste gas generated by the acylation reaction enters the filter box through the air inlet nozzle and the connecting pipe, and the filter screen in the filter box filters the waste gas and then is discharged through the exhaust port, so that the filter has the advantage of conveniently filtering the waste gas.
Description
Technical Field
The utility model relates to the technical field of erythropoietin processing, in particular to a machine for acylating and mixing a recombinant human erythropoietin processing stock solution.
Background
Erythropoietin is also known as erythropoietin or recombinant human erythropoietin. It is a glycoprotein produced by the kidneys that promotes erythropoiesis in the bone marrow hematopoietic microenvironment. In the prior art, an acylating agent is sometimes added to erythropoietin using an acylating mixer to produce an acylation reaction, which is capable of stimulating hematopoietic stem cells to form erythroid progenitor cells, or to act on erythroid progenitor cells and subsequent cells.
However, in the use process of the conventional acylation mixing device for the raw liquid for processing the recombinant human erythropoietin, waste gas generated by the acylation reaction is easy to be discharged into the air, so that the air is polluted.
Disclosure of utility model
The utility model provides a recombinant human erythropoietin processing stock solution acylation mixer, which solves the problems in the background technology.
In order to solve the technical problems, the utility model adopts the following technical scheme:
The utility model provides a reorganization people's erythropoietin processing stoste acylation mixes machine, includes the mixing box, the bottom fixed mounting of mixing box has the bottom plate, the inside of mixing box is provided with rabbling mechanism, one side of mixing box is provided with filtering mechanism, the rabbling mechanism is including first motor, puddler and stirring leaf, first motor fixed mounting is on one side inner wall of mixing box, puddler movable mounting is on the inner wall of mixing box, the puddler has two, stirring leaf fixed mounting is on the outer wall of puddler, filtering mechanism is including connecting pipe, rose box and filter screen, connecting pipe fixed mounting is on the inner wall of mixing box, rose box fixed mounting is at the top of bottom plate, the one end of connecting pipe extends to the inside of rose box and with the inner wall fixed connection of rose box, filter screen fixed mounting is on the inner wall of rose box.
The technical scheme of the utility model is further improved as follows: the top of mixing box has seted up the opening, the top fixed mounting of mixing box has the bracing piece, movable mounting has the turning block on the outer wall of bracing piece, the inner wall movable mounting of turning block has a door shape frame, the inner wall movable mounting of door shape frame has the threaded rod.
The technical scheme of the utility model is further improved as follows: the bottom outer wall of threaded rod and the inner wall swing joint of turning block, the bottom fixed mounting of door shape frame has sealed pad, sealed bottom that fills up contacts with the top of mixing box, fixed mounting has the driving gear on the output shaft of first motor, fixed mounting has driven gear on the outer wall of puddler, the outer wall of driving gear meshes with driven gear's outer wall.
The technical scheme of the utility model is further improved as follows: one end fixed mounting of connecting pipe has the air inlet nozzle, fixed mounting has the backup pad on the outer wall of one side of mixing box, the top fixed mounting of backup pad has the second motor, fixed mounting has two-way threaded rod on the output shaft of second motor, the outer wall and the inner wall swing joint of mixing box of two-way threaded rod, movable mounting has the slider on the outer wall of two-way threaded rod, the slider has two, the gas vent has been seted up at the top of rose box.
The technical scheme of the utility model is further improved as follows: the inner wall movable mounting of slider has the guide bar, the one end of guide bar and one side inner wall fixed connection of mixing box, the top fixed mounting of slider has the connecting block, the top fixed mounting of connecting block has the rubber circle, the top fixed mounting of rubber circle has the cleaning brush.
The technical scheme of the utility model is further improved as follows: the top of cleaning brush contacts with the bottom of filter screen, the bottom fixed mounting of cleaning brush has the gag lever post, the outer wall of gag lever post and the inner wall swing joint of connecting block, the discharge port has been seted up to the bottom of rose box, the inside of discharge port is provided with the sealing plug.
By adopting the technical scheme, compared with the prior art, the utility model has the following technical progress:
1. The utility model provides a recombined human erythropoietin processing stock solution acylation mixer, which is characterized in that under the interaction of a first motor, a stirring rod, a rotating block, a door-shaped frame, a threaded rod and a sealing gasket, the recombined human erythropoietin stock solution and an acylating agent are placed into a mixing box through an opening, the rotating block is rotated, the threaded rod is rotated to drive the door-shaped frame to drive the sealing gasket to move downwards, the opening is sealed, the first motor is started to drive a driving gear to drive the stirring rod on a driven gear to rotate, and the stirring rod drives a stirring blade to rotate, so that the recombined human erythropoietin stock solution and the acylating agent are fully mixed, the acylation reaction efficiency is increased, and the advantages of convenience in mixing are achieved.
2. The utility model provides a recombined human erythropoietin processing stock solution acylation mixer, which is characterized in that under the interaction of a connecting pipe, a filter box, a filter screen, an air inlet nozzle, a sliding block bidirectional threaded rod, a cleaning brush, a rubber ring and a connecting block, waste gas generated by acylation reaction enters the filter box through the air inlet nozzle and the connecting pipe, and the filter screen in the filter box filters the waste gas and then discharges the waste gas through an exhaust port, so that the utility model has the advantage of conveniently filtering the waste gas.
Drawings
FIG. 1 is a schematic diagram of the structure of the present utility model;
FIG. 2 is a schematic cross-sectional view of a structural agitation mechanism of the present utility model;
FIG. 3 is a schematic cross-sectional view of a structural filter mechanism of the present utility model;
fig. 4 is an enlarged schematic view of the structure a portion of the present utility model.
In the figure: 1. a mixing box; 11. a bottom plate; 2. a stirring mechanism; 21. a first motor; 22. a stirring rod; 23. stirring the leaves; 24. a rotating block; 25. a door-shaped frame; 26. a threaded rod; 27. a sealing gasket; 3. a filtering mechanism; 31. a connecting pipe; 32. a filter box; 33. a filter screen; 34. an air inlet nozzle; 35. a slide block; 36. a two-way threaded rod; 37. a cleaning brush; 38. a rubber ring; 39. and (5) connecting a block.
Detailed Description
The utility model is further illustrated by the following examples:
Example 1
As shown in fig. 1-4, the utility model provides a recombined human erythropoietin processing stock solution acylation mixer, which comprises a mixing box 1, a bottom plate 11 is fixedly arranged at the bottom of the mixing box 1, a stirring mechanism 2 is arranged in the mixing box 1, a filtering mechanism 3 is arranged at one side of the mixing box 1, the stirring mechanism 2 comprises a first motor 21, a stirring rod 22 and stirring blades 23, the first motor 21 is fixedly arranged on the inner wall of one side of the mixing box 1, the stirring rod 22 is movably arranged on the inner wall of the mixing box 1, the stirring blades 22 are two, the stirring blades 23 are fixedly arranged on the outer wall of the stirring rod 22, the filtering mechanism 3 comprises a connecting pipe 31, a filtering box 32 and a filter screen 33, the connecting pipe 31 is fixedly arranged on the inner wall of the mixing box 1, the filtering box 32 is fixedly arranged at the top of the bottom plate 11, one end of the connecting pipe 31 extends to the inside of the filtering box 32 and is fixedly connected with the inner wall of the filtering box 32, the filter screen 33 is fixedly arranged on the inner wall of the filtering box 32, the top of the box 1 is provided with an opening, a supporting rod is fixedly arranged at the top of the mixing box 1, a movable block 24 is movably arranged on the outer wall of the supporting rod, a movable block 24 is movably arranged on the outer wall of the driving rod is movably arranged on the driving rod 25, the driving rod is movably arranged on the driving rod 25 is fixedly connected with the bottom end 25, the driving rod is fixedly arranged on the driving rod 25, the driving rod is fixedly connected with the driving rod 25, and the driving rod is fixedly arranged on the driving rod 25, and the driving rod 25 is fixedly connected with the driving rod 25.
In this embodiment, the recombinant human erythropoietin stock solution and the acylating agent are placed into the mixing box 1 through the opening, the rotating block 24 drives the sealing gasket 27 on the door-shaped frame 25 to move to the upper side of the opening, the rotating threaded rod 26 drives the door-shaped frame 25 to move downwards, the door-shaped frame 25 drives the sealing gasket 27 to move downwards, the opening is sealed, the first motor 21 is started to drive the driving gear to rotate, the driving gear drives the stirring rod 22 on the driven gear to rotate, and the stirring rod 22 drives the stirring blade 23 to rotate, so that the recombinant human erythropoietin stock solution and the acylating agent are fully mixed, and the acylation reaction efficiency is increased.
Example 2
As shown in fig. 1-4, on the basis of embodiment 1, the present utility model provides a technical solution: preferably, one end of the connecting pipe 31 is fixedly provided with an air inlet nozzle 34, one side outer wall of the mixing box 1 is fixedly provided with a supporting plate, the top of the supporting plate is fixedly provided with a second motor, an output shaft of the second motor is fixedly provided with a two-way threaded rod 36, the outer wall of the two-way threaded rod 36 is movably connected with the inner wall of the mixing box 1, the outer wall of the two-way threaded rod 36 is movably provided with two sliding blocks 35, and the top of the filtering box 32 is provided with an air outlet.
In this embodiment, the exhaust gas generated during the acylation reaction in the mixing box 1 enters the connecting pipe 31 through the air inlet nozzle 34, the connecting pipe 31 conveys the exhaust gas into the filter box 32, and the filter screen 33 in the filter box 32 filters the exhaust gas and then discharges the exhaust gas through the air outlet.
Example 3
As shown in fig. 1-4, on the basis of embodiment 1, the present utility model provides a technical solution: preferably, the inner wall movable mounting of slider 35 has the guide bar, the one end of guide bar and the one side inner wall fixed connection of mixing box 1, the top fixed mounting of slider 35 has connecting block 39, the top fixed mounting of connecting block 39 has rubber circle 38, the top fixed mounting of rubber circle 38 has cleaning brush 37, the top of cleaning brush 37 contacts with the bottom of filter screen 33, the bottom fixed mounting of cleaning brush 37 has the gag lever post, the outer wall of gag lever post and the inner wall swing joint of connecting block 39, the discharge port has been seted up to the bottom of rose box 32, the inside of discharge port is provided with the sealing plug.
In this embodiment, when the filter screen 33 is blocked by impurities after long-term use, the second motor is started to drive the bidirectional threaded rod 36 to rotate, the bidirectional threaded rod 36 drives the two sliding blocks 35 to move, the sliding blocks 35 drive the limiting rods on the connecting blocks 39 to move, the limiting rods drive the cleaning brushes 37 to move, impurities on the filter screen 33 are brushed, the set rubber rings 38 have elasticity, the cleaning brushes 37 are always spring with the filter screen 33 when moving, and the brushing impurity removing effect is improved.
The working principle of the acylation mixer for the processing stock solution of the recombinant human erythropoietin is specifically described below.
As shown in fig. 1 to 4, when the acylation reaction is required to be carried out on the stock solution of the recombinant human erythropoietin, the stock solution of the recombinant human erythropoietin and the acylating agent are put into the mixing box 1 through the opening, the rotary block 24 drives the sealing gasket 27 on the door-shaped frame 25 to move to the upper part of the opening, the rotary threaded rod 26 drives the door-shaped frame 25 to move downwards, the door-shaped frame 25 drives the sealing gasket 27 to move downwards, the opening is sealed, the first motor 21 is started to drive the driving gear to rotate, the driving gear drives the stirring rod 22 on the driven gear to rotate, the stirring rod 22 drives the stirring blade 23 to rotate, the stock solution of the recombinant human erythropoietin and the acylating agent are fully mixed, the acylation reaction efficiency is improved, the convenient mixing is provided, when the acylation reaction is carried out in the mixing box 1, the generated waste gas enters the connecting pipe 31 through the air inlet nozzle 34, the connecting pipe 31 conveys the waste gas into the filter box 32, the filter screen 33 in the filter box 32 filters the waste gas and discharges the waste gas through the air outlet, when the filter screen 33 is blocked by impurities after long-term use, the second motor is started to drive the bidirectional threaded rod 36 to rotate, the bidirectional threaded rod 36 drives the two sliding blocks 35 to move, the sliding blocks 35 drive the limiting rod on the connecting block 39 to move, the limiting rod drives the cleaning brush 37 to move, the impurities on the filter screen 33 are brushed, the arranged rubber ring 38 has elasticity, the cleaning brush 37 is always spring with the filter screen 33 when moving, the impurity brushing effect is increased, and the device has the advantage of conveniently filtering the waste gas.
The foregoing utility model has been generally described in great detail, but it will be apparent to those skilled in the art that modifications and improvements can be made thereto. Accordingly, it is intended to cover modifications or improvements within the spirit of the inventive concepts.
Claims (6)
1. The utility model provides a recombined human erythropoietin processing stoste acylation mixes machine, includes mixing box (1), the bottom fixed mounting of mixing box (1) has bottom plate (11), its characterized in that: the inside of mixing box (1) is provided with rabbling mechanism (2), one side of mixing box (1) is provided with filtering mechanism (3), rabbling mechanism (2) are including first motor (21), puddler (22) and stirring leaf (23), first motor (21) fixed mounting is on one side inner wall of mixing box (1), puddler (22) movable mounting is on the inner wall of mixing box (1), puddler (22) have two, stirring leaf (23) fixed mounting is on the outer wall of puddler (22), filtering mechanism (3) are including connecting pipe (31), rose box (32) and filter screen (33), connecting pipe (31) fixed mounting is on the inner wall of mixing box (1), the top of rose box (32) fixed mounting is at bottom plate (11), the one end of connecting pipe (31) extends to the inside of rose box (32) and with the inner wall fixed connection of rose box (32), filter screen (33) fixed mounting is on the inner wall of rose box (32).
2. The acylation mixer for recombinant human erythropoietin processing stock solution as set forth in claim 1, wherein: the top of mixing box (1) has seted up the opening, the top fixed mounting of mixing box (1) has the bracing piece, movable mounting has rotor block (24) on the outer wall of bracing piece, the inner wall movable mounting of rotor block (24) has door shape frame (25), the inner wall movable mounting of door shape frame (25) has threaded rod (26).
3. The acylation mixer for recombinant human erythropoietin processing stock solution according to claim 2, wherein: the bottom outer wall of threaded rod (26) and the inner wall swing joint of turning block (24), the bottom fixed mounting of door shape frame (25) has sealed pad (27), the bottom of sealed pad (27) contacts with the top of mixing box (1), fixed mounting has the driving gear on the output shaft of first motor (21), fixed mounting has driven gear on the outer wall of puddler (22), the outer wall of driving gear meshes with driven gear's outer wall.
4. The acylation mixer for recombinant human erythropoietin processing stock solution as set forth in claim 1, wherein: one end fixed mounting of connecting pipe (31) has suction nozzle (34), fixed mounting has the backup pad on the outer wall of one side of mixing box (1), the top fixed mounting of backup pad has the second motor, fixed mounting has two-way threaded rod (36) on the output shaft of second motor, the outer wall and the inner wall swing joint of mixing box (1) of two-way threaded rod (36), movable mounting has slider (35) on the outer wall of two-way threaded rod (36), slider (35) have two, the gas vent has been seted up at the top of rose box (32).
5. A recombinant human erythropoietin processing stock solution acylation mixer as set forth in claim 4, wherein: the inner wall movable mounting of slider (35) has the guide bar, the one end of guide bar and one side inner wall fixed connection of mixing box (1), the top fixed mounting of slider (35) has connecting block (39), the top fixed mounting of connecting block (39) has rubber circle (38), the top fixed mounting of rubber circle (38) has cleaning brush (37).
6. A recombinant human erythropoietin processing stock solution acylation mixer as set forth in claim 5, wherein: the top of cleaning brush (37) contacts with the bottom of filter screen (33), the bottom fixed mounting of cleaning brush (37) has the gag lever post, the outer wall of gag lever post and the inner wall swing joint of connecting block (39), the discharge port has been seted up to the bottom of rose box (32), the inside of discharge port is provided with the sealing plug.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202322623807.8U CN220835060U (en) | 2023-09-26 | 2023-09-26 | Acylation mixer for recombinant human erythropoietin processing stock solution |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202322623807.8U CN220835060U (en) | 2023-09-26 | 2023-09-26 | Acylation mixer for recombinant human erythropoietin processing stock solution |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN220835060U true CN220835060U (en) | 2024-04-26 |
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ID=90787245
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202322623807.8U Active CN220835060U (en) | 2023-09-26 | 2023-09-26 | Acylation mixer for recombinant human erythropoietin processing stock solution |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN220835060U (en) |
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2023
- 2023-09-26 CN CN202322623807.8U patent/CN220835060U/en active Active
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