CN220812423U - Cell screening device - Google Patents
Cell screening device Download PDFInfo
- Publication number
- CN220812423U CN220812423U CN202322555883.XU CN202322555883U CN220812423U CN 220812423 U CN220812423 U CN 220812423U CN 202322555883 U CN202322555883 U CN 202322555883U CN 220812423 U CN220812423 U CN 220812423U
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- Prior art keywords
- screening
- separator
- screening storehouse
- cell
- storehouse
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- 238000012216 screening Methods 0.000 title claims abstract description 118
- 238000012423 maintenance Methods 0.000 claims description 7
- 238000003756 stirring Methods 0.000 claims description 5
- 238000001914 filtration Methods 0.000 claims description 4
- 230000008878 coupling Effects 0.000 claims description 3
- 238000010168 coupling process Methods 0.000 claims description 3
- 238000005859 coupling reaction Methods 0.000 claims description 3
- 230000000694 effects Effects 0.000 abstract description 3
- 210000004027 cell Anatomy 0.000 description 39
- 239000012530 fluid Substances 0.000 description 4
- 238000000926 separation method Methods 0.000 description 4
- 230000004069 differentiation Effects 0.000 description 2
- 239000004744 fabric Substances 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 230000007246 mechanism Effects 0.000 description 2
- 230000002093 peripheral effect Effects 0.000 description 2
- 238000007873 sieving Methods 0.000 description 2
- 210000000130 stem cell Anatomy 0.000 description 2
- 208000024172 Cardiovascular disease Diseases 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 238000012258 culturing Methods 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000005802 health problem Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 239000011550 stock solution Substances 0.000 description 1
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- Sampling And Sample Adjustment (AREA)
Abstract
The utility model belongs to the technical field of screening devices, and particularly relates to a cell screening device which comprises a separator and a screening device, wherein the screening device comprises a first screening bin, a second screening bin and a third screening bin, the lower ends of the first screening bin, the second screening bin and the third screening bin are fixedly provided with a collecting hopper, the separator is connected with the first screening bin, step pipes are fixedly connected between every two of the first screening bin, the second screening bin and the third screening bin, control valves are arranged on the two step pipes, and fine filter plates, middle filter plates and coarse filter plates are respectively arranged in the first screening bin, the second screening bin and the third screening bin. According to the utility model, multistage screening can be realized, and cell clusters with different sizes are gradually screened from small to large, so that the influence on screening quality and effect caused by the fact that the cell clusters with different sizes enter the same collecting hopper is avoided, and the screening structure is simple and effective in design and ordered in screening and is not disordered.
Description
Technical Field
The utility model relates to a screening device, in particular to a cell screening device.
Background
Along with the increasing standard of living of people, health problems caused by various diseases are getting more and more attention, such as treatment of diabetes, cardiovascular diseases and tumor diseases. The differentiation of stem cells is usually studied by disrupting tissues and filtering the tissue and culturing the tissue to obtain a cell mass, but the cell mass is not uniform in size in the cell fluid obtained by separation from the filtration, which affects the study of the differentiation of stem cells.
The cell separation and screening device comprises a separator main body, wherein the separator main body comprises an inner cavity, a filter plate and a screening plate are fixedly arranged in the inner cavity, the filter plate is close to the top of the inner cavity, the screening plate is close to the bottom of the inner cavity, and the filter plate and the screening plate divide the inner cavity into a crushing cavity, a separation and screening cavity and a liquid storage cavity from top to bottom in sequence; the crushing cavity is provided with crushing subassembly, separation screening cavity is provided with the pressurization subassembly, the screening board is provided with the different screen cloth of a plurality of apertures, the stock solution intracavity be provided with a plurality of screen cloth complex toper chamber. The device is provided with different separating openings, different filter screens are arranged at the separating openings, the operation is convenient, the crushing, separating and screening are integrated, and the subsequent utilization is convenient. In the above technology, although the applicant has many advantages, the applicant has the following drawbacks during the use: although a plurality of screens with different apertures are arranged, the screening of cell clusters with different sizes can be realized, the screening of the screens is simultaneously carried out in the separator main body, so that smaller cell clusters can pass through the screens with larger apertures, the sizes of the cell clusters collected in the conical cavities below the smaller cell clusters are different, and the screening result is not ideal.
Disclosure of utility model
The present disclosure is directed to a cell screening device, and is directed to a cell screening device for effectively solving the problems of the prior art.
In order to achieve the above purpose, the technical scheme adopted by the utility model is as follows:
The utility model provides a cell sieving mechanism, includes separator and selector, the selector is by first screening storehouse, second screening storehouse and third screening storehouse, and the equal fixed mounting in lower extreme of three has the collecting hopper, the separator is connected with first screening storehouse, fixedly connected with advance the order pipe between two liang in first screening storehouse, second screening storehouse and the third screening storehouse, and all installs the control valve on two advance pipes, fine filter plate, well filter plate and coarse filter plate are installed respectively in first screening storehouse, second screening storehouse and third screening storehouse.
Preferably, the diameters of the filter holes of the fine filter plate, the middle filter plate and the coarse filter plate are sequentially increased.
Preferably, the bottom fixedly connected with main flow channel of separator, main flow channel's lower extreme fixed connection is in the upper end of first screening storehouse, the side fixed mounting of separator has the interpolation mouth.
Preferably, outlets of the three collecting hoppers are fixedly connected with discharge pipes, and manual valves are arranged on the discharge pipes.
Preferably, a pressurizing pipe connected with an external pressurizing device is fixedly arranged at the upper end of the separator.
Preferably, the top of separator fixed mounting has the motor, the inside rotation of separator is installed the dwang, and dwang and the output rigid coupling of motor, the surface of dwang is the spiral and installs the stirring piece.
Preferably, the top of first screening storehouse, second screening storehouse and third screening storehouse has all been seted up the clearance mouth, the clearance mouth internal rotation has the screw thread maintenance lid, the top surface fixedly connected with of screw thread maintenance lid moves the handle soon.
In view of this, compared with the prior art, the beneficial effects of the utility model are:
In the application, cell fluid (cell mass) is injected into the separator for subsequent screening, the cell fluid enters the first screening bin from the main flow channel, at the moment, the two control valves are in a closed state, so that the fine filter plate in the first screening bin is used for primary screening of cells, smaller cells pass through the fine filter plate, the first control valve is opened, the cell fluid passes through the advanced pipe and enters the second screening bin, then the middle filter plate is used for screening the cell mass again, the middle filter plate is used for passing through the second control valve, finally, the cell mass enters the third screening bin, and the rough filter plate is used for final screening, thus not only realizing multistage screening, but also gradually screening the cell masses with different sizes from small to large, further avoiding the influence on screening quality and effect due to the fact that the cell masses with different sizes enter the same collecting hopper, and the screening structure is simple and effective in design, and ordered screening is not disordered.
Drawings
FIG. 1 is a cross-sectional view showing the structure of a cell screening apparatus according to the present utility model;
FIG. 2 is a schematic view of a portion of the structure of FIG. 1;
Fig. 3 shows an exploded view of the second screening cartridge.
Icon:
1-a separator; 2-a first screening bin; 201-fine filter plates; 3-a second screening bin; 301-middle filter plates; 4-a third screening bin; 401-coarse filter plates; 5-collecting hoppers; 6-a discharge pipe; 7-a manual valve; 8-a main flow channel; 9-an advanced pipe; 10-a control valve; 11-a pressurizing tube; 12-an electric motor; 13-rotating the rod; 14-stirring sheets; 15-an addition port; 16-thread service cover; 17-quick-shift handle.
Detailed Description
The following description of the embodiments of the present utility model will be made clearly and completely with reference to the accompanying drawings, in which it is apparent that the embodiments described are only some embodiments of the present utility model, but not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the utility model without making any inventive effort, are intended to be within the scope of the utility model.
Referring to fig. 1-3, the present utility model provides the following embodiments:
The utility model provides a cell sieving mechanism, including separator 1 and screener, the screener is by first screening storehouse 2, second screening storehouse 3 and third screening storehouse 4, and the equal fixed mounting in lower extreme of three has collecting hopper 5, separator 1 is connected with first screening storehouse 2, fixedly connected with advance pipe 9 between two liang of first screening storehouse 2, second screening storehouse 3 and third screening storehouse 4, and all install control valve 10 on two advance pipes 9, install thin filter plate 201 in first screening storehouse 2, second screening storehouse 3 and the third screening storehouse 4 respectively, well filter plate 301 and coarse filter plate 401, the filtration pore diameter of thin filter plate 201, well filter plate 301 and coarse filter plate 401 three increases in proper order.
Specifically, the bottom fixedly connected with main flow channel 8 of separator 1, the lower extreme fixed connection of main flow channel 8 is in the upper end of first screening storehouse 2, and the side fixed mounting of separator 1 has interpolation mouth 15, and the upper end fixed mounting of separator 1 has the pressure tube 11 that is connected with the pressure device of peripheral hardware, is connected pressure tube 11 with the pressure device of peripheral hardware, and pressure device pressurizes in to separator 1 to help the cell mass to get into each screening storehouse.
Specifically, the outlets of the three collecting hoppers 5 are fixedly connected with a discharge pipe 6, manual valves 7 are arranged on the discharge pipe 6, the collecting hoppers 5 are used for collecting cell clusters with different sizes, and the manual valves 7 on the corresponding collecting hoppers 5 are opened to discharge the cell clusters.
Specifically, the top fixed mounting of separator 1 has motor 12, and the inside rotation of separator 1 is installed dwang 13, and dwang 13 and motor 12's output rigid coupling, and the surface of dwang 13 is the spiral and installs stirring piece 14, and motor 12 drives dwang 13 and stirring piece 14 rotation to disperse the cell mass that gets into in the separator 1, avoid appearing gathering the condition, provide convenience for subsequent screening.
Specifically, the clearance mouth has all been seted up at the top of first screening storehouse 2, second screening storehouse 3 and third screening storehouse 4, and the clearance mouth internal rotation has screw thread maintenance lid 16, and screw thread maintenance lid 16's top surface fixedly connected with moves handle 17 soon, can twist and move handle 17 soon, makes screw thread maintenance lid 16 break away from the clearance mouth, conveniently carries out cleaning treatment in each screening storehouse.
The specific implementation manner of the embodiment is as follows: cell sap (cell mass) is injected into the separator 1 to perform subsequent screening, the cell sap enters the first screening bin 2 from the main flow channel 8, at this time, the two control valves 10 are in a closed state, so that the fine filter plate 201 in the first screening bin 2 performs primary screening on cells, smaller cells pass through the fine filter plate 201, the first control valve 10 is opened, the cell sap passes through the step tube 9 to enter the second screening bin 3, then the middle filter plate 301 screens the cell mass again, the middle filter plate 301 is opened finally, the second control valve 10 is opened, the cell mass enters the third screening bin 4, and the coarse filter plate 401 performs final screening, the cell mass with different sizes is gradually screened in sequence, the cell mass with different sizes is prevented from entering the same collecting hopper 5 from being sequentially reduced, the screening quality and effect are affected, the screening structure design is simple and effective, and the screening is orderly and not disordered.
In the description of the present specification, the descriptions of the terms "one embodiment," "example," "specific example," and the like, mean that a particular feature, structure, material, or characteristic described in connection with the embodiment or example is included in at least one embodiment or example of the present utility model. In this specification, schematic representations of the above terms do not necessarily refer to the same embodiments or examples. Furthermore, the particular features, structures, materials, or characteristics described may be combined in any suitable manner in any one or more embodiments or examples.
The preferred embodiments of the utility model disclosed above are intended only to assist in the explanation of the utility model. The preferred embodiments are not exhaustive or to limit the utility model to the precise form disclosed. Obviously, many modifications and variations are possible in light of the above teaching. The embodiments were chosen and described in order to best explain the principles of the utility model and the practical application, to thereby enable others skilled in the art to best understand and utilize the utility model. The utility model is limited only by the claims and the full scope and equivalents thereof.
Claims (7)
1. A cell screening device, characterized in that: including separator (1) and selector, the selector is by first screening storehouse (2), second screening storehouse (3) and third screening storehouse (4), and the equal fixed mounting of lower extreme of three has collecting hopper (5), separator (1) is connected with first screening storehouse (2), fixedly connected with advance step pipe (9) between two liang of first screening storehouse (2), second screening storehouse (3) and third screening storehouse (4), and all install control valve (10) on two advance step pipes (9), install thin filter plate (201), well filter plate (301) and coarse filtration board (401) in first screening storehouse (2), second screening storehouse (3) and the third screening storehouse (4) respectively.
2. The cell screening device according to claim 1, wherein: the diameters of the filter holes of the fine filter plate (201), the middle filter plate (301) and the coarse filter plate (401) are sequentially increased.
3. A cell screening apparatus according to claim 2, wherein: the bottom of separator (1) fixedly connected with main flow channel (8), the lower extreme fixed connection of main flow channel (8) is in the upper end of first screening storehouse (2), the side fixed mounting of separator (1) has interpolation mouth (15).
4. A cell screening device according to claim 3, wherein: the outlets of the three collecting hoppers (5) are fixedly connected with discharge pipes (6), and manual valves (7) are arranged on the discharge pipes (6).
5. The cell screening device according to claim 1, wherein: the upper end of the separator (1) is fixedly provided with a pressurizing pipe (11) connected with an external pressurizing device.
6. The cell screening device according to claim 1, wherein: the top of separator (1) fixed mounting has motor (12), the inside rotation of separator (1) is installed dwang (13), and dwang (13) and the output rigid coupling of motor (12), the surface of dwang (13) is spiral and installs stirring piece (14).
7. The cell screening device according to claim 1, wherein: the top of first screening storehouse (2), second screening storehouse (3) and third screening storehouse (4) has all seted up the clearance mouth, the clearance mouth internal rotation has screw thread maintenance lid (16), the top surface fixedly connected with of screw thread maintenance lid (16) moves handle (17 soon).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202322555883.XU CN220812423U (en) | 2023-09-20 | 2023-09-20 | Cell screening device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202322555883.XU CN220812423U (en) | 2023-09-20 | 2023-09-20 | Cell screening device |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN220812423U true CN220812423U (en) | 2024-04-19 |
Family
ID=90704892
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202322555883.XU Active CN220812423U (en) | 2023-09-20 | 2023-09-20 | Cell screening device |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN220812423U (en) |
-
2023
- 2023-09-20 CN CN202322555883.XU patent/CN220812423U/en active Active
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