CN220803176U - Microchannel structure for continuous synthesis reaction - Google Patents
Microchannel structure for continuous synthesis reaction Download PDFInfo
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- CN220803176U CN220803176U CN202322575485.4U CN202322575485U CN220803176U CN 220803176 U CN220803176 U CN 220803176U CN 202322575485 U CN202322575485 U CN 202322575485U CN 220803176 U CN220803176 U CN 220803176U
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- 238000003786 synthesis reaction Methods 0.000 title claims abstract description 14
- 239000000243 solution Substances 0.000 claims abstract description 21
- 239000011259 mixed solution Substances 0.000 claims abstract description 11
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 11
- 238000006243 chemical reaction Methods 0.000 abstract description 14
- 238000004891 communication Methods 0.000 abstract description 2
- 230000000694 effects Effects 0.000 abstract description 2
- 108091006146 Channels Proteins 0.000 abstract 23
- 102000010637 Aquaporins Human genes 0.000 abstract 1
- 108010063290 Aquaporins Proteins 0.000 abstract 1
- 238000002474 experimental method Methods 0.000 description 16
- 239000007788 liquid Substances 0.000 description 10
- GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical compound O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 description 9
- QAOWNCQODCNURD-UHFFFAOYSA-N sulfuric acid Substances OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 9
- 229910017604 nitric acid Inorganic materials 0.000 description 6
- MLPVBIWIRCKMJV-UHFFFAOYSA-N 2-ethylaniline Chemical compound CCC1=CC=CC=C1N MLPVBIWIRCKMJV-UHFFFAOYSA-N 0.000 description 4
- LQNUZADURLCDLV-UHFFFAOYSA-N nitrobenzene Chemical compound [O-][N+](=O)C1=CC=CC=C1 LQNUZADURLCDLV-UHFFFAOYSA-N 0.000 description 4
- RFFLAFLAYFXFSW-UHFFFAOYSA-N 1,2-dichlorobenzene Chemical compound ClC1=CC=CC=C1Cl RFFLAFLAYFXFSW-UHFFFAOYSA-N 0.000 description 2
- WDCYWAQPCXBPJA-UHFFFAOYSA-N 1,3-dinitrobenzene Chemical compound [O-][N+](=O)C1=CC=CC([N+]([O-])=O)=C1 WDCYWAQPCXBPJA-UHFFFAOYSA-N 0.000 description 2
- MMZWMCKTKJKIMC-UHFFFAOYSA-N 2-ethyl-5-nitroaniline Chemical compound CCC1=CC=C([N+]([O-])=O)C=C1N MMZWMCKTKJKIMC-UHFFFAOYSA-N 0.000 description 2
- ZZJVNPRHHLLANO-UHFFFAOYSA-N 2-propan-2-yloxybenzaldehyde Chemical compound CC(C)OC1=CC=CC=C1C=O ZZJVNPRHHLLANO-UHFFFAOYSA-N 0.000 description 2
- CCRNCEKMSVYFLU-UHFFFAOYSA-N 4,5-dinitro-1h-imidazole Chemical compound [O-][N+](=O)C=1N=CNC=1[N+]([O-])=O CCRNCEKMSVYFLU-UHFFFAOYSA-N 0.000 description 2
- VYDWQPKRHOGLPA-UHFFFAOYSA-N 5-nitroimidazole Chemical compound [O-][N+](=O)C1=CN=CN1 VYDWQPKRHOGLPA-UHFFFAOYSA-N 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- NTBYINQTYWZXLH-UHFFFAOYSA-N 1,2-dichloro-4-nitrobenzene Chemical compound [O-][N+](=O)C1=CC=C(Cl)C(Cl)=C1 NTBYINQTYWZXLH-UHFFFAOYSA-N 0.000 description 1
- TZPVPJUHWLYGSL-UHFFFAOYSA-N 5-nitro-2-propan-2-yloxybenzaldehyde Chemical compound CC(C)OC1=CC=C([N+]([O-])=O)C=C1C=O TZPVPJUHWLYGSL-UHFFFAOYSA-N 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 238000003889 chemical engineering Methods 0.000 description 1
- 238000005112 continuous flow technique Methods 0.000 description 1
- 208000012839 conversion disease Diseases 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 239000012847 fine chemical Substances 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000010791 quenching Methods 0.000 description 1
- 230000000171 quenching effect Effects 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
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Abstract
The utility model discloses a micro-channel structure for continuous synthesis reaction, which is internally carved on a plate and comprises at least two solution inlet channels, a plurality of groups of special-shaped channels, a connecting channel and a solution outlet channel, wherein the special-shaped channels are connected into a mixed solution channel through the connecting channel, the solution inlet channels are connected with inlets of the mixed solution channel after being converged, outlets of the mixed solution channel are connected with the solution outlet channel, each group of special-shaped channels comprises a plurality of three-dimensional channel units which are mutually communicated, each three-dimensional channel unit comprises a horizontal triangular converging channel, a vertical channel and an inclined triangular branching channel, water outlets of the inclined triangular branching channels are inclined downwards and are respectively connected with the lower end of one vertical channel, the upper ends of the two vertical channels are vertically connected with water inlets of the horizontal triangular converging channel, and water outlets of the horizontal triangular converging channel are connected with the other inclined triangular branching channel to complete the communication of the three-dimensional channel units. The utility model effectively improves the mixing effect of the solution and the reaction rate.
Description
Technical Field
The utility model belongs to the technical field of micro-reactions, and particularly relates to a micro-channel structure for continuous synthesis reaction.
Background
The continuous flow process is widely applied in the field of organic synthesis, has intrinsic safety property, and has been widely focused in the fields of fine chemical engineering and medicine in recent years. In the current design of the micro-reactor channel, various modifications are generally carried out on the planar micro-channel structure to cause secondary flow with the direction different from the main flow direction, so that a series of changes such as stretching, folding, splitting and the like are carried out on the fluid unit, the mixing degree between fluids is improved, the contact area is further improved, and the mass transfer efficiency is further improved. However, the change of the channel structure is mainly based on a two-dimensional structure on a plane at present, and depends on the convection effect, and the pressure drop caused by strong convection also brings a burden to the operation of the equipment.
Disclosure of utility model
In view of the above problems, it is an object of the present utility model to provide a microchannel structure for continuous synthesis reaction.
The specific technical scheme is as follows:
A micro-channel structure for continuous synthesis reaction is carved on a plate and comprises at least two solution inlet channels, a plurality of groups of special-shaped channels, a connecting channel and a solution outlet channel, wherein the plurality of groups of special-shaped channels are connected into a mixed solution channel through the connecting channel, the at least two solution inlet channels are connected into a pipeline and then connected with the inlet of the mixed solution channel, the outlet of the mixed solution channel is connected with the solution outlet channel, each group of special-shaped channels comprises a plurality of three-dimensional channel units which are mutually communicated, each three-dimensional channel unit comprises a horizontal triangular converging channel, a vertical channel and an inclined triangular branching channel, two water outlets of the inclined triangular branching channels of the three-dimensional channel units are inclined downwards and are respectively connected with the lower end of one vertical channel, the upper ends of the two vertical channels are vertically connected with two water inlets of the horizontal triangular converging channel, and the water outlet of the horizontal triangular converging channel is connected with the inclined triangular branching channel of the other three-dimensional channel unit, so that the three-dimensional channel units are communicated with the three-dimensional channel units.
Further, the connecting channel is a U-shaped circular tube, so that the occupied area of the whole micro-channel structure is reduced, and meanwhile, smooth passing of the solution in the channel is ensured.
Further, the horizontal triangular converging channel is a rectangular channel, the vertical channel is a circular tube channel, and the inclined triangular branching channel is a rectangular channel.
Further, the inclined triangular branch channel and the vertical channel form 30-60 degrees.
Further, the ratio of the inner diameter of the vertical channel to the inner width of the horizontal triangular converging channel is 0.3-2:1, the height of the vertical channels should not be too high, which would reduce the easy flow forces in the channels.
The utility model has the beneficial effects that:
The micro-channel structure is not limited in a two-dimensional plane any more, the extension path of the channel structure is expanded into a three-dimensional space, the plane is not simply stretched, the flow interface can be effectively destroyed in a third direction, a large amount of secondary flow is ensured to be generated in the flow process, and the mixing is promoted.
Drawings
FIG. 1 is a schematic plan view of the present utility model;
FIG. 2 is a schematic perspective view of the present utility model;
Fig. 3 is an enlarged detail view at a.
In the figure: 1. a solution inlet channel; 2. a connection channel; 3. a solution outlet channel; 4. a three-dimensional channel unit; 41. a horizontal triangular converging channel; 42. a vertical channel; 43. inclined triangular branch channels.
Detailed Description
The utility model will be further described with reference to the drawings, but the scope of the utility model is not limited thereto.
As shown in fig. 1 to 3, a microchannel structure for continuous synthesis reaction, engraved on a plate, comprises two solution inlet channels 1, a connecting channel 2, a solution outlet channel 3 and a plurality of three-dimensional channel units 4, wherein each three-dimensional channel unit 4 comprises a horizontal triangular converging channel 41, a vertical channel 42 and an inclined triangular branching channel 43, the horizontal triangular converging channel 41 is a rectangular channel, the vertical channel 42 is a circular tube channel, the inclined triangular branching channel 43 is a rectangular channel, two water outlets of the inclined triangular branching channel 43 of the three-dimensional channel unit 4 are inclined downwards and are respectively connected with the lower end of one vertical channel 42, the upper ends of the two vertical channels 42 are vertically connected with two water inlets of the horizontal triangular converging channel 41, the water outlets of the horizontal triangular converging channel 41 are connected with the inclined triangular branching channel 43 of the other three-dimensional channel unit 4, so as to complete the communication between the three-dimensional channel unit 4 and the three-dimensional channel unit 4, a plurality of groups of special channels are connected into a mixed solution channel through the connecting channel 2, the connecting channel 2 is a U-shaped circular tube, the two solution inlet channels 1 are connected into a pipeline, and then connected with the outlet of the mixed solution 3.
Two different solutions respectively enter through the corresponding solution inlet channels 1 and enter the three-dimensional channel unit 4 together after being converged to further react, and the efficiency of the reaction is further improved due to the three-dimensional up-down fall, converging and splitting.
Example 1
By using the micro-channel structure reactor for experiments, the total liquid holdup of the reactor used for the experiments is 20mL, the mass ratio of the three raw materials of the o-dichlorobenzene, the concentrated nitric acid and the concentrated sulfuric acid is 1:2:4, the total flow rate of the liquid is 16mL/min, the reaction residence time is about 1min15 s, the reaction temperature is 50 ℃, the reaction pressure is normal pressure, the highest yield of the 3, 4-dichloronitrobenzene can reach about 94.8%, the result is a preliminary experiment result, and the possible yield is higher if the experimental condition is further optimized.
Example 2
The micro-channel structure reactor of the utility model is used for experiments, the total liquid holdup of the reactor used for the experiments is 20mL, 2-isopropoxybenzaldehyde and nitric acid are synthesized to prepare 2-isopropoxy-5-nitrobenzaldehyde, and the molar ratio of the 2-isopropoxybenzaldehyde to fuming nitric acid is 1:6.5, a total liquid flow rate of 24mL/min, a reaction residence time of about 50S, a reaction selectivity of about 89.5% and a yield of about 68%, which is a preliminary experimental result, and a higher yield is possible if experimental conditions are further optimized.
Example 3
The micro-channel structure reactor of the utility model is used for experiments, the total liquid holdup of the reactor used for the experiments is 20mL, 2-ethyl aniline, nitric acid and sulfuric acid are synthesized to prepare 2-ethyl-5-nitroaniline, and the mass ratio of the three raw materials of 2-ethyl aniline, nitric acid and sulfuric acid is 1:1:8, the total flow rate of the liquid is 20mL/min, the reaction residence time is about 1min, the reaction temperature is 75 ℃, and the 2-ethyl-5-nitroaniline product is obtained through post-treatment such as quenching, PH value adjustment and the like, the total yield of the product can reach 90%, and the result is a preliminary experiment result, and if the experiment condition is further optimized, the yield is possibly higher.
Example 4
By using the micro-channel structure reactor for experiments, the total liquid holdup of the reactor used for the experiments is 5mL, 4-nitroimidazole reacts with fuming nitric acid to prepare 4, 5-dinitroimidazole, the molar ratio of 4-nitroimidazole to fuming nitric acid is 1:1.6, the total flow rate of liquid is 0.5mL/min, the reaction temperature is 100 ℃, the yield of 4, 5-dinitroimidazole can reach 82%, the result is a preliminary experiment result, and if experimental conditions are further optimized, the yield can be higher.
Example 5
The micro-channel structure reactor of the utility model is used for experiments, the total liquid holdup of the reactor used for the experiments is 10mL, the synthesis of nitrobenzene, nitric acid and sulfuric acid is carried out to prepare m-dinitrobenzene, and the mass ratio of the nitrobenzene, the nitric acid and the sulfuric acid is 1:1:4, the total flow rate of the liquid is 10mL/min, the reaction residence time is about 1min, the reaction temperature is 85 ℃, the reaction pressure is normal pressure, the reaction conversion rate is 99%, the yield of m-dinitrobenzene can reach 85%, the result is a preliminary experiment result, and the yield can be higher if the experiment condition is further optimized.
Claims (5)
1. The micro-channel structure for continuous synthesis reaction is internally carved on a plate and is characterized by comprising at least two solution inlet channels (1), a plurality of groups of channels, a connecting channel (2) and a solution outlet channel (3), wherein the groups of channels are connected into a mixed solution channel through the connecting channel (2), the at least two solution inlet channels (1) are converged and connected into a pipeline and then are connected with the inlet of the mixed solution channel, the outlet of the mixed solution channel is connected with the solution outlet channel (3), each group of channels comprises a plurality of three-dimensional channel units (4) which are mutually communicated, each three-dimensional channel unit (4) comprises a horizontal triangular converging channel (41), a vertical channel (42) and an inclined triangular branching channel (43), two water outlets of the inclined triangular branching channel (43) of the three-dimensional channel unit (4) are obliquely downward and are respectively connected with the lower end of one vertical channel (42), the upper ends of the two vertical channels (42) are vertically connected with two water inlets of the horizontal triangular converging channel (41), and the water outlets of the horizontal triangular converging channel (41) are connected with the inclined triangular branching channel (43) of the other three-dimensional channel unit (4), so that the three-dimensional channel unit (4) is communicated with the three-dimensional channel unit (4).
2. A microchannel structure for a continuous synthesis reaction according to claim 1, wherein the connecting channels (2) are U-shaped round tubes.
3. A microchannel structure for continuous synthesis reaction according to claim 1, wherein the horizontal triangular converging channel (41) is a rectangular channel, the vertical channel (42) is a circular tube channel, and the inclined triangular branching channel (43) is a rectangular channel.
4. A microchannel structure for a continuous synthesis reaction according to claim 3, wherein the inclined triangular branch channels (43) are located at 30-60 ° to the vertical channels (42).
5. A microchannel structure for a continuous synthesis reaction according to claim 3, wherein the ratio of the internal diameter of the vertical channels (42) to the internal width of the horizontal triangular converging channels (41) is 0.3-2:1.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202322575485.4U CN220803176U (en) | 2023-09-22 | 2023-09-22 | Microchannel structure for continuous synthesis reaction |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202322575485.4U CN220803176U (en) | 2023-09-22 | 2023-09-22 | Microchannel structure for continuous synthesis reaction |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN220803176U true CN220803176U (en) | 2024-04-19 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202322575485.4U Active CN220803176U (en) | 2023-09-22 | 2023-09-22 | Microchannel structure for continuous synthesis reaction |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN220803176U (en) |
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2023
- 2023-09-22 CN CN202322575485.4U patent/CN220803176U/en active Active
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