CN220803169U - Micro-channel continuous flow reactor for drug synthesis - Google Patents
Micro-channel continuous flow reactor for drug synthesis Download PDFInfo
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- CN220803169U CN220803169U CN202322416719.0U CN202322416719U CN220803169U CN 220803169 U CN220803169 U CN 220803169U CN 202322416719 U CN202322416719 U CN 202322416719U CN 220803169 U CN220803169 U CN 220803169U
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- continuous flow
- equipment box
- flow reactor
- impeller
- reactor
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- 239000003814 drug Substances 0.000 title claims description 18
- 230000015572 biosynthetic process Effects 0.000 title claims description 11
- 229940079593 drug Drugs 0.000 title claims description 11
- 238000003786 synthesis reaction Methods 0.000 title claims description 11
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 46
- 238000003756 stirring Methods 0.000 claims description 7
- 230000002194 synthesizing effect Effects 0.000 claims description 6
- 230000000903 blocking effect Effects 0.000 claims description 5
- 238000004891 communication Methods 0.000 claims description 2
- 239000012530 fluid Substances 0.000 abstract description 25
- 238000001816 cooling Methods 0.000 abstract description 8
- 230000000694 effects Effects 0.000 abstract description 5
- 239000007788 liquid Substances 0.000 abstract description 3
- 230000007547 defect Effects 0.000 abstract description 2
- 238000006243 chemical reaction Methods 0.000 description 13
- 238000002156 mixing Methods 0.000 description 3
- 239000003153 chemical reaction reagent Substances 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 238000001704 evaporation Methods 0.000 description 2
- 230000008020 evaporation Effects 0.000 description 2
- 238000012423 maintenance Methods 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000007599 discharging Methods 0.000 description 1
- 230000017525 heat dissipation Effects 0.000 description 1
- 230000000149 penetrating effect Effects 0.000 description 1
- 238000005086 pumping Methods 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 239000000376 reactant Substances 0.000 description 1
- 230000035484 reaction time Effects 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 238000001308 synthesis method Methods 0.000 description 1
- 238000010189 synthetic method Methods 0.000 description 1
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- Physical Or Chemical Processes And Apparatus (AREA)
Abstract
The utility model relates to the technical field of reactors, and aims to solve the defects that in the prior art, fluid carrying heat for liquid cooling cannot be timely and rapidly cooled and then is recycled, so that the cooling effect is weakened.
Description
Technical Field
The utility model relates to the technical field of reactors, in particular to a micro-channel continuous flow reactor for drug synthesis.
Background
Conventional batch synthesis methods generally require large amounts of reagents and solvents, have long reaction times, are complicated to operate, and have difficulty in controlling the temperature, pressure, and mixing conditions of the reaction.
To overcome these problems, scientists have begun to explore new synthetic methods, one of which is the microchannel continuous flow reaction. The microchannel reactor consists of a plurality of channels with micrometer size, reactants flow in the channels and react in the flowing process, and the device has the advantages of high reaction efficiency, accurate reaction control, reagent and solvent saving, high safety and the like, but the reaction process is accompanied by a great deal of heat dissipation in time, so that the safety of the reaction is ensured.
In the prior art, a reaction unit is bridged between a water inlet channel and a water outlet channel by a micro-channel continuous flow reactor (publication number: CN 218307881U), heat exchange plates arranged in a plurality of reaction units are arranged in parallel, heat generated by reaction carried away by liquid cooling heat exchange ensures the safety of reaction fluid reaction in the reaction plates, but water carrying heat can be pumped into a water inlet channel for heat exchange by a water pump again after not being cooled after entering a water tank, so that the cooling effect is greatly reduced, and therefore, the design of the micro-channel continuous flow reactor for the drug synthesis, which can rapidly cool the water carrying heat, is needed.
Disclosure of utility model
The utility model aims to solve the defects that in the prior art, fluid for liquid cooling cannot carry heat to be timely and rapidly cooled and then is recycled, so that the cooling effect is weakened, and provides a medicine synthesis micro-channel continuous flow reactor.
In order to achieve the above purpose, the present utility model adopts the following technical scheme:
The utility model provides a medicine synthesis microchannel continuous flow reactor, includes basin and reactor main part, reactor main part fixed mounting is in the basin top, one side rotates in the basin and installs the impeller, the impeller top is located to the outlet conduit water outlet of reactor main part, impeller one side fixed mounting has the main shaft, main shaft surface fixed mounting has a plurality of stirring leaves that are circumference evenly distributed.
As a further technical scheme of the utility model, an equipment box is fixedly arranged on one side outside the water tank, an adapter is fixedly arranged in the equipment box, the interior of the adapter is of a hollow structure, a water inlet hole and a water outlet hole are formed, and the water outlet hole is communicated with the interior of the water tank.
As a further technical scheme of the utility model, a chute is arranged at the top of the adapter, and a blocking block is slidably arranged in the chute.
As a further technical scheme of the utility model, a rack is slidably arranged on one side in the equipment box, an L-shaped bracket is fixedly arranged at the top of the rack, one end of the L-shaped bracket is fixedly arranged at the top of the plugging block, a tension spring is fixedly arranged at the bottom of the rack, and the other end of the tension spring is fixedly connected with the equipment box.
As a further technical scheme of the utility model, the incomplete gear is rotatably arranged in the equipment box, and one side of the incomplete gear is fixedly arranged through a connecting shaft penetrating through a water tank and the rotation center of the impeller.
As a further technical scheme of the utility model, one side of the equipment box is in an open structure, and an access door is hinged in the opening of the equipment box.
The beneficial effects of the utility model are as follows:
Through setting up the impeller, after carrying thermal fluid and discharging from the outlet pipe of reactor main part, drive the impeller through the impeller and rotate, the fluid also drives the main shaft rotation simultaneously under the stirring of impeller, and then drive stirring leaf and make carrying thermal fluid and the fluid in the basin quick mixing, make the fluid that the water pump pumps all be after the cooling, improved the cooling radiating effect of equipment, further ensured the safety of medicine synthetic reaction.
Drawings
FIG. 1 is a schematic diagram of a continuous flow reactor for synthesizing a drug in a microchannel according to the present utility model;
FIG. 2 is an enlarged schematic view of FIG. 1 at A;
FIG. 3 is a schematic diagram of the internal structure of a water tank of a microchannel continuous flow reactor for drug synthesis according to the present utility model;
Fig. 4 is a schematic view of the structure of an adaptor of a microchannel continuous flow reactor for drug synthesis according to the present utility model.
In the figure: 1. a water tank; 2. a reactor body; 3. an access door; 4. an equipment box; 5. an incomplete gear; 6. a rack; 7. a tension spring; 8. an adapter; 9. an L-shaped bracket; 10. blocking; 11. a main shaft; 12. stirring the leaves; 13. an impeller; 801. a water outlet hole; 802. a chute; 803. and a water inlet hole.
Detailed Description
The utility model is further described in connection with the following detailed description, in order to make the technical means, the creation characteristics, the achievement of the purpose and the effect of the utility model easy to understand.
In the description of the present utility model, it should be noted that the directions or positional relationships indicated by the terms "upper", "lower", "inner", "outer", "front", "rear", "both ends", "one end", "the other end", etc. are based on the directions or positional relationships shown in the drawings, are merely for convenience of describing the present utility model and simplifying the description, and do not indicate or imply that the devices or elements referred to must have a specific direction, be configured and operated in the specific direction, and thus should not be construed as limiting the present utility model. Furthermore, the terms "first," "second," and the like, are used for descriptive purposes only and are not to be construed as indicating or implying relative importance.
In the description of the present utility model, it should be noted that, unless explicitly specified and limited otherwise, the terms "mounted," "provided," "connected," and the like are to be construed broadly, and may be fixedly connected, detachably connected, or integrally connected, for example; can be mechanically or electrically connected; can be directly connected or indirectly connected through an intermediate medium, and can be communication between two elements. The specific meaning of the above terms in the present utility model will be understood in specific cases by those of ordinary skill in the art.
Referring to fig. 1-4, a microchannel continuous flow reactor for synthesizing medicines comprises a water tank 1 and a reactor main body 2, wherein the reactor main body 2 is fixedly arranged at the top of the water tank 1, an impeller 13 is rotatably arranged at one side in the water tank 1, a water outlet of a water outlet pipeline of the reactor main body 2 is arranged above the impeller 13, a main shaft 11 is fixedly arranged at one side of the impeller 13, a plurality of stirring blades 12 which are uniformly distributed circumferentially are fixedly arranged on the surface of the main shaft 11, the fluid carrying heat in the reactor main body 2 can be rapidly vaporized and radiated through the arrangement of the reactor, and heat can be sufficiently and rapidly mixed with other fluids to be conducted, so that the fluid carrying heat is effectively prevented from being extracted by a water pump, the heat radiation efficiency of the reactor is improved, and the safety of medicine synthesis is better ensured.
Referring to fig. 1 and 3, in a preferred embodiment, an equipment box 4 is fixedly installed at one side of the water tank 1, an adapter 8 is fixedly installed in the equipment box 4, the interior of the adapter 8 is hollow, a water inlet 803 and a water outlet 801 are formed, the water outlet 801 is communicated with the interior of the water tank 1, a chute 802 is formed at the top of the adapter 8, a blocking block 10 is slidably installed in the chute 802, one end of the adapter 8 is communicated with the interior of the water tank 1, the other end of the adapter is connected with a water pipe for conveying fluid, fluid lost by evaporation in the water tank 1 can be timely replenished, and the blocking block 10 can be used for closing a channel of the adapter 8 to prevent the fluid from entering the water tank 1.
Referring to fig. 1 and 2, in a preferred embodiment, a rack 6 is slidably mounted on one side in a device box 4, an L-shaped bracket 9 is fixedly mounted on the top of the rack 6, one end of the L-shaped bracket 9 is fixedly mounted on the top of a block 10, a tension spring 7 is fixedly mounted on the bottom of the rack 6, the other end of the tension spring 7 is fixedly connected with the device box 4, an incomplete gear 5 is rotatably mounted in the device box 4, one side of the incomplete gear 5 passes through a connecting shaft and is fixedly mounted through the rotation center of a water tank 1 and an impeller 13, one side of the device box 4 is in an open structure, an access door 3 is hinged in the opening of the device box 4, the incomplete gear 5 and the rack 6 are arranged, the rack 6 is driven to rotate while the impeller 13 rotates, the rack 6 is driven to slide upwards when the incomplete gear 5 is meshed with the rack 6, the block 10 is driven by the L-shaped bracket 9, and then the passage of an adapter 8 is opened, so that new fluid enters the device box 1, the amount of the fluid is nearly leveled with the amount lost, the intermittent fluid replenishing in the water tank 1 can be realized, the total amount of the fluid is kept unchanged, the degree of the fluid is improved, the maintenance of the device box 4 is convenient to maintain the device box 4, and the maintenance part is maintained.
Working principle: when the reactor is used, fluid for heat exchange passes through the reactor main body 2 and falls from the impeller 13 to the water tank 1, the falling process drives the impeller 13 to rotate, heat-carrying fluid rapidly evaporates and dissipates after passing through the impeller 13, after falling into the water tank 1, the impeller 13 rotates to drive the main shaft 11 to rotate, the main shaft 11 drives the stirring blades 12 to rotate, the mixing of the heat-carrying fluid and other fluids is accelerated, heat conduction is further realized, the water pump is prevented from directly pumping the fluid which does not dissipate heat completely, the impeller 13 rotates and drives the incomplete gear 5 to rotate, the incomplete gear 5 drives the rack 6 to slide upwards when being meshed with the rack 6, the rack 6 drives the block 10 to slide in the chute 802 through the L-shaped bracket 9, a channel of the adapter 8 is opened, new fluid enters the water tank 1 to supplement the loss of evaporation and dissipation, and after the incomplete gear 5 is disengaged from the rack 6, the tension spring 7 resets to drive the rack 6 to slide downwards, and then the block 10 is driven to block the channel of the adapter 8.
Furthermore, it should be understood that although the present disclosure describes embodiments, not every embodiment is provided with a separate embodiment, and that this description is provided for clarity only, and that the disclosure is not limited to the embodiments described in detail below, and that the embodiments described in the examples may be combined as appropriate to form other embodiments that will be apparent to those skilled in the art.
Claims (6)
1. The utility model provides a medicine synthesis microchannel continuous flow reactor, includes basin (1) and reactor main part (2), reactor main part (2) fixed mounting is in basin (1) top, a serial communication port, impeller (13) are installed in one side rotation in basin (1), impeller (13) top is located at the outlet pipe way outlet of reactor main part (2), impeller (13) one side fixed mounting has main shaft (11), main shaft (11) surface fixed mounting has a plurality of stirring leaf (12) that are circumference evenly distributed.
2. The micro-channel continuous flow reactor for drug synthesis according to claim 1, wherein an equipment box (4) is fixedly arranged on one side outside the water tank (1), an adapter (8) is fixedly arranged in the equipment box (4), the interior of the adapter (8) is of a hollow structure, a water inlet hole (803) and a water outlet hole (801) are formed, and the water outlet hole (801) is communicated with the interior of the water tank (1).
3. The microchannel continuous flow reactor for synthesizing medicine according to claim 2, wherein a chute (802) is arranged at the top of the adapter (8), and a block (10) is slidably arranged in the chute (802).
4. A microchannel continuous flow reactor for synthesizing medicaments according to claim 3, wherein a rack (6) is slidably arranged on one side in the equipment box (4), an L-shaped bracket (9) is fixedly arranged on the top of the rack (6), one end of the L-shaped bracket (9) is fixedly arranged on the top of the blocking block (10), a tension spring (7) is fixedly arranged on the bottom of the rack (6), and the other end of the tension spring (7) is fixedly connected with the equipment box (4).
5. The microchannel continuous flow reactor for synthesizing drugs according to claim 4, wherein the incomplete gear (5) is rotatably installed in the equipment box (4), and one side of the incomplete gear (5) is fixedly installed with the rotation center of the impeller (13) through the water tank (1) by a connecting shaft.
6. The microchannel continuous flow reactor for synthesizing drugs according to claim 5, wherein one side of the equipment box (4) is in an open structure, and an access door (3) is hinged in the open side of the equipment box (4).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202322416719.0U CN220803169U (en) | 2023-09-06 | 2023-09-06 | Micro-channel continuous flow reactor for drug synthesis |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202322416719.0U CN220803169U (en) | 2023-09-06 | 2023-09-06 | Micro-channel continuous flow reactor for drug synthesis |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN220803169U true CN220803169U (en) | 2024-04-19 |
Family
ID=90709135
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202322416719.0U Active CN220803169U (en) | 2023-09-06 | 2023-09-06 | Micro-channel continuous flow reactor for drug synthesis |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN220803169U (en) |
-
2023
- 2023-09-06 CN CN202322416719.0U patent/CN220803169U/en active Active
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