CN220780284U - Novel automatic microfluidic device for synthesizing lipid nanoparticles - Google Patents
Novel automatic microfluidic device for synthesizing lipid nanoparticles Download PDFInfo
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- CN220780284U CN220780284U CN202322378267.1U CN202322378267U CN220780284U CN 220780284 U CN220780284 U CN 220780284U CN 202322378267 U CN202322378267 U CN 202322378267U CN 220780284 U CN220780284 U CN 220780284U
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- movable door
- box
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- 150000002632 lipids Chemical class 0.000 title claims abstract description 18
- 239000002105 nanoparticle Substances 0.000 title claims abstract description 17
- 230000002194 synthesizing effect Effects 0.000 title claims abstract description 9
- 238000007789 sealing Methods 0.000 claims abstract description 35
- 230000007246 mechanism Effects 0.000 claims description 12
- 230000000694 effects Effects 0.000 claims description 11
- 230000015572 biosynthetic process Effects 0.000 claims description 7
- 238000003786 synthesis reaction Methods 0.000 claims description 7
- 230000009471 action Effects 0.000 abstract description 4
- 238000001125 extrusion Methods 0.000 abstract description 2
- 238000000034 method Methods 0.000 description 4
- 238000011084 recovery Methods 0.000 description 4
- 239000003814 drug Substances 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 239000003344 environmental pollutant Substances 0.000 description 2
- 231100000719 pollutant Toxicity 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 230000004075 alteration Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 230000000975 bioactive effect Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
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Abstract
The utility model relates to the technical field of microfluidic devices, and discloses novel microfluidic devices for automatically synthesizing lipid nanoparticles, which comprise: the operation panel, the top fixed mounting of operation panel has the fixed box. According to the utility model, by arranging the movable door body, the round rod, the first spring and the sealing bottom plate, an operator can pull the handle downwards, so that the movable door body is driven to move downwards, when one end of the movable rod enters the first limiting hole, the movable door body is fixed, and at the moment, the sealing bottom plate is pushed to move downwards by virtue of the downward movement extrusion of the movable door body, so that the two hinge rods push the two movable blocks to move in opposite directions, the first spring is stretched, and at the moment, the first spring pulls the two movable blocks to move in opposite directions under the elastic restoring action, so that the hinge rods push the sealing bottom plate upwards, and the sealing bottom plate can be tightly attached to the bottom of the movable door body.
Description
Technical Field
The utility model relates to the technical field of microfluidic devices, in particular to a novel microfluidic device for automatically synthesizing lipid nanoparticles.
Background
The lipid nanoparticle takes a biocompatible lipid material as a carrier, and is a novel drug carrying system for dissolving, wrapping or attaching drugs or other bioactive substances on the surface of the lipid nanoparticle.
At present, the microfluidic is considered to have great development potential and wide application prospect in biological and medical research, and most of devices used for synthesizing lipid nanoparticles are microfluidic devices, however, when the conventional microfluidic devices are specifically used, due to the fact that no interaction force exists between a movable door and an operation box, the movable door cannot be tightly attached to the operation box after being closed, and therefore the operation box cannot be sealed, external air can be led to enter the operation box, and therefore influence is caused on synthesis operations with very high requirements, and improvement is needed.
Disclosure of Invention
In order to overcome the defects of the prior art, the utility model provides novel microfluidic equipment for automatically synthesizing lipid nanoparticles, which has the advantage of being convenient for sealing the inside of an operation box.
In order to achieve the above purpose, the present utility model provides the following technical solutions: a novel microfluidic device for automatically synthesizing lipid nanoparticles, which comprises:
the operation panel, the top fixed mounting of operation panel has the fixed box, the top fixed mounting of fixed box has the limiting plate that is located the box front, the movable door body has been cup jointed in the activity between the limiting plate, the second spacing hole has been seted up at the top of limiting plate surface;
the sealing mechanism is arranged inside the fixed box;
the switch mechanism is arranged in the movable door body;
the sealing mechanism comprises a round rod, the outer surface of the round rod is fixedly sleeved with the inner wall of the fixed box, movable blocks are movably sleeved on two sides of the outer surface of the round rod, a first spring is fixedly connected to the outer side of each movable block, the other end of each first spring is fixedly connected with the inner wall of the fixed box, a hinge rod is hinged to the inner portion of the top end of each movable block, a sealing bottom plate is hinged to the top end of each hinge rod, the hinge rod can be pushed to move by the movable blocks, the top of each sealing bottom plate is movably connected with the bottom of the corresponding movable door body, and the outer surface of each sealing bottom plate is movably sleeved with the inner wall of the corresponding fixed box.
As a preferred technical solution of the present utility model, the switching mechanism includes:
the first limiting hole is formed in the outer surface of the fixed box;
the outer surface of the movable rod is movably sleeved with the inner walls of the movable door body and the first limiting holes, a second spring is fixedly connected between the movable rods, a fixed block is fixedly arranged on the outer surface of the movable rod, and the other end of the fixed block penetrates through the movable door body and extends to the outer portion of the movable door body and is movably connected with the inner wall of the movable door body.
As a preferable technical scheme of the utility model, the bottom of the operating platform is movably provided with the movable wheel, and the front surface of the movable door body is fixedly provided with the handle.
As a preferable technical scheme of the utility model, the inner surface of the box body is fixedly provided with a cylinder, and the inside of the cylinder is movably sleeved with a supporting rod.
As a preferable technical scheme of the utility model, the outer surface of the cylinder is movably sleeved with the sliding block, the outer surface of the sliding block is movably connected with the inner surface of the box body, the top of the sliding block is fixedly provided with the object placing plate, and the bottom of the object placing plate is fixedly connected with the top end of the supporting rod.
As a preferable technical scheme of the utility model, a motor is fixedly arranged at the bottom of the inner surface of the box body, the other end of the motor output shaft is fixedly connected with a rotating shaft, and the outer surface of the rotating shaft is fixedly sleeved with a rotating rod.
As a preferable technical scheme of the utility model, the left end of the rotating rod is hinged with a push-pull rod, the other end of the push-pull rod is hinged with the back surface of the sliding block, and the rotating rod moves to enable the push-pull rod to push the sliding block to move.
Compared with the prior art, the utility model has the following beneficial effects:
1. according to the utility model, through the arrangement of the movable door body, the round rod, the first spring and the sealing bottom plate, an operator can pull the handle downwards, so that the movable door body is driven to move downwards, when one end of the movable rod enters the inside of the first limiting hole, the movable door body is fixed, at the moment, the sealing bottom plate is pushed to move downwards by virtue of the downward movement extrusion of the movable door body, so that the two hinge rods push the two movable blocks to move in opposite directions, the first spring is stretched, and at the moment, the first spring pulls the two movable blocks to move in opposite directions under the elastic force recovery effect, so that the hinge rods push the sealing bottom plate upwards, the sealing bottom plate can be tightly attached to the bottom of the movable door body, and therefore, the box body can be sealed, and the pollutants in the outside air are prevented from entering the inside of the box body.
2. According to the utility model, by arranging the cylinder, the support rod, the sliding block and the motor, when an operator needs to work on the upper surface of the object placing plate, the motor is started, so that the rotating shaft can drive the rotating rod to rotate, and the sliding rod can push the sliding block to move outwards, so that the object placing plate is driven to move outwards, the object placing plate is convenient for the operator to take and place objects on the upper surface of the object placing plate, the phenomenon that the operation of the operator is blocked due to too deep internal space of the box body is avoided, and when the object placing plate moves outwards, the support rod moves outwards in the cylinder, so that the support rod can support the object placing plate.
Drawings
FIG. 1 is a schematic diagram of the structure of the present utility model;
FIG. 2 is a schematic cross-sectional view of the round bar of the present utility model;
FIG. 3 is a schematic cross-sectional view of a cylinder of the present utility model;
FIG. 4 is a schematic cross-sectional view of the support bar of the present utility model;
FIG. 5 is a schematic cross-sectional view of a slider of the present utility model;
fig. 6 is a schematic view of a partial enlarged structure at a in fig. 2.
In the figure: 1. an operation table; 2. a fixed box; 3. a case; 4. a limiting plate; 5. a movable door body; 6. a round bar; 7. a movable block; 8. a first spring; 9. a hinge rod; 10. sealing the bottom plate; 11. a first limiting hole; 12. a movable rod; 13. a second spring; 14. a fixed block; 15. a second limiting hole; 16. a handle; 17. a cylinder; 18. a support rod; 19. a slide block; 20. a storage plate; 21. a motor; 22. a rotating shaft; 23. a rotating rod; 24. a push-pull rod; 25. and a movable wheel.
Detailed Description
The following description of the embodiments of the present utility model will be made clearly and completely with reference to the accompanying drawings, in which it is apparent that the embodiments described are only some embodiments of the present utility model, but not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the utility model without making any inventive effort, are intended to be within the scope of the utility model.
As shown in fig. 1 to 6, the present utility model provides a novel microfluidic device for automatically synthesizing lipid nanoparticles, comprising:
the operation panel 1, the top of the operation panel 1 is fixedly provided with a fixed box 2, the top of the fixed box 2 is fixedly provided with a box body 3, the top of the fixed box 2 is fixedly provided with a limiting plate 4 positioned on the front surface of the box body 3, a movable door body 5 is movably sleeved between the limiting plates 4, and the top of the outer surface of the limiting plate 4 is provided with a second limiting hole 15;
the sealing mechanism is arranged inside the fixed box 2;
the switch mechanism is arranged in the movable door body 5;
wherein, sealing mechanism is including round bar 6, round bar 6's surface and the fixed inner wall of case 2 are fixed cup joints, movable block 7 has all been cup jointed to the both sides of round bar 6 surface, the first spring 8 of the outside fixedly connected with of movable block 7, the other end of first spring 8 and the inner wall fixed connection of fixed case 2, the inside on movable block 7 top articulates there is articulated rod 9, articulated rod 9's top articulates there is sealing bottom plate 10, the movement of movable block 7 can make articulated rod 9 promote sealing bottom plate 10 and move, sealing bottom plate 10's top and the bottom swing joint of dodge gate body 5, sealing bottom plate 10's surface and the inner wall activity of fixed case 2 cup joint.
Through setting up sealing bottom plate 10 for sealing bottom plate 10 can seal the inside of box 3 when contacting with the bottom of dodge gate body 5, will promote sealing bottom plate 10 downstream when dodge gate body 5 downstream contacts sealing bottom plate 10's upper surface, thereby make two articulated pole 9 can promote two first springs 8 and take place the opposite movement, thereby make first spring 8 be stretched, first spring 8 will pull two movable blocks 7 and take place the motion of backing up under elasticity recovery effect, thereby make articulated pole 9 can upwards promote sealing bottom plate 10, and then make sealing bottom plate 10's surface can closely laminate with the bottom of dodge gate body 5.
Wherein, switch mechanism includes:
the first limiting hole 11 is formed in the outer surface of the fixed box 2;
the movable rod 12, the surface of movable rod 12 and the inner wall activity of movable door body 5 and first spacing hole 11 cup joint, fixedly connected with second spring 13 between the movable rod 12, the surface fixed mounting of movable rod 12 has fixed block 14, and the fixed block 14 other end runs through movable door body 5 and extends to the outside of movable door body 5 and with the inner wall swing joint of movable door body 5.
The operator can push the two fixed blocks 14, so that the two fixed blocks 14 move in opposite directions, and the two movable rods 12 are separated from the first limiting hole 11, so that the fixing effect on the movable door body 5 is relieved.
Wherein, the bottom of the operation table 1 is movably provided with a movable wheel 25, and the front surface of the movable door body 5 is fixedly provided with a handle 16.
Through setting up running wheel 25 for operating personnel can be more convenient to the operation panel 1 whole remove.
Wherein, the inner surface of the box body 3 is fixedly provided with a cylinder 17, and a supporting rod 18 is movably sleeved in the cylinder 17.
The inner surface of the cylinder 17 is smooth, so that the support bar 18 can be more smoothly moved back and forth inside the cylinder 17.
The outer surface of the cylinder 17 is movably sleeved with a sliding block 19, the outer surface of the sliding block 19 is movably connected with the inner surface of the box body 3, the top of the sliding block 19 is fixedly provided with a storage plate 20, and the bottom of the storage plate 20 is fixedly connected with the top end of the supporting rod 18.
By arranging the sliding block 19, the sliding block 19 can drive the object placing plate 20 to move when moving.
Wherein, the bottom fixed mounting of box 3 internal surface has motor 21, and the other end fixedly connected with pivot 22 of motor 21 output shaft, and pivot 22's surface stationary cup joints rotary rod 23.
An operator can start the motor 21 so that the rotating shaft 22 can drive the rotating rod 23 to rotate.
The left end of the rotating rod 23 is hinged with a push-pull rod 24, the other end of the push-pull rod 24 is hinged with the back surface of the sliding block 19, and the sliding rod 24 pushes the sliding block 19 to move when the rotating rod 23 moves.
When the rotating rod 23 rotates, the push-pull rod 24 is driven to move, so that the push-pull rod 24 can push the sliding block 19 to move outwards along the outer surface of the cylinder 17.
The working principle and the using flow of the utility model are as follows:
when an operator needs to open the movable door body 5, the two fixed blocks 14 can be pushed to move in opposite directions, so that the movable rod 12 is driven to be separated from the inner part of the first limiting hole 11, the fixing effect on the movable door body 5 is relieved, at the moment, the operator pulls the handle 16 upwards, the second spring 13 pushes the two movable rods 12 to move in opposite directions under the elastic force recovery effect, one end of the movable rod 12 enters the inner part of the second limiting hole 15, the movable door body 5 is fixed, at the moment, the operator can drive the rotary rod 23 to rotate through the motor 21 by starting the rotary shaft 22, the sliding rod 24 can push the sliding block 19 to move outwards along the outer surface of the cylinder 17, the cylinder 17 drives the object placing plate 20 to move outwards, accordingly, the situation that the operator is convenient to take and place objects on the upper surface of the object placing plate 20 is avoided, the operation of the operator is blocked due to the fact that the inner space of the box 3 is too deep, when the object placing plate 20 moves outwards, the support rod 18 is driven to move outwards in the inner part of the cylinder 17, and the support rod 18 can support the object placing plate 20.
When the operator needs to seal the box 3, can be through pushing two fixed blocks 14 for movable rod 12 breaks away from the inside of second spacing hole 15, then through pulling handle 16 downwards, make movable door body 5 downwardly moving, when the one end of movable rod 12 gets into the inside of first spacing hole 11 under the promotion of second spring 13, movable rod 12 will fix movable door body 5, this moment because sealing bottom plate 10 receives the downward pressure of movable door body 5, thereby make articulated rod 9 promote two movable blocks 7 and take place the opposite movement, thereby make first spring 8 be stretched, and then first spring 8 can pull two first springs 8 and take place the opposite movement under the elasticity recovery effect, thereby make articulated rod 9 upwards promote sealing bottom plate 10, and then make sealing bottom plate 10 can closely laminate with the bottom of movable door body 5, thereby seal box 3, the pollutant in the external air has avoided entering to the inside of box 3.
It is noted that relational terms such as first and second, and the like are used solely to distinguish one entity or action from another entity or action without necessarily requiring or implying any actual such relationship or order between such entities or actions. Moreover, the terms "comprises," "comprising," or any other variation thereof, are intended to cover a non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements does not include only those elements but may include other elements not expressly listed or inherent to such process, method, article, or apparatus.
Although embodiments of the present utility model have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made therein without departing from the principles and spirit of the utility model, the scope of which is defined in the appended claims and their equivalents.
Claims (7)
1. The novel microfluidic device for automatically synthesizing lipid nanoparticles is characterized by comprising the following components:
the operation panel (1), fixed box (2) is fixedly installed at the top of operation panel (1), box (3) is fixedly installed at the top of fixed box (2), limiting plate (4) located in front of box (3) is fixedly installed at the top of fixed box (2), movable door body (5) has been cup jointed in the activity between limiting plate (4), second spacing hole (15) have been seted up at the top of limiting plate (4) surface;
the sealing mechanism is arranged inside the fixed box (2);
the switch mechanism is arranged in the movable door body (5);
the sealing mechanism comprises a round rod (6), the outer surface of the round rod (6) is fixedly sleeved with the inner wall of a fixed box (2), two sides of the outer surface of the round rod (6) are movably sleeved with movable blocks (7), the outer sides of the movable blocks (7) are fixedly connected with first springs (8), the other ends of the first springs (8) are fixedly connected with the inner wall of the fixed box (2), hinge rods (9) are hinged to the inner sides of the top ends of the movable blocks (7), sealing bottom plates (10) are hinged to the top ends of the hinge rods (9), the hinge rods (9) can be pushed by the movement of the movable blocks (7), the top of the sealing bottom plates (10) are movably sleeved with the bottom of a movable door body (5), and the outer surfaces of the sealing bottom plates (10) are movably sleeved with the inner wall of the fixed box (2).
2. The novel microfluidic device for automated synthesis of lipid nanoparticles according to claim 1, wherein: the switch mechanism comprises:
the first limiting hole (11) is formed in the outer surface of the fixed box (2);
the movable rod (12), the surface of movable rod (12) cup joints with the inner wall activity of movable door body (5) and first spacing hole (11), fixedly connected with second spring (13) between movable rod (12), the surface fixed mounting of movable rod (12) has fixed block (14), the fixed block (14) other end runs through movable door body (5) and extends to the outside of movable door body (5) and with the inner wall swing joint of movable door body (5).
3. The novel microfluidic device for automated synthesis of lipid nanoparticles according to claim 1, wherein: the bottom of the operating platform (1) is movably provided with a movable wheel (25), and the front surface of the movable door body (5) is fixedly provided with a handle (16).
4. The novel microfluidic device for automated synthesis of lipid nanoparticles according to claim 1, wherein: the inner surface of the box body (3) is fixedly provided with a cylinder (17), and a supporting rod (18) is movably sleeved in the cylinder (17).
5. The novel microfluidic device for automated synthesis of lipid nanoparticles according to claim 4, wherein: the outer surface of the cylinder (17) is movably sleeved with a sliding block (19), the outer surface of the sliding block (19) is movably connected with the inner surface of the box body (3), a storage plate (20) is fixedly arranged at the top of the sliding block (19), and the bottom of the storage plate (20) is fixedly connected with the top end of the supporting rod (18).
6. The novel microfluidic device for automated synthesis of lipid nanoparticles according to claim 1, wherein: the motor (21) is fixedly mounted at the bottom of the inner surface of the box body (3), the other end of the output shaft of the motor (21) is fixedly connected with a rotating shaft (22), and a rotating rod (23) is fixedly sleeved on the outer surface of the rotating shaft (22).
7. The novel microfluidic device for automated synthesis of lipid nanoparticles according to claim 6, wherein: the left end of the rotating rod (23) is hinged with a push-pull rod (24), the other end of the push-pull rod (24) is hinged with the back surface of the sliding block (19), and the sliding rod (24) can push the sliding block (19) to move when the rotating rod (23) moves.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202322378267.1U CN220780284U (en) | 2023-09-01 | 2023-09-01 | Novel automatic microfluidic device for synthesizing lipid nanoparticles |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202322378267.1U CN220780284U (en) | 2023-09-01 | 2023-09-01 | Novel automatic microfluidic device for synthesizing lipid nanoparticles |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN220780284U true CN220780284U (en) | 2024-04-16 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202322378267.1U Active CN220780284U (en) | 2023-09-01 | 2023-09-01 | Novel automatic microfluidic device for synthesizing lipid nanoparticles |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN220780284U (en) |
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2023
- 2023-09-01 CN CN202322378267.1U patent/CN220780284U/en active Active
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