CN220757511U - Auxiliary device for drug administration of nude mouse ovarian cancer transplantation tumor model - Google Patents
Auxiliary device for drug administration of nude mouse ovarian cancer transplantation tumor model Download PDFInfo
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- CN220757511U CN220757511U CN202321734785.6U CN202321734785U CN220757511U CN 220757511 U CN220757511 U CN 220757511U CN 202321734785 U CN202321734785 U CN 202321734785U CN 220757511 U CN220757511 U CN 220757511U
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- Prior art keywords
- clamping cylinder
- ovarian cancer
- nude mouse
- tubular clamping
- transplantation tumor
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- 238000011580 nude mouse model Methods 0.000 title claims abstract description 77
- 206010033128 Ovarian cancer Diseases 0.000 title claims abstract description 34
- 206010061535 Ovarian neoplasm Diseases 0.000 title claims abstract description 34
- 206010028980 Neoplasm Diseases 0.000 title claims abstract description 33
- 238000002054 transplantation Methods 0.000 title claims abstract description 31
- 238000001647 drug administration Methods 0.000 title description 8
- 230000007246 mechanism Effects 0.000 claims abstract description 13
- 238000003825 pressing Methods 0.000 claims abstract description 13
- 238000012377 drug delivery Methods 0.000 claims abstract description 7
- 239000003814 drug Substances 0.000 claims description 52
- 238000003756 stirring Methods 0.000 claims description 14
- 229940079593 drug Drugs 0.000 claims description 8
- 101000623895 Bos taurus Mucin-15 Proteins 0.000 claims description 6
- 238000004891 communication Methods 0.000 claims description 3
- 241000699660 Mus musculus Species 0.000 abstract description 21
- 238000000034 method Methods 0.000 abstract description 13
- 230000008569 process Effects 0.000 abstract description 12
- 238000013461 design Methods 0.000 abstract description 6
- 208000027418 Wounds and injury Diseases 0.000 abstract description 3
- 230000009471 action Effects 0.000 abstract description 3
- 230000006378 damage Effects 0.000 abstract description 3
- 208000014674 injury Diseases 0.000 abstract description 3
- 235000017166 Bambusa arundinacea Nutrition 0.000 description 7
- 235000017491 Bambusa tulda Nutrition 0.000 description 7
- 241001330002 Bambuseae Species 0.000 description 7
- 235000015334 Phyllostachys viridis Nutrition 0.000 description 7
- 239000011425 bamboo Substances 0.000 description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 6
- 238000010586 diagram Methods 0.000 description 4
- 239000000243 solution Substances 0.000 description 4
- 238000002474 experimental method Methods 0.000 description 3
- 239000000203 mixture Substances 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 description 1
- 241000700159 Rattus Species 0.000 description 1
- BPEGJWRSRHCHSN-UHFFFAOYSA-N Temozolomide Chemical compound O=C1N(C)N=NC2=C(C(N)=O)N=CN21 BPEGJWRSRHCHSN-UHFFFAOYSA-N 0.000 description 1
- 230000008878 coupling Effects 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
- 238000005859 coupling reaction Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 230000001404 mediated effect Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 229960004964 temozolomide Drugs 0.000 description 1
Landscapes
- Medicinal Preparation (AREA)
Abstract
The utility model discloses an auxiliary device for drug delivery of a nude mouse ovarian cancer transplantation tumor model, in particular to the field of nude mouse ovarian cancer transplantation tumor, which comprises a chute, wherein a fixing mechanism for the nude mouse ovarian cancer transplantation tumor is arranged around the chute, the fixing mechanism comprises a first hydraulic component, a second tubular clamping cylinder, a second hydraulic component, a plug-in block, a pressing plate and a second tubular clamping cylinder, and one end of the first hydraulic component is fixedly connected with the first tubular clamping cylinder; according to the utility model, through the structural design of the fixing mechanism, when the device is used in the later period, a user places the nude mice in the grooves on the fixing mechanism, then the first hydraulic component and the second hydraulic component are started to enable the first tubular clamping cylinder and the second tubular clamping cylinder to be relatively pushed to be close to each other until the first tubular clamping cylinder and the second tubular clamping cylinder are attached to each other, so that a pipeline space is formed for clamping the nude mice to limit the action of the nude mice, the fixing of the nude mice in the process of administering ovarian cancer transplantation tumor of the nude mice is improved, the injury phenomenon of the nude mice in the use process is prevented, and the safety of the experimental process is ensured.
Description
Technical Field
The utility model relates to the field of nude mouse ovarian cancer transplantations, in particular to an auxiliary drug administration device for a nude mouse ovarian cancer transplantations model.
Background
Due to the special constitution of the nude mice, the nude mice can be used for researching different drug-mediated nude mice transplantation tumor models, and plays an important role in scientific research; nude mice generally include nude mice and nude rats, and administration by nude mice is often required during nude mice research, which requires the use of a nude mice administration aid.
The relevant patent is not searched after the search.
The inventors found that the following problems exist in the prior art in the process of implementing the present utility model:
when the current nude mouse ovarian cancer transplantation tumor model drug administration auxiliary device is used, the nude mouse needs to be fixed manually when being studied, then the nude mouse needs to be fixed mechanically, and when the drug administration is carried out, the nude mouse is often bitten by people because of artificial frightening, so that the operation of wearing gloves is needed, but the wearing of the gloves can influence the study drug administration accuracy of the nude mouse.
Therefore, a nude mouse ovarian cancer transplantation tumor model drug administration auxiliary device is provided for solving the problems.
Disclosure of Invention
In order to overcome the above-mentioned drawbacks of the prior art, the present utility model provides an auxiliary device for administering a nude mouse ovarian cancer transplantation tumor model, so as to solve the above-mentioned problems in the prior art.
In order to achieve the above purpose, the present utility model provides the following technical solutions: the utility model provides an auxiliary device that doses of nude mouse ovarian cancer transplantation tumor model, includes the spout, be provided with the fixed establishment that is used for nude mouse ovarian cancer to transplant the tumor around the spout, fixed establishment includes hydraulic assembly one, tubular clamp section of thick bamboo one, hydraulic assembly two, plug-in block, clamp plate and tubular clamp section of thick bamboo two, the one end fixedly connected with tubular clamp section of thick bamboo one of hydraulic assembly one.
One end fixedly connected with hydraulic pressure subassembly two of tubulose clamp section of thick bamboo, the other end of tubulose clamp section of thick bamboo one is provided with tubulose clamp section of thick bamboo two, one side of tubulose clamp section of thick bamboo two is provided with the grafting piece, the surface swing joint of grafting piece has the clamp plate.
Preferably, the first tubular clamping cylinder and the second hydraulic assembly form a telescopic structure, and the first hydraulic assembly is provided with two groups and is symmetrically distributed.
Preferably, the tubular clamping cylinder II and the hydraulic assembly II form a telescopic structure, and the hydraulic assembly II is provided with two groups and is symmetrically distributed.
Preferably, the inner wall of the plug block is tightly attached to the outer wall of the pressing plate, and two groups of plug grooves are formed in the surface of the plug block.
Preferably, the inside swing joint of spout has the support, fixedly connected with collar between the support, the inside movable mounting of collar has the medicine storehouse, the top fixed mounting in medicine storehouse has the motor, the bottom fixedly connected with puddler of motor, the fixed surface of puddler has cup jointed the stirring leaf, the bottom fixed intercommunication in medicine storehouse has the pipe of dosing, the surface movable mounting of pipe of dosing has the valve.
Preferably, the support slides in the spout, and closely laminate between the lateral wall of support and the outer wall of collar.
Preferably, the inner dimension of the mounting ring is matched with the outer dimension of the medicine bin, and a communication structure is formed between the medicine bin and the medicine feeding pipe.
Preferably, the drug delivery tube is closed through valve control, and the top outer wall of the drug bin is tightly attached to the bottom outer wall of the motor.
The utility model has the technical effects and advantages that:
1. compared with the prior art, the auxiliary device for the nude mouse ovarian cancer transplantation tumor model drug delivery is designed through the structure of the fixing mechanism, when the auxiliary device is used in the later period, a user places the nude mouse in the groove on the fixing mechanism, then the first tubular clamping cylinder and the second tubular clamping cylinder are pushed to be close to each other until the two tubular clamping cylinders are attached by starting the first hydraulic component and the second hydraulic component, so that a pipeline space is formed to clamp and limit the action of the nude mouse, then the inserting groove on the inserting block is determined according to the individual size of the nude mouse, the pressing plate penetrates through the inserting groove to limit and fix the head of the nude mouse, the fixing of the nude mouse in the nude mouse ovarian cancer transplantation tumor drug delivery process is improved, the injury phenomenon of the nude mouse in the use process is prevented, and the safety of the experimental process is ensured.
2. Compared with the prior art, this nude mouse ovarian cancer transplants tumor model auxiliary device that doses passes through the structural design of medicine storehouse, a motor, puddler and stirring leaf, when later stage uses, water injection and medicine mix in the medicine storehouse, start the motor simultaneously, make the output of motor pass through the shaft coupling and drive the puddler rotatory, and then drive stirring leaf rotation makes water and medicine intensive mixing become solution, improve nude mouse ovarian cancer transplants tumor experiment and doses the in-process to the mixing efficiency of medicine, make medicine and water mix fully, improve experimental structure's accuracy.
Drawings
FIG. 1 is a schematic diagram of the overall structure of the present utility model.
Fig. 2 is a schematic diagram of the split structure of the stent and the drug storage of the utility model.
Fig. 3 is a schematic diagram of a two-back view structure of the tubular clip of the present utility model.
FIG. 4 is a schematic diagram of the stirring structure of the present utility model.
The reference numerals are: 1. a fixing mechanism; 101. a first hydraulic component; 102. a tubular clamping cylinder I; 103. a second hydraulic component; 104. a plug block; 105. a pressing plate; 106. a tubular clamping cylinder II; 2. a chute; 3. a bracket; 4. a mounting ring; 5. a medicine bin; 6. a motor; 7. a drug administration tube; 8. a valve; 9. a stirring rod; 10. stirring the leaves.
Detailed Description
The following description of the embodiments of the present utility model will be made clearly and completely with reference to the accompanying drawings, in which it is apparent that the embodiments described are only some embodiments of the present utility model, but not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the utility model without making any inventive effort, are intended to be within the scope of the utility model.
Example 1
The auxiliary device for the administration of the nude mouse ovarian cancer transplantation tumor model shown in the drawings 1 and 3 comprises a sliding groove 2, wherein a fixing mechanism 1 for the nude mouse ovarian cancer transplantation tumor is arranged around the sliding groove 2, the fixing mechanism 1 comprises a first hydraulic component 101, a first tubular clamping cylinder 102, a second hydraulic component 103, an inserting block 104, a pressing plate 105 and a second tubular clamping cylinder 106, and one end of the first hydraulic component 101 is fixedly connected with the first tubular clamping cylinder 102.
One end of the first tubular clamping cylinder 102 is fixedly connected with a second hydraulic component 103, the other end of the first tubular clamping cylinder 102 is provided with a second tubular clamping cylinder 106, one side of the second tubular clamping cylinder 106 is provided with an inserting block 104, and the surface of the inserting block 104 is movably connected with a pressing plate 105.
The tubular clamping cylinder I102 and the hydraulic component II 103 form a telescopic structure through the hydraulic component I101, and the hydraulic component I101 is provided with two groups which are symmetrically distributed; the tubular clamping cylinder II 106 and the hydraulic component II 103 form a telescopic structure through the hydraulic component I101, and the hydraulic component II 103 is provided with two groups which are symmetrically distributed; the inner wall of the plug block 104 is tightly attached to the outer wall of the pressing plate 105, and two groups of plug grooves are formed in the surface of the plug block 104.
Wherein: a user places a nude mouse in a groove on the fixing mechanism 1, then drives the tubular clamping cylinder I102 and the tubular clamping cylinder II 106 to be close to each other oppositely until the nude mouse is attached by starting the hydraulic component I101 and the hydraulic component II 103, so that a pipeline space is formed to clamp and limit the action of the nude mouse, then the inserting groove on the inserting block 104 is determined according to the individual size of the nude mouse, the pressing plate 105 penetrates through the inserting groove to limit and fix the head of the nude mouse, the fixing of the nude mouse in the administration process of ovarian cancer transplantation tumor of the nude mouse is improved, the injury phenomenon of the nude mouse in the use process is prevented, and the safety of the experimental process is ensured.
Example two
On the basis of the first embodiment, the scheme in the first embodiment is further introduced in detail in combination with the following specific working modes, and the details are described below:
referring to figures 1-4 of the drawings,
as a preferred embodiment, a bracket 3 is movably connected in the chute 2, a mounting ring 4 is fixedly connected between the brackets 3, a medicine bin 5 is movably mounted in the mounting ring 4, a motor 6 is fixedly mounted at the top end of the medicine bin 5, a stirring rod 9 is fixedly connected at the bottom end of the motor 6, a stirring blade 10 is fixedly sleeved on the surface of the stirring rod 9, a medicine feeding pipe 7 is fixedly communicated with the bottom end of the medicine bin 5, and a valve 8 is movably mounted on the surface of the medicine feeding pipe 7; furthermore, through the design of the mounting ring 4, the medicine bin 5 is used for supporting and mounting, so that the medicine can be processed at a position before the medicine is filled into the nude mice, and the quality of the medicine for the nude mice ovarian cancer transplantation tumor is improved.
As a preferred embodiment, the bracket 3 slides in the chute 2, and the side wall of the bracket 3 is tightly attached to the outer wall of the mounting ring 4; furthermore, through the design of the chute 2, the bracket 3 can slide in the chute 2, so that medicines are fed into the fixed nude mice through sliding to be infused, and the infusion efficiency of the nude mice ovarian cancer transplantation tumor is ensured.
As a preferred embodiment, the inner dimension of the mounting ring 4 is matched with the outer dimension of the medicine bin 5, and a communication structure is formed between the medicine bin 5 and the medicine feeding tube 7; furthermore, by the design of the administration tube 7, the prepared medicine is inserted into the mouth of the nude mouse through the administration tube 7, so that the convenience of administration of the nude mouse ovarian cancer transplantation tumor is improved.
As a preferred embodiment, the drug delivery tube 7 is controlled to be closed through the valve 8, and the outer wall of the top end of the drug bin 5 is tightly attached to the outer wall of the bottom end of the motor 6; furthermore, through the design of the motor 6, the motor 6 drives the stirring rod 9 to rotate, and then drives the stirring blade 10 to mix the temozolomide mesylate medicine with water, so that the administration efficiency of the nude mice ovarian cancer transplantation tumor is improved.
The electrical components are all connected with an external main controller and 220V mains supply, and the main controller can be conventional known equipment for controlling a computer and the like.
The working process of the utility model is as follows:
firstly, when a user uses the auxiliary device for drug delivery of the nude mouse ovarian cancer transplantation tumor model, the user places the nude mouse in a groove on the fixing mechanism 1, then drives the first tubular clamping cylinder 102 and the second tubular clamping cylinder 106 to be relatively close to each other until the two tubular clamping cylinders are attached by starting the first hydraulic component 101 and the second hydraulic component 103, so that a pipeline space is formed to clamp the nude mouse, the nude mouse is limited to move, then a plug-in groove on the plug-in block 104 is determined according to the individual size of the nude mouse, and the pressing plate 105 penetrates through the plug-in groove to limit and fix the head of the nude mouse by the pressing plate 105; after the nude mice are fixed, preparing medicines for nude mice experiments, pouring the medicines used for the experiments into a medicine bin 5, and integrally sleeving the medicine bin 5 on a mounting ring 4 and supporting the medicine bin on the top of the device by a bracket 3; then water is injected into the medicine bin 5 and medicine is mixed, the motor 6 is started simultaneously, the output end of the motor 6 drives the stirring rod 9 to rotate through the coupler, the stirring blade 10 is driven to rotate, water and medicine are fully mixed into solution, a user pushes the support 3, the support 3 slides to one side in the sliding groove 2 and then stops when the support slides to the top end of the head of the nude mouse, then the medicine feeding pipe 7 is aligned with the mouth of the nude mouse and stretches into the medicine feeding pipe 7 of the part, and then the user unscrews the valve 8 to enable medicine solution to be filled into the mouth of the nude mouse and finally enter the body, and the experimental process is observed.
Finally: the foregoing description of the preferred embodiments of the utility model is not intended to limit the utility model to the precise form disclosed, and any such modifications, equivalents, and alternatives falling within the spirit and principles of the utility model are intended to be included within the scope of the utility model.
Claims (8)
1. The utility model provides a nude mouse ovarian cancer transplants tumour model auxiliary device that doses, includes spout (2), its characterized in that: the fixing mechanism (1) for nude mouse ovarian cancer transplantation tumor is arranged around the sliding groove (2), the fixing mechanism (1) comprises a first hydraulic component (101), a second tubular clamping cylinder (102), a second hydraulic component (103), a plug-in block (104), a pressing plate (105) and a second tubular clamping cylinder (106), and one end of the first hydraulic component (101) is fixedly connected with the first tubular clamping cylinder (102);
one end of the first tubular clamping cylinder (102) is fixedly connected with a second hydraulic component (103), the other end of the first tubular clamping cylinder (102) is provided with a second tubular clamping cylinder (106), one side of the second tubular clamping cylinder (106) is provided with an inserting block (104), and the surface of the inserting block (104) is movably connected with a pressing plate (105).
2. The nude mouse ovarian cancer transplantation tumor model administration assisting device according to claim 1, wherein: the first tubular clamping cylinder (102) and the second hydraulic assembly (103) form a telescopic structure through the first hydraulic assembly (101), and the first hydraulic assembly (101) is provided with two groups and is symmetrically distributed.
3. The nude mouse ovarian cancer transplantation tumor model administration assisting device according to claim 1, wherein: the tubular clamping cylinder II (106) and the hydraulic component II (103) form a telescopic structure through the hydraulic component I (101), and the hydraulic component II (103) is provided with two groups which are symmetrically distributed.
4. The nude mouse ovarian cancer transplantation tumor model administration assisting device according to claim 1, wherein: the inner wall of the plug block (104) is tightly attached to the outer wall of the pressing plate (105), and two groups of plug grooves are formed in the surface of the plug block (104).
5. The nude mouse ovarian cancer transplantation tumor model administration assisting device according to claim 1, wherein: inside swing joint of spout (2) has support (3), fixedly connected with collar (4) between support (3), the inside movable mounting of collar (4) has medicine storehouse (5), the top fixed mounting of medicine storehouse (5) has motor (6), the bottom fixedly connected with puddler (9) of motor (6), the fixed surface of puddler (9) has cup jointed stirring leaf (10), the bottom fixed intercommunication of medicine storehouse (5) has medicine feeding pipe (7), the surface movable mounting of medicine feeding pipe (7) has valve (8).
6. The administration assisting device for nude mouse ovarian cancer transplantation tumor model according to claim 5, wherein: the support (3) slides in the chute (2), and the side wall of the support (3) is tightly attached to the outer wall of the mounting ring (4).
7. The administration assisting device for nude mouse ovarian cancer transplantation tumor model according to claim 6, wherein: the inner dimension of the mounting ring (4) is matched with the outer dimension of the medicine bin (5), and a communication structure is formed between the medicine bin (5) and the medicine feeding pipe (7).
8. The administration assisting device for nude mouse ovarian cancer transplantation tumor model according to claim 7, wherein: the drug delivery pipe (7) is controlled to be closed through the valve (8), and the outer wall of the top end of the drug bin (5) is tightly attached to the outer wall of the bottom end of the motor (6).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202321734785.6U CN220757511U (en) | 2023-07-04 | 2023-07-04 | Auxiliary device for drug administration of nude mouse ovarian cancer transplantation tumor model |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202321734785.6U CN220757511U (en) | 2023-07-04 | 2023-07-04 | Auxiliary device for drug administration of nude mouse ovarian cancer transplantation tumor model |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN220757511U true CN220757511U (en) | 2024-04-12 |
Family
ID=90599247
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202321734785.6U Active CN220757511U (en) | 2023-07-04 | 2023-07-04 | Auxiliary device for drug administration of nude mouse ovarian cancer transplantation tumor model |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN220757511U (en) |
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2023
- 2023-07-04 CN CN202321734785.6U patent/CN220757511U/en active Active
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