CN220714584U

CN220714584U - Liquid radioactive source applying device

Info

Publication number: CN220714584U
Application number: CN202321843310.0U
Authority: CN
Inventors: 张宏涛
Original assignee: Individual
Current assignee: Individual
Priority date: 2023-07-13
Filing date: 2023-07-13
Publication date: 2024-04-05
Anticipated expiration: 2033-07-13

Abstract

The utility model relates to a liquid radioactive source applying device which is structurally characterized in that a nuclide channel is arranged in an applying source guide pipe, a plurality of nuclide balloons are arranged at the front end of the applying source guide pipe along the applying source guide pipe, the nuclide balloons are communicated with the nuclide channel, a nuclide inlet communicated with the nuclide channel is arranged at the rear end of the applying source guide pipe, a retractable positioning support is arranged at the front end of the applying source guide pipe, the applying source guide pipe is positioned at the center of the positioning support, a support recovery inner sleeve pipe is sleeved outside the applying source guide pipe, an anti-radiation outer sleeve pipe is sleeved outside the support recovery inner sleeve pipe, a traction wire is connected to the positioning support, and the traction wire penetrates through the support recovery inner sleeve pipe and stretches out from the rear end of the support recovery inner sleeve pipe. The nuclides of the utility model are not lost, and are not gathered in other organs and cause damage. The dose can be accurately calculated, so that the curative effect and the complications can be accurately predicted. The dose distribution of the organs at risk around the target region can be accurately assessed.

Description

Liquid radioactive source applying device

Technical Field

The utility model relates to a source applying device, in particular to a liquid radioactive source applying device.

Background

Liquid radionuclides are widely used for the treatment of various diseases, such as iodine-131 nuclide treatment of hyperthyroidism, yttrium-90 nuclide embolism treatment of liver cancer, and the like. The mechanism of the treatment is to collect nuclides in the focus area by oral administration or intravascular injection, and kill focus cells by the radiation released by the radionuclides to achieve the treatment effect. Such a method has the following disadvantages: 1. the nuclides are lost, the nuclides cannot completely reach the target focus, and the nuclide dosage of the target focus is difficult to accurately calculate; 2. nuclides enter the patient's blood circulation, and there may be radiodamage caused by nuclides accumulating in other organs; 3. cannot be used for tumors lacking blood supply or physiological no nuclear uptake; 4. the accurate two-dimensional and three-dimensional dose distribution of the target focus cannot be accurately calculated; 5. the organ-at-risk dose cannot be accurately assessed; 6. the efficacy and complications cannot be accurately predicted; 7. previous methods of oral or intravascular injection of liquid radionuclides have failed to treat vascular stenosis. Thus, existing methods of liquid radionuclide injection orally or intravascularly often lead to recurrence of the therapeutic condition due to inaccuracy of the target dose, and nuclides that accumulate in other organs are prone to complications.

Disclosure of Invention

The utility model aims to provide a liquid radioactive source applying device, which solves the problems that the dosage of a target area is inaccurate and nuclides are lost due to the existing liquid radionuclide through an oral or intravascular injection method.

The utility model is realized in the following way: the utility model provides a liquid radioactive source device of applying source is equipped with the nuclide passageway in the source pipe of applying source the front end of source pipe is equipped with a plurality of nuclide sacculus along the source pipe of applying, the nuclide sacculus with nuclide passageway intercommunication the rear end of source pipe of applying is equipped with the nuclide entry of nuclide passageway intercommunication the front end of source pipe of applying is provided with collapsible locating support, just the source pipe of applying is located the center of locating support the source pipe has cup jointed the support and has retrieved the interior sleeve pipe outside the support retrieves interior sleeve pipe and has cup jointed the anti-radiation outer tube be connected with the haulage wire on the locating support, the haulage wire passes the support retrieves interior sleeve pipe and stretches out from the support retrieves interior sleeve pipe rear end.

The front end of the source applying catheter is provided with a far-end mark, the front end of the radiation-proof outer sleeve is provided with a near-end mark, and the near-end mark and the far-end mark are X-ray development marks.

A guide wire channel is also arranged in the source applying catheter, and the guide wire channel penetrates through the whole source applying catheter.

The locating support comprises a support wall of a reticular structure, a support frame is uniformly arranged on the inner wall of the support wall around an axle center, the support frame is in contact with the outer wall of the source applying catheter or the outer wall of the nuclide saccule, an annular recovery line is arranged at the rear end of the support wall, and the traction line is connected with the recovery line.

The front end of the support recovery inner sleeve is a horn-shaped recovery port, the recovery port is composed of a plurality of valve bodies, and the valve bodies incline outwards in the radial direction of the support recovery inner sleeve.

The nuclear injection device comprises a radiation protection box body, an injector shell is arranged in the radiation protection box body, two ends of the injector shell are respectively communicated with a water inlet pipe and a nuclear species outlet pipe, the nuclear species outlet pipe is used for being communicated with a nuclear species inlet, a water-driven piston is arranged in the injector shell body, the inner cavity of the injector shell body is divided into two cavities, and the cavities communicated with the nuclear species outlet pipe are used for containing liquid nuclear species.

And a pressure measuring pipe is communicated with a cavity communicated with the water inlet pipe in the injector shell, and extends out of the radiation-proof box body and is connected with a pressure measuring device.

The utility model is used for the source operation of the liquid radionuclide, and the liquid radionuclide is not directly taken orally or injected into a human body, but is conveyed into the nuclide saccule, and the nuclide does not enter the blood circulation in the nuclide saccule and the source catheter, so that the nuclide is not lost, and is not accumulated in other organs and is not damaged. The number and the size of the nuclide sacculus can be controlled, so that the dosage can be accurately calculated, and the curative effect and the complications can be accurately predicted. Can be used for radiotherapy by puncturing tumor or natural human body cavity, and can be theoretically applied to various tumors. The accurate two-dimensional and three-dimensional dose distribution of the target focus can be accurately calculated on the basis of CT, MRI and other images. The dose distribution of the organs at risk around the target region can be accurately assessed. And can be used for treating vascular stenosis.

The utility model can ensure the accuracy of the target area dosage, avoid the recurrence of the illness state and avoid the complications caused by the aggregation of nuclides in other organs.

Drawings

Fig. 1 is a structural diagram of the present utility model.

FIG. 2 is a block diagram of the nuclide injection device of the present utility model.

FIG. 3 is a block diagram of a cross-section of an applicator catheter of the present utility model.

FIG. 4 is a schematic representation of the present utility model after inflation of a nuclide balloon.

In the figure: 1. an applicator catheter; 2. nuclide balloon; 3. a positioning bracket; 4. a traction wire; 5. the bracket recovers the inner sleeve; 6. a radiation-proof outer sleeve; 7. a distal marker; 8. a proximal marker; 9. a radiation protection box body; 10. a syringe housing; 11. a hydrodynamic piston; 12. a water inlet pipe; 13. a nuclide outflow tube; 14. a pressure measuring tube; 1-1, nuclide inlet; 1-2, nuclide channels; 1-3, a guide wire channel; 3-1, a stent wall; 3-2, supporting frames; 5-1, a recovery port.

Detailed Description

As shown in fig. 1, the utility model is a liquid radioactive source applying device, which is structurally characterized in that a nuclide channel 1-2 is arranged in an applying source catheter 1, a plurality of nuclide balloons 2 are arranged at the front end of the applying source catheter 1 along the applying source catheter 1, the nuclide balloons 2 are communicated with the nuclide channel 1-2, a nuclide inlet 1-1 communicated with the nuclide channel 1-2 is arranged at the rear end of the applying source catheter 1, a retractable positioning bracket 3 is arranged at the front end of the applying source catheter 1, the applying source catheter 1 is positioned at the center of the positioning bracket 3, a bracket recovery inner sleeve 5 is sleeved outside the applying source catheter 1, a radiation-proof outer sleeve 6 is sleeved outside the bracket recovery inner sleeve 5, a traction wire 4 is connected to the positioning bracket 3, and the traction wire 4 penetrates through the bracket recovery inner sleeve 5 and extends out of the rear end of the bracket recovery inner sleeve 5.

As shown in FIG. 3, the applicator catheter 1 of the present utility model has a dual channel structure, including a nuclide channel 1-2 and a guidewire channel 1-3. The guide wire channel 1-3 is used for threading a guide wire, so that the guide wire channel 1-3 penetrates through the whole application catheter 1, and the guide wire can be transmitted from the rear end of the application catheter 1 and can be threaded out from the front end of the application catheter 1 in use. The nuclide channel 1-2 is used for delivering liquid nuclide, so that the rear end of the nuclide channel 1-2 is communicated with the nuclide inlet 1-1, and meanwhile, the front part of the nuclide channel 1-2 is communicated with the nuclide balloons 2 on the applying catheter 1, and the liquid nuclide injected from the nuclide inlet 1-1 enters each nuclide balloon 2 through the nuclide channel 1-2. A switch is arranged on the nuclide inlet 1-1.

The applicator catheter 1 can be guided by a guide wire to the treatment area.

The nuclide balloon 2 is made of flexible materials, the nuclide balloon 2 is propped up when liquid nuclide enters the nuclide balloon 2, and the diameter of the nuclide balloon 2 can be determined according to the requirement, so that the dosage of the nuclide is controlled. The nuclide balloons 2 have a certain length, and a plurality of nuclide balloons 2 can be connected end to end in sequence or can be spaced at certain distance as required, so that the distribution of the dosage is controlled.

However, not all the liquid nuclides in the nuclide balloon 2 can play a therapeutic role, the radiation protection outer sleeve 6 is sleeved outside the source application catheter 1, the unused nuclide balloon 2 is shielded through the radiation protection outer sleeve 6 according to the design requirement of dose distribution, and only the nuclide balloon 2 extending to the front of the radiation protection outer sleeve 6 can act on a target area, so that the length of the radionuclide can be controlled. Meanwhile, if the nuclide balloon 2 is in the radiation protection outer sleeve 6, the nuclide balloon 2 in the radiation protection outer sleeve 6 cannot be filled when the liquid nuclide is injected, so that the nuclide balloon 2 in the radiation protection outer sleeve 6 cannot play a role in treatment. The relative position of the radiation protection sleeve 6 and the applicator catheter 1 can be adjusted according to the length of the tumor, thereby determining the length of the actual treatment.

A distal marker 7 is arranged at the forefront end of the application catheter 1, and a proximal marker 8 is arranged at the forefront end of the radiation-proof outer sleeve 6. The distal marker 7 is used to determine the position of the front end of the applicator catheter 1, and the distal marker 7 is developed under X-rays to locate the starting position of the nuclide balloon 2. The proximal marker 8 is used to determine the frontal position of the front end of the radiation-protective outer sleeve 6, and the proximal marker 8 is developed under X-rays to locate the end position of the nuclide balloon 2 acting on the target. The nuclide balloon 2 can be accurately enabled to act on a preset position by matching the far-end mark 7 and the near-end mark 8 with an X-ray developing technology, and the length of an effective nuclide region (namely the part of the nuclide balloon 2 which is not shielded by the radiation-proof outer sleeve 6 and can directly act on surrounding tissues) can be accurately controlled.

The positioning bracket 3 comprises a bracket wall 3-1 with a reticular structure, a supporting frame 3-2 is uniformly arranged on the inner wall of the bracket wall 3-1 around the axis, the supporting frame 3-2 is contacted with the outer wall of the source applying catheter 1 or the outer wall of the nuclide saccule 2, an annular recovery line is arranged at the rear end of the bracket wall 3-1, and the traction line 4 is connected with the recovery line.

The positioning bracket 3 is made of metal materials or biological materials, the bracket wall 3-1 is cylindrical as a whole, meshes are uniformly formed on the bracket wall 3-1 to form a net structure, and the bracket wall 3-1 of the net structure has certain supporting capacity and can be folded and contracted under the action of certain external force. The support wall 3-1 is contacted with the outer wall of the source applying catheter 1 or the outer wall of the nuclide saccule 2 through the support frame 3-2 with a sheet or column structure, and the support frame 3-2 is uniformly distributed around the axis of the positioning support 3, so that the source applying catheter 1 is positioned at the center of the positioning support 3 under the centering action of the support frame 3-2, and the distances from the nuclide saccule 2 to surrounding human tissues are consistent, so that the radiation dose of nuclide uniformly acts on the surrounding tissues.

The positioning bracket 3 is in a contracted state initially and is hidden in the bracket recovery inner sleeve 5, the positioning bracket 3 advances along with the source application catheter 1, and after the nuclide balloon 2 reaches a preset position, the positioning bracket 3 is released by the retreating bracket recovery inner sleeve 5 and the radiation protection outer sleeve 6, and the positioning bracket 3 is unfolded after the release. The positioning stent 3 is hidden in the stent recovery inner sleeve 5 during the advancing process of the device, thereby preventing the device from being influenced by the advancing process.

Optimally, the support frame 3-2 of the positioning support 3 is in contact with the outer wall of the source catheter 1, the support frame 3-2 has elasticity, the positioning support 3 is sleeved at the corresponding position of the source catheter 1 in the preparation stage, the support frame 3-2 is kept away from the position of the nuclide balloon 2, the support frame 3-2 is in contact with the outer wall of the source catheter 1 between two adjacent nuclide balloons 2, then the positioning support 3 is contracted, the support recovery inner sleeve 5 and the radiation protection outer sleeve 6 are sequentially sleeved on the source catheter 1, the positioning support 3 is hidden, and the positioning support 3 can integrally move along with the device.

The utility model is suitable for the treatment of vascular stenosis due to the presence of the positioning stent 3.

Release of the positioning stent 3 is easy to achieve, but recovery of the positioning stent 3 is difficult to achieve, and it is common in the prior art to keep the positioning stent 3 in the human body or to make it of a degradable material. However, in the present utility model, the positioning bracket 3 generally needs to be taken out and recovered, and in order to ensure that the positioning bracket 3 can be recovered conveniently, a special design is made in the present utility model.

The recovery of the positioning bracket 3 is realized by a recovery wire, a traction wire 4 and a bracket recovery inner sleeve 5.

The rear end of the bracket wall 3-1 is provided with an annular recovery line, the traction line 4 is connected with the recovery line, and because the bracket wall 3-1 is of a net structure, the recovery line passes through all meshes in turn, when the recovery line is pulled by the traction line 4, the recovery line can reduce the shrinkage of the end part of the bracket wall 3-1, and the reduced positioning bracket 3 is pulled out and recovered by the bracket recovery inner sleeve 5.

In order to facilitate the recovery of the positioning support 3, the front end of the support recovery inner sleeve 5 is provided with a horn mouth-shaped recovery port 5-1, the positioning support 3 is contracted under the action of the inclined plane of the horn mouth after entering the horn mouth, and the positioning support can smoothly enter the support recovery inner sleeve 5 after contraction.

Optimally, the recovery port 5-1 is composed of a plurality of petals which are inclined outwardly in the radial direction of the stent recovery inner sleeve 5. The whole stent recovery inner sleeve 5 or the recovery port 5-1 is made of flexible materials, the valve body can swing under the action of external force, and the diameter of the profile of the valve body is smaller than the inner diameter of the stent recovery inner sleeve 5 when all the valve bodies are gathered together. The recovery port 5-1 can be formed by cutting the material at the end of the support recovery inner sleeve 5, that is, a plurality of cuts are uniformly cut around the axis at the end of the support recovery inner sleeve 5, so that a plurality of petals are formed by the material at the end of the support recovery inner sleeve 5, and then the petals are bent outwards along the root of the petals, thereby forming the bell-mouth-shaped recovery port 5-1.

The stent recovery inner sleeve 5 is positioned in the radiation protection outer sleeve 6 at the beginning, and the bell mouth is also folded and hidden in the radiation protection outer sleeve 6 at the moment, thereby preventing the device from being influenced in advancing in the blood vessel or tissue of the human body. When the positioning support 3 needs to be recovered, the support recovery inner sleeve 5 is pushed forwards relative to the radiation-proof outer sleeve 6, and the valve body at the front end of the support recovery inner sleeve 5 is outwards opened to form a horn mouth after the support recovery inner sleeve 6 is not bound.

The utility model also includes a nuclide injection device for delivering a liquid nuclide into the nuclide balloon 2 of the applicator catheter 1.

The nuclide injection device comprises a radiation protection box body 9, wherein an injector shell 10 is arranged in the radiation protection box body 9, two ends of the injector shell 10 are respectively communicated with a water inlet pipe 12 and a nuclide outlet pipe 13, the nuclide outlet pipe 13 is communicated with a nuclide inlet 1-1, a water-driven piston 11 is arranged in the injector shell 10, the inner cavity of the injector shell 10 is divided into two cavities by the water-driven piston 11, and the cavities communicated with the nuclide outlet pipe 13 are used for containing liquid nuclides.

A pressure measuring tube 14 is communicated with a cavity communicated with the water inlet tube 12 in the syringe shell 10, and the pressure measuring tube 14 extends out of the radiation protection box body 9 and is connected with a pressure measuring device.

The radiation-proof box body 9 is used for shielding rays of liquid nuclide, the injection of the liquid nuclide is driven by water power, direct contact or exposure of operators to the rays is avoided, water is conveyed into the syringe shell 10 through the water inlet pipe 12, the water-driven piston 11 is pushed to move, the liquid nuclide is conveyed to the nuclide inlet 1-1 through the nuclide outflow pipe 13, and the liquid nuclide enters the nuclide balloon 2 through the nuclide channel 1-2. When the nuclide balloon 2 is inflated to the maximum, the liquid pressure of the liquid nuclide is increased, the pressure is conducted to the pressure measuring tube 14 and is obtained through monitoring by the pressure measuring device, the injection of water is stopped after the pressure value displayed by the pressure measuring device reaches a preset value, and the size of the nuclide balloon 2 meets the requirement.

The radiation-proof case 9 is supported by lead glass, and can shield rays and observe the internal condition from the outside.

When the utility model is used for treating tumors, the steps are as follows:

1. establishing a treatment area channel: the percutaneous puncture can be used for establishing a channel by using a thicker trocar after the tumor is directly reached to treat the tumor, and a guide wire is arranged in the channel; for cavity tumor, the guide wire can be put into the normal cavity of human body to establish the channel; for vascular stenosis, a channel may be established for placement of a guidewire through a vascular interventional approach.

2. The applicator catheter 1 is placed into the treatment area: the end of the guide wire is inserted into the established treatment area channel, the tail of the guide wire is inserted into the head end of the source application catheter 1 after the guide wire reaches a preset position, the position of the guide wire is ensured to be unchanged after the tail of the guide wire comes out of the tail end of the source application catheter, and the guide wire passes through the guide wire channel 1-3 in the source application catheter 1. The source catheter 1, the positioning bracket 3, the bracket recovery inner sleeve 5 and the radiation protection outer sleeve 6 are inserted into a treatment area, the position of the far-end mark 7 is observed in real time through X rays and the like, and when the front end of the nuclide balloon 2 reaches a preset position, the length required to be treated is determined according to images. The retreating bracket recovers the inner sleeve 5 and the radiation-proof outer sleeve 6, and releases the positioning bracket 3. Meanwhile, the number of the balloons to be released is calculated according to the length of each balloon, the stent recovery inner sleeve 5 and the radiation protection outer sleeve 6 are continuously retracted, and when the proximal mark 8 reaches a preset position, the condition that enough nuclide balloons 2 are released is indicated.

3. Liquid nuclide preparation: the cavity in the syringe housing 10 communicated with the nuclide outflow tube 13 is filled with liquid nuclide and contrast medium, then the syringe housing 10 is put into the radiation protection box 9, and the water inlet tube 12 and the nuclide outflow tube 13 respectively extend out of the holes on the two side walls of the radiation protection box 9. The nuclide outflow tube 13 is connected with the nuclide inlet 1-1, and the pressure measuring tube 14 is connected with a pressure measuring device.

4. Liquid nuclide injection: the nuclide inlet 1-1 is opened and water is delivered into the syringe housing 10 through the water inlet pipe 12 using a syringe or a liquid pumping device, the position of the water piston 11 in the syringe housing 10 can be observed through lead glass, and the balloon expansion condition can be observed under X-ray perspective. And observing the pressure value measured by the pressure measuring device, stopping injection when the pressure reaches a preset pressure value, and closing the switch of the nuclide inlet 1-1. At this time, the nuclide balloon 2 is filled with the liquid nuclide as shown in fig. 4, and the nuclide balloon 2 is filled with the liquid nuclide.

5. Nuclide treatment: scanning a treatment area CT or MRI, calculating the time required to be treated according to the size, depth, length and the like of the tumor, opening a switch of the nuclide inlet 1-1 after the treatment time is reached, and extracting the liquid nuclide in the nuclide balloon 2.

6. Withdrawing the dispensing catheter 1: the inner sleeve 5 for stent recovery is pushed forward, the front end of the inner sleeve 5 for stent recovery stretches out of the outer sleeve 6 for radiation protection, the horn mouth at the front end of the inner sleeve opens as shown in fig. 1, then the recovery wire is pulled back, and the stent 3 to be positioned completely enters the inner sleeve 5 for stent recovery and then the source catheter 1 is pulled out along the guide wire. The extracted parts are all placed in a radiation-proof container for innocent treatment.

The utility model is used for the application operation of liquid radionuclides, and the liquid radionuclides are not directly taken orally or injected into a human body, but are conveyed into the nuclide balloon 2, and the nuclides are not lost in the nuclide balloon 2 and the application catheter 1, so that the nuclides are not accumulated in other organs and are not damaged. The number and the size of the nuclide balloons 2 can be controlled, so that the dosage can be accurately calculated, and the curative effect and the complications can be accurately predicted. Can be used for radiotherapy by puncturing tumor or natural human body cavity, and can be theoretically applied to various tumors. The accurate two-dimensional and three-dimensional dose distribution of the target focus can be accurately calculated on the basis of CT, MRI and other images. The dose distribution of the organs at risk around the target region can be accurately assessed. And can be used for treating vascular stenosis.

Claims

1. The utility model provides a liquid radioactive source device, its characterized in that is equipped with the nuclide passageway in the source catheter the front end of source catheter is equipped with a plurality of nuclide sacculus along the source catheter, the nuclide sacculus with nuclide passageway intercommunication the rear end of source catheter be equipped with the nuclide entry of nuclide passageway intercommunication the front end of source catheter is provided with collapsible locating support, just source catheter is located the center of locating support the source catheter has cup jointed the support and has retrieved the interior sleeve pipe outside the source catheter the support retrieves interior sleeve pipe has cup jointed the anti-radiation outer tube outside the support retrieves interior sleeve pipe and is connected with the haulage wire on the locating support, the haulage wire passes the support retrieves interior sleeve pipe and stretches out from the rear end of support retrieval interior sleeve pipe.

2. The liquid radiation source application device as defined in claim 1, wherein a distal marker is provided at a foremost end of said application catheter, a proximal marker is provided at a foremost end of said radiation protective outer sleeve, and said proximal marker and said distal marker are X-ray developing markers.

3. The liquid radiation source applicator of claim 1 wherein a guidewire channel is also provided within the applicator catheter, the guidewire channel extending through the entire applicator catheter.

4. The liquid radiation source applying device according to claim 1, wherein the positioning bracket comprises a bracket wall with a net structure, a supporting frame is uniformly arranged on the inner wall of the bracket wall around the axis, the supporting frame is in contact with the outer wall of the applying catheter or the outer wall of the nuclide balloon, an annular recovery line is arranged at the rear end of the bracket wall, and the traction line is connected with the recovery line.

5. The liquid radiation source applying apparatus as claimed in claim 1, wherein a bell mouth-shaped recovery port is provided at a front end of the stent recovery inner tube, the recovery port being composed of a plurality of petals which are inclined outwardly in a radial direction of the stent recovery inner tube.

6. The liquid radiation source application device according to claim 1, further comprising a nuclide injection device, wherein the nuclide injection device comprises a radiation protection box body, an injector shell is arranged in the radiation protection box body, two ends of the injector shell are respectively communicated with a water inlet pipe and a nuclide outlet pipe, the nuclide outlet pipe is communicated with the nuclide inlet, a water-driven piston is arranged in the injector shell body, the water-driven piston divides an inner cavity of the injector shell body into two cavities, and the cavities communicated with the nuclide outlet pipe are used for containing liquid nuclides.

7. The liquid radiation source applying apparatus as defined in claim 6, wherein a pressure measuring tube is connected to a cavity in the syringe housing connected to the water inlet tube, and the pressure measuring tube extends out of the radiation proof housing and is connected to a pressure measuring device.