CN220663277U - Immune magnetic bead storage device - Google Patents
Immune magnetic bead storage device Download PDFInfo
- Publication number
- CN220663277U CN220663277U CN202321823616.XU CN202321823616U CN220663277U CN 220663277 U CN220663277 U CN 220663277U CN 202321823616 U CN202321823616 U CN 202321823616U CN 220663277 U CN220663277 U CN 220663277U
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- CN
- China
- Prior art keywords
- housing
- box body
- box
- control device
- immunomagnetic bead
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- 239000011324 bead Substances 0.000 title claims abstract description 33
- 238000004321 preservation Methods 0.000 claims abstract description 23
- 238000005381 potential energy Methods 0.000 claims abstract description 4
- 238000007789 sealing Methods 0.000 claims description 17
- 230000001276 controlling effect Effects 0.000 claims description 10
- 230000001681 protective effect Effects 0.000 claims description 6
- 239000007788 liquid Substances 0.000 claims description 5
- 230000001105 regulatory effect Effects 0.000 claims description 4
- 230000002093 peripheral effect Effects 0.000 claims description 3
- 239000004005 microsphere Substances 0.000 description 8
- 238000000034 method Methods 0.000 description 4
- 239000003761 preservation solution Substances 0.000 description 3
- 239000004793 Polystyrene Substances 0.000 description 2
- 230000002776 aggregation Effects 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 229920002223 polystyrene Polymers 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- WHXSMMKQMYFTQS-UHFFFAOYSA-N Lithium Chemical compound [Li] WHXSMMKQMYFTQS-UHFFFAOYSA-N 0.000 description 1
- 238000005054 agglomeration Methods 0.000 description 1
- 238000004220 aggregation Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000005611 electricity Effects 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 239000006260 foam Substances 0.000 description 1
- 238000007710 freezing Methods 0.000 description 1
- 230000008014 freezing Effects 0.000 description 1
- 229910052744 lithium Inorganic materials 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
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- Packages (AREA)
Abstract
The utility model discloses an immunomagnetic bead preservation device, which comprises a hollow box body and a plurality of preservation bottles, wherein a plurality of fixed positions are arranged in the box body, a storage box is detachably connected in the fixed positions, a plurality of preservation bottles are detachably stored in the storage box, a gap is arranged between the storage box and the inner wall of the box body, a temperature control device and a control device are also arranged in the box body, the temperature control device is used for controlling the temperature in the box body, an insulating layer is arranged on the wall of the box body, the fixed positions comprise grooves, a limiting device is arranged at the fixed positions, the limiting device comprises a limiting seat which can be fixedly connected with the fixed positions, a limiting strip is slidably connected in the limiting seat, one end of the limiting strip can extend out of the limiting seat and limit the storage box, and the other end of the limiting strip is connected with the limiting seat through an elastic piece for accumulating elastic potential energy; can be stored in batches and taken in batches without interference.
Description
Technical Field
The utility model relates to the technical field of biology, in particular to an immunomagnetic bead storage device.
Background
Immunomagnetic microspheres (Immunomagnetic Microspheres, IMMS), or immunomagnetic beads (Immunomagnetic Beads, IMMS), are magnetic microspheres with monoclonal antibodies bound to their surface. Since it is necessary to bind an appropriate antibody to the surface of the magnetic microsphere, the magnetic microsphere used is required to be capable of binding to the monoclonal antibody by a chemical gene on the surface thereof or to have a large surface adsorption force capable of firmly binding to the monoclonal antibody. The crosslinked polystyrene microsphere has high strength, and the surface is easy to be chemically modified, so that the crosslinked polystyrene microsphere is an ideal framework material for preparing the immunomagnetic microsphere.
However, in practical application, it is found that freezing or high-temperature preservation can cause aggregation and agglomeration of magnetic beads to reduce extraction performance, so that a general magnetic bead solution cannot be stored and transported under low-temperature or high-temperature conditions, and the proper preservation temperature is 4-28 ℃, however, when extremely cold or high-temperature weather is met, high requirements are often put on transportation and storage conditions of the magnetic bead kit, and practical application effects and product popularization are hindered. At present, the preservation method based on preservation solution is proposed by Chinese patent CN202111603667.7, but when the preservation method is applied, no more requirements are put on other environments, and problems such as how to take and put, how to avoid pollution interference and the like are encountered in practical application.
The device for storing the immunomagnetic beads can further store the immunomagnetic beads in batches based on a storage liquid in a separated mode, and the immunomagnetic beads can be taken in batches without interference.
Disclosure of Invention
In view of the above-mentioned shortcomings existing at present, the present utility model provides an immunomagnetic bead preservation device, which can further carry out batch separation preservation on the basis of preservation solution, and can be taken in batches without interference.
In order to achieve the above purpose, the embodiment of the present utility model adopts the following technical scheme:
the utility model provides an immunomagnetic bead save set, includes hollow box and a plurality of embeds the save bottle that has the immunomagnetic bead that is preserved by the preservation liquid, be equipped with a plurality of fixed position in the box, can dismantle in the fixed position and be connected with the storage box, can dismantle in the storage box and deposit a plurality of save bottles, be equipped with the clearance between storage box and the box inner wall, still be equipped with temperature regulating device and controlling means in the box, temperature regulating device is used for controlling the box internal temperature, be equipped with the heat preservation on the box wall, the fixed position includes the recess, recess inner wall shape with storage box outer wall shape is unanimous, fixed position department is equipped with stop device, stop device includes but fixed connection is at the spacing seat of fixed position, but sliding connection has spacing in the spacing seat, spacing one end can stretch out spacing seat and carry out spacing to the storage box, spacing other end with be connected through an elastic component of accumulating elastic potential energy between the spacing seat.
According to one aspect of the utility model, the storage box comprises a box body and a box body cover, wherein the box body and the box body cover can be in sealed buckling connection, and a limiting part is arranged on the outer wall of the box body.
According to one aspect of the utility model, a power supply device is arranged in the box body, and the power supply device is a rechargeable battery.
According to one aspect of the utility model, the box body comprises a lower box body and a box body cover which can be mutually buckled, and a handle is arranged at the top of the box body cover.
According to one aspect of the utility model, the upper edge of the lower box body is provided with a sealing groove in a ring, and a sealing strip is arranged in the sealing groove and can form sealing fit with the cover edge of the box body cover.
According to one aspect of the utility model, the box body is provided with an external power interface which is connected with an external power supply through an external power line, and the control device also comprises a manual switch which is arranged outside the wall of the box body.
According to one aspect of the utility model, the control device comprises a protective shell, wherein a control circuit board is arranged in the protective shell, a microprocessor and a peripheral circuit thereof are arranged on the control circuit board, and the control circuit board is electrically connected with the temperature control device through an electrical connection wire.
According to one aspect of the utility model, the control device further comprises a display screen, wherein the display screen is arranged on the outer wall of the box body, and the control device is in sealing connection with the box body.
According to one aspect of the utility model, a humidity control device is also arranged in the box body and is used for controlling the humidity in the box body.
According to one aspect of the utility model, a temperature sensor and a humidity sensor are provided in the housing.
The implementation of the utility model has the advantages that: the immune magnetic beads stored in the preservation solution are placed in the preservation bottle in batches, the preservation bottle is placed in the storage box, the storage box is detachably placed in the groove at the fixed position in the box body, the storage box is fixed through the limiting device at the fixed position, when the immune magnetic beads are taken out, the storage boxes in other grooves are not affected by releasing the limiting device, and the box body can be closed again for preservation; the storage box can be added at any time for storage; the method can realize the taking of the immune magnetic beads in batches, and does not affect the preservation of other immune magnetic beads which are not taken.
Drawings
In order to more clearly illustrate the technical solutions of the embodiments of the present utility model, the drawings that are needed in the embodiments will be briefly described below, and it is obvious that the drawings in the following description are only some embodiments of the present utility model, and other drawings may be obtained according to these drawings without inventive effort for a person skilled in the art.
FIG. 1 is a schematic diagram of an immunomagnetic bead storage device according to the present utility model;
FIG. 2 is a schematic view of a storage box according to the present utility model;
fig. 3 is a schematic structural view of a limiting device according to the present utility model.
Detailed Description
The following description of the embodiments of the present utility model will be made clearly and completely with reference to the accompanying drawings, in which it is apparent that the embodiments described are only some embodiments of the present utility model, but not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the utility model without making any inventive effort, are intended to be within the scope of the utility model.
As shown in fig. 1, fig. 2 and fig. 3, an immunomagnetic bead preservation device comprises a hollow box body 1 and a plurality of preservation bottles in which immunomagnetic beads are preserved by preservation liquid (the preservation liquid can be preserved by adopting patent number CN 202111603667.7), wherein a plurality of fixing positions 2 are arranged in the box body, a storage box 3 is detachably connected in the fixing positions, a plurality of preservation bottles are detachably stored in the storage box, a gap is arranged between the storage box and the inner wall of the box body, a temperature control device 4 and a control device 5 are further arranged in the box body, the temperature control device is used for controlling the temperature in the box body, a heat preservation layer is arranged on the wall of the box body, the fixing positions comprise grooves 21, the shape of the inner wall of each groove is consistent with that of the outer wall of the storage box, the storage box body comprises a box body 31 and a box body cover 32, structures such as foam boards or other flexible fixing materials are arranged in the box body, a limit position 33 is arranged on the outer wall of the box body, a limit seat 6 can be fixedly connected with one end of the limit seat, and the limit seat 61 can be fixedly connected with one end of the limit seat through the limit seat, and the limit seat 61 can be fixedly connected with the limit seat.
In practical application, be equipped with spacing portion on the box body outer wall, fixed position department is equipped with stop device, stop device is including but fixed connection is at the spacing seat of fixed position, but sliding connection has spacing in the spacing seat, spacing one end can stretch out spacing seat and with spacing portion cooperation carries out spacingly to the box body, spacing other end with be connected through an elastic component of accumulating elastic potential energy between the spacing seat, the optional spring. When the storage box is placed in the groove, one end of the limiting strip is compressed into the limiting seat by the box body, when the storage box is completely placed in the groove, the limiting strip and the limiting part are just located at the same position, the limiting part is of a concave structure, and the limiting strip is extruded into the limiting part by the elastic piece at the moment, so that the storage box is limited, and the storage box is not easy to separate from the groove.
In practical application, the power supply device 7 is disposed in the case, and the power supply device is a rechargeable battery, for example, a rechargeable lithium battery may be used.
In practical application, the box body comprises a lower box body 11 and a box body cover 12 which can be mutually buckled, and a handle is arranged at the top of the box body cover.
In practical application, the upper ring of the box edge of the lower box body is provided with a sealing groove 13, a sealing strip is arranged in the sealing groove, and the sealing strip can be in sealing fit with the cover edge of the box body cover.
In practical application, the box body is provided with an external power interface 14, and is connected with an external power supply through an external power line, and the control device further comprises a manual switch 51, and the manual switch is arranged outside the wall of the box body.
In practical application, controlling means includes the protective housing, is equipped with control circuit board in the protective housing, be equipped with microprocessor and peripheral circuit on the control circuit board, control circuit board through the electric connection line with controlling means electricity is connected, preset control program in the microprocessor, control program can be according to conventional programming technique realization basic function design, presets the target temperature value, carries out the temperature control operation in the control means to the box according to target temperature value until the temperature reaches the target temperature value in the box.
In practical application, the control device further comprises a display screen 52, the display screen is arranged on the outer wall of the box body, the control device is in sealing connection with the box body, and the display screen is used for displaying information such as temperature, humidity and the like.
In practical application, the box body is also internally provided with a humidity control device 8 for controlling the humidity in the box body.
In practical application, a temperature sensor and a humidity sensor are arranged in the box body, the humidity sensor is used for acquiring humidity information in the box body and sending the humidity information to a control device, and the control device displays the humidity information on a display screen; the temperature sensor collects temperature information in the box body and sends the temperature information to the control device, and the control device obtains the temperature information and then displays the temperature information on the display screen. The control device can set a preset temperature parameter through pre-programming, the temperature parameter is adjustable, the preset temperature parameter is a target value, and the temperature control device works according to the preset temperature parameter. The temperature sensor collects temperature information in the box body, the control device compares the temperature information with preset temperature parameters, and when the temperature information in the box body does not reach the preset temperature parameters, the control device controls the temperature control device to heat, so that the temperature of the box body is adjusted; when the temperature information in the box body exceeds the preset temperature parameter, the control device controls the temperature control device to cool down, so that the temperature of the box body is adjusted.
The foregoing is merely illustrative of the present utility model, and the present utility model is not limited thereto, and any changes or substitutions easily contemplated by those skilled in the art within the technical scope of the present utility model should be included in the scope of the present utility model. Therefore, the protection scope of the present utility model shall be subject to the protection scope of the claims.
Claims (10)
1. The utility model provides an immunomagnetic bead save set, includes hollow box and a plurality of embeds the save bottle that has the immunomagnetic bead that is preserved by the preservation liquid, its characterized in that, be equipped with a plurality of fixed position in the box, be connected with the storage box in the fixed position can dismantle, can dismantle in the storage box and deposit a plurality of save bottles, be equipped with the clearance between storage box and the box inner wall, still be equipped with temperature regulating device and controlling means in the box, temperature regulating device is used for controlling the temperature in the box, be equipped with the heat preservation on the box wall, the fixed position includes the recess, recess inner wall shape with storage box outer wall shape is unanimous, fixed position department is equipped with stop device, stop device includes the spacing seat of fixed connection at the fixed position, but sliding connection has the spacing in the spacing seat, spacing one end can stretch out the spacing seat and carry out spacing to the storage box, the spacing other end with be connected through an elastic component of accumulating elastic potential energy between the spacing seat.
2. The immunomagnetic bead holder of claim 1, wherein the storage case comprises a case body and a case body cover, wherein the case body and the case body cover are in a sealing and buckling connection, and a limiting part is arranged on the outer wall of the case body.
3. The immunomagnetic bead holder of claim 1, wherein a power supply device is disposed in the housing, and wherein the power supply device is a rechargeable battery.
4. The immunomagnetic bead holder of claim 1, wherein the housing includes a lower housing and a housing cover that are snap-engageable with each other, the housing cover having a handle at a top thereof.
5. The immunomagnetic bead holder of claim 4, wherein the upper rim of the lower housing is annularly provided with a sealing groove, a sealing strip is provided in the sealing groove, and the sealing strip is in sealing engagement with the rim of the housing cover.
6. The immunomagnetic bead holding device of claim 1, wherein the housing is provided with an external power interface connected to an external power source via an external power cord, and the control device further comprises a manual switch disposed outside the housing wall.
7. The immunomagnetic bead holding device of claim 1, wherein the control device comprises a protective housing, a control circuit board is arranged in the protective housing, a microprocessor and a peripheral circuit thereof are arranged on the control circuit board, and the control circuit board is electrically connected with the temperature control device through an electrical connection wire.
8. The immunomagnetic bead holder of claim 6, wherein said control device further comprises a display screen disposed on an outer wall of the housing, said control device being sealingly coupled to said housing.
9. The immunomagnetic bead holding apparatus of any one of claims 1 to 7, further comprising a humidity control device in said housing for controlling humidity in said housing.
10. The immunomagnetic bead holder of claim 8, wherein a temperature sensor and a humidity sensor are disposed within the housing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202321823616.XU CN220663277U (en) | 2023-07-11 | 2023-07-11 | Immune magnetic bead storage device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202321823616.XU CN220663277U (en) | 2023-07-11 | 2023-07-11 | Immune magnetic bead storage device |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN220663277U true CN220663277U (en) | 2024-03-26 |
Family
ID=90328005
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202321823616.XU Active CN220663277U (en) | 2023-07-11 | 2023-07-11 | Immune magnetic bead storage device |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN220663277U (en) |
-
2023
- 2023-07-11 CN CN202321823616.XU patent/CN220663277U/en active Active
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| GR01 | Patent grant | ||
| GR01 | Patent grant |