CN220657552U - Hyaluronic acid crosslinking reaction equipment - Google Patents
Hyaluronic acid crosslinking reaction equipment Download PDFInfo
- Publication number
- CN220657552U CN220657552U CN202322237142.7U CN202322237142U CN220657552U CN 220657552 U CN220657552 U CN 220657552U CN 202322237142 U CN202322237142 U CN 202322237142U CN 220657552 U CN220657552 U CN 220657552U
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- CN
- China
- Prior art keywords
- heating interlayer
- stirring
- tank body
- heating
- hyaluronic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Links
- 238000004132 cross linking Methods 0.000 title claims abstract description 22
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 title claims abstract description 17
- 229920002674 hyaluronan Polymers 0.000 title claims abstract description 17
- 229960003160 hyaluronic acid Drugs 0.000 title claims abstract description 17
- 238000010438 heat treatment Methods 0.000 claims abstract description 75
- 238000003756 stirring Methods 0.000 claims abstract description 67
- 239000011229 interlayer Substances 0.000 claims abstract description 54
- 239000002994 raw material Substances 0.000 claims abstract description 51
- 239000012530 fluid Substances 0.000 claims abstract description 7
- 238000004519 manufacturing process Methods 0.000 abstract description 2
- 230000000694 effects Effects 0.000 description 6
- 239000013529 heat transfer fluid Substances 0.000 description 6
- 230000004888 barrier function Effects 0.000 description 4
- 229920002385 Sodium hyaluronate Polymers 0.000 description 3
- 229940010747 sodium hyaluronate Drugs 0.000 description 3
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 description 3
- 210000004027 cell Anatomy 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 210000000056 organ Anatomy 0.000 description 2
- 238000012856 packing Methods 0.000 description 2
- AEMOLEFTQBMNLQ-AQKNRBDQSA-N D-glucopyranuronic acid Chemical compound OC1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O AEMOLEFTQBMNLQ-AQKNRBDQSA-N 0.000 description 1
- IAJILQKETJEXLJ-UHFFFAOYSA-N Galacturonsaeure Natural products O=CC(O)C(O)C(O)C(O)C(O)=O IAJILQKETJEXLJ-UHFFFAOYSA-N 0.000 description 1
- 210000004381 amniotic fluid Anatomy 0.000 description 1
- 210000001188 articular cartilage Anatomy 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000004891 communication Methods 0.000 description 1
- 210000000695 crystalline len Anatomy 0.000 description 1
- 210000000805 cytoplasm Anatomy 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 210000004207 dermis Anatomy 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 230000002900 effect on cell Effects 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 229940097043 glucuronic acid Drugs 0.000 description 1
- 239000010410 layer Substances 0.000 description 1
- 230000001050 lubricating effect Effects 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 210000002826 placenta Anatomy 0.000 description 1
- 229920002545 silicone oil Polymers 0.000 description 1
- 210000003491 skin Anatomy 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Landscapes
- Mixers Of The Rotary Stirring Type (AREA)
Abstract
The utility model provides hyaluronic acid crosslinking reaction equipment, which relates to the technical field of gel manufacturing experimental equipment and comprises the following components: the tank body is provided with a reaction cavity, and a raw material inlet and a raw material outlet which are communicated with the reaction cavity; a stirring member rotatably disposed in the tank body under the drive of the power member; the tank is characterized in that a first heating interlayer is arranged on the side wall surface of the tank body, a second heating interlayer communicated with the first heating interlayer is arranged in the stirring piece, heat carrier fluid is arranged in each heating interlayer, and a heating port and a drain port communicated with any heating interlayer are also arranged on the tank body. The utility model solves the problem that the internal raw materials of the conventional hyaluronic acid crosslinking reaction equipment are heated unevenly.
Description
Technical Field
The utility model relates to the technical field of gel manufacturing experimental equipment, in particular to hyaluronic acid crosslinking reaction equipment.
Background
Sodium hyaluronate is an inherent component in the human body, is a glucuronic acid, has no species specificity, and is widely present in placenta, amniotic fluid, lens, articular cartilage, dermis of skin and other tissues; it is distributed in cytoplasm and cell interstitium in organ and has lubricating and nourishing effects on cells and cell organ itself.
Since the reaction temperature is generally controlled in the crosslinking reaction, the conventional reaction device for sodium hyaluronate can refer to patent publication No. CN206396103U, which provides an extraction device for crosslinked sodium hyaluronate gel, by adding each raw material into a heat-preserving stirring tank, and then stirring uniformly by a vertical stirring rod, so that the raw materials are fully contacted and reacted.
Then in the structure, each raw material is heated from outside to inside through a heating pipe on the tank body, so that the temperature difference of the raw material at a part close to the inner wall surface of the tank body and the center of the tank body is large, the raw material is heated unevenly, the crosslinking uniformity is poor, and high-efficiency crosslinking cannot be realized.
Disclosure of Invention
Aiming at the defects existing in the prior art, the utility model provides hyaluronic acid crosslinking reaction equipment, which solves the problem that the internal raw materials of the conventional hyaluronic acid crosslinking reaction equipment are heated unevenly.
According to an embodiment of the present utility model, a hyaluronic acid crosslinking reaction apparatus includes:
the tank body is provided with a reaction cavity, and a raw material inlet and a raw material outlet which are communicated with the reaction cavity;
a stirring member rotatably disposed in the tank body under the drive of the power member;
the tank is characterized in that a first heating interlayer is arranged on the side wall surface of the tank body, a second heating interlayer communicated with the first heating interlayer is arranged in the stirring piece, heat carrier fluid is arranged in each heating interlayer, and a heating port and a drain port communicated with any heating interlayer are also arranged on the tank body.
The technical scheme provided by the disclosure has at least the following beneficial effects:
1. the first heating interlayer and the second heating interlayer are respectively arranged on the side wall of the tank body and the stirring piece, and the raw materials are heated by the two layers at the same time, so that the raw materials are heated more uniformly, and the crosslinking effect between the raw materials is better;
2. through setting up first heating interlayer and second heating interlayer intercommunication, the accessible lets in the higher heat carrier fluid of temperature to the heating mouth, makes above-mentioned heat carrier fluid can flow between first heating interlayer and second heating interlayer, and then to the raw materials heating, and it is comparatively convenient to use, and through the warm raw materials of liquid, avoids the raw materials to press close to each heating interlayer department temperature too big, damage raw materials.
In another embodiment, the stirring piece comprises a stirring shaft, a shell and stirring blades which are sequentially connected from inside to outside, wherein,
one end of the stirring shaft is connected with a stirring motor, the shell is vertically connected with the stirring shaft in a sliding manner, and a gap is reserved between the shell and the stirring shaft to form the second heating interlayer.
In another embodiment, the top and bottom ends of the second heating barrier are in communication with the first heating barrier.
In another embodiment, the top and bottom ends of the housing are both rotatably connected within the tank, and each rotatably connected point is rotatably sealed.
In another embodiment, the stirring blades are vertically distributed along the shell, and each stirring blade is internally provided with a third heating interlayer, and the third heating interlayers are communicated with the second heating interlayers.
In another embodiment, each of the stirring vanes extends vertically helically.
In another embodiment, the raw material inlets are at least two and distributed at the top end of the tank body.
In another embodiment, the raw material outlet is located at the bottom of the tank body, and the raw material outlet is provided with a switch valve.
Drawings
Fig. 1 is a schematic structural diagram of one embodiment of the present utility model.
Fig. 2 is a schematic structural view of a stirring element according to an embodiment of the present utility model.
In the above figures:
1. a tank body; 2. a stirring motor; 3. a raw material inlet; 4. a heating port; 5. a stirring shaft; 6. a first heating barrier; 7. stirring blades; 8. a raw material outlet; 9. a drain port; 10. a switch valve; 11. a second heating barrier; 12. a housing.
Detailed Description
Various embodiments of the utility model are disclosed in the accompanying drawings, and for purposes of explanation, numerous practical details are set forth in the following description. However, it should be understood that these practical details are not to be taken as limiting the utility model. That is, in some embodiments of the utility model, these practical details are unnecessary. Furthermore, for the purpose of simplifying the drawings, some of the presently available structures and elements are shown in a simplified schematic form, and the same reference numerals will be used throughout the drawings to designate the same or similar elements. Features of different embodiments may be applied interactively without conflict.
Referring to fig. 1 and 2, an embodiment of the present utility model provides a hyaluronic acid crosslinking reaction apparatus, which includes a tank 1 and a stirring member disposed in the tank 1, wherein,
the reaction chamber is reserved in the tank body 1, at least two raw material inlets 3 are arranged at the top of the tank body 1, the specific number of the raw material inlets 3 can be determined according to the number of actual raw material types, each raw material inlet 3 is communicated with the reaction chamber, a raw material outlet 8 is also arranged at the bottom of the tank body 1, a switch valve 10 is arranged on the raw material outlet 8, and after the reaction of each raw material in the reaction chamber is completed, the switch valve 10 is opened, so that the raw material in the tank body 1 can be discharged; the structure of the switch valve 10 and its specific implementation are all of the prior art, and are not described here again;
the stirring piece comprises a stirring blade 7, a shell 12 and a stirring shaft 5, wherein the shell 12 is hollow and cylindrical, the stirring shaft 5 is positioned in the shell 12 and is coaxially arranged, the stirring shaft 5 and the shell 12 are fixedly connected through a connecting block, or the stirring shaft 5 is vertically and slidably connected with the shell 12 through a vertically extending sliding rail, and the stirring shaft 5 can be separated from the shell 12 through vertically and upwardly sliding the stirring shaft 5, so that the stirring shaft 5 and the shell 12 are convenient to clean or replace; the stirring blade 7 is fixedly arranged on the shell 12;
the top of the stirring shaft 5 is connected with a stirring motor 2, and the stirring shaft 5 can be driven to drive the shell 12 and the stirring blade 7 to rotate by controlling the running of the stirring motor 2;
the top of the shell 12 is rotatably connected with the top of the tank body 1, the shell and the tank body are rotatably sealed, and the bottom of the shell 12 is rotatably connected with the bottom of the tank body 1, and the shell and the tank body are also rotatably sealed; the above-mentioned rotary seal can be realized by rotary seal ring/piece, or utilize mechanical seal, oil seal, packing seal (packing), its concrete structure is the prior art, will not be repeated here;
a second heating interlayer 11 extending vertically is reserved between the shell 12 and the stirring shaft 5, and meanwhile, a first heating interlayer 6 is reserved on the wall surface of the tank body 1, and the top and the bottom of the first heating interlayer 6 and the second heating interlayer 11 are communicated;
meanwhile, the top and the bottom of the tank body 1 are also provided with a heating port 4 and a draining port 9, and the heating port 4 and the draining port 9 are communicated with the first heating interlayer 6; by the arrangement, a worker can introduce heated heat transfer fluid, such as silicone oil, water vapor, etc., into the heating port 4, so that the heat transfer fluid can be filled into the first heating interlayer 6 and the second heating interlayer 11, heat the raw materials in the tank body 1, and then flow out through the drain port 9.
The present utility model also proposes another embodiment, which differs from the above embodiment in that the present embodiment provides a stirring vane 7 structure to enhance the heating effect on the raw material;
the stirring vane 7 is internally provided with a third heating interlayer, and the third heating interlayer can be a cavity reserved in the stirring vane 7 or can be a pipeline distributed on the stirring vane 7, in the embodiment, the cavity is reserved in the stirring vane 7 and is communicated with the second heating interlayer 11 to be arranged so as to be capable of receiving heat transfer fluid flowing from the second heating interlayer 11;
after the arrangement, the heat transfer fluid can circulate into the stirring blade 7, and the raw materials of the tank body 1 are continuously heated along with the rotation of the stirring blade 7, so that the heating effect of the equipment is more uniform;
further, please refer to fig. 2 herein, in order to enhance the contact area between the stirring blade 7 and the raw material, and further enhance the heating effect of the apparatus on the raw material; in the embodiment, the stirring blades 7 are arranged in pairs and are symmetrically distributed on the shell 12 along the horizontal direction, and meanwhile, a plurality of groups of stirring blades 7 are vertically distributed on the shell 12, and each stirring blade 7 extends upwards along the same spiral direction;
after the scheme is adopted, the method comprises the following steps:
adding raw materials into the raw material inlet 3, and starting the stirring motor 2 to drive the stirring shaft 5, the shell 12 and the stirring blade 7 to rotate;
the first heating interlayer 6 and the second heating interlayer 11 are respectively arranged on the side wall of the tank body 1 and the stirring piece, and the raw materials are heated by the inside and the outside of the first heating interlayer 6 and the second heating interlayer 11, so that the raw materials are heated more uniformly, and the crosslinking effect between the raw materials is better;
meanwhile, through the arrangement of the first heating interlayer 6 and the second heating interlayer 11 in a communicating manner, the heat-carrying fluid with higher temperature is introduced into the heating port 4, so that the heat-carrying fluid can flow between the first heating interlayer 6 and the second heating interlayer 11 from top to bottom, the raw materials are heated, the raw materials are more convenient to use, and the raw materials are prevented from being damaged due to overlarge temperature at the positions of the raw materials close to the heating interlayers through liquid heating.
When the heat transfer fluid flows into the second heating interlayer 11, the heat transfer fluid can flow into the third heating interlayer again and rotate together with the stirring blades 7, so that the uniform heating effect of the device on the raw materials is enhanced.
Finally, it is noted that the above embodiments are only for illustrating the technical solution of the present utility model and not for limiting the same, and although the present utility model has been described in detail with reference to the preferred embodiments, it should be understood by those skilled in the art that modifications and equivalents may be made thereto without departing from the spirit and scope of the technical solution of the present utility model, which is intended to be covered by the scope of the claims of the present utility model.
Claims (8)
1. A hyaluronic acid crosslinking reaction apparatus, characterized by comprising:
a tank (1) having a reaction chamber, a raw material inlet (3) and a raw material outlet (8) communicating with the reaction chamber;
the stirring piece is rotatably arranged in the tank body (1) under the drive of the power piece;
the novel heating tank is characterized in that a first heating interlayer (6) is arranged on the side wall surface of the tank body (1), a second heating interlayer (11) communicated with the first heating interlayer (6) is arranged in the stirring piece, heat carrier fluid is arranged in each heating interlayer, and a heating port (4) and a draining port (9) communicated with any heating interlayer are also arranged on the tank body (1).
2. A hyaluronic acid cross-linking reaction device according to claim 1, characterized in that: the stirring piece comprises a stirring shaft (5), a shell (12) and a stirring blade (7) which are sequentially connected from inside to outside,
one end of the stirring shaft (5) is connected with a stirring motor (2), the shell (12) is vertically connected with the stirring shaft (5) in a sliding manner, and a gap is reserved between the shell and the stirring shaft to form the second heating interlayer (11).
3. A hyaluronic acid cross-linking reaction device according to claim 2, characterized in that: the top end and the bottom end of the second heating interlayer (11) are communicated with the first heating interlayer (6).
4. A hyaluronic acid cross-linking reaction device according to claim 3, characterized in that: the top and the bottom of the shell (12) are both rotatably connected in the tank body (1), and each rotary connection point is rotatably sealed.
5. A hyaluronic acid cross-linking reaction device according to any of claims 2-4, characterized in that: the stirring blades (7) are vertically distributed along the shell (12), a third heating interlayer is arranged in each stirring blade (7), and the third heating interlayer is communicated with the second heating interlayer (11).
6. The hyaluronic acid crosslinking reaction apparatus of claim 5, wherein: each stirring blade (7) extends vertically and spirally.
7. A hyaluronic acid cross-linking reaction device according to claim 1, characterized in that: the raw material inlets (3) are at least two and distributed at the top end of the tank body (1).
8. A hyaluronic acid cross-linking reaction device according to claim 1, characterized in that: the raw material outlet (8) is positioned at the bottom of the tank body (1), and the raw material outlet (8) is provided with a switch valve (10).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202322237142.7U CN220657552U (en) | 2023-08-18 | 2023-08-18 | Hyaluronic acid crosslinking reaction equipment |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202322237142.7U CN220657552U (en) | 2023-08-18 | 2023-08-18 | Hyaluronic acid crosslinking reaction equipment |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN220657552U true CN220657552U (en) | 2024-03-26 |
Family
ID=90334941
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202322237142.7U Active CN220657552U (en) | 2023-08-18 | 2023-08-18 | Hyaluronic acid crosslinking reaction equipment |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN220657552U (en) |
-
2023
- 2023-08-18 CN CN202322237142.7U patent/CN220657552U/en active Active
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| GR01 | Patent grant | ||
| GR01 | Patent grant |