CN220657074U

CN220657074U - Concentrating device

Info

Publication number: CN220657074U
Application number: CN202322250222.6U
Authority: CN
Inventors: 吴阳超; 黄成�; 胡渠江; 高路
Original assignee: Shanghai Zhaowei Bioengineering Co ltd; Shanghai Hongene Biotech Corp
Current assignee: Shanghai Zhaowei Bioengineering Co ltd; Shanghai Hongene Biotech Corp
Priority date: 2023-08-21
Filing date: 2023-08-21
Publication date: 2024-03-26
Anticipated expiration: 2033-08-21

Abstract

The application provides a enrichment facility belongs to concentrator and makes the field. The concentrating device comprises a mother liquor collecting unit, a pressurizing unit, a nanofiltration membrane unit and a reverse osmosis membrane unit. The pressurizing unit is communicated with the mother liquor collecting unit and is used for providing pressure for mother liquor conveying and separating; the nanofiltration membrane unit is communicated with the mother liquor collecting unit and comprises a first concentrated solution conveying pipe and a first clear solution conveying pipe, wherein the first concentrated solution conveying pipe is used for outputting concentrated solution, and the first clear solution conveying pipe is used for outputting clear solution; reverse osmosis membrane unit and first clear solution conveyer pipe intercommunication, reverse osmosis membrane unit include second concentrate conveyer pipe and second clear solution conveyer pipe, and second concentrate conveyer pipe is used for exporting the concentrate, and second clear solution conveyer pipe is used for exporting the clear solution, and this enrichment facility can improve the rate of recovery of nucleotide in the concentration process to a certain extent.

Description

Concentrating device

Technical Field

The application relates to the field of concentrating equipment manufacturing, in particular to a concentrating device.

Background

The nucleotide is a basic structural unit of nucleic acid, is a very important low-molecular compound in organisms, plays a leading role in important life phenomena such as organism development, propagation, inheritance and the like, and is widely applied to industries such as food, medicine, agriculture, fine chemical industry and the like. In the prior art, a concentration device is generally needed in the nucleotide preparation process, however, the existing concentration device has the problem of low nucleotide recovery rate, and thus the yield of the nucleotide is affected.

Disclosure of Invention

The purpose of the present application is to provide a concentration device that can improve the recovery rate of nucleotides in the concentration process to a certain extent.

Embodiments of the present application are implemented as follows:

the embodiment of the application provides a concentration device, including mother liquor collection unit, pressurization unit, nanofiltration membrane unit and reverse osmosis membrane unit. The pressurizing unit is communicated with the mother liquor collecting unit and is used for providing pressure for mother liquor conveying and separating; the nanofiltration membrane unit is communicated with the mother liquor collecting unit and comprises a first concentrated solution conveying pipe and a first clear solution conveying pipe, wherein the first concentrated solution conveying pipe is used for outputting concentrated solution, and the first clear solution conveying pipe is used for outputting clear solution; the reverse osmosis membrane unit is communicated with the first clear liquid conveying pipe and comprises a second concentrated liquid conveying pipe and a second clear liquid conveying pipe, the second concentrated liquid conveying pipe is used for outputting concentrated liquid, and the second clear liquid conveying pipe is used for outputting clear liquid.

Among the above-mentioned technical scheme, enrichment facility is including the nanofiltration membrane that sets gradually and the separation recovery unit of reverse osmosis membrane two types, wherein, nanofiltration membrane unit is arranged in retrieving most nucleotide in the mother liquor, reverse osmosis membrane unit and nanofiltration membrane unit's first clear liquid conveyer pipe intercommunication for retrieve remaining nucleotide in the clear liquid, compare in only setting up single type separation recovery unit or with reverse osmosis membrane unit and nanofiltration membrane unit's first concentrate conveyer pipe intercommunication (carrying out separation recovery twice in succession promptly to the mother liquor), can effectively reduce the loss volume of nucleotide in the concentration process, thereby improve the rate of recovery of nucleotide in the concentration process to a certain extent.

In some alternative embodiments, the osmotic pressure of the nanofiltration membrane unit is not lower than the osmotic pressure of the reverse osmosis membrane unit.

In the above technical scheme, the nanofiltration membrane unit is located at the upstream of the reverse osmosis membrane unit, the osmotic pressure of the nanofiltration membrane unit is set to be not lower than that of the reverse osmosis membrane unit (namely, the nanofiltration membrane with a higher osmotic pressure is selected), so that clear liquid passing through the nanofiltration membrane unit still has higher pressure, the reverse osmosis membrane unit is also carried out under a proper pressure, and the advantages of better separation effect and higher separation efficiency are achieved.

In some alternative embodiments, the liquid inlet pipe of the nanofiltration membrane unit is mounted at the lower end of the nanofiltration membrane unit, and the first concentrate delivery pipe and the first clear liquid delivery pipe are both mounted at the upper end of the nanofiltration membrane unit.

Among the above-mentioned technical scheme, install the feed liquor pipe, first concentrate conveyer pipe and the first clear liquid conveyer pipe of nanofiltration membrane unit respectively in above-mentioned specific position, can make feed liquor pipe and drain pipe interval farther to effectively avoid the pipeline crossing, have the advantage of being convenient for carry out the pipeline overall arrangement.

In some alternative embodiments, the first concentrate delivery pipe and the second concentrate delivery pipe are in communication with the same concentrate delivery main line for delivering concentrate.

Among the above-mentioned technical scheme, first concentrate conveyer pipe and second concentrate conveyer pipe are connected in same concentrate delivery main line earlier, and rethread concentrate delivery main line is with concentrate output, compares in setting up two concentrate delivery main lines respectively and exports concentrate, can reduce the cost of pipeline overall arrangement, simultaneously, less pipeline quantity still has the space occupation and is less and be convenient for carry out the advantage of pipeline overall arrangement.

In some alternative embodiments, the concentrate delivery main line is provided with a heat exchange unit.

In the above technical scheme, the main concentrated solution conveying pipeline is additionally provided with the heat exchange unit, so that the temperature of the concentrated solution can be reduced through the heat exchange of the heat exchange unit (the separation and recovery of the nucleotide are realized through pressurization, so that the temperature of the solution is increased), thereby facilitating the subsequent treatment of the recovered concentrated solution.

In some alternative embodiments, the first clear liquid transfer pipe is provided with a first pressure regulating valve and/or the infusion line between the mother liquor collection unit and the nanofiltration membrane unit is provided with a second pressure regulating valve.

In some alternative embodiments, the first concentrate delivery pipe and/or the second concentrate delivery pipe is provided with a third pressure regulating valve.

According to the technical scheme, the pressure regulating valves are arranged on the corresponding pipelines, so that the pressure of corresponding management can be monitored and regulated in real time, and the safety of a concentration process is considered under the condition of ensuring the concentration efficiency.

In some alternative embodiments, the pressurizing unit includes a booster pump in communication with the mother liquor collection unit and the nanofiltration membrane unit, respectively, and a detection assembly in communication with the booster pump and configured to be capable of detecting a water level within the booster pump.

Among the above-mentioned technical scheme, adopt the booster pump to provide liquid transport's power, have conveying efficiency height and carry the good advantage of stability, in addition, set up detection component, can detect whether the water level in the booster pump is normal before the booster pump starts to effectively reduce the fault rate of booster pump.

In some alternative embodiments, the detection assembly includes a water delivery line in communication with a water line within the booster pump and a first valve for opening or closing the water delivery line.

Among the above-mentioned technical scheme, through the cooperation of water delivery pipeline and first valve, can conveniently, swiftly realize the water level detection of booster pump before the start, have the higher advantage of detection efficiency, simultaneously, still have simple structure's advantage.

In some alternative embodiments, the bottom of the nanofiltration membrane unit and the bottom of the reverse osmosis membrane unit are both provided with a purge line, and a second valve for opening or closing the purge line.

In the technical scheme, the nanofiltration membrane unit and the reverse osmosis membrane unit are provided with the cleaning pipeline and the valve for controlling the opening and closing of the cleaning pipeline, so that the separation recovery unit can be cleaned regularly, and the cleanliness of the concentrated solution is ensured.

Drawings

In order to more clearly illustrate the technical solutions of the embodiments of the present application, the drawings that are needed in the embodiments will be briefly described below, it being understood that the following drawings only illustrate some embodiments of the present application and therefore should not be considered limiting the scope, and that other related drawings may be obtained according to these drawings without inventive effort for a person skilled in the art.

Fig. 1 is a schematic structural diagram of a first concentrating device according to an embodiment of the present disclosure;

fig. 2 is a schematic structural diagram of a second concentrating device according to an embodiment of the present disclosure;

fig. 3 is a schematic structural diagram of a third concentration device according to an embodiment of the present disclosure;

fig. 4 is a schematic structural diagram of a fourth concentrating device according to an embodiment of the present disclosure.

Icon: 10-concentrating means; 100-a mother liquor collecting unit; 110-a second pressure regulating valve; 200-pressurizing units; 210-a booster pump; 220-a detection component; 221-a water delivery pipeline; 222-a first valve; 300-nanofiltration membrane unit; 310-a first concentrate delivery tube; 311-a third pressure regulating valve; 320-a first clear liquid transfer tube; 321-a first pressure regulating valve; 400-reverse osmosis membrane unit; 410-a second concentrate delivery tube; 420-a second clear liquid conveying pipe; 500-a main concentrate conveying pipeline; 510-heat exchange unit.

Detailed Description

For the purposes of making the objects, technical solutions and advantages of the embodiments of the present application more clear, the technical solutions of the embodiments of the present application will be clearly and completely described below with reference to the drawings in the embodiments of the present application, and it is apparent that the described embodiments are some embodiments of the present application, but not all embodiments. The components of the embodiments of the present application, which are generally described and illustrated in the figures herein, may be arranged and designed in a wide variety of different configurations.

Thus, the following detailed description of the embodiments of the present application, as provided in the accompanying drawings, is not intended to limit the scope of the application, as claimed, but is merely representative of selected embodiments of the application. All other embodiments, which can be made by one of ordinary skill in the art without undue burden from the present disclosure, are within the scope of the present disclosure.

It should be noted that: like reference numerals and letters denote like items in the following figures, and thus once an item is defined in one figure, no further definition or explanation thereof is necessary in the following figures.

In the description of the present application, it should be noted that, the terms "upper," "lower," "inner," "outer," and the like indicate an orientation or a positional relationship based on the orientation or the positional relationship shown in the drawings, or an orientation or a positional relationship conventionally put in use of the product of the application, merely for convenience of description and simplification of the description, and do not indicate or imply that the apparatus or element to be referred to must have a specific orientation, be configured and operated in a specific orientation, and therefore should not be construed as limiting the present application. Furthermore, the terms "first," "second," "third," and the like are used merely to distinguish between descriptions and should not be construed as indicating or implying relative importance.

In the description of the present application, it should also be noted that, unless explicitly specified and limited otherwise, the terms "disposed," "mounted," and "connected" are to be construed broadly, and may be, for example, fixedly connected, detachably connected, or integrally connected; can be directly connected or indirectly connected through an intermediate medium, and can be communication between two elements. The specific meaning of the terms in this application will be understood by those of ordinary skill in the art in a specific context.

The following describes a concentrating device provided in the embodiment of the present application.

Referring to fig. 1, an embodiment of the present application provides a concentrating apparatus 10, which includes a mother liquor collecting unit 100, a pressurizing unit 200, a nanofiltration membrane unit 300, and a reverse osmosis membrane unit 400. The pressurizing unit 200 communicates with the mother liquor collecting unit 100 for providing pressure for mother liquor transportation and separation; the nanofiltration membrane unit 300 is communicated with the mother liquor collecting unit 100, and the nanofiltration membrane unit 300 comprises a first concentrated solution conveying pipe 310 and a first clear solution conveying pipe 320, wherein the first concentrated solution conveying pipe 310 is used for outputting concentrated solution, and the first clear solution conveying pipe 320 is used for outputting clear solution; the reverse osmosis membrane unit 400 is in communication with the first clear liquid transfer pipe 320, and the reverse osmosis membrane unit 400 includes a second concentrate transfer pipe 410 and a second clear liquid transfer pipe 420, the second concentrate transfer pipe 410 being for outputting a concentrate, and the second clear liquid transfer pipe 420 being for outputting a clear liquid.

It should be noted that, the installation position of the pressurizing unit 200 is not limited, and may be adjusted accordingly according to the type of the pressurizing unit 200, for example, the pressurizing unit 200 may be in communication with the mother liquor collecting unit 100, or may be in communication with a liquid conveying pipeline between the nanofiltration membrane unit 300 and the mother liquor collecting unit 100.

In this application, enrichment facility 10 is including the nanofiltration membrane that sets gradually and two types of separation recovery unit of reverse osmosis membrane, wherein, nanofiltration membrane unit 300 is arranged in retrieving most nucleotide in the mother liquor, reverse osmosis membrane unit 400 and nanofiltration membrane unit 300's first clear solution conveyer pipe 320 intercommunication for retrieve remaining nucleotide in the clear solution, through the combined action of two types of separation recovery units, compare in only setting up single type separation recovery unit or with reverse osmosis membrane unit 400 and nanofiltration membrane unit 300's first concentrate conveyer pipe 310 intercommunication (carry out twice separation recovery in succession to the mother liquor promptly), can effectively reduce the loss volume of nucleotide at the concentrated in-process, thereby improve the rate of recovery of nucleotide at the concentrated in-process to a certain extent.

The specific model and size of the nanofiltration membrane unit 300 and the reverse osmosis membrane unit 400 are not limited, and may be adjusted according to actual needs.

As an example, the pore size of the membrane elements in the nanofiltration membrane unit 300 is 1-2 nm, and the pore size of the membrane elements in the reverse osmosis membrane unit 400 is < 1nm.

It is to be understood that the combination of the osmotic pressures of the nanofiltration membrane unit 300 and the reverse osmosis membrane unit 400 (the osmotic pressures corresponding to the different types of membrane units are different) is not limited, and for example, the two may be the same, the larger one, the smaller one, or the larger one.

As an example, the osmotic pressure of the nanofiltration membrane unit 300 is not lower than that of the reverse osmosis membrane unit 400.

In this embodiment, the nanofiltration membrane unit 300 is located at the upstream of the reverse osmosis membrane unit 400, and the osmotic pressure of the nanofiltration membrane unit 300 is set to be not lower than the osmotic pressure of the reverse osmosis membrane unit 400 (i.e. the nanofiltration membrane with a higher osmotic pressure is selected), so that the clear liquid passing through the nanofiltration membrane unit 300 still has a higher pressure, so that the reverse osmosis membrane unit 400 is also performed under a more suitable pressure, and the advantages of better separation effect and higher separation efficiency are achieved.

As an example, the back pressure of the nanofiltration membrane unit 300 is 1.5 to 2MPa, and the back pressure of the reverse osmosis membrane unit 400 is 0.8 to 1.2MPa.

By "back pressure" is meant the pressure of the liquid after passing through the membrane element.

It should be noted that the layout of the corresponding pipelines in the nanofiltration membrane unit 300 is not limited.

As an example, the liquid inlet pipe of the nanofiltration membrane unit 300 is installed at the lower end of the nanofiltration membrane unit 300, and the first concentrate delivery pipe 310 and the first clear liquid delivery pipe 320 are both installed at the upper end of the nanofiltration membrane unit 300.

In this embodiment, the liquid inlet pipe, the first concentrated liquid conveying pipe 310 and the first clear liquid conveying pipe 320 of the nanofiltration membrane unit 300 are respectively installed at the specific positions, so that the liquid inlet pipe and the liquid outlet pipe can be separated far, and therefore, the cross of pipelines is effectively avoided, and the advantages of being convenient for pipeline layout are achieved.

The layout of the corresponding piping in the reverse osmosis membrane unit 400 is not limited, and the layout may be performed with reference to the nanofiltration membrane unit 300.

As an example, the length direction of the nanofiltration membrane unit 300 and/or the length direction of the reverse osmosis membrane unit 400 is the same as the height direction of the concentration device 10.

In this embodiment, the above-described installation method has the advantage of a smaller length of the production line and a smaller floor space.

It is understood that the communication mode between the two concentrated solution delivery pipes and the outside is not limited, for example, a corresponding pipeline may be respectively arranged to communicate with the outside, or the two concentrated solution delivery pipes may also communicate with the outside through the same pipeline.

As an example, the first and second concentrate delivery pipes 310 and 410 are in communication with the same concentrate delivery main pipe 500, and the concentrate delivery main pipe 500 is used to deliver concentrate.

In this embodiment, the first concentrate delivery pipe 310 and the second concentrate delivery pipe 410 are connected to the same concentrate delivery main pipe 500, and then concentrate is delivered through the concentrate delivery main pipe 500, so that compared with the case that two concentrate delivery main pipes 500 are respectively provided to deliver concentrate, the cost of the pipe layout can be reduced, and meanwhile, the smaller number of pipes still has the advantages of smaller space occupation and convenience in pipe layout.

It will be appreciated that, since the different types of separation and recovery units are all operated at high pressure, the temperature of the liquid will be increased continuously, and the structure of the main concentrate delivery line 500 may be adjusted for better subsequent treatment of the concentrated concentrate.

Referring to fig. 2, as an example, a concentrate delivery main pipe 500 is provided with a heat exchange unit 510.

In this embodiment, the heat exchange unit 510 is added to the main concentrate conveying pipe 500, and the temperature of the concentrate can be reduced by heat exchange of the heat exchange unit 510, so that the recovered concentrate can be conveniently subjected to subsequent treatment.

It will be appreciated that the greater the flow rate of the liquid, the higher the concentration efficiency, but the greater the flow rate and the corresponding pressure, the greater the pressure is, which is likely to cause safety accidents, and the structure of the concentrating apparatus 10 may be adjusted in consideration of the concentration efficiency and the safety of the concentration process.

Referring to fig. 3, as an example, the first clear liquid transfer pipe 320 is provided with a first pressure regulating valve 321, and/or the transfer line between the mother liquid collecting unit 100 and the nanofiltration membrane unit 300 is provided with a second pressure regulating valve 110.

As an example, the first concentrate delivery pipe 310 and/or the second concentrate delivery pipe 410 is provided with a third pressure regulating valve 311.

It should be noted that the "pressure regulating valve" refers to a device capable of displaying the pressure of the corresponding line and adjusting the pressure of the corresponding line by adjusting the flow rate, and furthermore, the pressure regulating valve may be integrally provided or may be separately provided (i.e., one portion is used for displaying the pressure and the other portion is used for adjusting the flow rate).

In the embodiment, the pressure regulating valves are arranged on the corresponding pipelines, so that the pressure of corresponding management can be monitored and regulated in real time, and the safety of the concentration process is considered under the condition of ensuring the concentration efficiency.

Referring to fig. 4, as an example, the pressurizing unit 200 includes a pressurizing pump 210 and a detecting assembly 220, the pressurizing pump 210 being respectively communicated with the mother liquor collecting unit 100 and the nanofiltration membrane unit 300, and the detecting assembly 220 being communicated with the pressurizing pump 210 and configured to be able to detect a water level within the pressurizing pump 210.

In this embodiment, the booster pump 210 is used to provide the power for liquid delivery, which has the advantages of high delivery efficiency and good delivery stability, and the detection assembly 220 is provided to detect whether the water level in the booster pump 210 is normal before the booster pump 210 is started, so that the failure rate of the booster pump 210 is effectively reduced.

As an example, the detection assembly 220 includes a water delivery pipe 221 and a first valve 222, the water delivery pipe 221 being in communication with a water pipe within the booster pump 210, the first valve 222 being for opening or closing the water delivery pipe 221.

In this embodiment, through the cooperation of the water delivery pipeline 221 and the first valve 222, the water level detection of the booster pump 210 before starting can be conveniently and rapidly realized, and the device has the advantage of higher detection efficiency, and meanwhile, the device also has the advantage of simple structure.

It will be appreciated that during the concentration process, the nanofiltration membrane unit 300 and the reverse osmosis membrane unit 400 will have liquid residues, and the long-term residues of the liquid will cause the separation and recovery unit to be polluted, so that the structure of the separation and recovery unit can be optimized in consideration of the cleanliness of the concentrated solution.

As an example, the bottom of the nanofiltration membrane unit 300 and the bottom of the reverse osmosis membrane unit 400 are each provided with a cleaning line (not shown in the drawing) and a second valve (not shown in the drawing) for opening or closing the cleaning line.

In this embodiment, the nanofiltration membrane unit 300 and the reverse osmosis membrane unit 400 are provided with a cleaning pipeline and a valve for controlling the opening and closing of the cleaning pipeline, so that the separation recovery unit can be cleaned periodically, and the cleanliness of the concentrated solution is ensured.

The structure or the components of the concentrating device 10, which are not specifically described or defined, are not limited, and may be selected and arranged according to the conventional method in the art.

As an example, the water outlet end of the mother liquor collecting unit 100 is further provided with a third valve (not shown in the drawing) for opening or closing the mother liquor collecting unit 100.

The foregoing description is only of the preferred embodiments of the present application and is not intended to limit the same, but rather, various modifications and variations may be made by those skilled in the art. Any modification, equivalent replacement, improvement, etc. made within the spirit and principles of the present application should be included in the protection scope of the present application.

Claims

1. A concentrating apparatus, comprising:

a mother liquor collecting unit;

the pressurizing unit is communicated with the mother liquor collecting unit and is used for providing pressure for mother liquor conveying and separating;

the nanofiltration membrane unit is communicated with the mother liquor collecting unit and comprises a first concentrated solution conveying pipe and a first clear solution conveying pipe, wherein the first concentrated solution conveying pipe is used for outputting concentrated solution, and the first clear solution conveying pipe is used for outputting clear solution; and

the reverse osmosis membrane unit is communicated with the first clear liquid conveying pipe and comprises a second concentrated liquid conveying pipe and a second clear liquid conveying pipe, wherein the second concentrated liquid conveying pipe is used for outputting concentrated liquid, and the second clear liquid conveying pipe is used for outputting clear liquid.

2. The concentrating apparatus of claim 1 wherein the nanofiltration membrane unit has an osmotic pressure that is not lower than the osmotic pressure of the reverse osmosis membrane unit.

3. The concentrating apparatus of claim 1 wherein the liquid inlet tube of the nanofiltration membrane unit is mounted at the lower end of the nanofiltration membrane unit, and the first concentrate delivery tube and the first clear liquid delivery tube are both mounted at the upper end of the nanofiltration membrane unit.

4. The concentrating apparatus of claim 1 wherein the first concentrate delivery pipe and the second concentrate delivery pipe are in communication with a common concentrate delivery main line for delivering concentrate.

5. The concentrating apparatus of claim 4 wherein the concentrate delivery main line is provided with a heat exchange unit.

6. The concentrating apparatus according to any one of claims 1 to 5, wherein the first clear liquid delivery pipe is provided with a first pressure regulating valve and/or an infusion line between the mother liquid collection unit and the nanofiltration membrane unit is provided with a second pressure regulating valve.

7. The concentrating apparatus of claim 6 wherein the first concentrate delivery pipe and/or the second concentrate delivery pipe is provided with a third pressure regulating valve.

8. The concentrating apparatus according to any one of claims 1 to 5, wherein the pressurizing unit comprises a booster pump in communication with the mother liquor collecting unit and the nanofiltration membrane unit, respectively, and a detection assembly in communication with the booster pump and configured to be able to detect a water level within the booster pump.

9. The concentrating apparatus of claim 8 wherein the detection assembly comprises a water delivery line and a first valve, the water delivery line communicating with a water line in the booster pump, the first valve for opening or closing the water delivery line.

10. The concentrating apparatus according to any one of claims 1 to 5, wherein a cleaning line and a second valve for opening or closing the cleaning line are provided at both the bottom of the nanofiltration membrane unit and the bottom of the reverse osmosis membrane unit.