CN220643137U

CN220643137U - Swinging type reactor

Info

Publication number: CN220643137U
Application number: CN202321579186.1U
Authority: CN
Inventors: 吴学超; 马鼎; 赵红霞; 赵世国
Original assignee: Suzhou Hanchao Medical Technology Co ltd
Current assignee: Suzhou Hanchao Medical Technology Co ltd
Priority date: 2023-06-20
Filing date: 2023-06-20
Publication date: 2024-03-22
Anticipated expiration: 2033-06-20

Abstract

The application discloses swing type reactor, including swing box, wabble mechanism and weighing machine construct, the swing box is used for holding the liquid sample that waits to mix: the swinging mechanism is used for supporting and controlling the swinging box body to swing; the weighing mechanism is used for weighing the liquid sample to be mixed in the swinging box body; the swinging mechanism comprises a first driving assembly and a second driving assembly, the first driving assembly drives the swinging box body to swing along a first direction, and the second driving assembly drives the swinging box body to swing along a second direction. The utility model provides a swing type reactor holds the liquid sample that waits to mix through swinging the box, weighs the liquid sample in the box of swaing through weighing machine, supports and controls the box of swaing through the mechanism of swaing and sways, specifically, first drive assembly drives the box of swaing and sways along first direction, and the second drive assembly drives the box of swaing and sways along the second direction to the liquid sample that waits to mix in the messenger sways the box mixes evenly.

Description

Swinging type reactor

Technical Field

The application relates to the field of bio-pharmaceuticals, in particular to a swinging type reactor.

Background

In the biopharmaceutical field, in the processes of cell culture, preparation and mixing, mass transfer, dissolved oxygen and the like are usually realized by performing operations such as mixing and temperature control on a reaction system in order to enhance a mixing effect. At present, the swing type bioreactor has very low shearing force due to no stirring blade, and is very suitable for the biotechnological processes of cell culture, nucleic acid reaction, vaccine and the like which are sensitive to the shearing force. The conventional swinging type reactor only fixes the continuous swinging in one direction, is not easy to form a turbulent full mixing area, has poor mixing effect, affects mass transfer and oxygen transfer of cell culture, and is especially unfavorable for mixed reaction or preparation with certain viscosity for liquid medicine or cell culture with higher dissolved oxygen requirement.

Disclosure of Invention

In view of the above, the present application provides a swing reactor capable of achieving both-direction swing. The reactor controls the swinging box body to swing in two directions through the first driving assembly and the second driving assembly.

The application provides a swinging type reactor, which comprises a swinging box body, a swinging mechanism and a weighing mechanism,

the swing box is used for containing liquid samples to be mixed:

the swinging mechanism is used for supporting and controlling the swinging box body to swing;

the weighing mechanism is used for weighing the liquid sample to be mixed in the swinging box body;

the swinging mechanism comprises a first driving assembly and a second driving assembly, the first driving assembly drives the swinging box body to swing along a first direction, and the second driving assembly drives the swinging box body to swing along a second direction.

Further, the swinging mechanism also comprises a fixed component, the fixed component comprises a fixed bottom plate and fixed columns,

one end of the fixed column is fixedly arranged on the fixed bottom plate, and one end of the fixed column, which is far away from the fixed bottom plate, is connected with the swing box body.

Further, the fixed column comprises a connecting column and a third universal joint, the third universal joint is located at one end, close to the swinging box body, of the connecting column, and the connecting column is connected with the swinging box body through the third universal joint.

Further, the first driving assembly comprises a first power source, a first driving rod and a first universal joint, the first driving rod is connected with the first power source and the first universal joint respectively, the first universal joint is positioned at the end part of the first driving rod, and the first universal joint is connected with the swing box body; or (b)

The second driving assembly comprises a second power source, a second driving rod and a second universal joint, wherein the second driving rod is connected with the second power source and the second universal joint respectively, the second universal joint is located at the end part of the second driving rod, and the second universal joint is connected with the swing box body.

Further, the first driving rod and the second driving rod are fixedly arranged on the fixed bottom plate, and the first driving rod, the second driving rod and the fixed column are parallel and perpendicular to the fixed bottom plate.

Further, the fixed column is connected with the center of the fixed bottom plate,

the first driving rod is connected with a position close to the first edge of the fixed bottom plate;

the second driving rod is connected with a position close to the second edge of the fixed bottom plate;

an included angle formed between the first edge and the second edge is larger than 0 degrees.

Further, when the fixed bottom plate is a rectangular plate, an included angle formed by the first edge and the second edge bracket is 90 degrees.

Further, the swinging box body comprises a box body and a box cover, and the box body is fixedly connected with the box cover.

Further, a heating blanket and a temperature sensor are arranged in the box body, and the temperature sensor is in contact with the heating blanket; the heating blanket is used for heating the liquid sample in the box body; the temperature sensor is used for recording the temperature of the liquid sample; or (b)

The cover is provided with a turnover cover.

Further, a display screen is further arranged on the box body and is electrically connected with the temperature sensor, the heating blanket, the weighing mechanism, the first driving component and the second driving component, and the running states of the temperature sensor, the heating blanket, the weighing mechanism, the first driving component and the second driving component are controlled and displayed through the display screen.

The application provides a swing type reactor holds through the box that sways and wait to mix, through weighing machine constructs the weighing machine is constructed liquid sample in the box sways, through the mechanism that sways supports and controls sways the box, specifically, first drive assembly drives the box sways along first direction, second drive assembly drives the box sways along the second direction, thereby makes the liquid sample that waits to mix in the box sways misce bene.

Drawings

The drawings are included to provide a better understanding of the present application and are not to be construed as unduly limiting the present application. Wherein:

fig. 1 is a schematic structural diagram of a swing reactor provided herein.

Fig. 2 is a schematic structural diagram of the swing reactor provided in the present application.

Fig. 3 is a schematic view of a part of the structure of the rocking mechanism provided in the present application.

Description of the reference numerals

The device comprises a 1-flip cover, a 2-swing box body, a 3-first driving component, a 4-fixed column, a 5-display screen, a 6-swing mechanism, a 7-weighing mechanism, an 8-first universal joint, a 9-second universal joint, a 10-third universal joint, an 11-connecting column, a 12-first driving rod, a 13-second driving rod, a 14-second power source, a 15-first power source, a 16-control element and a 17-fixed bottom plate.

Detailed Description

Exemplary embodiments of the present application are described below, including various details of embodiments of the present application to facilitate understanding, which should be considered as merely exemplary. Accordingly, one of ordinary skill in the art will recognize that various changes and modifications of the embodiments described herein can be made without departing from the scope and spirit of the present application. Also, descriptions of well-known functions and constructions are omitted in the following description for clarity and conciseness. The upper and lower positions in this application depend on the direction of incidence of the light, where the light is incident.

As shown in fig. 1-3, the present application provides a swing reactor comprising a swing tank 2, a swing mechanism 6 and a weighing mechanism 7,

the swinging box body 2 is used for containing liquid samples to be mixed:

the swinging mechanism 6 is used for supporting and controlling the swinging box body 2 to swing;

the weighing mechanism 7 is used for weighing the liquid sample to be mixed in the swing box body 2;

the swinging mechanism 6 comprises a first driving component 3 and a second driving component, the first driving component 3 drives the swinging box body 2 to swing along a first direction, and the second driving component drives the swinging box body 2 to swing along a second direction.

The first direction swing can be left-right swing or front-back swing.

The second direction swing can be left-right swing or front-back swing.

The first direction is different from the second direction.

When the first direction is the front-back direction, and the second direction is the left-right direction, the first driving component 3 can drive the swing box 2 to swing back and forth, and the second driving component can drive the swing box 2 to swing left and right.

When the first direction is the left-right direction, and the second direction is the front-back direction, the first driving component 3 can drive the swing box 2 to swing left and right, and the second driving component can drive the swing box 2 to swing back and forth.

The application provides a swing type reactor holds through swing box 2 and waits to mix the liquid sample, through weighing machine constructs 7 weighs liquid sample in the swing box 2, through 6 supports of swing machine control swing box 2 sways, specifically, first drive assembly 3 drives swing box 2 sways along first direction, second drive assembly drives swing box 2 sways along the second direction, thereby makes wait to mix the liquid sample misce bene in the swing box 2.

In this application, the rocking mechanism 6 further comprises a fixed assembly, comprising a fixed base plate 17 and a fixed column 4,

one end of the fixed column 4 is fixedly arranged on the fixed bottom plate 17, and one end of the fixed column, which is far away from the fixed bottom plate 17, is connected with the swing box body 2.

The fixed column 4 comprises a connecting column 11 and a third universal joint 10, the third universal joint 10 is located at one end, close to the swinging box body 2, of the connecting column 11, and the connecting column 11 is connected with the swinging box body 2 through the third universal joint 10.

The third universal joint 10 is detachably connected with the connecting column 11, for example by a bolt connection.

The third universal joint 10 is detachably connected with the swing case 2, for example, by a bolt connection.

Specifically, the third universal joint 10 includes a fixed portion and a rotating portion, the rotating portion is rotatably connected with the fixed portion through a connecting shaft, and the rotating portion can rotate 360 ° with the connecting shaft as a rotation axis. The fixed part is connected with the connecting column 11, the rotating part is connected with the swinging box body 2, and the swinging box body 2 can be driven to rotate 360 degrees by taking the connecting shaft as a rotating shaft through the rotating part.

In this application, the first driving assembly 3 includes a first power source 15, a first driving rod 12 and a first universal joint 8, where the first driving rod 12 is connected to the first power source 15 and the first universal joint 8, and the first universal joint 8 is located at an end of the first driving rod 12, and the first universal joint 8 is connected to the swing case 2.

The second driving assembly comprises a second power source 14, a second driving rod 13 and a second universal joint 9, wherein the second driving rod 13 is respectively connected with the second power source 14 and the second universal joint 9, the second universal joint 9 is positioned at the end part of the second driving rod 13, and the second universal joint 9 is connected with the swinging box body 2.

The first universal joint 8, the second universal joint 9 and the third universal joint 10 have the same structure, and specific reference is made to the structure of the third universal joint 10.

The first universal joint 8 is detachably connected to the first driving rod 12, for example by means of a screw connection.

The first universal joint 8 is detachably connected with the swing case 2, for example, by a bolt connection.

The second universal joint 9 is detachably connected to the second drive rod 13, for example by means of a screw connection.

The second universal joint 9 is detachably connected with the swing case 2, for example, by a bolt connection.

The first driving rod 12 and the second driving rod 13 are all fixed on the fixed bottom plate 17, and the first driving rod 12, the second driving rod 13 and the fixed column 4 are all parallel and are all perpendicular to the fixed bottom plate 17.

Further, the fixed column 4 is connected with the center of the fixed bottom plate 17,

the first driving rod 12 is connected with a position close to the first edge of the fixed bottom plate 17;

the second driving rod 13 is connected with a position close to the second edge of the fixed bottom plate 17;

Further, the first driving rod 12 and the second driving rod 13 cannot operate simultaneously, before the reactor is started, the heights of the first driving rod 12, the second driving rod 13 and the connecting column 11 are the same, the first driving rod 12, the second driving rod 13 and the connecting column 11 support the swinging box body 2 in a horizontal standing state, when the swinging box body 2 is required to swing along a first direction, the second driving component is not started, the first driving component 3 is started, the first power source 15 drives the first driving rod 12 to perform lifting/lowering motion, the first driving rod 12 drives the first universal joint 8 to perform lifting/lowering motion, so that the swinging box body 2 is driven to perform lifting/lowering at a first edge position, and further the swinging box body 2 cannot maintain a horizontal state due to lifting of a local position, so that the swing case 2 is lowered/raised away from the first edge, thereby causing the first gimbal 8 to rotate with the raising/lowering of the swing case 2 at different positions, i.e., the first gimbal 8 rotates from a position close to the first edge to a position far away from the first edge, while the third gimbal 10 also rotates with the swing of the swing case 2 due to the influence of the swing of the third gimbal 10, the rotation direction of the third gimbal 10 is the same as that of the first gimbal 8, the swing case 2 swings with the position of the third gimbal 10 at the junction thereof as the swing center, and additionally because the rotation directions of the first gimbal 8 and the third gimbal 10 are the same, thus reducing the resistance of the swing case 2 during the swing.

In the same way, when the swinging box body 2 is required to swing along the second direction, the first driving component 3 is not started, the second driving component is started, the second driving source 14 drives the second driving rod 13 to perform lifting/lowering motion, so that the second driving rod 13 drives the second universal joint 9 to perform lifting/lowering, thereby driving the swinging box body 2 to perform lifting/lowering at the position of the second edge, further enabling the swinging box body 2 to be unable to keep stable due to lifting of the local position, enabling the swinging box body 2 to be far away from the position of the second edge to perform lifting/lowering, thereby causing the second universal joint 9 to rotate along with lifting/lowering of the swinging box body 2 at different positions, namely, the second universal joint 9 rotates from the position close to the second edge to the position far away from the second edge, meanwhile, as the third universal joint 10 is affected by swinging box body 2 swinging, the third universal joint 10 also rotates along with the swinging box body 2, and the rotation of the third universal joint 10 is in the same direction as the swinging box body 2, and the rotation of the third universal joint 10 is reduced along with the rotation direction of the swinging box body 2.

In some embodiments, when the fixed bottom plate 17 is a rectangular plate, the first edge forms an angle of 90 ° with the second edge support.

In some embodiments, the first driving rod 12 is connected to a midpoint position near the first edge of the fixed base plate 17, and the second driving rod 13 is connected to a midpoint position near the second edge of the fixed base plate 17. By adopting the design, the stability and the movement efficiency of the whole equipment can be enhanced, and the swinging angle can be increased.

The first power source and the second power source can be servo motors, and the servo motors can accurately regulate the speed according to actual requirements because the servo motors have a speed for responding to control signals quickly. The servo motor can accurately control the lifting time and distance of the first driving assembly and the second driving assembly. And the servo motor has the advantages of small volume, stable power, easy maintenance and the like.

In this application, the swing case 2 includes a case body and a case cover, and the case body is fixedly connected with the case cover.

A heating blanket and a temperature sensor are further arranged in the box body, and the temperature sensor is in contact with the heating blanket; the heating blanket is used for heating the liquid sample in the box body; the temperature sensor is used for recording the temperature of the liquid sample;

the cover is provided with a turnover cover 1 which can be turned over.

In some embodiments, an opening is provided at the center of the heating blanket for placing a liquid sample or a container containing a liquid sample to facilitate heating the liquid sample.

In some embodiments, the flip cover 1 may flip 45 ° -180 °, such as 45 °, 90 °, 120 °, 180 °, etc.

The flip cover 1 can be made of ABS material, and has the characteristics of no toxicity, no harm, high impact strength, wear resistance, high temperature resistance and the like. The material of case lid is ABS material.

The box is internally provided with a control element 16, the box is also provided with a display screen 5, the display is connected with the control element 16, the control element 16 is electrically connected with the temperature sensor, the heating blanket, the weighing mechanism 7, the first driving component 3 and the second driving component, and the display screen 5 controls and displays the running states of the temperature sensor, the heating blanket, the weighing mechanism 7, the first driving component 3 and the second driving component through the control element 16.

The control element 16 includes components such as a PLC, driver, power supply, weighing rail meter, etc.

Examples

The experimental methods used in the following examples are conventional methods, if no special requirements are imposed.

Materials, reagents and the like used in the examples described below are commercially available unless otherwise specified.

Example 1

The swinging type reactor in the embodiment is shown in fig. 1-3, and comprises a swinging box body 2, a swinging mechanism 6 and a weighing mechanism 7 which are sequentially arranged from top to bottom,

the swinging box body 2 comprises a cube-shaped box body and a box cover, the box body is fixedly connected with the box cover, the bottom of the box body is connected with the swinging mechanism 6, a heating blanket and a temperature sensor are arranged on the bottom of the box body, the heating blanket is positioned at the center of the bottom of the box body, the middle part of the heating blanket is provided with a circular opening, and the temperature sensor is in contact with the heating blanket; the heating blanket is used for heating the liquid sample in the box body; the temperature sensor is used for recording the temperature of the liquid sample; the cover is provided with a flip cover 1 which can be turned over by 90 degrees.

The rocking mechanism 6 comprises a shell (the shell can be prismatic), a fixed bottom plate 17 with a rectangular cross section is arranged at the bottom in the shell, two groups of driving components and fixed columns 4 are arranged on the fixed bottom plate 17, each fixed column 4 comprises a connecting column 11 and a third universal joint 10, the third universal joint 10 is arranged at one end of the connecting column 11, which is far away from the third universal joint 10, is vertically arranged at the center of the fixed bottom plate 17, and the third universal joint 10 is connected with the center of the bottom of the rocking box 2. The two groups of driving assemblies are a first driving assembly 3 and a second driving assembly respectively, the first driving assembly 3 comprises a first power source 15 (servo motor), a first driving rod 12 and a first universal joint 8, the first universal joint 8 is arranged at one end, far away from the fixed bottom plate 17, of the first driving rod 12, and the first universal joint 8 is connected with the bottom of the swinging box body 2, close to the midpoint of the edge thereof. The second driving assembly comprises a second power source 14 (servo motor), a second driving rod 13 and a second universal joint 9, wherein the second universal joint 9 is arranged at two ends of the second driving rod 13, which are far away from the fixed bottom plate 17, and the second universal joint 9 is connected with the bottom of the swing box 2, which is close to the midpoint of the edge of the swing box. The first driving rod 12 is vertically arranged at the midpoint of the swinging bottom plate close to the first edge of the swinging bottom plate, and the second driving rod 13 is vertically arranged at the midpoint of the swinging bottom plate close to the second edge of the swinging bottom plate, and the first edge and the second edge are adjacent edges.

The box is internally provided with a control element 16, the box is also provided with a display screen 5, the display is connected with the control element 16, the control element 16 is electrically connected with the temperature sensor, the heating blanket, the weighing mechanism 7, the first driving component 3 and the second driving component, and the display screen 5 controls and displays the running states of the temperature sensor, the heating blanket, the weighing mechanism 7, the first driving component 3 and the second driving component through the control element 16. The control element 16 includes components such as a PLC, driver, power supply, weighing rail meter, etc. PLC selects: 1200PLCCPU transistor output, SIE.6ES7214-1AG40-0XB0; weighing instrument: mettleertoledlnd 141.

Although described above in connection with the embodiments of the present application, the present application is not limited to the specific embodiments and fields of application described above, which are intended to be illustrative, instructive, and not limiting. Those skilled in the art, having the benefit of this disclosure, may make numerous forms, and equivalents thereof, without departing from the scope of the utility model as defined by the claims.

Claims

1. A swinging type reactor comprises a swinging box body, a swinging mechanism and a weighing mechanism,

the swing box is used for containing liquid samples to be mixed:

2. The reactor of claim 1, wherein the rocking mechanism further comprises a fixed assembly comprising a fixed base plate and fixed posts,

3. The reactor of claim 2, wherein the fixed column comprises a connection column and a third universal joint, the third universal joint is located at an end of the connection column near the swing case, and the connection column is connected with the swing case through the third universal joint.

4. A reactor according to claim 3, wherein the first drive assembly comprises a first power source, a first drive rod and a first universal joint, the first drive rod being connected to the first power source and the first universal joint, respectively, and the first universal joint being located at an end of the first drive rod, the first universal joint being connected to the swing case; or (b)

The second driving assembly comprises a second power source, a second driving rod and a second universal joint, the second driving rod is connected with the second power source and the second universal joint respectively, the second universal joint is located at the end part of the second driving rod, and the second universal joint is connected with the swinging box body.

5. The reactor of claim 4, wherein the first driving rod and the second driving rod are all fixed on the fixed bottom plate, and the first driving rod, the second driving rod and the fixed column are all parallel and all perpendicular to the fixed bottom plate.

6. The reactor according to claim 5, wherein the fixing column is connected to the center of the fixing base plate,

7. The reactor of claim 6, wherein the first edge forms an angle of 90 ° with the second edge support when the fixed bottom plate is a rectangular plate.

8. The reactor of claim 1, wherein the swing box comprises a box and a box cover, the box being fixedly connected to the box cover.

9. The reactor of claim 8, wherein a heater blanket and a temperature sensor are also disposed within the tank, the temperature sensor being in contact with the heater blanket; the heating blanket is used for heating the liquid sample in the box body; the temperature sensor is used for recording the temperature of the liquid sample; or (b)

The cover is provided with a turnover cover.

10. The reactor of claim 9, wherein a display screen is further provided on the tank, the display screen being electrically connected to the temperature sensor, the heating blanket, the weighing mechanism, the first driving assembly and the second driving assembly, and an operating state of the temperature sensor, the heating blanket, the weighing mechanism, the first driving assembly and the second driving assembly being controlled and displayed by the display screen.