CN220634326U - Hyaluronic acid crosslinking reaction device - Google Patents
Hyaluronic acid crosslinking reaction device Download PDFInfo
- Publication number
- CN220634326U CN220634326U CN202322209288.0U CN202322209288U CN220634326U CN 220634326 U CN220634326 U CN 220634326U CN 202322209288 U CN202322209288 U CN 202322209288U CN 220634326 U CN220634326 U CN 220634326U
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- CN
- China
- Prior art keywords
- shell
- hyaluronic acid
- wall
- reaction
- acid crosslinking
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Links
- 238000006243 chemical reaction Methods 0.000 title claims abstract description 73
- 238000004132 cross linking Methods 0.000 title claims abstract description 42
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 title claims abstract description 31
- 229920002674 hyaluronan Polymers 0.000 title claims abstract description 31
- 229960003160 hyaluronic acid Drugs 0.000 title claims abstract description 31
- 238000003756 stirring Methods 0.000 claims abstract description 12
- 235000017166 Bambusa arundinacea Nutrition 0.000 claims abstract description 11
- 235000017491 Bambusa tulda Nutrition 0.000 claims abstract description 11
- 241001330002 Bambuseae Species 0.000 claims abstract description 11
- 235000015334 Phyllostachys viridis Nutrition 0.000 claims abstract description 11
- 239000011425 bamboo Substances 0.000 claims abstract description 11
- 238000007789 sealing Methods 0.000 claims description 20
- 238000007790 scraping Methods 0.000 claims description 16
- 230000006978 adaptation Effects 0.000 claims description 6
- 239000000376 reactant Substances 0.000 abstract description 17
- 229920002385 Sodium hyaluronate Polymers 0.000 abstract description 7
- 229940010747 sodium hyaluronate Drugs 0.000 abstract description 7
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 abstract description 7
- 239000000126 substance Substances 0.000 abstract description 6
- 238000010438 heat treatment Methods 0.000 description 5
- 239000011324 bead Substances 0.000 description 4
- 238000010586 diagram Methods 0.000 description 4
- 238000004140 cleaning Methods 0.000 description 3
- 238000010382 chemical cross-linking Methods 0.000 description 2
- 239000003431 cross linking reagent Substances 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 229910052751 metal Inorganic materials 0.000 description 2
- 239000002184 metal Substances 0.000 description 2
- 239000002253 acid Substances 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 230000005484 gravity Effects 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
Landscapes
- Polysaccharides And Polysaccharide Derivatives (AREA)
Abstract
The utility model belongs to the technical field of hyaluronic acid reaction, in particular to a hyaluronic acid crosslinking reaction device, which aims at solving the problems that a stirring paddle cannot be separated from a reactant in the crosslinking reaction process, gel is unevenly distributed and heated; the cross-linked sodium hyaluronate gel reaction can be pasted on the inner wall, is difficult to clear up, and cross-linking homogeneity hardly obtains the problem of assurance, proposes following scheme, and it includes the shell, and the top of shell is provided with the inlet, and the bottom of shell is provided with four supporting legs, and the outside of shell is provided with the controller switch, is provided with the hot plate on the inner wall of shell, and the reaction section of thick bamboo is installed in the shell internal rotation, and the fixed intercommunication in bottom of reaction section of thick bamboo has the pipeline, the bottom of shell is provided with sealed bearing. The utility model has simple structure, and the hyaluronic acid crosslinking reactant is stirred, so that the hyaluronic acid crosslinking reactant reacts uniformly, the inner wall of the reaction cylinder can be cleaned, and substances are prevented from being stuck on the inner wall of the reaction cylinder.
Description
Technical Field
The utility model relates to the technical field of hyaluronic acid reaction, in particular to a hyaluronic acid crosslinking reaction device.
Background
The crosslinked sodium hyaluronate gel has good physical and chemical properties and biocompatibility, and is prepared by crosslinking reaction of sodium hyaluronate by using a chemical crosslinking agent, and the chemical crosslinking agent, sodium hyaluronate and a solvent are mixed to form a loose reactant containing a large number of bubbles, so that the crosslinking reaction is affected.
The traditional crosslinking mode is to put reactants in a metal stirrer, naturally flatten the gel under the action of gravity in the metal stirrer, and then carry out crosslinking reaction. The crosslinking mode has very slow natural gel paving process, and the sodium hyaluronate material is kept stand for relatively long in alkali or acid reaction system to avoid obvious degradation. The publication No. CN202849302U discloses a device for preparing high-concentration hyaluronic acid for crosslinking reaction. The main body of the device is a reactor capable of rotating automatically, a stirrer is arranged in the reactor, a heating sleeve is attached to the wall of the reactor, and a crosslinking reaction substrate is heated by the heating sleeve to complete the crosslinking reaction.
The device can not separate the stirring paddle from the reactant in the crosslinking reaction process, the gel is unevenly distributed and heated; the crosslinked sodium hyaluronate gel reaction can be stuck on the inner wall, so that the cleaning is difficult, and the crosslinking uniformity is difficult to ensure.
Disclosure of Invention
The utility model aims to solve the problems that the stirring paddle cannot be separated from reactants in the crosslinking reaction process, the gel is unevenly distributed and heated; the cross-linked sodium hyaluronate gel reaction can be stuck on the inner wall, so that the cleaning is difficult, and the cross-linking uniformity is difficult to ensure.
In order to achieve the above purpose, the present utility model adopts the following technical scheme:
the utility model provides a hyaluronic acid crosslinking reaction device, includes the shell, and the top of shell is provided with the filler neck, and the bottom of shell is provided with four supporting legs, and the outside of shell is provided with the controller switch, is provided with the hot plate on the inner wall of shell, and the reaction section of thick bamboo is installed in the shell internal rotation, and the fixed intercommunication in bottom of reaction section of thick bamboo has the pipeline, the bottom of shell is provided with sealed bearing, and pipeline and sealed bearing's inner circle fixed connection, pipeline extend to the bottom of shell, and the bottom of shell is provided with power unit, and power unit and pipeline looks adaptation, the outside of shell is provided with electric putter, installs the top cap on electric putter's the output shaft, and the holding tank has been seted up to the bottom of top cap, has inlayed a plurality of balls on the bottom inner wall of holding tank, a plurality of balls all with the top mouth sliding connection of reaction section of thick bamboo, be provided with on the top cap and scrape wall rabbling mechanism, the bottom of scraping wall rabbling mechanism is provided with the sealing plug, sealing plug and the top mouth looks adaptation of pipeline.
Preferably, the power mechanism comprises a servo motor, the servo motor is arranged at the bottom of the shell, a driving gear is arranged on an output shaft of the servo motor, a driven gear is sleeved on the outer side of the pipeline, and the driving gear is meshed with the driven gear.
Preferably, a fixed ring is fixedly arranged on the inner wall of the shell, a limit groove is formed in the inner side of the fixed ring, the limit ring is slidably arranged in the limit groove, and the limit ring is fixedly connected with the outer side of the reaction cylinder.
Preferably, the scraping wall stirring mechanism comprises a central shaft, the central shaft is fixedly arranged at the bottom of the top cover, a plurality of stirring rods are arranged at the outer side of the central shaft, the bottom end of the central shaft is rotationally connected with the top of the sealing plug, and the sealing plug is of a semicircular structure.
Preferably, two branch bars are symmetrically arranged on the outer side of the central shaft, arc-shaped scraping plates are fixedly arranged on the outer sides of the two branch bars, and the arc-shaped scraping plates are attached to the inner wall of the reaction cylinder.
In the utility model, the hyaluronic acid crosslinking reaction device has the beneficial effects that:
according to the scheme, the hyaluronic acid crosslinking reactant is added into the reaction cylinder through the inlet, the temperature of the heating plate is controlled through the controller switch, then heat is conducted to the reaction cylinder, the servo motor is started to drive the driven gear to rotate through the driving gear, the driven gear drives the pipeline to rotate, the pipeline drives the reaction cylinder and the sealing plug to rotate, the sealing plug is rotationally connected with the central shaft, the central shaft is fixedly arranged, and the central shaft is used for stirring the hyaluronic acid crosslinking reactant through the cooperation of the branch bars, so that the hyaluronic acid crosslinking reactant is uniform in reaction;
according to the scheme, the central shaft cleans the inner wall of the reaction cylinder through the two branch rods and the two arc-shaped scraping plates, substances are prevented from being stuck on the inner wall of the reaction cylinder, the reaction cylinder drives the limiting ring to slide in the limiting groove, after the work is completed, the electric push rod is started to push the top cover to move upwards, the top cover drives the central shaft to move upwards, the central shaft slides upwards on the inner wall of the reaction cylinder, the central shaft drives the sealing plug to leave the pipeline, and the hyaluronic acid crosslinking reactant is led out through the pipeline;
the utility model has simple structure, and the hyaluronic acid crosslinking reactant is stirred, so that the hyaluronic acid crosslinking reactant reacts uniformly, the inner wall of the reaction cylinder can be cleaned, and substances are prevented from being stuck on the inner wall of the reaction cylinder.
Drawings
FIG. 1 is a schematic diagram of a cross-linking reaction device for hyaluronic acid according to the present utility model;
FIG. 2 is a schematic cross-sectional view of FIG. 1 according to the present utility model;
FIG. 3 is a schematic structural diagram of part A of a hyaluronic acid crosslinking reaction device according to the present utility model;
fig. 4 is a schematic diagram of a portion B of a cross-linking reaction apparatus for hyaluronic acid according to the present utility model.
In the figure: 1. support legs; 2. a housing; 3. an electric push rod; 4. a top cover; 5. a central shaft; 6. a stirring rod; 7. a branch rod; 8. an arc-shaped scraping plate; 9. a sealing plug; 10. a pipe; 11. a driven gear; 12. a reaction cylinder; 13. a servo motor; 14. a drive gear; 15. sealing the bearing; 16. a receiving groove; 17. a ball; 18. a fixing ring; 19. a limit groove; 20. a limiting ring; 21. a sliding bead; 22. a heating plate; 23. and a controller switch.
Detailed Description
The technical solutions of the present embodiment will be clearly and completely described below with reference to the drawings in the present embodiment, and it is apparent that the described embodiments are only some embodiments of the present embodiment, not all embodiments.
Examples
Referring to fig. 1-4, a hyaluronic acid crosslinking reaction device, which comprises a housing 2, the top of housing 2 is provided with the inlet, the bottom of housing 2 is provided with four supporting legs 1, the outside of housing 2 is provided with controller switch 23, be provided with hot plate 22 on the inner wall of housing 2, reaction section of thick bamboo 12 is installed to the housing 2 internal rotation, the fixed intercommunication in bottom of reaction section of thick bamboo 12 has pipeline 10, the bottom of housing 2 is provided with sealed bearing 15, pipeline 10 and sealed bearing 15's inner circle fixed connection, pipeline 10 extends to the bottom of housing 2, the bottom of housing 2 is provided with power unit, power unit and pipeline 10 looks adaptation, the outside of housing 2 is provided with electric putter 3, installs top cap 4 on electric putter's the output shaft, holding tank 16 has been seted up to the bottom of top cap 4, the bottom inner wall of holding tank 16 is embedded with a plurality of balls 17, a plurality of balls 17 all with the top mouth sliding connection of reaction section of thick bamboo 12, be provided with on top cap 4 and scrape wall rabbling mechanism, the bottom of scraping wall rabbling mechanism is provided with sealing plug 9, 9 and 10's top mouth looks adaptation.
In this embodiment, the power mechanism includes a servo motor 13, the servo motor 13 is installed at the bottom of the housing 2, a driving gear 14 is installed on an output shaft of the servo motor 13, a driven gear 11 is sleeved on the outer side of the pipeline 10, and the driving gear 14 is meshed with the driven gear 11.
In the embodiment, a fixed ring 18 is fixedly arranged on the inner wall of the shell 2, a limit groove 19 is formed in the inner side of the fixed ring 18, a limit ring 20 is slidably arranged in the limit groove 19, and the limit ring 20 is fixedly connected with the outer side of the reaction cylinder 12; the reaction cylinder 12 drives the limiting ring 20 to slide in the limiting groove 19, so that the stable rotation of the reaction cylinder 12 can be ensured.
In the embodiment, the scraping and stirring mechanism comprises a central shaft 5, wherein the central shaft 5 is fixedly arranged at the bottom of a top cover 4, a plurality of stirring rods 6 are arranged on the outer side of the central shaft 5, the bottom end of the central shaft 5 is rotationally connected with the top of a sealing plug 9, the sealing plug 9 is of a semicircular structure, two branch rods 7 are symmetrically arranged on the outer side of the central shaft 5, arc scraping plates 8 are fixedly arranged on the outer sides of the two branch rods 7, and the arc scraping plates 8 are attached to the inner wall of a reaction cylinder 12; the central shaft 5 cleans the inner wall of the reaction cylinder 12 through the two branch rods 7 and the two arc scraping plates 8, and avoids substances from being stuck on the inner wall of the reaction cylinder 12.
When the reaction tube 12 is used, an external power supply and a controller switch 23 are connected, a hyaluronic acid crosslinking reactant is added into the reaction tube 12 through an inlet, the temperature of a heating plate 22 is controlled through the controller switch 23, then heat conduction is conducted to the reaction tube 12, a servo motor 13 is started to drive a driving gear 14 to rotate, the driving gear 14 drives a driven gear 11 to rotate, the driven gear 11 drives a pipeline 10 to rotate, the pipeline 10 drives the reaction tube 12 and a sealing plug 9 to rotate, the sealing plug 9 is rotationally connected with a central shaft 5, the central shaft 5 is fixedly arranged, the central shaft 5 is matched with a branch rod 7 to stir the hyaluronic acid crosslinking reactant, so that the hyaluronic acid crosslinking reactant uniformly reacts, meanwhile, the central shaft 5 is used for cleaning the inner wall of the reaction tube 12 through two branch rods 7 and two arc scraping plates 8, substances are prevented from being stuck on the inner wall of the reaction tube 12, the reaction tube 12 drives a limiting ring 20 to slide in a limiting groove 19, after the operation is completed, an electric push rod 3 is started to push a top cover 4 to move upwards, the top cover 4 drives the central shaft 5 to move upwards, the central shaft 5 slides upwards on the inner wall of the reaction tube 12, the central shaft 5 drives the sealing plug 9 to leave the pipeline 10, and the hyaluronic acid crosslinking reactant is led out of the pipeline 10 through the pipeline 10.
Examples
The difference between the second embodiment and the first embodiment is that: the outside of spacing ring 20 is embedded to have the sliding bead 21, and sliding bead 21 and the inner wall sliding connection of spacing groove 19, and the sliding bead 21 of setting can reduce the frictional force of spacing ring 20 at the inner wall of spacing groove 19, and all structures in this application all can carry out the selection of material and length according to the actual use condition, and the drawing is the schematic structure diagram, and specific actual size can make appropriate adjustment.
The foregoing is only a preferred embodiment of the present utility model, but the scope of the present utility model is not limited thereto, and any person skilled in the art will be able to apply equally to the technical solution of the present utility model and the inventive concept thereof, within the scope of the present utility model.
Claims (6)
1. The utility model provides a hyaluronic acid crosslinking reaction device, includes shell (2), and the top of shell (2) is provided with the inlet, and the bottom of shell (2) is provided with four supporting legs (1), and the outside of shell (2) is provided with controller switch (23), is provided with hot plate (22) on the inner wall of shell (2), a serial communication port, reaction section of thick bamboo (12) are installed in shell (2) internal rotation, and the fixed intercommunication in bottom of reaction section of thick bamboo (12) has pipeline (10), and pipeline (10) extend to the bottom of shell (2), and the bottom of shell (2) is provided with power unit, and power unit and pipeline (10) looks adaptation, and the outside of shell (2) is provided with electric putter (3), installs top cap (4) on the output shaft of electric putter (3), and holding tank (16) are seted up to the bottom of top cap (4), and are embedded on the bottom inner wall of holding tank (16) a plurality of balls (17) all with the top mouth sliding connection of reaction section of thick bamboo (12), are provided with on top cap (4) and scrape wall rabbling mechanism, and the bottom of scraping wall rabbling mechanism is provided with sealing plug (9) looks adaptation.
2. The hyaluronic acid crosslinking reaction device according to claim 1, wherein a sealing bearing (15) is arranged at the bottom of the housing (2), and the pipeline (10) is fixedly connected with an inner ring of the sealing bearing (15).
3. The hyaluronic acid crosslinking reaction device according to claim 1, wherein the power mechanism comprises a servo motor (13), the servo motor (13) is arranged at the bottom of the shell (2), a driving gear (14) is arranged on an output shaft of the servo motor (13), a driven gear (11) is sleeved on the outer side of the pipeline (10), and the driving gear (14) is meshed with the driven gear (11).
4. The hyaluronic acid crosslinking reaction device according to claim 1, wherein a fixed ring (18) is fixedly arranged on the inner wall of the shell (2), a limiting groove (19) is formed in the inner side of the fixed ring (18), a limiting ring (20) is slidably arranged in the limiting groove (19), and the limiting ring (20) is fixedly connected with the outer side of the reaction cylinder (12).
5. The hyaluronic acid crosslinking reaction device according to claim 1, wherein the wall scraping stirring mechanism comprises a central shaft (5), the central shaft (5) is fixedly arranged at the bottom of the top cover (4), a plurality of stirring rods (6) are arranged on the outer side of the central shaft (5), the bottom end of the central shaft (5) is rotationally connected with the top of the sealing plug (9), and the sealing plug (9) is of a semicircular structure.
6. The hyaluronic acid crosslinking reaction device according to claim 5, wherein two branch rods (7) are symmetrically arranged on the outer side of the central shaft (5), arc-shaped scraping plates (8) are fixedly arranged on the outer sides of the two branch rods (7), and the arc-shaped scraping plates (8) are attached to the inner wall of the reaction cylinder (12).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202322209288.0U CN220634326U (en) | 2023-08-17 | 2023-08-17 | Hyaluronic acid crosslinking reaction device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202322209288.0U CN220634326U (en) | 2023-08-17 | 2023-08-17 | Hyaluronic acid crosslinking reaction device |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN220634326U true CN220634326U (en) | 2024-03-22 |
Family
ID=90289499
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202322209288.0U Active CN220634326U (en) | 2023-08-17 | 2023-08-17 | Hyaluronic acid crosslinking reaction device |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN220634326U (en) |
-
2023
- 2023-08-17 CN CN202322209288.0U patent/CN220634326U/en active Active
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