CN220589937U - Adjustable spray type micro sample adding device for magnetic bead production - Google Patents
Adjustable spray type micro sample adding device for magnetic bead production Download PDFInfo
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- CN220589937U CN220589937U CN202322163588.XU CN202322163588U CN220589937U CN 220589937 U CN220589937 U CN 220589937U CN 202322163588 U CN202322163588 U CN 202322163588U CN 220589937 U CN220589937 U CN 220589937U
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- injection
- connector
- magnetic bead
- spray
- bead production
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- 239000007921 spray Substances 0.000 title claims abstract description 36
- 239000011324 bead Substances 0.000 title claims abstract description 28
- 238000004519 manufacturing process Methods 0.000 title claims abstract description 23
- 238000002347 injection Methods 0.000 claims abstract description 90
- 239000007924 injection Substances 0.000 claims abstract description 90
- 239000007788 liquid Substances 0.000 claims abstract description 19
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims abstract description 11
- 239000000741 silica gel Substances 0.000 claims abstract description 11
- 229910002027 silica gel Inorganic materials 0.000 claims abstract description 11
- 238000005507 spraying Methods 0.000 claims description 18
- 238000006243 chemical reaction Methods 0.000 abstract description 24
- 239000003153 chemical reaction reagent Substances 0.000 abstract description 14
- 238000000034 method Methods 0.000 abstract description 5
- 230000035484 reaction time Effects 0.000 abstract description 3
- 230000009286 beneficial effect Effects 0.000 abstract description 2
- 238000001125 extrusion Methods 0.000 abstract description 2
- 230000001105 regulatory effect Effects 0.000 description 10
- 238000001802 infusion Methods 0.000 description 8
- 238000009434 installation Methods 0.000 description 3
- 238000010586 diagram Methods 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000005452 bending Methods 0.000 description 1
- 238000006555 catalytic reaction Methods 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000005611 electricity Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 239000008204 material by function Substances 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 230000007170 pathology Effects 0.000 description 1
- 230000035479 physiological effects, processes and functions Effects 0.000 description 1
- 238000009987 spinning Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
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- Physical Or Chemical Processes And Apparatus (AREA)
Abstract
The utility model discloses an adjustable spray type microscale sample adding device for magnetic bead production, which relates to the technical field of magnetic bead production and comprises an injector, wherein a liquid outlet end of the injector is connected with an injection hose, the other end of the injection hose is connected with an injection straight pipe, a silica gel plug is fixedly sleeved on the injection straight pipe, a connector is fixedly connected with a liquid outlet end of the injection straight pipe, and an injection spray assembly is detachably connected with a liquid outlet end of the connector. The beneficial effects are that: the injection straight tube is directly inserted into the silica gel plug, so that the error of sample injection caused by extrusion of the silica gel plug in the sample injection process is prevented, manual constant observation and adjustment are not needed, the labor cost is saved, the spray head is used for replacing the transfusion tube head, the blade is arranged in the connector, the reagent impacts the blade during injection, the rotating inner sleeve drives the injection spray assembly to rotate, the contact area of the reagent and the magnetic beads is enlarged, the reaction is more complete, the reaction time is shortened, and the production efficiency is improved.
Description
Technical Field
The utility model relates to the technical field of magnetic bead production, in particular to an adjustable spray type microscale sample adding device for magnetic bead production.
Background
In recent years, with development of nano science and technology, the nano magnetic beads not only can be applied to the traditional fields of chemical industry, optics, electricity, catalysis, environmental protection, spinning, aerospace, cultural relics protection and the like, but also can show great application prospects in the biomedical field which is vital to human life due to the remarkable surface and volume effects and the characteristic of controllable movement under an external magnetic field. Particularly, as researchers carry out surface modification on different nano magnetic beads, a plurality of biological functional materials are prepared and widely applied to the biomedical fields of pathology, physiology, pharmacology, microorganism, biochemistry, molecular genetics and the like. The requirements on the amount and the quality of the nano magnetic beads are increasingly strict, so that a special sample adding device is needed in the process of producing the magnetic beads, and the practical requirement on the sample adding device is higher.
The existing sample adding device has the defects that: the existing sample adding device is an infusion hose connected with an injector, a rubber plug is directly plugged on the side wall of a nozzle of a reaction container, the infusion tube head is hung into the reaction container, the position of the hose cannot be fixed, the hose can be easily contacted with magnetic beads in the reaction container, the infusion tube is polluted, and the waste of the infusion tube is caused; in addition, the infusion tube head is smaller, the contact area between the infusion tube head and the magnetic beads in the reaction container is too small when the reagent is added, the reaction efficiency of the system is reduced, the infusion tube head is extremely easy to block, the production is stopped, and the production efficiency is reduced; the infusion tube is disposable, can not be replaced and cleaned and can not be reused, and the production cost is increased.
Disclosure of Invention
The utility model aims to solve the problems and provide an adjustable spray type microscale sample adding device for magnetic bead production.
The utility model realizes the above purpose through the following technical scheme:
the utility model provides a can regulate and control spraying formula trace sample application device for magnetic bead production, includes the syringe, the play liquid end of syringe is connected with the injection hose, the injection hose other end is connected with the injection straight tube, the fixed silica gel stopper that has cup jointed on the injection straight tube, injection straight tube play liquid end fixedly connected with connector, the connector goes out liquid end and can dismantle and be connected with injection spray subassembly, the connector includes the shell, sliding connection has the rotation endotheca in the shell, set up the mounting groove on the rotation endotheca inner wall, be provided with in the mounting groove and be used for quick assembly disassembly injection spray subassembly's locking component, fixedly connected with blade on the rotation endotheca inner wall.
Preferably, the injection spraying assembly comprises an injection hard tube, one end of the injection hard tube is inserted into the rotating inner sleeve, and the other end of the injection hard tube is fixedly connected with a spraying head.
Preferably, the spray head is provided with a regulating valve, and the regulating valve is provided with a plurality of gears to regulate the spray area and the spray quantity of the spray head.
Preferably, the locking assembly comprises a locking ball and a spring which are arranged in the mounting groove, the diameter of an opening of the mounting groove on the inner wall of the rotating inner sleeve is smaller than that of the locking ball, a spherical groove is formed in the outer wall of the top end of the injection hard tube, and the locking ball is matched with the spherical groove.
Preferably, a movable ball head is slidably embedded in the outer wall of the rotating inner sleeve, an annular groove is formed in the inner wall of the outer shell, and the movable ball head is matched with the annular groove.
Preferably, the two ends of the injection hose are respectively provided with a first connector and a second connector, the first connector is connected with the liquid outlet end of the injector, and the second connector is connected with the liquid inlet end of the injection straight tube.
The beneficial effects are that: according to the utility model, the injection straight pipe is directly inserted into the silica gel plug, so that the error of sample injection caused by extrusion of the silica gel plug in the sample injection process is prevented, manual constant observation and adjustment are not needed, and the labor cost is saved;
the injection spraying component is detachably connected to the connecting head, and can be replaced according to different reaction containers and reaction systems, so that the injection spraying component with different bending degrees and lengths can be replaced more conveniently and practically;
the spray head is used for replacing the transfusion tube head, so that the contact area between the reagent and the magnetic beads in the reaction container is enlarged, the blades are arranged in the connector, and the reagent impacts the blades during injection, so that the rotating inner sleeve drives the injection spray assembly to rotate, the contact area between the reagent and the magnetic beads is further enlarged, the reaction is more complete, the reaction time is shortened, the production efficiency is improved, and the risk of blockage is avoided;
the spray head is provided with the regulating valve, so that the spray area can be regulated according to the size of a reaction system or the reaction rate requirements of different reagents, and the purposes of multiple purposes, economy, accuracy and convenience are realized.
Additional features and advantages of the utility model will be set forth in the description which follows, or may be learned by practice of the utility model.
Drawings
The accompanying drawings are included to provide a further understanding of the utility model, and are incorporated in and constitute a part of this specification, illustrate the utility model and together with the description serve to explain, without limitation, the utility model. In the drawings:
FIG. 1 is a schematic perspective view of an adjustable spray-type microsampling device for magnetic bead production;
FIG. 2 is a schematic diagram showing the connection structure between a connector and an injection spray assembly of the adjustable spray type microscale sample injection device for magnetic bead production;
FIG. 3 is a schematic diagram of the internal structure of a connector of the adjustable spray-type microscale sample-adding device for magnetic bead production.
The reference numerals are explained as follows: 1. a syringe; 2. an injection hose; 201. a first joint; 202. a second joint; 3. injecting a straight tube; 4. a silica gel plug; 5. a connector; 501. a housing; 502. rotating the inner sleeve; 503. a mounting groove; 504. a locking assembly; 5041. a locking ball; 5042. a spring; 505. a blade; 506. a movable ball head; 6. an injection spray assembly; 601. injecting a hard tube; 602. a spray head; 6021. a regulating valve; 603. spherical grooves.
Detailed Description
The following description of the embodiments of the present utility model will be made clearly and completely with reference to the accompanying drawings, in which it is apparent that the embodiments described are only some embodiments of the present utility model, but not all embodiments.
In the description of the present utility model, it should be understood that the terms "upper," "lower," "front," "rear," "left," "right," "top," "bottom," "inner," "outer," and the like indicate or are based on the orientation or positional relationship shown in the drawings, merely to facilitate description of the present utility model and to simplify the description, and do not indicate or imply that the devices or elements referred to must have a specific orientation, be configured and operated in a specific orientation, and thus should not be construed as limiting the present utility model.
The utility model is further described below with reference to the accompanying drawings:
as shown in fig. 1-3, an adjustable spraying type micro sample adding device for magnetic bead production comprises an injector 1, wherein a liquid outlet end of the injector 1 is connected with an injection hose 2, the other end of the injection hose 2 is connected with an injection straight pipe 3, a silica gel plug 4 is fixedly sleeved on the injection straight pipe 3, the injection straight pipe 3 is connected with a charging port of a reaction vessel through the silica gel plug 4, the stability of the injection straight pipe 3 is ensured, a connector 5 is fixedly connected with a liquid outlet end of the injection straight pipe 3, a liquid outlet end of the connector 5 is detachably connected with an injection spraying component 6, the connector 5 comprises a shell 501, a rotating inner sleeve 502 is slidably connected in the shell 501, an installation groove 503 is formed in the inner wall of the rotating inner sleeve 502, a locking component 504 for quickly disassembling the injection spraying component 6 is arranged in the installation groove 503, a blade 505 is fixedly connected on the inner wall of the rotating inner sleeve 502, and during liquid injection, a reagent impacts the blade 505, so that the blade 505 drives the rotating inner sleeve 502 to rotate, the rotating inner sleeve 502 drives the injection spraying component 6 to rotate through the locking component 504, and the spraying area of the injection spraying component 6 is increased;
the injection spraying assembly 6 comprises an injection hard tube 601, one end of the injection hard tube 601 is inserted into the rotary inner sleeve 502, the other end of the injection hard tube 601 is fixedly connected with a spraying head 602, and the contact area of the reagent and the magnetic beads can be enlarged through the spraying head 602, so that the reaction is more sufficient, and the reaction time is shortened;
the spray head 602 is provided with the regulating valve 6021, the regulating valve 6021 is provided with three gears, and the spray area and the spray quantity of the spray head 602 are regulated according to the size of a reaction system or the reaction rates of different reagents, so that one object is multipurpose, and the method is more economical, accurate and convenient;
the locking component 504 comprises a locking ball 5041 and a spring 5042 which are arranged in a mounting groove 503, the diameter of an opening of the mounting groove 503 on the inner wall of the rotating inner sleeve 502 is smaller than the diameter of the locking ball 5041, the locking ball 5041 is ensured not to deviate from the mounting groove 503, the locking ball 5041 is partially positioned outside the mounting groove 503, a spherical groove 603 is formed in the outer wall of the top end of the injection hard tube 601, the locking ball 5041 is matched with the spherical groove 603, when the injection spray component 6 is mounted, one end of the injection hard tube 601 is inserted into the rotating inner sleeve 502, the injection hard tube 601 firstly presses the locking ball 5041, when the spherical groove 603 moves to the locking ball 5041, the spring 5042 pushes the locking ball 5041 to move, the locking ball 5041 is clamped into the spherical groove 603, when the injection spray component 6 is required to be dismounted, the injection spray component 6 can be drawn out with force, and the injection spray component 6 with different curvatures and lengths can be replaced according to different reaction containers and reaction systems, and the use is convenient;
the movable ball head 506 is slidably embedded in the outer wall of the rotating inner sleeve 502, an annular groove is formed in the inner wall of the outer shell 501, the movable ball head 506 is matched with the annular groove, and friction force between the rotating inner sleeve 502 and the outer shell 501 is reduced by the movable ball head 506, so that the blades 505 can drive the rotating inner sleeve 502 to rotate more easily;
the two ends of the injection hose 2 are respectively provided with a first connector 201 and a second connector 202, the first connector 201 is connected with the liquid outlet end of the injector 1, and the second connector 202 is connected with the liquid inlet end of the injection straight pipe 3;
working principle: when the injection hard tube 601 is used, according to different reaction containers and reaction systems, an injection hard tube 601 with proper curvature and length is selected, one end of the injection hard tube 601 is inserted into a rotating inner sleeve 502, firstly, the injection hard tube 601 extrudes a locking ball 5041, when a spherical groove 603 moves to the locking ball 5041, a spring 5042 pushes the locking ball 5041 to move, the locking ball 5041 is clamped into a spherical groove 603, the installation of an injection spray assembly 6 is completed, when the injection spray assembly 6 is required to be detached, the injection hard tube 601 can be pulled out by force, according to the size of the reaction system or the reaction rate of different reagents, a regulating valve 6021 is regulated to a proper gear, then a spray head 602 and an injection straight tube 3 are inserted into the reaction container, a reaction container opening is sealed by a silica gel plug 4, the injection straight tube 3 is fixed, then, the injection is carried out by the injector 1, reagents sequentially pass through an injection hose 2, the injection straight tube 3, the rotating inner sleeve 502 and the injection hard tube 601, in the process of the injection hard tube 502, the reagents are atomized and sprayed out by the spray head 602, the reagents impact on blades 505, the blades 505 generate rotary power, the blades 505 drive the rotating inner sleeve 502, the blades 505 to drive the rotating inner sleeve 502 to rotate, the rotating body 502, the rotary sleeve 502 drives the rotary sleeve 502 to rotate, the rotary sleeve 502 rotates the rotary ball 502 and the rotary sleeve 502 rotates the rotary sleeve 502 to rotate with the rotary sleeve 502, and the rotary sleeve 502 rotates the rotary sleeve 502 and rotates the rotary sleeve 502 to rotate with the rotary sleeve 502, and the rotary body is driven by the rotary sleeve 502.
The foregoing has shown and described the basic principles, principal features and advantages of the utility model. It will be understood by those skilled in the art that the present utility model is not limited to the embodiments described above, and that the above embodiments and descriptions are merely illustrative of the principles of the present utility model, and various changes and modifications may be made without departing from the spirit and scope of the utility model, which is defined in the appended claims. The scope of the utility model is defined by the appended claims and their equivalents.
Claims (6)
1. The utility model provides a can regulate and control spraying formula trace sample application device for magnetic bead production, includes syringe (1), the play liquid end of syringe (1) is connected with injection hose (2), its characterized in that: injection hose (2) other end is connected with injection straight tube (3), fixed sleeve has cup jointed silica gel stopper (4) on injection straight tube (3), injection straight tube (3) play liquid end fixedly connected with connector (5), connector (5) play liquid end can be dismantled and are connected with injection spray subassembly (6), connector (5) are including shell (501), sliding connection has rotation endotheca (502) in shell (501), install mounting groove (503) have been seted up on rotation endotheca (502) inner wall, be provided with in mounting groove (503) and be used for quick assembly disassembly locking subassembly (504) of injection spray subassembly (6), fixedly connected with blade (505) on rotation endotheca (502) inner wall.
2. The adjustable spray-type microsampling device for magnetic bead production according to claim 1, wherein: the injection spraying assembly (6) comprises an injection hard tube (601), one end of the injection hard tube (601) is inserted into the rotating inner sleeve (502), and the other end of the injection hard tube (601) is fixedly connected with a spraying head (602).
3. The adjustable spray-type microscale sample application device for magnetic bead production according to claim 2, wherein: install governing valve (6021) on atomising head (602), governing valve (6021) are provided with a plurality of gears in order to adjust atomising area and the spraying volume of atomising head (602).
4. The adjustable spray-type microscale sample application device for magnetic bead production according to claim 2, wherein: the locking assembly (504) comprises a locking ball (5041) and a spring (5042) which are arranged in the mounting groove (503), the diameter of an opening of the mounting groove (503) on the inner wall of the rotating inner sleeve (502) is smaller than that of the locking ball (5041), a spherical groove (603) is formed in the outer wall of the top end of the injection hard tube (601), and the locking ball (5041) is matched with the spherical groove (603).
5. The adjustable spray-type microsampling device for magnetic bead production according to claim 1, wherein: the movable ball head (506) is embedded in the outer wall of the rotating inner sleeve (502) in a sliding mode, an annular groove is formed in the inner wall of the outer shell (501), and the movable ball head (506) is matched with the annular groove.
6. The adjustable spray-type microsampling device for magnetic bead production according to claim 1, wherein: the injection hose (2) is characterized in that a first connector (201) and a second connector (202) are respectively arranged at two ends of the injection hose, the first connector (201) is connected with the liquid outlet end of the injector (1), and the second connector (202) is connected with the liquid inlet end of the injection straight tube (3).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202322163588.XU CN220589937U (en) | 2023-08-11 | 2023-08-11 | Adjustable spray type micro sample adding device for magnetic bead production |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202322163588.XU CN220589937U (en) | 2023-08-11 | 2023-08-11 | Adjustable spray type micro sample adding device for magnetic bead production |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN220589937U true CN220589937U (en) | 2024-03-15 |
Family
ID=90168074
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202322163588.XU Active CN220589937U (en) | 2023-08-11 | 2023-08-11 | Adjustable spray type micro sample adding device for magnetic bead production |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN220589937U (en) |
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2023
- 2023-08-11 CN CN202322163588.XU patent/CN220589937U/en active Active
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