CN220584829U - A focus ultrasonic ablation test simulation model for near vascular target - Google Patents
A focus ultrasonic ablation test simulation model for near vascular target Download PDFInfo
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- 238000002604 ultrasonography Methods 0.000 claims abstract description 21
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Abstract
The utility model relates to the technical field of medical assistance, and discloses a simulation model for a focused ultrasound ablation test of a near vascular target, which comprises the following components: a tissue body membrane, wherein a human target spot is arranged inside the tissue body membrane; a respiration simulation apparatus comprising: the tissue membrane is fixedly arranged on the breathing simulator; a vascular mobile device, comprising: the sliding rail and the sliding block are arranged on the sliding rail in a sliding manner, and the sliding block is also provided with a through hole; a blood simulation device comprising: the simulated blood vessel utilizes the multichannel pressure pump to extract simulated blood from the liquid storage tank and passes through the perforation to form closed loop connection; and the control module is electrically connected with the driving module and the multichannel pressure pump respectively. The utility model can simulate not only target movement caused by human respiration, but also target heat dissipation caused by blood flow at different flow rates and distances.
Description
Technical Field
The utility model relates to the technical field of medical assistance, in particular to a focused ultrasound ablation test simulation model for a near-vascular target spot.
Background
High-Intensity Focused Ultrasound (HIFU) is an advanced medical technology, which uses focused ultrasound beams to focus energy to target tissue, thereby inducing High temperature effect, and is used for treating tumor, hyperplasia, etc. The HIFU technology utilizes the unique characteristics of acoustic wave energy, and can directly act on a specific area inside a human body under the condition of not invading skin, thereby realizing the noninvasive treatment effect.
However, in the implementation process of the HIFU technology, on one hand, the target area position is continuously changed due to the respiration of the patient, so that the accurate positioning difficulty is high. On the other hand, the human tissue organ can generate heat conduction and heat diffusion, and when the temperature in the target area is too high, the heat can diffuse to the surrounding tissue organ, so that the normal tissue organ is damaged; when the temperature is too low, the target tissue is difficult to ablate, and the blood flow around the target tissue also causes a large amount of heat dissipation, so that the difficulty of temperature control is increased. Thus, there is a need for a simulation model that can simulate blood flow and is used in focused ultrasound ablation experiments.
Disclosure of Invention
In view of the above, the utility model provides a focused ultrasound ablation test simulation model for a near-vascular target spot, so as to solve the problem that accurate positioning and accurate temperature control are difficult to realize in practical application.
In a first aspect, the present utility model provides a focused ultrasound ablation test simulation model for a near-vascular target, the simulation model comprising:
the tissue body membrane is internally provided with at least one human body target spot used for simulating an ultrasonic ablation test;
a respiration simulation apparatus comprising: the device comprises a respiration simulator and a driving module, wherein a tissue membrane is fixedly arranged on the respiration simulator, and the driving module is used for driving the respiration simulator to simulate human body respiratory motion;
a vascular mobile device, comprising: the tissue membrane tissue device comprises a sliding rail and a sliding block, wherein one end of the sliding rail is fixedly connected with the tissue membrane, the other end of the sliding rail is far away from the tissue membrane, the sliding block is arranged on the sliding rail in a sliding manner, and a through hole is further formed in the sliding block;
a blood simulation device comprising: the simulated blood vessel utilizes the multichannel pressure pump to extract simulated blood from the liquid storage tank, and passes through the perforation to form closed-loop connection, and the multichannel pressure pump is used for regulating blood flow speed;
and the control module is electrically connected with the driving module and the multichannel pressure pump respectively.
In an alternative embodiment, the simulation model further comprises:
the water tank, the tissue membrane, the respiration simulation device and the blood vessel moving device are all arranged in the water tank.
In an alternative embodiment, the water tank further comprises:
and the heating pipe is electrically connected with the control module and is used for heating water in the water tank so as to simulate the body temperature of a human body.
In an alternative embodiment, the blood simulation device further comprises:
the two-way six-position valve is connected with the simulated blood vessel in series and is electrically connected with the control module for controlling the blood flow velocity.
In an alternative embodiment, the simulation model further comprises:
a flow sensor;
the first temperature sensor, the flow sensor and the first temperature sensor are connected in series on the simulated blood vessel;
and/or a second temperature sensor arranged inside the water tank;
and/or a third temperature sensor for monitoring the temperature of the tissue volume membrane.
In an alternative embodiment, the number of the sliding rails is two, and the sliding rails are arranged in parallel, and each sliding rail is provided with a sliding block.
In an alternative embodiment, the breathing simulation device is a water bladder or an air bladder.
In an alternative embodiment, the drive module is a respiratory pressure pump.
In an alternative embodiment, the tissue membrane is an agar block made of agar powder and water according to a preset proportion.
In an alternative embodiment, plexiglas is used as the target.
Before clinical focused ultrasound ablation surgery is performed, the motion frequency and amplitude of the breathing simulator can be continuously adjusted through the simulation model provided by the embodiment of the utility model so as to simulate the breathing motion of a human body, and then the target movement caused by the breathing of the human body can be simulated. Meanwhile, the relative distance between the simulated blood vessel and the tissue membrane can be continuously adjusted through the sliding block, and the blood flow speed in the simulated blood vessel can be adjusted through the multichannel pressure pump so as to simulate the blood vessel flow speed of a human body, and then the heat dissipation of a target area caused by the blood flow at different flow speeds and distances can be simulated. Through the simulation model provided in the embodiment, not only the real human body operation environment can be simulated, but also the treatment effect of the operation equipment can be verified, the performance of the operation equipment is further improved, and the positioning accuracy of clinical operation and the accuracy of temperature control are improved.
Drawings
In order to more clearly illustrate the embodiments of the present utility model or the technical solutions in the prior art, the drawings that are needed in the description of the embodiments or the prior art will be briefly described, and it is obvious that the drawings in the description below are some embodiments of the present utility model, and other drawings can be obtained according to the drawings without inventive effort for a person skilled in the art.
Fig. 1 is a schematic structural diagram of a specific example of a focused ultrasound ablation test simulation model for a near-vascular target in accordance with an embodiment of the present utility model.
Detailed Description
For the purpose of making the objects, technical solutions and advantages of the embodiments of the present utility model more apparent, the technical solutions of the embodiments of the present utility model will be clearly and completely described below with reference to the accompanying drawings in the embodiments of the present utility model, and it is apparent that the described embodiments are some embodiments of the present utility model, but not all embodiments of the present utility model. All other embodiments, which can be made by those skilled in the art based on the embodiments of the utility model without making any inventive effort, are intended to be within the scope of the utility model.
In the description of the present utility model, it should be noted that the directions or positional relationships indicated by the terms "center", "upper", "lower", "left", "right", "vertical", "horizontal", "inner", "outer", etc. are based on the directions or positional relationships shown in the drawings, are merely for convenience of describing the present utility model and simplifying the description, and do not indicate or imply that the devices or elements referred to must have a specific orientation, be configured and operated in a specific orientation, and thus should not be construed as limiting the present utility model. Furthermore, the terms "first," "second," and "third" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance.
In the description of the present utility model, it should be noted that, unless explicitly specified and limited otherwise, the terms "mounted," "connected," and "connected" are to be construed broadly, and may be either fixedly connected, detachably connected, or integrally connected, for example; can be mechanically or electrically connected; the two components can be directly connected or indirectly connected through an intermediate medium, or can be communicated inside the two components, or can be connected wirelessly or in a wired way. The specific meaning of the above terms in the present utility model will be understood in specific cases by those of ordinary skill in the art.
In addition, the technical features of the different embodiments of the present utility model described below may be combined with each other as long as they do not collide with each other.
Focused ultrasound ablation is the use of high intensity ultrasound waves to focus energy into a target tissue region, creating enough heat to destroy the tissue in that region. In practice, ultrasound ablation requires precise localization of the target tissue region, otherwise excessive energy may damage normal cells around the target region. However, the breathing of the patient inevitably brings up fluctuations of the human body and displacements of the organs, so that the target position is changed continuously, and the difficulty of accurate positioning is increased. Although the patient can be anesthetized and then breathing of the human body is controlled by a breathing machine, irreversible damage is generated to the human body by using the breathing machine for a long time.
Moreover, controlling the energy temperature of the ultrasound output is also one of the most important parts in the focused ultrasound ablation test, and directly determines the success or failure of the operation. However, the heat conduction and diffusion of the human tissue and organs, and the flow rate of blood vessels all bring about a great deal of heat loss, and the distance between the target area and the blood vessels, the flow rates of blood of different human bodies, and the like all increase the difficulty of temperature control.
In view of this, in this embodiment, a simulation model of focused ultrasound ablation test for a near-vascular target is provided, which not only can simulate the target movement caused by human respiration, but also can accurately simulate the blood flow at different flow rates and the position of the blood vessel from the target region. Referring to fig. 1, a schematic structural diagram of a simulation model of a focused ultrasound ablation test for a near-vascular target is shown, which includes a tissue membrane 1, a respiration simulation device, a vascular moving device, a blood simulation device and a control module, and is specifically as follows.
The tissue body membrane 1, the inside of the tissue body membrane 1 is provided with at least one human target 11 used for simulating an ultrasonic ablation test. The target 11 may be used as a target tissue for an ultrasound ablation test, wherein the material used to simulate the target 11 is different from the material of the tissue volume membrane 1.
A respiration simulation apparatus comprising: the breathing simulator 21 and the driving module 22, the tissue body membrane 1 is fixedly arranged on the breathing simulator 21, and the driving module 22 is used for driving the breathing simulator 21 to simulate the breathing motion of a human body. When the breathing simulator 21 simulates breathing movements under the control of the drive module 22, the tissue body membrane 1 also moves along with the movements of the breathing simulator 21, and thus the target points 11 arranged inside the tissue body membrane 1 are also shifted continuously along with the movements of the tissue body membrane 1. The experimenter can summarize rules according to the position change of the target point 11 in the simulation model, thereby realizing accurate positioning during clinical operation.
A vascular mobile device, comprising: slide rail 31 and slider 32, the one end and the tissue body membrane 1 fixed connection of slide rail 31, the other end of slide rail 31 keeps away from tissue body membrane 1, and slider 32 slip sets up on slide rail 31, still is provided with the perforation on the slider 32. The simulated blood vessel 41 can pass through the perforation on the slide block 32, and the slide block 32 and the slide rail 31 can be fixed by utilizing the screw by adjusting the position of the slide block 32 on the slide rail 31, so that the relative position of the simulated blood vessel 41 and the tissue membrane 1 can be fixed. Graduations can also be arranged on the sliding rail 31, so that the accuracy of position adjustment is improved.
A blood simulation device comprising: the simulated blood vessel 41 draws simulated blood from the reservoir 42 using the multichannel pressure pump 43 and through the perforations to form a closed loop connection, the multichannel pressure pump 43 being used to regulate the blood flow velocity in the simulated blood vessel 41, the reservoir 42, the multichannel pressure pump 43. In the embodiment, the artificial blood vessel is matched with the blood injection simulation to simulate the real human blood vessel, so that the simulation accuracy is improved.
A control module (not shown) is electrically connected to the drive module 22 and the multi-channel pressure pump 43, respectively. The driving module 22 can be controlled by the control module to drive the breathing simulator 21 to simulate the breathing motion of a human body, and meanwhile, the multichannel pressure pump 43 can be controlled by the control module to regulate the blood flow speed.
The control module utilizes the embedded MCU control component and a specific algorithm to realize driving, temperature monitoring, heating control and the like, and has the advantages of high temperature control precision and strong instantaneity. In addition, the programmability of the temperature control algorithm also provides guarantee for continuous optimization of products. And through a control program written in the embedded MCU, the temperature measurement, heating, multichannel pressure pump and respiratory pressure pump are synchronously controlled through a certain communication protocol.
Before clinical focused ultrasound ablation surgery is performed, the motion frequency and amplitude of the breathing simulator 21 can be continuously adjusted through the simulation model provided in the embodiment so as to simulate the breathing motion of a human body, and then target movement caused by human body breathing can be simulated. At the same time, the relative distance between the simulated blood vessel 41 and the tissue membrane 1 can be continuously adjusted through the sliding block 32, and the blood flow velocity in the simulated blood vessel 41 can be adjusted through the multi-channel pressure pump 43 so as to simulate the blood flow velocity of a human body, and further simulate the target region heat loss caused by blood flow at different flow velocities and distances. Through the simulation model provided in the embodiment, not only the real human body operation environment can be simulated, but also the treatment effect of the operation equipment can be verified, the performance of the operation equipment is further improved, and the positioning accuracy of clinical operation and the accuracy of temperature control are improved.
In some alternative embodiments, the simulation model further comprises:
the water tank 5, the tissue membrane 1, the respiration simulation device and the blood vessel moving device are all arranged in the water tank 5. The human body environment can be simulated, and the simulation accuracy is improved.
In some alternative embodiments, the water tank 5 further comprises: the heating pipe 51 is electrically connected with the control module and is used for heating water in the water tank 5 so as to simulate the body temperature of a human body.
In some alternative embodiments, the blood simulation device further comprises:
the two-way six-position valve 44 is connected in series with the simulated blood vessel 41 and is electrically connected with the control module for controlling the blood flow velocity.
In some technologies, a peristaltic pump is adopted to simulate blood flow, however, due to the principle constraint of the peristaltic pump, accurate flow control cannot be realized, and therefore targeted simulation cannot be performed according to the specific blood flow condition of a target patient. In this embodiment, not only the multi-channel pressure pump 43 is adopted, but also the two-way six-position valve 44 is added, and the multi-channel pressure pump 43 and the two-way six-position valve 44 are matched for use, so that fluid circulation can be more accurately realized to simulate blood flow.
Referring to fig. 1, a simulated blood vessel 41 is connected in series with a multi-channel pressure pump 43, and simulated blood flows out of a reservoir 42 filled with simulated blood, flows through a valve of a two-way six-position valve 44 for the first time, then flows through a flow sensor 45, a first temperature sensor 46 and flows into a valve of the two-way six-position valve 44 again in sequence, then flows into the reservoir 42 filled with simulated blood again, and finally is connected back to the multi-channel pressure pump 43. The multichannel pressure pump 43 can realize high-precision flow control by matching with the two-way six-position valve 44. Wherein, flow sensor 45 can read the flow of imitative blood in real time, and first temperature sensor and can read imitative blood's temperature in real time.
In some alternative embodiments, the simulation model further comprises:
the flow sensor 45 can monitor the flow of blood in the simulated blood vessel 41 in real time.
The first temperature sensor 46, the flow sensor 45 and the first temperature sensor 46 are connected in series with the simulated blood vessel 41, so that the temperature of the simulated blood in the simulated blood vessel 41 can be monitored in real time.
And/or a second temperature sensor 52, arranged inside said tank 5. A waterproof second temperature sensor 52 can be installed on the inner wall of the water tank 5, and can be used for monitoring the water temperature in real time. Meanwhile, a U-shaped electric heating tube 51 can be installed on the side wall of the water tank 5, a control module is externally connected, a negative feedback algorithm is realized through programming, and the heating behavior of the heating tube 51 is started or stopped in real time to control the water temperature in the water tank 5, so that the electric heating tube can be used for simulating the internal temperature of a human body.
The target heat loss may be determined based on the flow rate of the blood-like substance monitored by the flow sensor 45 and the temperature of the blood-like substance monitored by the first temperature sensor 46. For example, a set of temperatures may be measured at a simulated blood vessel 41 at a blood flow rate a and a set of temperatures may be measured at a blood flow rate b to determine the target heat loss from blood flow at different flow rates. And the flow rate can be adjusted according to the blood flow rate of the human body to be measured.
In this embodiment, a third temperature sensor (not shown in the figure) may be further provided for monitoring the temperature of the tissue body membrane, and the third temperature sensor may be a thermocouple sensor and may be provided inside the tissue body membrane 1 to monitor the temperature of the target tissue in real time, so that the energy of the focused ultrasound beam may be adjusted in real time.
In some alternative embodiments, the number of the sliding rails 31 is two, and the sliding rails 31 are arranged in parallel, and one sliding block 32 is arranged on each sliding rail 31. The sliding blocks 32 on the two sliding rails 31 are respectively slid, so that the distance between the simulated blood vessel 41 and the tissue membrane can be adjusted, the angle can be adjusted, and the heat dissipation capacity of patients with different blood flow rates to the target area can be accurately simulated.
In some alternative embodiments, the respiration simulation device is a water bladder or an air bladder.
In some alternative embodiments, the drive module 22 is a respiratory pressure pump connected to a water bladder or air bladder.
In some technologies, a stepping motor is adopted to match with an injector to draw a water sac for respiratory simulation, so that the machine is too complex, meanwhile, the injector possibly brings larger errors due to the existence of strong friction force, the complex structure can bring error superposition, and the simulation effect is poor. The simulation model provided by the embodiment has the advantages of simple structure, obvious effect and small error.
In this embodiment, on the basis of adopting the water sac as the respiration simulation device, the respiration pressure pump can be connected with the water sac, and the water sac is sucked and pumped through the respiration pressure pump, so that the fluctuation of the water sac is realized, and the respiration of the body surface is simulated. The breathing pressure pump can be controlled by the upper computer programming, and the water sucking and pumping accords with the theory of a high-order cosine function, namely:
f(t)＝a 0 +∑[a n cos(nθ)+b n sin(nθ)]
wherein a is 0 Is a constant, a n B n The cosine coefficients of the nth order are respectively shown, and are experimental values summarized by actual data and experimental results.
It should be noted that, the embodiment of the present utility model mainly introduces the structure and hardware of the simulation model, and the structure and the components included in the simulation model to be protected by the present utility model may completely adopt the existing technology as to the contents of the methods such as calculation and the like.
In some alternative embodiments, the tissue membrane 1 is an agar block made of agar powder and water according to a preset ratio. The thermodynamic and acoustic properties of agar are similar to those of human organs, and the propagation condition of ultrasound in human body can be well simulated.
In some alternative embodiments, organic glass is used as the target 11, the organic glass is similar to human tissue, the organic glass can be filled in the agar block, and the agar block is fixed above the respiration simulation device, namely the water sac or the air sac, so that the agar block follows the movement of the respiration simulation device, and the simulation of the movement of the target area along with the respiration can be realized.
In the whole, the simulation model provided by the utility model fully considers important factors influencing the treatment effect such as human body temperature, tissue acoustic effect, thermal effect and the like, and aims to simulate the real clinical environment. The ultrasonic ablation system can well simulate the body temperature of a human body, the acoustic impedance of the human body, the respiration of the human body and the heat dissipation of blood flow to a target area, and can be used for preclinical experimental effect detection of the ultrasonic ablation system.
Although embodiments of the present utility model have been described in connection with the accompanying drawings, various modifications and variations may be made by those skilled in the art without departing from the spirit and scope of the utility model, and such modifications and variations fall within the scope of the utility model as defined by the appended claims.
Claims (10)
1. A simulation model for a focused ultrasound ablation test of a near vascular target, comprising:
the tissue body membrane is internally provided with at least one human target spot for simulating an ultrasonic ablation test;
a respiration simulation apparatus comprising: the tissue body membrane is fixedly arranged on the breathing simulator, and the driving module is used for driving the breathing simulator to simulate human breathing motion;
a vascular mobile device, comprising: the tissue membrane device comprises a sliding rail and a sliding block, wherein one end of the sliding rail is fixedly connected with the tissue membrane, the other end of the sliding rail is far away from the tissue membrane, the sliding block is arranged on the sliding rail in a sliding manner, and a through hole is further formed in the sliding block;
a blood simulation device comprising: the blood flow control device comprises a simulated blood vessel, a liquid storage tank and a multichannel pressure pump, wherein the simulated blood vessel utilizes the multichannel pressure pump to extract simulated blood from the liquid storage tank, and passes through a perforation to form closed loop connection, and the multichannel pressure pump is used for regulating blood flow speed;
and the control module is electrically connected with the driving module and the multichannel pressure pump respectively.
2. The simulation model of claim 1, further comprising:
the tissue membrane, the respiration simulation device and the blood vessel moving device are all arranged in the water tank.
3. The simulation model of claim 2, wherein the water tank further comprises:
and the heating pipe is electrically connected with the control module and is used for heating water in the water tank so as to simulate the body temperature of a human body.
4. The simulation model of claim 1, wherein the blood simulation device further comprises:
and the two-to-six-position valve is connected with the simulated blood vessel in series and is electrically connected with the control module for controlling the blood flow speed.
5. The simulation model of claim 2, further comprising:
a flow sensor;
the flow sensor and the first temperature sensor are connected in series on the simulated blood vessel;
and/or a second temperature sensor arranged inside the water tank;
and/or a third temperature sensor for monitoring the temperature of the tissue volume membrane.
6. The simulation model according to claim 1 or 2, wherein the number of the sliding rails is two, and the sliding rails are arranged in parallel, and each sliding rail is provided with one sliding block.
7. The simulation model of claim 1, wherein the breathing simulation device is a water bag or an air bag.
8. The simulation model of claim 6, wherein the drive module is a respiratory pressure pump.
9. The simulation model of claim 1, wherein the tissue membrane is an agar block made of agar powder and water according to a predetermined ratio.
10. Simulation model according to claim 1, characterized in that plexiglas is used as target.
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| CN202322169915.2U CN220584829U (en) | 2023-08-11 | 2023-08-11 | A focus ultrasonic ablation test simulation model for near vascular target |
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| CN202322169915.2U CN220584829U (en) | 2023-08-11 | 2023-08-11 | A focus ultrasonic ablation test simulation model for near vascular target |
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