CN220558338U - Polypropylene patch with nano coating - Google Patents
Polypropylene patch with nano coating Download PDFInfo
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- CN220558338U CN220558338U CN202321851908.4U CN202321851908U CN220558338U CN 220558338 U CN220558338 U CN 220558338U CN 202321851908 U CN202321851908 U CN 202321851908U CN 220558338 U CN220558338 U CN 220558338U
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- polypropylene
- patch
- base layer
- nano coating
- nanocoating
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- -1 Polypropylene Polymers 0.000 title claims abstract description 112
- 239000004743 Polypropylene Substances 0.000 title claims abstract description 110
- 229920001155 polypropylene Polymers 0.000 title claims abstract description 110
- 239000002103 nanocoating Substances 0.000 title claims abstract description 75
- 239000000463 material Substances 0.000 claims abstract description 15
- 238000009940 knitting Methods 0.000 claims abstract description 9
- 229920001577 copolymer Polymers 0.000 claims description 8
- 238000000034 method Methods 0.000 claims description 8
- 230000008569 process Effects 0.000 claims description 8
- 229920001661 Chitosan Polymers 0.000 claims description 5
- 229920001610 polycaprolactone Polymers 0.000 claims description 5
- 239000004632 polycaprolactone Substances 0.000 claims description 5
- 239000011148 porous material Substances 0.000 claims description 4
- 229910003460 diamond Inorganic materials 0.000 claims description 2
- 239000010432 diamond Substances 0.000 claims description 2
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Landscapes
- Materials For Medical Uses (AREA)
Abstract
The utility model discloses a polypropylene patch with a nano coating, which comprises a polypropylene base layer, wherein the polypropylene base layer is formed by warp knitting polypropylene monofilaments, and a polypropylene lead is arranged on the polypropylene base layer; the nano coating is coated on the polypropylene base layer, the nano coating is made of degradable materials, and the nano coating is provided with drainage holes. According to the polypropylene patch with the nano coating, the degradable nano coating is coated on the polypropylene base layer, on one hand, the nano coating is in direct contact with tissues and organs, and complications such as postoperative infection and tissue adhesion of an organism are effectively prevented due to good compatibility and anti-adhesion performance of the nano coating; on the other hand, the polypropylene base layer can still provide certain tension after the nano coating is degraded, so that the recurrence rate of the operation is reduced.
Description
Technical Field
The utility model relates to the technical field of medical consumables, in particular to a polypropylene patch with a nano coating.
Background
Patches used clinically are mainly divided into 3 major categories: i.e., non-absorbable synthetic patches, biological patches, and absorbable patches.
Non-absorbable patch: mainly polyester, PP, etc. Such as Marlex polypropylene patches, mersilene polyethylene terephthalate patches, gore-Tex polytetrafluoroethylene sheets, and the like. After the patch is placed into a human body, enough tension can be provided for a defect part, but because the patch in the human body exists for a long time, complications such as infection, tissue adhesion and the like are easily caused after the operation of the human body, and the patch is generally not suitable for the patients with larger defect areas.
Biological patch: the patch is formed by decellularizing, sterilizing and the like of human cadaver-derived or animal tissues, and is used for repairing clinical defects. Mainly relates to three kinds of: 1) Autogenous or allograft, mainly thigh fascia lata, rectus abdominus fascia, vaginal wall tissue, etc.; 2) Allograft, e.g., donor or cadaveric fascia tissue; 3) Xenografts such as bovine fascia lata, porcine small intestine submucosa tissue, porcine dermal collagen, bovine pericardium, and the like. The patch has certain structural and functional proteins, can be used as a bracket to induce the regeneration of cells and tissues at the defect part after being placed into a human body, and can be completely absorbed and finally decomposed along with the time. But has limited mechanical properties, severe inflammatory reaction and fiber hyperplasia, and high cost.
Absorbable patch: mainly comprises Vicyl polysaccharide 910 patch, polylactide patch, polyglycolic acid and mixed fiber patch. The full absorbable patch has the greatest advantage of resisting infection, but the patch can relapse after being absorbed, and secondary operation is needed, so the absorbable patch is rarely used in the repair operation of a cleaning area independently.
Clinically, an ideal repair patch should have the following conditions: 1) The implant has chemical inertness after being implanted into a human body, and does not generate chemical reaction; 2) The physical properties in the liquid are not affected; 3) Can not cause cancerous lesions after being implanted into a human body; 4) The allergic reaction or anaphylactic reaction of the human body cannot be caused; 5) The material does not generate mechanical tension and has good toughness; 6) The material is easy to disinfect; 7) Can resist infection; 8) It is necessary to provide an anti-adhesion barrier in the tissue organ layers; 8) Can be cut at will without any dislocation.
At present, polypropylene (PP) is one of the most widely used non-absorbable patches. The polypropylene is nontoxic, has stable performance in any environment and high melting point, is favorable for high-temperature shaping and tissue growth. However, if only PP patch is used, it is easy to damage the organ to cause various complications. Such as intestinal fistula and severe intestinal adhesion caused by small intestine contact, esophageal perforation caused by esophagus contact, patch intraesophageal displacement, vas deferens occlusion caused by vas deferens contact, sterility and the like. On the basis of keeping the advantages of the PP patch, the defect that the PP patch may damage organs is overcome, and the problem to be solved is urgent at present.
Disclosure of Invention
In view of the defects in the prior art, the utility model provides the polypropylene patch with the nano coating, which takes a polypropylene material as a base layer, and retains the advantages of stable performance, high melting point and contribution to high-temperature qualitative performance of the polypropylene material; the nanometer coating is coated on the polypropylene base layer, and the nanometer coating is made of degradable materials, so that the nanometer coating can not adhere to organ tissues and can avoid damage to the organ tissues; meanwhile, a polypropylene lead is arranged on the polypropylene base layer, so that guiding and supporting effects are provided for coating of the nano coating, and the strength of the nano coating is improved.
In order to solve the problems, the utility model provides a polypropylene patch with a nano coating, which comprises
The polypropylene base layer is formed by warp knitting polypropylene monofilaments, and a polypropylene lead is arranged on the polypropylene base layer;
the nano coating is coated on the polypropylene base layer, the nano coating is made of degradable materials, and the nano coating is provided with drainage holes.
The polypropylene base layer is formed by warp knitting polypropylene monofilaments, the performance of the polypropylene is stable, and meanwhile, the tensile property of a repaired part is enhanced due to the higher porosity, and the degradable nano coating is coated on the polypropylene base layer to prevent damage to organs.
The polypropylene patch reserves the advantage of stable performance of polypropylene, and simultaneously coats the part which is in direct contact with tissues and organs with the degradable nano coating, so that the nano coating has excellent biocompatibility, can be degraded and absorbed, reduces the dosage of non-absorbable materials, and effectively reduces foreign body sensation and erosion rate brought by the patch.
As a preferred embodiment, the polypropylene filaments are medical grade polypropylene filaments.
As a more preferred embodiment, the polypropylene filaments have a diameter of less than 0.1mm and a strength of more than 5cN/dtex.
The base layer formed by warp knitting the polypropylene monofilaments has the advantages of light weight, good flexibility, large porosity and the like, can reduce foreign body sensation and long-term chronic pain of patients, is favorable for surrounding tissues to well fit into growth, and promotes tissue recovery.
As a preferred embodiment, the polypropylene base layer comprises a plurality of base layer units, the plurality of base layer units are formed by warp knitting polypropylene monofilaments, and the polypropylene leads are arranged on the base layer units.
The polypropylene leads are respectively arranged on each base unit and have guiding and supporting effects on the nano coating, so that the nano coating can be conveniently coated on the polypropylene base on one hand; on the other hand, the strength of the nano coating is increased, and deformation and damage of the nano coating in the implantation or use process are avoided.
As a preferred embodiment, the shape of the base unit is a circle, a hexagon or a diamond.
As a preferred embodimentFor example, the base unit has a pore size of 1-4mm and a mass of 20-100g/m 2 。
The patch manufactured by the base unit has light weight and large porosity, and enhances the tensile resistance of the repaired part.
As a more preferred embodiment, the aperture of the base unit is 3-4mm.
When the aperture of the base unit is larger than 3mm, the polypropylene patch is not easy to shrink, and the possibility of tissue bridging, hard blood stasis and postoperative recurrence is reduced.
As a preferred embodiment, the nano-coating is formed by electrostatic spraying using an electrostatic spraying process.
The nano coating is directly sprayed on the polypropylene base layer by adopting an electrostatic spraying process, so that a patch covered with the nano coating is obtained, the nano coating is attached to the base layer without additionally using a hot pressing technology, and the damage to the structure of the nano coating is avoided.
As a preferred embodiment, the material of the nano-coating is chitosan, polycaprolactone or polylactic acid-glycolic acid copolymer.
As a more preferable example, collagen is added to the polylactic acid-glycolic acid copolymer.
The chitosan, polycaprolactone or polylactic acid-glycolic acid copolymer is a biodegradable material, and has excellent biocompatibility and anti-adhesion performance.
As a preferred embodiment, the aperture of the drainage hole is 1-4mm.
The drainage holes are arranged, so that tissue fluid at a wound part is conveniently drained to other parts and absorbed, the tissue fluid is effectively prevented from being gathered, and seroma is avoided.
As a more preferable embodiment, the drainage holes are plural, and the array is arranged on the nano-coating.
The number of drainage holes can be determined according to actual needs, and long-term experiments and repeated fumbling show that when the drainage holes are arranged in the nano coating in a matrix array, the functions of the drainage holes can be exerted to the greatest extent.
Compared with the prior art, the utility model has the following beneficial effects:
(1) According to the polypropylene patch with the nano coating, the degradable nano coating is coated on the polypropylene base layer, on one hand, the nano coating is in direct contact with tissues and organs, and complications such as postoperative infection and tissue adhesion of an organism are effectively prevented due to good compatibility and anti-adhesion performance of the nano coating; on the other hand, the polypropylene base layer can still provide certain tension after the nano coating is degraded, so that the recurrence rate of the operation is reduced.
(2) The polypropylene patch with the nano coating selects the medical grade polypropylene monofilament warp-knitted polypropylene base layer with the diameter smaller than 0.1mm and the strength higher than 5cN/dtex, and the warp-knitted polypropylene base layer has light weight, good flexibility and large porosity, can obviously reduce the foreign body sensation of patients and is beneficial to tissue regeneration.
(3) According to the polypropylene patch with the nano coating, the nano coating is sprayed on the polypropylene base layer, so that the consumption of non-absorbable materials is reduced, and the risk of tissue adhesion is reduced.
The conception, specific structure, and technical effects of the present utility model will be further described with reference to the accompanying drawings to fully understand the objects, features, and effects of the present utility model.
Drawings
FIG. 1 is a schematic structural view of a polypropylene patch with a nanocoating;
fig. 2 is an exploded view of a polypropylene patch with a nanocoating.
In the figure: 1-drainage hole, 2-polypropylene base layer, 3-nano coating and 4-polypropylene lead
Detailed Description
The utility model is further described with reference to the following detailed description in order to make the technical means, the inventive features, the achieved objects and the effects of the utility model easy to understand. The present utility model is not limited to the following examples.
It should be understood that the structures, proportions, sizes, etc. shown in the drawings are for illustration purposes only and should not be construed as limiting the utility model to the extent that it can be practiced, since modifications, changes in the proportions, or otherwise, used in the practice of the utility model, are not intended to be critical to the essential characteristics of the utility model, but are intended to fall within the spirit and scope of the utility model.
The patch is widely used for repairing neurosurgery meninges, repairing esophageal cancer after excision and skull repairing, and after patients with plastic cosmetology and large-area burn, the patch is implanted into a human body according to the principles of molecular biology and immunology, a certain cell support effect can be achieved, missing tissues of damaged parts are filled, the performance of the repairing function of the human body is induced, new tissues are gradually grown, and the regeneration process of organ tissues is completed.
The polypropylene patch is used as a common patch, is nontoxic and has stable performance; however, polypropylene patches are prone to organ damage and complications. In view of this, the inventors of the present application considered that the polypropylene material is used as the base layer, and the degradable anti-adhesion nano-coating 3 is coated on the contact part with the wound tissue, and the stability of the nano-coating 3 directly affects the advantages and disadvantages of the patch implantation effect. The inventor of the present application found in experiments that when polypropylene monofilaments were woven into a net, polypropylene monofilaments were left as polypropylene leads 4 at each mesh, and the polypropylene leads penetrated through both ends of the mesh, which could support the nano-coating 3 and enhance the strength and stability of the nano-coating 3. Through ingenious design, the stable performance of the polypropylene patch can be maintained, the adhesion of tissues can be prevented, and the clinical application range of the polypropylene patch is widened.
Referring to fig. 1 and 2, a polypropylene patch with a nano-coating comprises a polypropylene base layer 2, wherein the polypropylene base layer 2 is formed by warp knitting polypropylene monofilaments, and medical grade polypropylene monofilaments, preferably TDA (textiledevelopment associates, lnc.), and model number HP570M polypropylene monofilaments are selected. The polypropylene monofilament of the model has the diameter smaller than 0.1mm, the strength higher than 5cN/dtex, light weight, good flexibility and large porosity, can reduce the foreign body sensation of patients and promote tissue regeneration.
The polypropylene filaments are warp knitted into a plurality of base units which make up the whole polypropylene base layer 2. Each base unit is hexagonal in shape and the aperture of the base unit is 1-4mm, preferably 3-4mm, because when the aperture is greater than 3mm, the entire polypropylene patch is less prone to shrinkage, reducing the likelihood of tissue bridging, thereby forming hard bruises and postoperative recurrence. The mass of the base unit is 20-100g/m 2 The weight is light, and the foreign body sensation of a patient can be reduced.
When warp knitting, polypropylene leads 4 are left on each base unit, and the polypropylene leads 4 connect both ends of the base unit.
The polypropylene base layer 2 is coated with the nano coating 3 by electrostatic spraying, and a nano particle film is prepared as a functional layer by an electrospinning and electrospraying technology, and the functional layer is compounded with a patch by hot pressing, so that the anti-inflammatory and analgesic effects of the functional layer are exerted, but the structure of the film can be damaged by hot pressing, and the film is easy to break. The application adopts an electrostatic spraying process, namely a coating method which utilizes a corona discharge principle to enable atomized paint to be negatively charged under the action of a high-voltage direct-current electric field and to be adsorbed on the surface of a positively charged substrate for discharging. The application directly sprays the nano coating 3 on the polypropylene base layer 2, so that the influence of high temperature on the nano coating 3 can be avoided. The nano-coating 3 is made of degradable material, preferably chitosan, polycaprolactone or polylactic acid-glycolic acid copolymer. The chitosan, polycaprolactone or polylactic acid-glycolic acid copolymer has excellent compatibility and anti-adhesion performance, and the phenomenon of tissue organ adhesion is avoided when the nano coating made of the material is in direct contact with tissue organs.
The polypropylene lead 4 has certain supporting and guiding functions on the nano coating 3, so that the coating of the nano coating 3 on the polypropylene base layer 2 during electrostatic spraying is facilitated, in addition, the strength of the nano coating 3 is increased by the polypropylene lead 4, and deformation or damage of the nano coating 3 in the implantation or use process is avoided.
The nano coating 3 is provided with a drainage hole 1. The aperture of the drainage hole 1 is 1-4mm. The wound part of the human body often has exudation of tissue fluid, and the drainage hole 1 is arranged, so that the tissue fluid at the wound part is conveniently drained to other parts and absorbed, the tissue fluid is effectively prevented from being gathered, and the occurrence of seroma is avoided.
The number of the drainage holes 1 is often set to be a plurality, the number of the drainage holes can be determined according to actual needs, and after long-term experiments and repeated searching, the inventor of the application finds that the drainage holes 1 can play the function of the drainage holes 1 to the greatest extent when the drainage holes 1 are arranged in a matrix array mode.
The preparation method of the polypropylene patch with the nano coating comprises the following steps:
(1) A polypropylene monofilament with the diameter of 0.08mm is used as a raw material, a net sheet with a hexagonal mesh structure is knitted on a three-bar raschel warp knitting machine with the machine number of 16E, namely a polypropylene base layer 2, and meanwhile, a polypropylene lead 4 is reserved on each base layer unit. The motion numbers of the three-comb yarn padding are as follows:
GB1：2-3/2-1/2-3/1-0/1-2/1-0//
GB2：1-1/1-0/1-0/2-2/2-3/2-3//
GB3：1-0/1-2/1-0/2-3/2-1/2-3//
(2) Weighing 0.032g of collagen by a balance, adding 30ml of hexafluoroisopropanol, sealing by a sealing film, and magnetically stirring in a refrigerator at 4 ℃ for 2-3 days; insoluble particles were filtered through filter paper. The collagen solution cannot contain insoluble particles. Weighing 3.2g of polylactic acid-glycolic acid copolymer, adding the polylactic acid-glycolic acid copolymer into the collagen solution, sealing by a sealing film, and magnetically stirring to dissolve the collagen solution to obtain a spinning solution. 10ml of spinning solution is extracted by a 10ml syringe, and is placed on a propeller, the voltage is set to be 12kV, the flow rate is 0.2mm/min, the receiving distance is 12cm, and the translation distance is 80mm. And (3) attaching the polypropylene base layer 2 to an aluminum foil of a receiving device, adjusting technological parameters, carrying out electrostatic spraying to obtain a nano coating 3, taking down the polypropylene base layer 2 covered with the nano coating after the process is finished, and drying the polypropylene base layer 2 in a vacuum oven at room temperature for 24 hours to obtain the polypropylene patch without drainage holes.
(3) And (3) accurately punching the nano coating 3 through a CCD positioning system of a laser cutting machine to obtain drainage holes 1 arranged in an array. Wherein the cutting speed of the laser cutting machine is 60mm/s, and the cutting power is 15%.
The foregoing describes in detail preferred embodiments of the present utility model. It should be understood that numerous modifications and variations can be made in accordance with the concepts of the utility model without requiring creative effort by one of ordinary skill in the art. Therefore, all technical solutions which can be obtained by logic analysis, reasoning or limited experiments based on the prior art by the person skilled in the art according to the inventive concept shall be within the scope of protection defined by the claims.
Claims (10)
1. A polypropylene patch with a nanocoating comprising
The polypropylene base layer is formed by warp knitting polypropylene monofilaments, and a polypropylene lead is arranged on the polypropylene base layer;
the nano coating is coated on the polypropylene base layer, the nano coating is made of degradable materials, and the nano coating is provided with drainage holes.
2. The nanocoated polypropylene patch according to claim 1, wherein the polypropylene monofilaments are medical grade polypropylene monofilaments.
3. The nanocoated polypropylene patch of claim 1, wherein the polypropylene base layer comprises a plurality of base layer units, the plurality of base layer units being warp knitted from polypropylene monofilaments, the polypropylene leads being disposed on the base layer units.
4. A polypropylene patch with nanocoating according to claim 3, wherein the shape of the base unit is circular, hexagonal or diamond.
5. A polypropylene patch with nanocoating according to claim 3, wherein the base unit has a pore size of 1-4mm and a mass of 20-100g/m 2 。
6. The nanocoated polypropylene patch according to claim 5, wherein the base unit has a pore size of 3-4mm.
7. The polypropylene patch with nanocoating of claim 1, wherein the nanocoating is electrostatically sprayed using an electrostatic spray process.
8. The polypropylene patch with nanocoating of claim 1, wherein the nanocoating is made of chitosan, polycaprolactone, or polylactic acid-glycolic acid copolymer.
9. The nanocoated polypropylene patch according to claim 1, wherein the drainage aperture has a pore size of 1-4mm.
10. The nanocoated polypropylene patch according to claim 1, wherein the drainage apertures are in a plurality of arrays arranged on the nanocoating.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202321851908.4U CN220558338U (en) | 2023-07-14 | 2023-07-14 | Polypropylene patch with nano coating |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202321851908.4U CN220558338U (en) | 2023-07-14 | 2023-07-14 | Polypropylene patch with nano coating |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN220558338U true CN220558338U (en) | 2024-03-08 |
Family
ID=90095952
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202321851908.4U Active CN220558338U (en) | 2023-07-14 | 2023-07-14 | Polypropylene patch with nano coating |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN220558338U (en) |
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2023
- 2023-07-14 CN CN202321851908.4U patent/CN220558338U/en active Active
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