CN220545729U - Low-temperature multilayer frozen storage bag - Google Patents
Low-temperature multilayer frozen storage bag Download PDFInfo
- Publication number
- CN220545729U CN220545729U CN202222960917.9U CN202222960917U CN220545729U CN 220545729 U CN220545729 U CN 220545729U CN 202222960917 U CN202222960917 U CN 202222960917U CN 220545729 U CN220545729 U CN 220545729U
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- freezing
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- 238000007710 freezing Methods 0.000 claims abstract description 72
- 230000008014 freezing Effects 0.000 claims abstract description 72
- 239000007788 liquid Substances 0.000 claims abstract description 18
- 238000002347 injection Methods 0.000 claims description 11
- 239000007924 injection Substances 0.000 claims description 11
- 238000003466 welding Methods 0.000 claims description 2
- 238000000034 method Methods 0.000 abstract description 4
- 230000008569 process Effects 0.000 abstract description 3
- 210000004027 cell Anatomy 0.000 description 7
- 210000004700 fetal blood Anatomy 0.000 description 6
- 239000000243 solution Substances 0.000 description 6
- 238000005336 cracking Methods 0.000 description 5
- 238000005138 cryopreservation Methods 0.000 description 4
- 210000003958 hematopoietic stem cell Anatomy 0.000 description 4
- 210000000130 stem cell Anatomy 0.000 description 4
- 238000002659 cell therapy Methods 0.000 description 3
- 238000011084 recovery Methods 0.000 description 3
- 238000010586 diagram Methods 0.000 description 2
- 230000036541 health Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 230000008439 repair process Effects 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- 208000032467 Aplastic anaemia Diseases 0.000 description 1
- 208000001738 Nervous System Trauma Diseases 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 210000001185 bone marrow Anatomy 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 238000004891 communication Methods 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 230000006806 disease prevention Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 208000019622 heart disease Diseases 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 230000003211 malignant effect Effects 0.000 description 1
- 239000011259 mixed solution Substances 0.000 description 1
- 208000028412 nervous system injury Diseases 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 210000005259 peripheral blood Anatomy 0.000 description 1
- 239000011886 peripheral blood Substances 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 238000011476 stem cell transplantation Methods 0.000 description 1
- 208000019553 vascular disease Diseases 0.000 description 1
Abstract
The utility model aims to solve the problem that the bag body of the conventional freezing bag is cracked in the using process, so that the liquid in the freezing bag is seriously polluted and wasted.
Description
Technical Field
The utility model relates to the technical field of umbilical cord blood and cell cryopreservation and resuscitation, in particular to a connection mode of a low-temperature multi-layer cryopreservation bag and safety guarantee of a double-layer cryopreservation bag structure.
Background
With the development of biological technology, cell therapy is rapidly developed and increasingly accepted worldwide, and stem cell research and clinical application of stem cells are the main subjects in cell therapy. In recent years, stem cell transplantation has been gradually applied to the treatment of radical treatment of malignant hematopathy, aplastic anemia, middle and late malignant solid tumors, heart diseases, nervous system injury, tissue and organ repair, diabetes, vascular diseases and the like, and the stem cells have strong health care and disease prevention functions, can strengthen the immunity of human bodies, repair diseased or aged tissues, prolong the service lives of people and the like. Stem cells are widely available and mainly exist in umbilical cord blood, bone marrow and peripheral blood. The national ministry of health approved the establishment of cord blood hematopoietic stem cell banks in 2001. And freezing, resuscitating and preventing contamination during operation of the cells are critical to achieving cell therapy. The utility model relates to a low-temperature multilayer freezing bag, which is widely applied to various biological research fields, and aims to prevent the freezing bag from cracking in the freezing and recovery process because the liquid in the freezing bag is seriously polluted and wasted due to the fact that the cracking of the bag body of the freezing bag frequently occurs in the using process of the current freezing bag.
Disclosure of Invention
The utility model aims to solve the problem that the bag body of the conventional freezing bag is cracked in the using process, so that the liquid in the freezing bag is seriously polluted and wasted.
In order to solve the technical problems, the utility model provides the following technical scheme: the low-temperature multilayer freezing bag comprises an input component and a puncture port, wherein the input component is used for inputting cells and freezing liquid, the puncture port is used for outputting the component, and the input component and the output component are communicated with the freezing bag.
Preferably, the input assembly comprises a first input pipeline, a second input pipeline, a frozen solution injection head, a Y-shaped tee joint interface, a first multipath branching device, a second multipath branching device, a first flow regulator, a luer male connector, a second flow regulator and a luer female connector, one end of the first input pipeline is communicated with the frozen solution bag, the other end of the first input pipeline is connected with the Y-shaped tee joint interface, the frozen solution injection head is arranged on the Y-shaped tee joint interface, the other end of the Y-shaped tee joint interface is connected with the second input pipeline, one end of the mouth of one branch pipeline is provided with a luer interface which can be multiple, the other branch pipeline of the first multipath branching device is connected with the second multipath branching device and is bifurcated into multiple branch pipelines, one end of the mouth of the multiple branch pipelines is provided with a luer interface, and the mouth of the other branch pipeline can be multiple branch pipelines, and the flow regulator can be multiple branch pipelines.
Preferably, the injection head and the Y-shaped three-way interface can be assembled and disassembled through a thread buckle, the Y-shaped three-way interface can be connected with a needleless injector after being disassembled, and the needle injector can be used for injecting liquid through the frozen liquid injection head after the frozen liquid injection head and the Y-shaped three-way interface are assembled.
Preferably, the output assembly comprises two puncture ports arranged on the freezing storage bag body.
Preferably, the freezing bag comprises a hanging hole, a tag storage area, a puncture port and a first input pipeline, wherein the puncture port and the input pipeline are at one end of the freezing bag, the freezing bag body is welded by a heat-seal heating device, the tag storage area is used for storing information of frozen cell samples in the freezing bag, and the hanging hole is used for hanging the freezing bag when the freezing bag is used for reinfusion.
Drawings
FIG. 1 is a schematic view of a connection structure of a low-temperature multi-layer freezing bag according to a first embodiment of the present utility model;
FIG. 2 is a schematic diagram of a low-temperature double-layer freezing bag structure according to the utility model;
reference numerals illustrate:
in the figure: a hanging hole 1; a label storage area 2; a freezing bag 3; a puncture port 4; a first input duct 5; a Y-shaped three-way interface 6; a second input duct 7; a first demultiplexer 8; a second demultiplexer 9; a first flow regulator 10; luer male connector 11; a second flow regulator 12; luer female connector 13; an injection head 14; a first layer of cryopreservation bags 15; a second layer of freezer bags 16.
Detailed Description
The technical solutions in the embodiments of the present utility model will be clarified by the following with reference to the drawings in the embodiments of the present utility model
It will be apparent that the embodiments described are only some, but not all, of the embodiments of the utility model. All other embodiments, which can be made by those skilled in the art based on the embodiments of the utility model without making any inventive effort, are intended to be within the scope of the utility model.
It should be noted that, in the description of the present utility model, terms such as "medium," "upper," "lower," "transverse," "inner," and the like indicate directions or positional relationships based on the directions or positional relationships shown in the drawings, which are merely for convenience of description, and do not indicate or imply that the apparatus or elements must have a specific orientation, be constructed and operated in a specific orientation, and thus should not be construed as limiting the present utility model.
Furthermore, it should be noted that, in the description of the present utility model, unless explicitly specified and limited otherwise, the terms "disposed," "mounted," "connected" and "connected" are to be construed broadly, and may be, for example, fixedly connected, detachably connected, or integrally connected; may be a mechanical connection; can be directly connected or indirectly connected through an intermediate medium, and can be communication between two elements.
The specific meaning of the above terms in the present utility model can be understood by those skilled in the art according to the specific circumstances.
Examples:
as shown in fig. 1, a connection structure schematic diagram of a low-temperature multi-layer freezing bag according to a first embodiment of the present utility model includes a freezing bag (3) for storing a cell sample at a low temperature, a first input pipe (5) for inputting a cell and a freezing solution, and a puncture port (4) for outputting a mixed solution of the cell and the freezing solution, wherein the first input pipe (5) and the puncture port (4) in an output assembly are both communicated with the freezing bag (3), and a hanging hole (1) and a label storage area (2) are provided on the freezing bag (3).
The input assembly comprises a first input pipeline (5), a second input pipeline (7), a frozen storage liquid injection head (14), a Y-shaped three-way connector (6), a second input pipeline (7), a first multi-way branching device (8), a second multi-way branching device (9), a first flow regulator (10), a luer male connector (11), a second flow regulator (12) and a luer female connector (13), wherein one end of the first input pipeline (5) is communicated with the frozen storage bag (3), the other end of the first input pipeline (5) is connected with the Y-shaped three-way connector (6), the frozen storage liquid injection head (14) and the other end of the Y-shaped three-way connector (6) are arranged on the Y-shaped three-way connector (6) and are connected with the second input pipeline (7), one end of a pipe orifice of one branch pipeline is provided with one luer male connector (11), the luer connector can be multiple types, each branch pipeline is provided with one end of the luer male connector (8) and is provided with one other end of the other branch pipeline (9), the other branch pipeline is provided with one luer connector (13), a second flow regulator (12) is arranged on each branch pipeline.
The use method of the first embodiment comprises the following steps:
opening a first flow regulator (10) or a second flow regulator (12), opening the flow regulator of which pipeline by using a luer connector on which multi-branch pipeline, closing the flow regulators of other multi-branch pipelines, connecting umbilical cord blood hematopoietic stem cells obtained by pretreatment with the luer connector (11) and transferring the umbilical cord blood hematopoietic stem cells into a freezing bag (3), injecting freezing protection liquid into the freezing bag (3) through a freezing liquid injection head (14), exhausting gas in the freezing bag (3) after the umbilical cord blood hematopoietic stem cells and the freezing protection liquid are transferred, sealing the first input pipeline (5) of the freezing bag (3) by using a heat seal pipeline instrument after the exhaustion is finished, placing the freezing bag (3) after the heat seal in a freezing protection box for low-temperature storage, and directly flowing liquid in the freezing bag (3) into a second freezing bag (16) to avoid serious pollution of the freezing bag (3) due to the serious cracking of the freezing bag body if the freezing bag (3) is subjected to the freezing cracking or the freezing bag body of the first layer (15) in the freezing protection box in the low-temperature storage and recovery process.
In summary, the low-temperature multi-layer freezing bag disclosed by the utility model can be used for completely storing the liquid in the freezing bag (3) by utilizing the double-layer film welding principle, and if the freezing bag (3) is cracked in the freezing or recovery process, the liquid in the freezing bag (3) can directly flow into the second-layer freezing bag (16), so that the liquid in the freezing bag (3) is completely prevented from being seriously polluted and wasted due to the cracking of the bag body.
It will be apparent to those skilled in the art that various modifications and variations can be made to the present utility model without departing from the spirit or scope of the utility model. Thus, it is intended that the present utility model also include such modifications and alterations insofar as they come within the scope of the appended claims or the equivalents thereof.
Claims (6)
1. The low-temperature multilayer freezing storage bag is characterized in that an input assembly and an output assembly are communicated with the freezing storage bag (3), the input assembly is composed of a first input pipeline (5), a freezing storage liquid injection head (14), a Y-shaped three-way connector (6), a second input pipeline (7), a first multi-way branching device (8), a second multi-way branching device (9), a first flow regulator (10), a luer male connector (11), a second flow regulator (12) and a luer female connector (13), one end of the first input pipeline (5) is communicated with the freezing storage bag (3), the other end of the first input pipeline (5) is connected with the Y-shaped three-way connector (6), the freezing storage liquid injection head (14) is arranged on the Y-shaped three-way connector (6), the other end of the Y-shaped three-way connector (6) is connected with the second input pipeline (7), the tail end of the second input pipeline (7) is connected with the first multi-way branching device (8) and is bifurcated into a plurality of branch pipelines, one end of one of the branch pipelines is provided with one end of the luer pipeline (12), one end of each branch pipeline (13) is provided with one end of the other branch pipeline (9), and the other branch pipeline (13) is provided with one end of the other branch pipeline (7) A luer connector (11) is provided with a second flow regulator (12) for each of the branch pipes.
2. A low-temperature multi-layer freezing bag according to claim 1, wherein the freezing bag (3) comprises a hanging hole (1), a label storage area (2), a puncture port (4) and a first input pipeline (5), and the puncture port (4) and the first input pipeline (5) are arranged at one end of the freezing bag (3).
3. The low-temperature multi-layer freezing storage bag according to claim 1, wherein the first multi-way branching device (8) and the second multi-way branching device (9) of the freezing storage bag (3) are branched into N multi-way branching devices, and the multi-way branching devices are connected with N input pipelines.
4. The low-temperature multi-layer freezing bag of claim 2, wherein the number of the puncture ports (4) is 1-10, and the puncture ports are welded at different positions of the freezing bag (3).
5. The low-temperature multi-layer freezing bag according to claim 1, wherein the freezing bag (3) is provided with a label storage area (2), and after the label storage area (2) is removed, the puncture port (4) is arranged at the upper end of the freezing bag (3) and the first input pipeline (5) is arranged at the lower end of the freezing bag (3).
6. The low-temperature multi-layer freezing bag according to claim 1, wherein the freezing bag (3) is formed by welding multi-layer films.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202222960917.9U CN220545729U (en) | 2022-11-08 | 2022-11-08 | Low-temperature multilayer frozen storage bag |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202222960917.9U CN220545729U (en) | 2022-11-08 | 2022-11-08 | Low-temperature multilayer frozen storage bag |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN220545729U true CN220545729U (en) | 2024-03-01 |
Family
ID=90004013
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202222960917.9U Active CN220545729U (en) | 2022-11-08 | 2022-11-08 | Low-temperature multilayer frozen storage bag |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN220545729U (en) |
-
2022
- 2022-11-08 CN CN202222960917.9U patent/CN220545729U/en active Active
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