CN220530735U - Automatic workstation for purifying gravity column - Google Patents
Automatic workstation for purifying gravity column Download PDFInfo
- Publication number
- CN220530735U CN220530735U CN202322024538.3U CN202322024538U CN220530735U CN 220530735 U CN220530735 U CN 220530735U CN 202322024538 U CN202322024538 U CN 202322024538U CN 220530735 U CN220530735 U CN 220530735U
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- Prior art keywords
- block
- gravity column
- movable
- shell
- gravity
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- 230000005484 gravity Effects 0.000 title claims abstract description 60
- 238000000746 purification Methods 0.000 claims abstract description 19
- 230000000007 visual effect Effects 0.000 claims abstract description 6
- 238000009434 installation Methods 0.000 claims description 8
- 239000000523 sample Substances 0.000 description 22
- 230000000694 effects Effects 0.000 description 7
- 102000007056 Recombinant Fusion Proteins Human genes 0.000 description 5
- 108010008281 Recombinant Fusion Proteins Proteins 0.000 description 5
- 239000007788 liquid Substances 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- 239000012488 sample solution Substances 0.000 description 3
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 239000007801 affinity label Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000011097 chromatography purification Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000003466 welding Methods 0.000 description 1
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- Devices For Opening Bottles Or Cans (AREA)
Abstract
The utility model discloses an automatic workstation for purifying a gravity column, which comprises a shell, wherein a fixed plate is fixedly arranged on the left side of the inside of the shell, a visual sensor is arranged on the upper side of the inside of the shell, a mounting rod is arranged on the outer side of the inside of the fixed plate, a moving block is arranged on the outer side of the mounting rod, and a movable block is connected to the upper side of the moving block; the storage rack is fixedly arranged on the middle side of the inside of the shell, a gravity column body is clamped and arranged on the middle side of the inside of the storage rack, a fixing structure is arranged on the outer side of the inside of the storage rack, the fixing structure comprises a moving plate, a spring, a clamping block and a connecting block, and a fixing frame is arranged on the right side of the storage rack; the solution tank is arranged at the lower side of the front end of the shell, and the solution flow pipe is arranged at the rear side of the solution tank. This an automatic workstation for gravity post purification, conveniently change the arm, conveniently fix the gravity post, and it is effectual to purify heavy albumen.
Description
Technical Field
The utility model relates to the technical field of gravity column purification, in particular to an automatic workstation for gravity column purification.
Background
The automatic workstation is a station body structure capable of automatically working, the gravity column purification is to purify proteins by adopting a gravity chromatography purification column (called as a gravity column for short), especially proteins containing affinity labels such as 6xHis, MBP, GST and the like, the automatic workstation is specially used in the gravity column purification using process, and the mechanical arm is replaced by a replacement structure in the use process of the automatic workstation for the gravity column purification, so that the using effect of the automatic workstation for the gravity column purification is improved.
Most prior art solutions suffer from the following drawbacks: when the mechanical arm is replaced, the mechanical arm is replaced by a bolt, the purification effect of the common automation on the recombinant protein is poor, and the fixation of the gravity column is not convenient enough, so the utility model provides an automatic workstation for purifying the gravity column, and the problems put forward above are solved.
Disclosure of Invention
The utility model aims to provide an automatic workstation for purifying a gravity column, which aims to solve the problems that the purification effect of common automatic engineering on recombinant proteins is poor and the fixation of the gravity column is not convenient enough when a mechanical arm is replaced by a bolt in the prior art.
In order to achieve the above purpose, the present utility model provides the following technical solutions: the automatic workstation for purifying the gravity column comprises a shell, wherein a fixed plate is fixedly arranged on the left side of the inside of the shell, a visual sensor is arranged on the upper side of the inside of the shell, a mounting rod is arranged on the outer side of the inside of the fixed plate, a moving block is arranged on the outer side of the mounting rod, a movable block is connected to the upper side of the moving block, a movable rod is slidably arranged on the inner side of the movable block, a limiting block is connected to the upper side of the movable block, and a mechanical arm is arranged on the inner side of the limiting block;
the storage rack is fixedly arranged on the middle side of the inside of the shell, a gravity column body is clamped and arranged on the middle side of the inside of the storage rack, a fixing structure is arranged on the outer side of the inside of the storage rack, the fixing structure comprises a moving plate, a spring, a clamping block and a connecting block, and a fixing frame is arranged on the right side of the storage rack;
the solution jar, its front end downside of installing at the casing, and solution runner pipe is installed to the rear side of solution jar, first sample mounting bracket is installed in the front end left side of casing, and the right-hand member fixed mounting of first sample mounting bracket has the second sample mounting bracket, the front end downside of casing is connected with the bottle lid and places the dish, and the front end upside of casing is fixed and be provided with the cylinder, the lower extreme of cylinder is connected with the mounting panel, and the internal connection of mounting panel has the bottle-opener.
Preferably, the movable plate is installed on the inner outer side of the placement frame, the connecting block is connected to the upper side of the movable plate, the clamping block is fixedly installed on the inner side of the movable plate, and springs are fixedly arranged on the outer side of the movable plate and the middle side of the connecting block.
Preferably, the solution runner pipe is connected with the fixing frame in a clamping manner, and the solution runner pipe is uniformly distributed on the upper side of the fixing frame.
Preferably, the mounting rod is connected with the movable block in a threaded mode, and the movable block is connected with the movable block in a rotary mode.
Preferably, the movable block is connected with the limiting block in a rotating mode, and the limiting block is connected with the mechanical arm in a clamping mode.
Preferably, the movable plate is connected with the placing frame in a sliding manner, and a groove-shaped structure is formed on the upper side of the movable plate.
Preferably, the connecting blocks are connected with the placing frames in a sliding mode, and the vertical section of the connecting blocks is of a T-shaped structure.
Preferably, the bottle opener is connected with the mounting plate in a rotating mode, and the bottle opener is of a T-shaped structure in vertical section.
Compared with the prior art, the utility model has the beneficial effects that: the automatic workstation for purifying the gravity column is convenient to replace the mechanical arm, convenient to fix the gravity column and good in purifying effect on recombinant protein;
1. the installation rod is rotated at the inner outer side of the fixed plate through rotating the installation rod, so that the moving block in threaded connection with the installation rod slides inwards, the moving block in rotary connection with the moving block slides at the lower side of the moving rod, the moving block at the upper side of the moving rod drives the limiting block to move, the limiting block is separated at the outer side of the mechanical arm, the mechanical arm is separated at the middle side of the fixed plate, and the mechanical arm is convenient to replace;
2. the gravity cylinder is arranged in the rack, the movable plate is pushed inwards, so that the movable plate slides inwards at the outer side of the inner side of the rack, the movable plate drives the clamping blocks to clamp the gravity cylinder, the connecting blocks are loosened, the springs drive the connecting blocks to slide downwards, the connecting blocks are clamped and connected at the upper side of the movable plate, and the gravity cylinder is conveniently fixed;
3. the mechanical arm is used for grabbing the sample bottle on the second sample mounting frame and then moving to the lower side of the bottle opener, the air cylinder is started, the air cylinder slides downwards, the bottle opener is located on the outer side of the sample bottle cap, the motor drives the bottle opener to rotate on the middle side of the mounting plate, the bottle opener is used for opening the cover of the sample bottle, the sample is poured into the gravity cylinder, and the empty pipe is covered and then is put back to the original position. The added sample solution is completely dripped under the action of gravity, so that the purification effect of recombinant protein is ensured to be good.
Drawings
FIG. 1 is a schematic diagram of a front cross-sectional structure of the present utility model;
FIG. 2 is an enlarged schematic view of the structure of FIG. 1A according to the present utility model;
FIG. 3 is an enlarged schematic view of the structure of FIG. 1B according to the present utility model;
FIG. 4 is a schematic top view of the present utility model;
fig. 5 is a schematic side sectional view of the present utility model.
In the figure: 1. a housing; 2. a fixing plate; 3. a mechanical arm; 4. a placing rack; 5. a gravity column; 6. a fixing frame; 7. a solution flow pipe; 8. a mounting rod; 9. a moving block; 10. a movable block; 11. a movable rod; 12. a limiting block; 13. a moving plate; 14. a spring; 15. a clamping block; 16. a connecting block; 17. a first sample mounting frame; 18. a second sample mounting bracket; 19. a bottle cap placing plate; 20. a solution tank; 21. a cylinder; 22. bottle opener; 23. and (3) mounting a plate.
Detailed Description
The following description of the embodiments of the present utility model will be made clearly and completely with reference to the accompanying drawings, in which it is apparent that the embodiments described are only some embodiments of the present utility model, but not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the utility model without making any inventive effort, are intended to be within the scope of the utility model.
Referring to fig. 1-5, the present utility model provides a technical solution: an automatic workstation for purifying a gravity column comprises a fixed plate 2 fixedly arranged on the left side of the inside of a shell 1, a visual sensor is arranged on the upper side of the inside of the shell 1, a mounting rod 8 is arranged on the outer side of the inside of the fixed plate 2, a moving block 9 is arranged on the outer side of the mounting rod 8, a moving block 10 is connected to the upper side of the moving block 9, a moving rod 11 is arranged on the inner side of the moving block 10 in a sliding manner, a limiting block 12 is connected to the upper side of the moving block 10, a mechanical arm 3 is arranged on the inner side of the limiting block 12 in a sliding manner, the mounting rod 8 is rotated on the outer side of the inside of the fixed plate 2, so that the moving block 9 connected with the mounting rod 8 slides inwards, the moving block 10 positioned on the upper side of the moving rod 11 drives the limiting block 12 to move, the limiting block 12 is separated on the outer side of the mechanical arm 3, the mechanical arm 3 is separated on the middle side of the fixed plate 2, and the mechanical arm 3 is convenient to replace;
the rack 4 is fixedly arranged on the middle side of the inside of the shell 1, the gravity column 5 is clamped and arranged on the middle side of the inside of the rack 4, a fixing structure is arranged on the outer side of the inside of the rack 4 and comprises a moving plate 13, a spring 14, a clamping block 15 and a connecting block 16, the right side of the rack 4 is provided with a fixing frame 6, the gravity column 5 is arranged in the rack 4, and the fixing structure is pushed inwards to clamp the gravity column 5, so that the gravity column 5 is conveniently fixed;
the solution jar 20 is installed in the front end downside of casing 1, and solution runner pipe 7 is installed to the rear side of solution jar 20, first sample mounting bracket 17 is installed in the front end left side of casing 1, and the right-hand member fixed mounting of first sample mounting bracket 17 has second sample mounting bracket 18, the front end mid-side of casing 1 is connected with bottle lid and places dish 19, and the front end upside of casing 1 is fixed and be provided with cylinder 21, the lower extreme of cylinder 21 is connected with mounting panel 23, and the internal connection of mounting panel 23 has bottle-opener 22, detect liquid in the gravity cylinder 5 through visual sensor, when there is not liquid outflow under the effect of gravity, carry out follow-up procedure, move to the downside of bottle-opener 22 after snatching the sample bottle on the second sample mounting bracket 18 through arm 3, start cylinder 21, make cylinder 21 slide downwards, thereby make bottle opener 22 be located the outside of sample bottle lid, the motor drive 22 rotate in the mid-side of mounting panel 23, make bottle opener 22 empty tube lid to sample bottle lid 5, and put back the original position after will. The added sample solution drops completely under the action of gravity, so that the mechanical arm 3 places the solution runner pipe 7 above the gravity column 5, a pump arranged at the rear side of the solution tank 20 is started, the solution in the solution tank 20 enters the inner protecting part of the gravity column 5 through the solution runner pipe 7, and the added solution drops completely from the gravity column 5 under the action of gravity, so that the purification effect of recombinant protein is guaranteed.
When the automatic workstation for purifying the gravity column is used, as shown in fig. 1 and 3, the gravity column 5 is installed in the rack 4, the movable plate 13 is connected with the rack 4 in a sliding manner, a groove-shaped structure is formed on the upper side of the movable plate 13, the movable plate 13 is pushed inwards to enable the movable plate 13 to slide inwards on the inner outer side of the rack 4, the movable plate 13 drives the clamping block 15 to clamp the gravity column 5, the connecting block 16 is connected with the rack 4 in a sliding manner, the vertical section of the connecting block 16 is of a T-shaped structure, the connecting block 16 is loosened, the spring 14 drives the connecting block 16 to slide downwards, and therefore the connecting block 16 is clamped and connected on the upper side of the movable plate 13, and the gravity column 5 is convenient to fix;
in particular, as shown in fig. 1, fig. 4 and fig. 5, the liquid in the gravity column 5 is detected by a visual sensor, when no liquid flows out under the action of gravity, a subsequent procedure is performed, the mechanical arm 3 is used for grabbing a sample bottle on the second sample mounting frame 18 and then moving to the lower side of the bottle opener 22, the air cylinder 21 is started to enable the air cylinder 21 to slide downwards, so that the bottle opener 22 is positioned on the outer side of the sample bottle cap, the bottle opener 22 is connected with the mounting plate 23 in a rotating manner, the vertical section of the bottle opener 22 is in a T-shaped structure, the motor drives the bottle opener 22 to rotate on the middle side of the mounting plate 23, the bottle opener 22 is used for opening the cover of the sample bottle, the opened bottle cap is placed on the upper side of the bottle cap placing plate 19, the sample is poured into the gravity column 5, the empty tube is capped and then put back to the original position, the added sample solution is completely dripped under the action of gravity, the solution flow tube 7 is connected with the fixing frame 6 in a clamping manner, the upper side of the fixing frame 6 is uniformly distributed, the solution flow tube 7 is placed on the upper side of the fixing frame 6, the solution flow tube 7 is placed above the gravity column 5, the vertical section of the bottle opener 22 is in the vertical section of the bottle opening structure, the bottle opening 20 is completely dripped into the gravity column 5, and the solution column is completely dripped from the inside the gravity column 5 through the bottle after the bottle opening 20 is completely through the bottle opening, and the bottle opening is completely inside the column, and the column is completely purified;
specifically, as shown in fig. 1 and 2, the installation rod 8 is rotated, the installation rod 8 is connected with the moving block 9 by adopting a threaded manner, the moving block 9 is connected with the moving block 10 by adopting a rotating manner, so that the installation rod 8 rotates at the inner outer side of the fixed plate 2, the moving block 9 in threaded connection with the installation rod 8 slides inwards, the moving block 10 in rotating connection with the moving block 9 slides at the lower side of the moving rod 11, the moving block 10 is connected with the limiting block 12 by adopting a rotating manner, and the limiting block 12 is connected with the mechanical arm 3 by adopting a clamping manner, so that the moving block 10 positioned at the upper side of the moving rod 11 drives the limiting block 12 to move, the limiting block 12 is separated at the outer side of the mechanical arm 3, the mechanical arm 3 is separated at the middle side of the fixed plate 2, and the mechanical arm 3 is convenient to replace.
Standard parts used in the utility model can be purchased from the market, special-shaped parts can be customized according to the description of the specification and the drawings, the specific connection modes of all parts adopt conventional means such as mature bolts, rivets and welding in the prior art, the machinery, the parts and the equipment adopt conventional modes in the prior art, and the circuit connection adopts conventional connection modes in the prior art, so that details are not described in detail in the specification, and the utility model belongs to the prior art known to the person skilled in the art.
Although the present utility model has been described with reference to the foregoing embodiments, it will be apparent to those skilled in the art that modifications may be made to the embodiments described, or equivalents may be substituted for elements thereof, and any modifications, equivalents, improvements and changes may be made without departing from the spirit and principles of the present utility model.
Claims (8)
1. An automated workstation for gravity column purification, comprising:
the device comprises a shell (1), wherein a fixed plate (2) is fixedly arranged on the left side of the inside of the shell, a visual sensor is arranged on the upper side of the inside of the shell (1), a mounting rod (8) is arranged on the outer side of the inside of the fixed plate (2), a moving block (9) is arranged on the outer side of the mounting rod (8), a movable block (10) is connected to the upper side of the moving block (9), a movable rod (11) is slidably arranged on the inner side of the movable block (10), a limiting block (12) is connected to the upper side of the movable block (10), and a mechanical arm (3) is arranged on the inner side of the limiting block (12);
the storage rack (4) is fixedly arranged on the middle side of the inside of the shell (1), the gravity column body (5) is clamped and arranged on the middle side of the inside of the storage rack (4), a fixed structure is arranged on the outer side of the inside of the storage rack (4), the fixed structure comprises a movable plate (13), a spring (14), a clamping block (15) and a connecting block (16), and a fixed frame (6) is arranged on the right side of the storage rack (4);
solution jar (20), its front end downside of installing at casing (1), and solution runner pipe (7) are installed to the rear side of solution jar (20), first sample mounting bracket (17) are installed in the front end left side of casing (1), and the right-hand member fixed mounting of first sample mounting bracket (17) has second sample mounting bracket (18), front end downside of casing (1) is connected with bottle lid and places dish (19), and the front end upside of casing (1) is fixed to be provided with cylinder (21), the lower extreme of cylinder (21) is connected with mounting panel (23), and the internal connection of mounting panel (23) has bottle-opener (22).
2. An automated workstation for gravity column purification according to claim 1, wherein: the movable plate (13) is installed on the inner outer side of the placement frame (4), the connecting block (16) is connected to the upper side of the movable plate (13), the clamping block (15) is fixedly installed on the inner side of the movable plate (13), and springs (14) are fixedly arranged on the outer side of the movable plate (13) and the middle side of the connecting block (16).
3. An automated workstation for gravity column purification according to claim 1, wherein: the solution runner pipe (7) is connected with the fixing frame (6) in a clamping way, and the solution runner pipe (7) is uniformly distributed on the upper side of the fixing frame (6).
4. An automated workstation for gravity column purification according to claim 1, wherein: the installation rod (8) is connected with the movable block (9) in a threaded mode, and the movable block (9) is connected with the movable block (10) in a rotating mode.
5. An automated workstation for gravity column purification as claimed in claim 4 wherein: the movable block (10) is connected with the limiting block (12) in a rotating mode, and the limiting block (12) is connected with the mechanical arm (3) in a clamping mode.
6. An automated workstation for gravity column purification according to claim 2, wherein: the movable plate (13) is connected with the placing frame (4) in a sliding mode, and a groove-shaped structure is formed in the upper side of the movable plate (13).
7. An automated workstation for gravity column purification according to claim 2, wherein: the connecting blocks (16) are connected with the placing frame (4) in a sliding mode, and the vertical section of each connecting block (16) is of a T-shaped structure.
8. An automated workstation for gravity column purification according to claim 1, wherein: the bottle opener (22) is connected with the mounting plate (23) in a rotating mode, and the bottle opener (22) is of a T-shaped structure in vertical section.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202322024538.3U CN220530735U (en) | 2023-07-31 | 2023-07-31 | Automatic workstation for purifying gravity column |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202322024538.3U CN220530735U (en) | 2023-07-31 | 2023-07-31 | Automatic workstation for purifying gravity column |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN220530735U true CN220530735U (en) | 2024-02-27 |
Family
ID=89966509
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202322024538.3U Active CN220530735U (en) | 2023-07-31 | 2023-07-31 | Automatic workstation for purifying gravity column |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN220530735U (en) |
-
2023
- 2023-07-31 CN CN202322024538.3U patent/CN220530735U/en active Active
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