CN220525582U - Front-end detection device for microfluidic sample injection - Google Patents

Abstract

The utility model belongs to the technical field of liquid fluidity detection, and particularly relates to a microfluidic sample injection front-end detection device, which comprises a shell, wherein a conversion part is slidably arranged at the bottom of the inner side of the shell, a circulation mechanism and a detection mechanism are rotationally embedded in the conversion part, the circulation mechanism is in transmission connection with the detection mechanism, the top end of the circulation mechanism and the top end of the detection mechanism are in sliding contact with the top wall of the shell, the bottom end of the circulation mechanism and the bottom end of the detection mechanism are in sliding contact with the bottom wall of the shell, the middle part of the outer side wall of the detection mechanism is fixedly connected with an angle adjusting part, the middle part of the outer side of the top wall of the shell is fixedly communicated with a liquid inlet pipe, the middle part of the outer side of the bottom wall of the shell is fixedly communicated with a liquid outlet pipe, and the bottom wall of the shell is provided with a waste liquid discharge hole. The device provided by the utility model can detect the liquid sample before flowing into the microfluidic chip and judge whether the liquid sample can cause the blocking of the microfluidic chip, so that the probability of blocking the microfluidic chip is reduced.

Description

Front-end detection device for microfluidic sample injection

Technical Field

The utility model belongs to the technical field of liquid fluidity detection, and particularly relates to a microfluidic sample introduction front-end detection device.

Background

The development of microfluidic technology has prompted the generation and development of the concept of "instant detection" in the field of clinical detection. The instant detection refers to a medical detection method which can be used at present for taking care of patients, and the detection equipment needs to have portability, simple operation, high detection speed and accurate and reliable result.

Microfluidic applications often involve the flow of liquids, which are not pure liquids, but liquids containing other molecular substances, which have a fluidity and viscosity that differ from those of pure liquids, and which can cause problems in clogging the microfluidic chip when it is passed through the microfluidic chip.

Therefore, a microfluidic sample introduction front-end detection device is required to be designed to solve the problems.

Disclosure of Invention

The utility model aims to provide a microfluidic sample introduction front-end detection device so as to solve the problems and achieve the purpose of solving the problem of blocking a microfluidic chip.

In order to achieve the above object, the present utility model provides the following solutions: the utility model provides a leading detection device of microfluidic sample introduction, includes the shell, the inboard bottom of shell slides and is provided with conversion portion, conversion portion internal rotation is inlayed and is equipped with circulation mechanism, detection mechanism, circulation mechanism with detection mechanism transmission is connected, circulation mechanism top detection mechanism top with shell roof sliding contact, circulation mechanism bottom detection mechanism bottom with shell diapire sliding contact, detection mechanism lateral wall middle part fixedly connected with angle adjustment portion, shell roof outside middle part fixedly connected with feed liquor pipe, shell diapire outside middle part fixedly connected with drain pipe, the waste liquid discharge hole has been seted up to the shell diapire.

Preferably, the detection mechanism comprises a second cylinder, the bottom of the second cylinder is rotationally embedded in the conversion part, the top end of the second cylinder is in sliding contact with the top wall of the shell, the bottom end of the second cylinder is in sliding contact with the bottom wall of the shell, the liquid flow velocity detection part is arranged inside the second cylinder, the second gear ring is fixedly sleeved on the top of the outer side wall of the second cylinder, the second gear ring is in transmission connection with the circulation mechanism, and the angle adjustment part is fixedly sleeved in the middle of the outer side wall of the second cylinder.

Preferably, the liquid flow rate detection portion includes a plurality of edges the detection passageway of seting up of second cylinder axis direction, a plurality of detection passageway is followed second cylinder circumference equidistant setting, a plurality of detection passageway diameter reduces in proper order, every the inside two liquid flow rate measurement portion that all is provided with of detection passageway, the collecting vat has been setted up to the inside bottom of second cylinder, a plurality of detection passageway bottom all with collecting vat top intercommunication.

Preferably, the two liquid flow velocity measuring parts are respectively arranged at the top and the bottom of the detection channel, the liquid flow velocity measuring parts comprise connecting rods, one ends of the connecting rods are fixedly embedded in the side wall of the detection channel, the other ends of the connecting rods are fixedly connected with flow velocity detectors, and the flow velocity detectors are positioned in spherical spaces formed by the detection channel.

Preferably, the circulation mechanism comprises a first cylinder, the bottom of the first cylinder is rotationally embedded in the conversion part, the top end of the first cylinder is in sliding contact with the top wall of the shell, the bottom end of the first cylinder is in sliding contact with the bottom wall of the shell, the liquid circulation part is arranged inside the first cylinder, a first gear ring is fixedly sleeved on the top of the outer side wall of the first cylinder, and the first gear ring is in transmission engagement with the second gear ring.

Preferably, the liquid circulation part comprises a plurality of circulation channels arranged along the axial direction of the first cylinder, the plurality of circulation channels are arranged at equal intervals along the circumferential direction of the first cylinder, the diameters of the plurality of circulation channels are sequentially reduced, and the circumferential arrangement mode of the circulation channels is in mirror symmetry with the circumferential arrangement mode of the detection channel.

Preferably, the angle adjusting part comprises a rotary ring, the middle part of the outer side wall of the second cylinder is fixedly sleeved with the rotary ring, the middle parts of the two opposite side walls of the shell are respectively provided with a yielding groove, and the rotary ring is matched with the yielding grooves.

Preferably, the conversion part comprises a moving plate, the moving plate is arranged at the bottom of the inner side of the shell in a sliding manner, a first round hole and a second round hole are arranged on the moving plate in parallel, the bottom of the first cylinder is rotationally embedded in the first round hole, the bottom of the second cylinder is rotationally embedded in the second round hole, push-pull rods are fixedly connected to the middle parts of two opposite side walls of the moving plate respectively, and the push-pull rods penetrate through the side walls of the shell in a sliding manner.

Preferably, an electric control valve is embedded in the middle of the bottom wall of the collecting tank.

Preferably, the middle part of the top wall of the shell is provided with a liquid inlet, the liquid inlet pipe is communicated with the liquid inlet, the middle part of the bottom wall of the shell is provided with a liquid outlet, and the liquid outlet pipe is communicated with the liquid outlet.

Compared with the prior art, the utility model has the following advantages and technical effects:

the device is arranged between the sample outlet of the liquid container and the microfluidic chip, can detect liquid before flowing into the microfluidic chip, and can detect the liquid sample in the detection mechanism through the liquid inlet pipe, after the detection result is qualified, the position of the detection mechanism and the position of the circulating mechanism are adjusted through the arranged conversion part, so that the circulating mechanism is communicated with the liquid inlet pipe and the liquid outlet pipe, the liquid sample can enter the microfluidic chip through the circulating mechanism, the liquid sample in the detection process is discharged through the waste liquid discharge hole and cannot flow into the microfluidic chip in the detection process, and the angle adjusting part can be used for rotatably adjusting the detection mechanism, so that the detection mechanism can correspond to the microfluidic chips with different particle sizes, and whether the liquid sample flowing into the microfluidic chip with different particle sizes can cause blockage to the microfluidic chip is detected.

Drawings

For a clearer description of an embodiment of the utility model or of the solutions of the prior art, the drawings that are needed in the embodiment will be briefly described, it being obvious that the drawings in the following description are only some embodiments of the utility model, and that other drawings can be obtained according to these drawings without inventive effort for a person skilled in the art:

FIG. 1 is a schematic diagram of the overall structure of the present utility model;

FIG. 2 is a schematic diagram of the internal structure of the present utility model;

FIG. 3 is an enlarged view of a portion of FIG. 2A;

FIG. 4 is an enlarged view of a portion of B in FIG. 2;

FIG. 5 is a schematic diagram of the connection of the flow mechanism and the detection mechanism according to the present utility model;

FIG. 6 is a top view of the present utility model;

FIG. 7 is a top view of a mobile plate of the present utility model;

FIG. 8 is a schematic diagram of a flow-through state of the present utility model;

FIG. 9 is a schematic diagram of the detection state of the present utility model.

Wherein, 1, the shell; 2. a first cylinder; 3. a second cylinder; 4. a flow channel; 5. a detection channel; 6. a spherical space; 7. a connecting rod; 8. a flow rate detector; 9. a first ring gear; 10. a second ring gear; 11. a rotating ring; 12. a moving plate; 13. a push-pull rod; 14. a collection tank; 15. an electric control valve; 16. a waste liquid discharge hole; 17. a liquid inlet pipe; 18. a liquid inlet hole; 19. a liquid outlet pipe; 20. a liquid outlet hole; 21. a first round hole; 22. a second round hole; 23. and (5) giving way.

Detailed Description

The following description of the embodiments of the present utility model will be made clearly and completely with reference to the accompanying drawings, in which it is apparent that the embodiments described are only some embodiments of the present utility model, but not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the utility model without making any inventive effort, are intended to be within the scope of the utility model.

In order that the above-recited objects, features and advantages of the present utility model will become more readily apparent, a more particular description of the utility model will be rendered by reference to the appended drawings and appended detailed description.

Referring to fig. 1-9, the utility model provides a microfluidic sample injection front-end detection device, which comprises a housing 1, wherein a conversion part is slidably arranged at the bottom of the inner side of the housing 1, a circulation mechanism and a detection mechanism are rotationally embedded in the conversion part, the circulation mechanism is in transmission connection with the detection mechanism, the top end of the circulation mechanism and the top end of the detection mechanism are in sliding contact with the top wall of the housing 1, the bottom end of the circulation mechanism and the bottom end of the detection mechanism are in sliding contact with the bottom wall of the housing 1, an angle adjusting part is fixedly connected with the middle part of the outer side wall of the detection mechanism, a liquid inlet pipe 17 is fixedly communicated with the middle part of the outer side of the top wall of the housing 1, a liquid outlet pipe 19 is fixedly communicated with the middle part of the outer side wall of the housing 1, and a waste liquid discharge hole 16 is formed in the bottom wall of the housing 1.

The device is arranged between the sample outlet of the liquid container and the microfluidic chip, can detect liquid before flowing into the microfluidic chip, and can detect the liquid sample in the detection mechanism through the liquid inlet pipe 17, after the detection result is qualified, the position of the detection mechanism and the position of the circulating mechanism are adjusted through the arranged conversion part, so that the circulating mechanism is communicated with the liquid inlet pipe 17 and the liquid outlet pipe 19, the liquid sample can enter the microfluidic chip through the circulating mechanism, the liquid sample in the detection process is discharged through the waste liquid discharge hole 16 and cannot flow into the microfluidic chip in the detection process, and the angle adjusting part can rotationally adjust the detection mechanism, so that the detection mechanism can correspond to the microfluidic chips with different particle diameters, and the detection mechanism can detect whether the liquid sample flowing into the microfluidic chips with different particle diameters can block the microfluidic chip.

Further optimizing scheme, detection mechanism includes second cylinder 3, and second cylinder 3 bottom rotates to inlay and establishes in the conversion part, and second cylinder 3 top and shell 1 roof sliding contact, second cylinder 3 bottom and shell 1 diapire sliding contact, and liquid velocity of flow detection portion has been seted up to second cylinder 3 inside, and the fixed cover in second cylinder 3 lateral wall top is equipped with second ring gear 10, and second ring gear 10 is connected with circulation mechanism transmission, and angle adjusting part fixed cover is established at second cylinder 3 lateral wall middle part.

Further optimizing scheme, liquid velocity of flow detection portion includes a plurality of detection channel 5 of seting up along the 3 axis direction of second cylinder, and a plurality of detection channel 5 set up along the 3 circumference equidistant of second cylinder, and a plurality of detection channel 5 diameters reduce in proper order, and every detection channel 5 is inside to be provided with two liquid velocity of flow measurement portions, and collecting vat 14 has been seted up to the inside bottom of second cylinder 3, and a plurality of detection channel 5 bottom all communicate with collecting vat 14 top.

Further optimizing scheme, two liquid flow velocity measurement portions set up respectively at detection channel 5 top and bottom, and liquid flow velocity measurement portion includes connecting rod 7, and connecting rod 7 one end is fixed to be inlayed and is established in detection channel 5 lateral wall, and connecting rod 7 other end fixedly connected with flow velocity detector 8, flow velocity detector 8 are located the spherical space 6 that detection channel 5 offered.

Further optimizing scheme, circulation mechanism includes first cylinder 2, and first cylinder 2 bottom rotates to inlay and establishes in the conversion portion, and first cylinder 2 top and shell 1 roof sliding contact, first cylinder 2 bottom and shell 1 diapire sliding contact, and liquid circulation portion has been seted up to inside the first cylinder 2, and the fixed cover in first cylinder 2 lateral wall top is equipped with first ring gear 9, first ring gear 9 and second ring gear 10 transmission meshing.

Further optimizing scheme, the liquid circulation portion includes a plurality of circulation passageway 4 of seting up along the 2 axis directions of first cylinder, and a plurality of circulation passageway 4 set up along the 2 circumference equidistant of first cylinder, and a plurality of circulation passageway 4 diameters reduce in proper order, and the circumference arrangement mode mirror symmetry of circulation passageway 4 and the circumference arrangement mode of detection passageway 5.

The arrangement of the flow channels 4 with different diameters in the first cylinder 2 is mirror symmetrical to the arrangement of the detection channels 5 with different diameters in the second cylinder 3, that is, when the second cylinder 3 is rotated by the angle adjusting part so that the detection channel 5 with the largest diameter in the second cylinder 3 is located closest to the first cylinder 2, the flow channel 4 with the largest diameter in the first cylinder 2 is also located closest to the second cylinder 3.

Further optimizing scheme, angle adjusting part includes swivel ring 11, and swivel ring 11 fixed cover is established at the second cylinder 3 lateral wall middle part, and the groove 23 of stepping down has been seted up respectively to shell 1 two opposite side wall middle parts, swivel ring 11 and groove 23 looks adaptation of stepping down.

Further optimizing scheme, the conversion part includes movable plate 12, and movable plate 12 slides and sets up in the inboard bottom of shell 1, and first round hole 21, second round hole 22 have been juxtaposed on the movable plate 12, and the rotation of first cylinder 2 bottom is inlayed and is established in first round hole 21, and the rotation of second cylinder 3 bottom is inlayed and is established in second round hole 22, and movable plate 12 two opposite side wall middle parts are fixedly connected with push-and-pull rod 13 respectively, and push-and-pull rod 13 slides and wears to establish in shell 1 lateral wall.

In a further optimized scheme, an electric control valve 15 is embedded in the middle of the bottom wall of the collecting tank 14.

Further optimizing scheme, liquid inlet 18 has been seted up at shell 1 roof middle part, and feed liquor pipe 17 and feed liquor 18 intercommunication have been seted up at shell 1 diapire middle part, and liquid outlet 20 has been seted up, and liquid outlet 19 and liquid outlet 20 intercommunication.

The working process of the utility model is as follows:

when the device is used for detecting liquid samples flowing into the space between the microfluidic chips, the device is firstly arranged between the outlet position of the liquid sample container and the microfluidic chips, then the moving plate 12 is shifted through the push-pull rod 13, so that the second cylinder 3 is positioned between the liquid inlet hole 18 and the liquid outlet hole 20, then the second cylinder 3 is rotated according to the particle size of the microfluidic chips, the detection channel 5 with the same particle size as the microfluidic chips is aligned to the liquid inlet hole 18, then the liquid samples are controlled to flow through the liquid inlet hole 18 and enter the detection channel 5, two flow rates of the liquid samples are detected by the upper flow rate detector 8 and the lower flow rate detector 8 in the detection channel 5, when the two flow rates are equal, the situation that the microfluidic chips are not blocked is indicated, and the angle of the second cylinder 3 is kept unchanged at the moment, the push-pull rod 13 is used for poking the moving plate 12 to enable the second cylinder 3 to leave between the liquid inlet hole 18 and the liquid outlet hole 20, the first cylinder 2 is enabled to enter between the liquid inlet hole 18 and the liquid outlet hole 20, the circulation channel 4 with the same diameter as the detection channel 5 for detecting the fluidity of the liquid sample is communicated with the liquid inlet hole 18 and the liquid outlet hole 20, the liquid sample can normally flow into the micro-fluidic chip, when the flow rate is detected to be reduced, the problem of blocking of the micro-fluidic chip is indicated, the position of the second cylinder 3 is kept unchanged at the moment, the liquid sample is adjusted, the liquid sample is detected again after the adjustment is completed, until the two flow rates are detected to be the same, the liquid sample in the detection process is temporarily stored in the collecting tank 14, when the detection result is qualified or a certain amount of the liquid sample is collected in the collecting tank 14, the second cylinder 3 is moved to enable the electric control valve 15 to be aligned with the waste liquid discharging hole 16, the electronically controlled valve 15 is then opened to expel the liquid sample.

In the description of the present utility model, it should be understood that the terms "longitudinal," "transverse," "upper," "lower," "front," "rear," "left," "right," "vertical," "horizontal," "top," "bottom," "inner," "outer," and the like indicate or are based on the orientation or positional relationship shown in the drawings, merely to facilitate description of the present utility model, and do not indicate or imply that the devices or elements referred to must have a particular orientation, be constructed and operated in a particular orientation, and thus should not be construed as limiting the present utility model.

The above embodiments are only illustrative of the preferred embodiments of the present utility model and are not intended to limit the scope of the present utility model, and various modifications and improvements made by those skilled in the art to the technical solutions of the present utility model should fall within the protection scope defined by the claims of the present utility model without departing from the design spirit of the present utility model.

Claims (10)

1. The utility model provides a leading detection device of microfluidic sample introduction, its characterized in that, including shell (1), the inboard bottom of shell (1) slides and is provided with conversion portion, conversion portion internal rotation is inlayed and is equipped with circulation mechanism, detection mechanism, circulation mechanism with detection mechanism transmission is connected, circulation mechanism top detection mechanism top with shell (1) roof sliding contact, circulation mechanism bottom detection mechanism bottom with shell (1) diapire sliding contact, detection mechanism lateral wall middle part fixedly connected with angle adjustment portion, shell (1) roof outside middle part fixedly communicates there is feed liquor pipe (17), shell (1) diapire outside middle part fixedly communicates there is drain pipe (19), waste liquid discharge hole (16) have been seted up to shell (1) diapire.

2. The microfluidic sample injection front-end detection device according to claim 1, wherein the detection mechanism comprises a second cylinder (3), the bottom of the second cylinder (3) is rotationally embedded in the conversion part, the top end of the second cylinder (3) is in sliding contact with the top wall of the housing (1), the bottom end of the second cylinder (3) is in sliding contact with the bottom wall of the housing (1), a liquid flow velocity detection part is arranged in the second cylinder (3), a second gear ring (10) is fixedly sleeved on the top of the outer side wall of the second cylinder (3), the second gear ring (10) is in transmission connection with the circulation mechanism, and the angle adjustment part is fixedly sleeved in the middle of the outer side wall of the second cylinder (3).

3. The microfluidic sample introduction front-end detection device according to claim 2, wherein the liquid flow rate detection part comprises a plurality of detection channels (5) arranged along the axis direction of the second cylinder (3), the detection channels (5) are arranged at equal intervals along the circumferential direction of the second cylinder (3), the diameters of the detection channels (5) are sequentially reduced, two liquid flow rate measurement parts are arranged in each detection channel (5), a collecting tank (14) is arranged at the bottom end in the second cylinder (3), and the bottom ends of the detection channels (5) are communicated with the top ends of the collecting tanks (14).

4. The microfluidic sample introduction front-end detection device according to claim 3, wherein two liquid flow rate measurement parts are respectively arranged at the top and the bottom of the detection channel (5), each liquid flow rate measurement part comprises a connecting rod (7), one end of each connecting rod (7) is fixedly embedded in the side wall of the detection channel (5), the other end of each connecting rod (7) is fixedly connected with a flow rate detector (8), and the flow rate detector (8) is positioned in a spherical space (6) formed in the detection channel (5).

5. The microfluidic sample introduction front-end detection device according to claim 3, wherein the circulation mechanism comprises a first cylinder (2), the bottom of the first cylinder (2) is rotationally embedded in the conversion part, the top end of the first cylinder (2) is in sliding contact with the top wall of the housing (1), the bottom end of the first cylinder (2) is in sliding contact with the bottom wall of the housing (1), the first cylinder (2) is internally provided with a liquid circulation part, a first gear ring (9) is fixedly sleeved on the top of the outer side wall of the first cylinder (2), and the first gear ring (9) is in driving engagement with the second gear ring (10).

6. The microfluidic sample introduction front-end detection device according to claim 5, wherein the liquid circulation part comprises a plurality of circulation channels (4) arranged along the axial direction of the first cylinder (2), the plurality of circulation channels (4) are arranged at equal intervals along the circumferential direction of the first cylinder (2), the diameters of the plurality of circulation channels (4) are sequentially reduced, and the circumferential arrangement mode of the circulation channels (4) is in mirror symmetry with the circumferential arrangement mode of the detection channels (5).

7. The microfluidic sample introduction front-end detection device according to claim 2, wherein the angle adjusting part comprises a rotary ring (11), the rotary ring (11) is fixedly sleeved at the middle part of the outer side wall of the second cylinder (3), the middle parts of two opposite side walls of the shell (1) are respectively provided with a yielding groove (23), and the rotary ring (11) is matched with the yielding groove (23).

8. The microfluidic sample introduction front-end detection device according to claim 5, wherein the conversion part comprises a moving plate (12), the moving plate (12) is slidably arranged at the bottom of the inner side of the housing (1), a first round hole (21) and a second round hole (22) are formed in the moving plate (12) in parallel, the bottom of the first cylinder (2) is rotationally embedded in the first round hole (21), the bottom of the second cylinder (3) is rotationally embedded in the second round hole (22), push-pull rods (13) are fixedly connected to the middle parts of two opposite side walls of the moving plate (12) respectively, and the push-pull rods (13) are slidably arranged in the side walls of the housing (1).

9. A microfluidic sample introduction front-end detection device according to claim 3, characterized in that an electric control valve (15) is embedded in the middle of the bottom wall of the collection tank (14).

10. The microfluidic sample introduction front-end detection device according to claim 1, wherein a liquid inlet hole (18) is formed in the middle of the top wall of the housing (1), the liquid inlet pipe (17) is communicated with the liquid inlet hole (18), a liquid outlet hole (20) is formed in the middle of the bottom wall of the housing (1), and the liquid outlet pipe (19) is communicated with the liquid outlet hole (20).