CN220460131U - A filter equipment for liposome preparation - Google Patents
A filter equipment for liposome preparation Download PDFInfo
- Publication number
- CN220460131U CN220460131U CN202320746982.3U CN202320746982U CN220460131U CN 220460131 U CN220460131 U CN 220460131U CN 202320746982 U CN202320746982 U CN 202320746982U CN 220460131 U CN220460131 U CN 220460131U
- Authority
- CN
- China
- Prior art keywords
- filter screen
- shell
- liposome
- rotating shaft
- fixed block
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Links
- 239000002502 liposome Substances 0.000 title abstract description 38
- 238000002360 preparation method Methods 0.000 title abstract description 9
- 238000001914 filtration Methods 0.000 claims abstract description 17
- 239000012535 impurity Substances 0.000 claims abstract description 14
- 230000001105 regulatory effect Effects 0.000 claims abstract description 13
- 230000005540 biological transmission Effects 0.000 claims description 9
- 238000007790 scraping Methods 0.000 claims description 8
- 238000004140 cleaning Methods 0.000 claims description 6
- 238000009472 formulation Methods 0.000 claims 5
- 239000000203 mixture Substances 0.000 claims 5
- 230000000694 effects Effects 0.000 abstract description 5
- 238000004519 manufacturing process Methods 0.000 abstract description 4
- 239000002245 particle Substances 0.000 description 9
- 238000000034 method Methods 0.000 description 3
- 239000011162 core material Substances 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000007709 nanocrystallization Methods 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000001276 controlling effect Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 238000001125 extrusion Methods 0.000 description 1
- 238000000265 homogenisation Methods 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 238000011282 treatment Methods 0.000 description 1
Landscapes
- Separation Using Semi-Permeable Membranes (AREA)
Abstract
The utility model belongs to the technical field of liposome production and processing, and particularly relates to a filtering device for a liposome preparation. Through set up drive assembly on the casing, drive assembly drives regulating plate and second filter screen and rotates, and the flow of regulating plate's rotation control liposome, and then improves the filter effect of liposome, realizes the filtration to the liposome through the mutually supporting of first filter screen and second filter screen, reduces the damage of second filter screen simultaneously, improves the life of second filter screen, through setting up the clearance subassembly below the second filter screen, can regularly clear up the impurity on the second filter screen, and then guarantees the filter effect of second filter screen to the liposome.
Description
Technical Field
The utility model belongs to the technical field of liposome production and processing, and particularly relates to a filtering device for a liposome preparation.
Background
The liposome is a core material of the nano-drug nowadays, and the medicament in the pharmaceutical industry has strict requirements on the particle size of the liposome, and the particle size must be within a certain unit and distributed uniformly. The core of liposome preparation is therefore the nanocrystallization of the liposomes and the precise control of the liposome particle size, which requires the nanocrystallization and homogenization treatments using a high-pressure homogenizer and an extrusion filter, respectively. In the existing liposome manufacturing and production process, particle impurities exist in the liposome, so that the purity and quality of the liposome are affected.
In view of the above, the present utility model is to design a filtration device for liposome preparation in order to solve the above problems.
Disclosure of Invention
The utility model aims to: the utility model aims at overcoming the defects in the prior art and provides a filtering device for liposome preparation.
The technical scheme is as follows: in order to achieve the above purpose, the utility model provides a filtering device for liposome preparation, comprising a shell, wherein the top and the bottom of the shell are respectively provided with a feed inlet and a discharge outlet, a transmission assembly is fixedly arranged on the shell and extends into the shell, and the transmission assembly is used for providing power for filtering impurities; the inside top of casing is equipped with the regulating plate of being connected with drive assembly, the regulation hole has been seted up on the regulating plate, the regulating plate below is equipped with fixed block of fixed connection on shells inner wall, the fixed block with drive assembly rotates to be connected, the feed port has been seted up on the fixed block, the feed port position with the regulation hole position is corresponding, the inside first filter screen that is equipped with of feed port, the fixed block below is equipped with the second filter screen of being connected with drive assembly, the second filter screen shape is the bucket form, leave the clearance between second filter screen and the shells inner wall, the below of second filter screen hollow part is equipped with the clearance subassembly, the clearance subassembly is used for clearing up the impurity of second filter screen inner wall.
Further, the transmission assembly comprises a motor fixedly connected to the top of the shell, a rotating shaft extending into the shell is fixedly connected to an output shaft of the motor, the rotating shaft sequentially penetrates through the adjusting plate, the fixing plate and the second filter screen, the rotating shaft is fixedly connected with the adjusting plate, the rotating shaft is rotatably connected with the fixing plate, and the rotating shaft is fixedly connected with the second filter screen.
Further, the cleaning component comprises a base arranged below the hollow part of the second filter screen, an annular groove is formed in the cleaning component, an air cylinder is arranged in the annular groove, and a scraping plate which is connected inside the annular groove in a sliding mode is arranged above the air cylinder.
Further, a door body is arranged on the side wall of the shell corresponding to the base.
Further, the aperture of the second filter screen is smaller than that of the first filter screen.
The beneficial effects are that: through set up drive assembly on the casing, drive assembly drives regulating plate and second filter screen and rotates, and the flow of regulating plate's rotation control liposome, and then improves the filter effect of liposome, realizes the filtration to the liposome through the mutually supporting of first filter screen and second filter screen, reduces the damage of second filter screen simultaneously, improves the life of second filter screen, through setting up the clearance subassembly below the second filter screen, can regularly clear up the impurity on the second filter screen, and then guarantees the filter effect of second filter screen to the liposome.
Drawings
FIG. 1 is a front view of the present utility model;
FIG. 2 is a front cross-sectional view of the present utility model;
FIG. 3 is a cross-sectional view of an adjustment plate of the present utility model;
fig. 4 is a cross-sectional view of a fixing plate of the present utility model.
List of reference numerals: the device comprises a shell 1, a feed inlet 2, a discharge outlet 3, an adjusting plate 4, an adjusting hole 5, a fixed block 6, a feed hole 7, a first filter screen 8, a second filter screen 9, a motor 10, a rotating shaft 11, a base 12, an annular groove 13, an air cylinder 14, a scraping plate 15 and a door body 16.
Description of the embodiments
The present utility model is further illustrated in the following drawings and detailed description, which are to be understood as being merely illustrative of the utility model and not limiting the scope of the utility model. It should be noted that the words "front", "rear", "left", "right", "upper" and "lower" used in the following description refer to directions in the drawings, and the words "inner" and "outer" refer to directions toward or away from, respectively, the geometric center of a particular component.
Example 1 is further illustrated with reference to fig. 1-4.
The utility model provides a filtering device for liposome preparations, which comprises a shell 1, wherein a feed inlet 2 and a discharge outlet 3 are respectively arranged at the top and the bottom of the shell 1, a transmission assembly is fixedly arranged on the shell 1 and extends into the shell 1, and the transmission assembly is used for providing power for filtering impurities; the inside top of casing 1 is equipped with the regulating plate 4 of being connected with drive assembly, regulation hole 5 has been seted up on the regulating plate 4, regulating plate 4 below is equipped with fixed block 6 of fixed connection on casing 1 inner wall, fixed block 6 with drive assembly rotates to be connected, feed port 7 has been seted up on the fixed block 6, feed port 7 position with regulation hole 5 position is corresponding, feed port 7 inside is equipped with first filter screen 8, fixed block 6 below is equipped with the second filter screen 9 of being connected with drive assembly, second filter screen 9 shape is the bucket, leave the clearance between second filter screen 9 and the casing 1 inner wall, the below of second filter screen 9 hollow part is equipped with the clearance subassembly, the clearance subassembly is used for clearing up the impurity of second filter screen 9 inner wall.
The transmission assembly comprises a motor 10 fixedly connected to the top of the shell 1, a rotating shaft 11 extending into the shell 1 is fixedly connected to an output shaft of the motor 10, the rotating shaft 11 sequentially penetrates through the adjusting plate 4, the fixing plate and the second filter screen 9, the rotating shaft 11 is fixedly connected with the adjusting plate 4, the rotating shaft 11 is rotatably connected with the fixing plate, and the rotating shaft 11 is fixedly connected with the second filter screen 9.
The cleaning component comprises a base 12 arranged below the hollow part of the second filter screen 9, an annular groove 13 is formed in the cleaning component, an air cylinder 14 is arranged in the annular groove 13, and a scraping plate 15 which is connected inside the annular groove 13 in a sliding mode is arranged above the air cylinder 14.
The door body 16 is installed on the corresponding side wall of the shell 1 of the base 12.
The aperture of the second filter screen 9 is smaller than that of the first filter screen 8.
When the particles in the liposome are required to be filtered, the liposome is poured into the shell 1 through a feed port 2 arranged at the top of the shell 1, then a motor 10 fixedly connected to the top of the shell 1 is started, an output shaft of the motor 10 rotates to drive a rotating shaft 11 which is arranged in the shell 1 and fixedly connected with the output shaft of the motor 10 to rotate, the rotating shaft 11 rotates to drive an adjusting plate 4 which is arranged above the inside of the shell 1 and is fixedly connected with the rotating shaft 11 to rotate, meanwhile, a second filter screen 9 which is arranged below a fixed block 6 and fixedly connected with the rotating shaft 11 is also driven to rotate, and as the adjusting plate 4 is provided with an adjusting hole 5, the position of the adjusting hole 5 corresponds to the position of the feed port 7 on the fixed block 6, the liposome can enter the feed port 7 through the adjusting hole 5, and as the adjusting hole 5 is smaller than the feed port 7, the speed of the liposome can be slowed down in the rotating process of the adjusting plate 4, the liposome filtering effect is improved, when the liposome enters the feed port 7, the first filter screen 8 arranged in the inside of the feed port 7 can filter larger particles in the liposome, and then the liposome moves to the second filter screen 9 through the second filter screen 9, and finally the liposome passes through the bottom wall 9 and moves to the bottom wall 9, and the second filter screen 9 is arranged in the side wall 1, and the side wall 9 is moved to the bottom the second filter screen 9, and the liposome is discharged from the bottom of the liposome through the second filter screen 9, and the second filter screen 9 is moved to the bottom the filter screen 1;
after the second filter screen 9 works for a long time, more impurities are accumulated on the second filter screen 9, so that an operator stops the motor 10, the cylinder 14 is lifted to drive the scraping plate 15 which is slidably connected to the inside of the annular groove 13 to move upwards by controlling the cylinder 14 arranged in the annular groove 13, impurities on the second filter screen 9 are scraped in the upward movement process of the scraping plate 15, the scraped impurities fall onto the upper surface of the scraping plate 15, after the impurities are scraped, the cylinder 14 moves downwards to drive the scraping plate 15 to move downwards, then the operator opens the door 16 arranged on the side wall of the shell 1 to take out the base 12 from the inside of the shell 1, the impurities are cleaned, and then the cleaned base 12 is put into the inside of the shell 1 by the operator to filter liposome again;
the aperture of the first filter screen 8 is larger than that of the second filter screen 9, so that the first filter screen 8 can filter particles with larger diameters first, and the second filter screen 9 filters smaller particles, so that the particles cannot damage the filter screens due to overlarge centrifugal force in the rotating process of the second filter screen 9, and the service life of the second filter screen 9 is prolonged.
While the foregoing is directed to embodiments of the present utility model, other and further details of the utility model may be had by the present utility model, it should be understood that the foregoing description is merely illustrative of the present utility model and that no limitations are intended to the scope of the utility model, except insofar as modifications, equivalents, improvements or modifications are within the spirit and principles of the utility model.
Claims (5)
1. A filtration device for a liposomal formulation, characterized by: the device comprises a shell, wherein a feed inlet and a discharge outlet are respectively arranged at the top and the bottom of the shell, a transmission assembly is fixedly arranged on the shell and extends into the shell, and the transmission assembly is used for providing power for filtering impurities; the inside top of casing is equipped with the regulating plate of being connected with drive assembly, the regulation hole has been seted up on the regulating plate, the regulating plate below is equipped with fixed block of fixed connection on shells inner wall, the fixed block with drive assembly rotates to be connected, the feed port has been seted up on the fixed block, the feed port position with the regulation hole position is corresponding, the inside first filter screen that is equipped with of feed port, the fixed block below is equipped with the second filter screen of being connected with drive assembly, the second filter screen shape is the bucket form, leave the clearance between second filter screen and the shells inner wall, the below of second filter screen hollow part is equipped with the clearance subassembly, the clearance subassembly is used for clearing up the impurity of second filter screen inner wall.
2. A filtration device for liposomal formulations as claimed in claim 1 wherein: the transmission assembly comprises a motor fixedly connected to the top of the shell, a rotating shaft extending into the shell is fixedly connected to an output shaft of the motor, the rotating shaft sequentially penetrates through the adjusting plate, the fixing plate and the second filter screen, the rotating shaft is fixedly connected with the adjusting plate, the rotating shaft is rotatably connected with the fixing plate, and the rotating shaft is fixedly connected with the second filter screen.
3. A filtration device for liposomal formulations as claimed in claim 1 wherein: the cleaning component comprises a base arranged below the hollow part of the second filter screen, an annular groove is formed in the cleaning component, an air cylinder is arranged in the annular groove, and a scraping plate which is connected inside the annular groove in a sliding mode is arranged above the air cylinder.
4. A filtration device for liposomal formulations as claimed in claim 3 wherein: and a door body is arranged on the side wall of the shell corresponding to the base.
5. A filtration device for liposomal formulations as claimed in claim 1 wherein: the aperture of the second filter screen is smaller than that of the first filter screen.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202320746982.3U CN220460131U (en) | 2023-04-07 | 2023-04-07 | A filter equipment for liposome preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202320746982.3U CN220460131U (en) | 2023-04-07 | 2023-04-07 | A filter equipment for liposome preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN220460131U true CN220460131U (en) | 2024-02-09 |
Family
ID=89804651
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202320746982.3U Active CN220460131U (en) | 2023-04-07 | 2023-04-07 | A filter equipment for liposome preparation |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN220460131U (en) |
-
2023
- 2023-04-07 CN CN202320746982.3U patent/CN220460131U/en active Active
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| Date | Code | Title | Description |
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| GR01 | Patent grant | ||
| GR01 | Patent grant |