CN220432807U - Refining system of prednisolone fermentation crude product - Google Patents
Refining system of prednisolone fermentation crude product Download PDFInfo
- Publication number
- CN220432807U CN220432807U CN202321464435.2U CN202321464435U CN220432807U CN 220432807 U CN220432807 U CN 220432807U CN 202321464435 U CN202321464435 U CN 202321464435U CN 220432807 U CN220432807 U CN 220432807U
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- China
- Prior art keywords
- filter
- reaction kettle
- prednisolone
- fermentation
- crude product
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 229960005205 prednisolone Drugs 0.000 title claims abstract description 56
- OIGNJSKKLXVSLS-VWUMJDOOSA-N prednisolone Chemical compound O=C1C=C[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 OIGNJSKKLXVSLS-VWUMJDOOSA-N 0.000 title claims abstract description 56
- 238000000855 fermentation Methods 0.000 title claims abstract description 46
- 230000004151 fermentation Effects 0.000 title claims abstract description 46
- 239000012043 crude product Substances 0.000 title claims abstract description 28
- 238000007670 refining Methods 0.000 title claims abstract description 25
- 238000003860 storage Methods 0.000 claims abstract description 19
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 29
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 12
- 239000002904 solvent Substances 0.000 claims description 9
- 238000005070 sampling Methods 0.000 claims description 8
- 238000003756 stirring Methods 0.000 claims description 8
- 229910052757 nitrogen Inorganic materials 0.000 claims description 6
- 239000000047 product Substances 0.000 abstract description 24
- 238000004519 manufacturing process Methods 0.000 abstract description 10
- 239000000126 substance Substances 0.000 abstract description 2
- 239000007788 liquid Substances 0.000 description 17
- 238000010992 reflux Methods 0.000 description 12
- 229910052799 carbon Inorganic materials 0.000 description 9
- 238000000034 method Methods 0.000 description 6
- 239000012535 impurity Substances 0.000 description 5
- 230000000694 effects Effects 0.000 description 4
- 239000000843 powder Substances 0.000 description 4
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- 238000001914 filtration Methods 0.000 description 3
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 238000004537 pulping Methods 0.000 description 2
- 238000012797 qualification Methods 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000002425 crystallisation Methods 0.000 description 1
- 230000008025 crystallization Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 230000010354 integration Effects 0.000 description 1
- 239000012046 mixed solvent Substances 0.000 description 1
- 229960004618 prednisone Drugs 0.000 description 1
- XOFYZVNMUHMLCC-ZPOLXVRWSA-N prednisone Chemical compound O=C1C=C[C@]2(C)[C@H]3C(=O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 XOFYZVNMUHMLCC-ZPOLXVRWSA-N 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 239000003270 steroid hormone Substances 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
Landscapes
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
The utility model belongs to the technical field of refining systems of pharmaceutical chemicals, and particularly relates to a refining system of a prednisolone fermentation crude product. The refining system of the prednisolone fermentation crude product comprises the following steps: comprises a filter, a reaction kettle, a filter and a load storage tank; the filter is connected with the reaction kettle, the reaction kettle is connected with the filter, and the filter is connected with the load storage tank; the reaction kettle is provided with a condenser, and the condenser is connected with the reaction kettle through a return pipeline. The refining system of the prednisolone fermentation crude product provided by the utility model shortens the production period, reduces the cost and improves the product quality by adding the reactor, the bag filter and the like.
Description
Technical Field
The utility model belongs to the technical field of refining systems of pharmaceutical chemicals, and particularly relates to a refining system of a prednisolone fermentation crude product.
Background
Prednisolone is a main product in steroid hormone series products, and as the yield increases, the prednisolone fermentation fine product production process exposes the following problems, and has great influence on the production progress and qualification rate of the products.
Firstly, the prednisolone fermentation crude product is detected to be qualified, the prednisolone fermentation crude product enters a load storage tank for temporary storage after being filtered by a filter, the filtering process of each batch of feed liquid is more than 25 hours, the filtering time is long, the feed liquid in the three-in-one filter and a pipeline is easy to crystallize and block the chassis and the conveying pipeline of the three-in-one filter, a large amount of solvents are required to be used for dredging the chassis and the conveying pipeline of the three-in-one filter, the labor force is occupied, the production efficiency is seriously affected, and the problems of long production period and low production efficiency of prednisolone products are caused.
In order to avoid the crystallization of the liquid in the load storage tank, the heat preservation and temporary storage are required to be carried out for a long time (about 60 hours/batch), the prednisolone belongs to a heat-sensitive material, the quality of the liquid is easy to change after long-time heating, the appearance difference between the upper half batch and the lower half batch of the prednisolone fermentation top quality is large, the impurities are obviously different, and the like.
And finally, the processes of the crude product and the secondary crude product of the prednisolone are mixed solvents of methylene dichloride and methanol, the decoloring effect of the added active carbon is poor, and the chromaticity reject ratio is over 90 percent when the product of the prednisolone with chromaticity requirement is produced only by means of the refining process for decoloring. In order to meet the sales requirement, prednisone Long Chengjing is prepared for 2-3 times for refining, so that the material loss is large, and the production cost is high.
Therefore, an improvement is needed to be made on the existing refining system of the prednisolone fermentation crude product to avoid the occurrence of the problems.
Disclosure of Invention
The utility model aims to overcome the defects in the prior art, and provides a refining system of a prednisolone fermentation crude product, which shortens the production period, reduces the cost and improves the product quality by adding a reactor, a bag filter and the like.
The utility model is realized by adopting the following technical scheme:
the refining system of the prednisolone fermentation crude product comprises the following steps: comprises a filter, a reaction kettle, a filter and a load storage tank; the filter is connected with the reaction kettle, the reaction kettle is connected with the filter, and the filter is connected with the load storage tank; the reaction kettle is provided with a condenser, and the condenser is connected with the reaction kettle through a return pipeline.
Preferably, the filter is a three-in-one filter.
Preferably, the filter is a bag filter.
Preferably, the filter is provided with a discharge port, and the discharge port is connected with the reaction kettle.
Preferably, a nitrogen pipeline is arranged on the filter.
Preferably, the reaction kettle is provided with a solvent pipe. The specification of the reaction kettle is 6000L.
Preferably, the reaction kettle is provided with an activated carbon adding port and a sampling port, and 10% of activated carbon is added into the reaction kettle for decoloring the feed liquid in each batch.
Preferably, a stirring device is arranged in the reaction kettle.
When the prednisolone crude fermentation product refining system is in operation, the newly added 6000L reaction kettle, condenser and matched reflux pipeline are used for dissolving and refluxing the prednisolone crude fermentation product, and 10% active carbon is added into the reaction kettle through an active carbon adding port for decoloring the feed liquid in each batch; the method comprises the steps that a discharge hole is added to a prednisolone fermentation crude product through a three-in-one filter, after sampling and detecting are carried out on the prednisolone fermentation crude product through a sampling hole of a reaction kettle, a solvent is added through a solvent pipe for pulping, stirring is carried out through a stirring device, the liquid is pressed into the newly added reaction kettle through a nitrogen pipeline by utilizing air pressure, a 100L bag filter is added between the reaction kettle and a load storage tank, the liquid in the reaction kettle is used for removing carbon and hypha, and the filtered liquid enters the load storage tank. The reflux liquid flows into the reaction kettle through the reflux pipeline, the activated carbon is added through the activated carbon adding port, reflux decoloration is realized, the impurity difference of the prednisolone fermentation essence produced in the upper half batch and the lower half batch is smaller, and the quality of the prednisolone fermentation essence in the upper half batch and the prednisolone fermentation essence in the lower half batch are basically uniform.
The beneficial effects of the utility model are as follows:
(1) According to the refining system of the prednisolone fermentation crude product, the reaction kettle is additionally arranged behind the three-in-one filter, and the condenser is arranged for reflux, so that the activated carbon inlet is additionally arranged, the decoloring effect of the prednisolone product is good, the decoloring reject ratio is reduced, the working efficiency is improved, and the cost is reduced.
(2) The utility model relates to a refining system of a prednisolone fermentation crude product, which is additionally provided with a bag filter, so that the product quality is improved.
Drawings
FIG. 1 is a schematic diagram of a refining system of a crude product of fermentation of prednisolone of the present utility model.
In the figure: 1. a filter; 2. a reaction kettle; 3. a condenser; 4. a filter; 5. a load storage tank; 6. a nitrogen pipeline; 7. a discharge port; 8. a solvent tube; 9. a stirring device; 10. a return line; 11. an activated carbon inlet; 12. and a sampling port.
Detailed Description
The utility model is further described below with reference to the accompanying drawings.
As shown in figure 1, the refining system of the prednisolone fermentation crude product comprises the following steps: comprises a filter 1, a reaction kettle 2, a filter 4 and a load storage tank 5; the filter 1 is connected with the reaction kettle 2, the reaction kettle 2 is connected with the filter 4, and the filter 4 is connected with the load storage tank 5; the reaction kettle 2 is provided with a condenser 3, and the condenser 3 is connected with the reaction kettle 2 through a return pipeline 10.
The filter 1 is a three-in-one filter.
The filter 4 is a bag filter.
The filter 1 is provided with a discharge port 7, and the discharge port 7 is connected with the reaction kettle 2.
The filter 1 is provided with a nitrogen pipeline 6.
The reaction kettle 2 is provided with a solvent pipe 8. The specification of the reaction kettle 2 is 6000L.
The reaction kettle 2 is provided with an activated carbon inlet 11 and a sampling port 12, and 10% of activated carbon is added into the reaction kettle for decoloring the feed liquid in each batch.
The reaction kettle 2 is internally provided with a stirring device 9.
When the prednisolone crude fermentation product refining system is in operation, a newly added 6000L reaction kettle 2, a condenser 3 and a matched reflux pipeline 10 are used for dissolving and refluxing the prednisolone crude fermentation product, and 10% active carbon is added into the reaction kettle 2 through an active carbon inlet 11 for decoloring feed liquid in each batch; the method comprises the steps that a discharge port 7 is added to a prednisolone fermentation crude product through a three-in-one filter 1, after sampling and detecting are carried out on the prednisolone fermentation crude product through a sampling port 12 of a reaction kettle 2, a solvent is added through a solvent pipe 8 for pulping, stirring is carried out through a stirring device 9, air pressure is utilized through a nitrogen pipeline 6, feed liquid is pressed into the newly added reaction kettle 2, a 100L bag filter 4 is added between the reaction kettle 2 and a load storage tank 5, feed liquid in the reaction kettle is used for removing carbon and hypha, and the filtered feed liquid enters the load storage tank 5. The reflux liquid flows into the reaction kettle 2 through the reflux pipeline 10, the active carbon is added through the active carbon adding port 11, reflux decoloration is realized, the impurity difference of the prednisolone fermentation essence produced in the upper half batch and the lower half batch is smaller, and the basically uniform quality of the prednisolone fermentation essence in the upper half batch and the lower half batch is realized.
Through the refining system of the prednisolone fermentation crude product, the prednisolone product is changed from yellow powder into light color or white powder, the appearance is improved, and the chromaticity is reduced from 0.3-0.4 of the raw materials to 0.03.
After the utility model is implemented, obvious effects are generated on the production cycle, the power cost, the intermediate quality and the like of the prednisolone fermentation fine product, and meanwhile, the integration rate of the prednisolone finished product with chromaticity requirements is improved, and the detailed effects are as follows:
(1) the filtering time of each batch of liquid of the prednisolone fermentation crude product is shortened from more than 25 hours to 4 hours, and compared with the prednisolone fermentation refined product before transformation, the capacity can be effectively improved by 1/3 (about 12t years), so that the product can meet the market demand. Meanwhile, the production cost of the prednisolone fermentation refined product is reduced.
(2) The temporary storage time of the prednisolone fermentation refined product in the load storage tank is shortened from more than 60 hours to about 35 hours, and the risk of impurity change is reduced.
(3) The use of activated carbon is increased in the reflux dissolution process, the appearance of the prednisolone fermentation essence is changed from yellow powder to light yellow or white-like powder, and the appearance is obviously improved: the impurity difference of the prednisolone fermentation essence produced in the upper half batch and the lower half batch is smaller, so that the quality of the prednisolone fermentation essence in the upper half batch and the prednisolone fermentation essence in the lower half batch is basically uniform.
(4) After the appearance of the prednisolone fermentation refined product is improved, the chromaticity of the prednisolone finished product is obviously improved, and the qualification rate of the prednisolone finished product is further improved.
Of course, the foregoing is merely preferred embodiments of the present utility model and is not to be construed as limiting the scope of the embodiments of the present utility model. The present utility model is not limited to the above examples, and those skilled in the art will appreciate that the present utility model is capable of equally varying and improving within the spirit and scope of the present utility model.
Claims (5)
1. A refining system of prednisolone fermentation crude product is characterized in that: comprises a filter (1), a reaction kettle (2), a filter (4) and a load storage tank (5); the filter (1) is connected with the reaction kettle (2), the reaction kettle (2) is connected with the filter (4), and the filter (4) is connected with the load storage tank (5); the reaction kettle (2) is provided with a condenser (3), and the condenser (3) is connected with the reaction kettle (2) through a return pipeline (10); the filter (1) is a three-in-one filter; the filter (4) is a bag filter; the reaction kettle (2) is provided with an activated carbon adding port (11) and a sampling port (12).
2. The system for refining a crude product of fermentation of prednisolone according to claim 1, characterized in that: the filter (1) is provided with a discharge hole (7), and the discharge hole (7) is connected with the reaction kettle (2).
3. The system for refining a crude product of fermentation of prednisolone according to claim 1, characterized in that: the filter (1) is provided with a nitrogen pipeline (6).
4. The system for refining a crude product of fermentation of prednisolone according to claim 1, characterized in that: the reaction kettle (2) is provided with a solvent pipe (8).
5. The system for refining a crude product of fermentation of prednisolone according to claim 1, characterized in that: the reaction kettle (2) is internally provided with a stirring device (9).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202321464435.2U CN220432807U (en) | 2023-06-08 | 2023-06-08 | Refining system of prednisolone fermentation crude product |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202321464435.2U CN220432807U (en) | 2023-06-08 | 2023-06-08 | Refining system of prednisolone fermentation crude product |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN220432807U true CN220432807U (en) | 2024-02-02 |
Family
ID=89699836
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202321464435.2U Active CN220432807U (en) | 2023-06-08 | 2023-06-08 | Refining system of prednisolone fermentation crude product |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN220432807U (en) |
-
2023
- 2023-06-08 CN CN202321464435.2U patent/CN220432807U/en active Active
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| GR01 | Patent grant | ||
| GR01 | Patent grant |